DUF4201 domain-containing protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2S2_LEIIN

TriTrypDb:

LINF_270018600

Length:

411

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 70
Promastigote/Amastigote: 388

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I2S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2S2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.453
CLV_C14_Caspase3-7	308	312	PF00656	0.524
CLV_C14_Caspase3-7	49	53	PF00656	0.525
CLV_NRD_NRD_1	211	213	PF00675	0.469
CLV_NRD_NRD_1	232	234	PF00675	0.460
CLV_NRD_NRD_1	257	259	PF00675	0.416
CLV_NRD_NRD_1	368	370	PF00675	0.429
CLV_NRD_NRD_1	372	374	PF00675	0.430
CLV_NRD_NRD_1	408	410	PF00675	0.548
CLV_NRD_NRD_1	68	70	PF00675	0.712
CLV_PCSK_FUR_1	366	370	PF00082	0.424
CLV_PCSK_KEX2_1	232	234	PF00082	0.593
CLV_PCSK_KEX2_1	257	259	PF00082	0.428
CLV_PCSK_KEX2_1	34	36	PF00082	0.507
CLV_PCSK_KEX2_1	368	370	PF00082	0.480
CLV_PCSK_KEX2_1	372	374	PF00082	0.472
CLV_PCSK_KEX2_1	68	70	PF00082	0.708
CLV_PCSK_KEX2_1	91	93	PF00082	0.390
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.572
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.390
CLV_PCSK_PC7_1	228	234	PF00082	0.537
CLV_PCSK_PC7_1	368	374	PF00082	0.556
CLV_PCSK_PC7_1	64	70	PF00082	0.600
CLV_PCSK_SKI1_1	103	107	PF00082	0.470
CLV_PCSK_SKI1_1	109	113	PF00082	0.487
CLV_PCSK_SKI1_1	183	187	PF00082	0.433
CLV_PCSK_SKI1_1	258	262	PF00082	0.506
CLV_Separin_Metazoa	184	188	PF03568	0.509
DEG_APCC_DBOX_1	257	265	PF00400	0.474
DEG_APCC_DBOX_1	371	379	PF00400	0.519
DOC_CYCLIN_RxL_1	100	110	PF00134	0.406
DOC_MAPK_gen_1	152	161	PF00069	0.482
DOC_MAPK_gen_1	31	39	PF00069	0.481
DOC_MAPK_MEF2A_6	171	178	PF00069	0.468
DOC_USP7_MATH_1	356	360	PF00917	0.507
DOC_USP7_MATH_1	67	71	PF00917	0.706
DOC_USP7_UBL2_3	380	384	PF12436	0.530
LIG_BIR_II_1	1	5	PF00653	0.477
LIG_Clathr_ClatBox_1	13	17	PF01394	0.537
LIG_FHA_2	194	200	PF00498	0.611
LIG_FHA_2	212	218	PF00498	0.461
LIG_FHA_2	243	249	PF00498	0.568
LIG_FHA_2	298	304	PF00498	0.608
LIG_FHA_2	358	364	PF00498	0.533
LIG_LIR_Nem_3	127	133	PF02991	0.477
LIG_Rb_pABgroove_1	320	328	PF01858	0.515
LIG_SH2_STAP1	326	330	PF00017	0.514
LIG_SH2_STAT5	130	133	PF00017	0.535
LIG_SH2_STAT5	249	252	PF00017	0.525
LIG_SH2_STAT5	29	32	PF00017	0.486
LIG_SH2_STAT5	374	377	PF00017	0.411
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.430
LIG_SUMO_SIM_par_1	5	10	PF11976	0.576
LIG_TRAF2_1	126	129	PF00917	0.440
LIG_UBA3_1	13	21	PF00899	0.528
MOD_CK1_1	2	8	PF00069	0.445
MOD_CK1_1	40	46	PF00069	0.539
MOD_CK1_1	53	59	PF00069	0.614
MOD_CK1_1	60	66	PF00069	0.590
MOD_CK1_1	98	104	PF00069	0.578
MOD_CK2_1	193	199	PF00069	0.563
MOD_CK2_1	2	8	PF00069	0.617
MOD_CK2_1	211	217	PF00069	0.449
MOD_CK2_1	357	363	PF00069	0.492
MOD_CK2_1	90	96	PF00069	0.602
MOD_GlcNHglycan	146	149	PF01048	0.608
MOD_GlcNHglycan	350	353	PF01048	0.599
MOD_GlcNHglycan	406	409	PF01048	0.578
MOD_GlcNHglycan	65	68	PF01048	0.662
MOD_GlcNHglycan	69	72	PF01048	0.647
MOD_GSK3_1	138	145	PF00069	0.508
MOD_GSK3_1	193	200	PF00069	0.488
MOD_GSK3_1	33	40	PF00069	0.462
MOD_GSK3_1	385	392	PF00069	0.455
MOD_GSK3_1	399	406	PF00069	0.482
MOD_GSK3_1	50	57	PF00069	0.493
MOD_GSK3_1	63	70	PF00069	0.558
MOD_LATS_1	355	361	PF00433	0.509
MOD_N-GLC_1	40	45	PF02516	0.484
MOD_NEK2_1	30	35	PF00069	0.445
MOD_NEK2_1	325	330	PF00069	0.430
MOD_NEK2_1	37	42	PF00069	0.462
MOD_NEK2_1	403	408	PF00069	0.473
MOD_NEK2_1	50	55	PF00069	0.388
MOD_NEK2_1	7	12	PF00069	0.442
MOD_PIKK_1	197	203	PF00454	0.517
MOD_PIKK_1	57	63	PF00454	0.570
MOD_PKA_2	211	217	PF00069	0.335
MOD_PKA_2	250	256	PF00069	0.486
MOD_PKA_2	30	36	PF00069	0.557
MOD_PKA_2	348	354	PF00069	0.422
MOD_PKA_2	385	391	PF00069	0.403
MOD_PKA_2	404	410	PF00069	0.596
MOD_PKA_2	50	56	PF00069	0.392
MOD_PKA_2	63	69	PF00069	0.696
MOD_Plk_1	357	363	PF00069	0.503
MOD_Plk_1	95	101	PF00069	0.469
MOD_Plk_4	2	8	PF00069	0.496
MOD_Plk_4	357	363	PF00069	0.461
MOD_Plk_4	389	395	PF00069	0.431
MOD_SUMO_for_1	117	120	PF00179	0.587
MOD_SUMO_rev_2	207	214	PF00179	0.441
MOD_SUMO_rev_2	38	48	PF00179	0.497
TRG_ENDOCYTIC_2	130	133	PF00928	0.444
TRG_ENDOCYTIC_2	280	283	PF00928	0.541
TRG_ER_diArg_1	257	259	PF00400	0.430
TRG_ER_diArg_1	366	369	PF00400	0.541
TRG_ER_diArg_1	372	374	PF00400	0.504
TRG_NES_CRM1_1	129	142	PF08389	0.462
TRG_NES_CRM1_1	284	297	PF08389	0.430
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHJ5	Leptomonas seymouri	63%	96%
A0A1X0P450	Trypanosomatidae	30%	100%
A0A3R7M124	Trypanosoma rangeli	29%	100%
A0A3S7X0N0	Leishmania donovani	100%	100%
A4HFP7	Leishmania braziliensis	72%	100%
D0A5Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ADA0	Leishmania major	88%	100%
E9AZ25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5AT73	Trypanosoma cruzi	29%	100%