Putative translation initiation factor eIF2B subunit-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor eIF2B delta subunit - putative

Species:

Leishmania infantum

UniProt:

A4I2S1_LEIIN

TriTrypDb:

LINF_270018500

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I2S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2S1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003743	translation initiation factor activity	4	9
GO:0005488	binding	1	9
GO:0008135	translation factor activity, RNA binding	3	9
GO:0045182	translation regulator activity	1	9
GO:0090079	translation regulator activity, nucleic acid binding	2	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.520
CLV_NRD_NRD_1	348	350	PF00675	0.496
CLV_NRD_NRD_1	366	368	PF00675	0.289
CLV_NRD_NRD_1	42	44	PF00675	0.504
CLV_NRD_NRD_1	528	530	PF00675	0.301
CLV_NRD_NRD_1	80	82	PF00675	0.499
CLV_PCSK_FUR_1	348	352	PF00082	0.528
CLV_PCSK_KEX2_1	152	154	PF00082	0.499
CLV_PCSK_KEX2_1	256	258	PF00082	0.670
CLV_PCSK_KEX2_1	348	350	PF00082	0.492
CLV_PCSK_KEX2_1	366	368	PF00082	0.294
CLV_PCSK_KEX2_1	38	40	PF00082	0.500
CLV_PCSK_KEX2_1	454	456	PF00082	0.356
CLV_PCSK_KEX2_1	47	49	PF00082	0.512
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.499
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.655
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.571
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.500
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.360
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.512
CLV_PCSK_PC7_1	43	49	PF00082	0.425
CLV_PCSK_SKI1_1	147	151	PF00082	0.510
CLV_PCSK_SKI1_1	153	157	PF00082	0.494
CLV_PCSK_SKI1_1	244	248	PF00082	0.704
CLV_PCSK_SKI1_1	33	37	PF00082	0.502
CLV_PCSK_SKI1_1	358	362	PF00082	0.486
CLV_PCSK_SKI1_1	393	397	PF00082	0.498
CLV_PCSK_SKI1_1	47	51	PF00082	0.525
CLV_PCSK_SKI1_1	530	534	PF00082	0.287
CLV_PCSK_SKI1_1	7	11	PF00082	0.567
DEG_APCC_DBOX_1	152	160	PF00400	0.628
DEG_COP1_1	320	328	PF00400	0.546
DEG_COP1_1	536	545	PF00400	0.527
DEG_SPOP_SBC_1	615	619	PF00917	0.519
DOC_CKS1_1	578	583	PF01111	0.602
DOC_CKS1_1	595	600	PF01111	0.452
DOC_MAPK_gen_1	452	459	PF00069	0.559
DOC_MAPK_gen_1	526	535	PF00069	0.501
DOC_MAPK_gen_1	7	17	PF00069	0.584
DOC_MAPK_MEF2A_6	286	294	PF00069	0.502
DOC_MAPK_MEF2A_6	526	535	PF00069	0.501
DOC_MAPK_MEF2A_6	540	547	PF00069	0.501
DOC_MIT_MIM_1	362	372	PF04212	0.490
DOC_PP2B_LxvP_1	323	326	PF13499	0.560
DOC_PP2B_LxvP_1	584	587	PF13499	0.557
DOC_PP4_FxxP_1	528	531	PF00568	0.501
DOC_USP7_MATH_1	103	107	PF00917	0.594
DOC_USP7_MATH_1	124	128	PF00917	0.601
DOC_USP7_MATH_1	206	210	PF00917	0.805
DOC_USP7_MATH_1	324	328	PF00917	0.615
DOC_USP7_MATH_1	378	382	PF00917	0.632
DOC_USP7_MATH_1	421	425	PF00917	0.560
DOC_USP7_MATH_1	615	619	PF00917	0.572
DOC_USP7_MATH_1	90	94	PF00917	0.549
DOC_USP7_UBL2_3	121	125	PF12436	0.738
DOC_USP7_UBL2_3	158	162	PF12436	0.533
DOC_USP7_UBL2_3	408	412	PF12436	0.506
DOC_USP7_UBL2_3	526	530	PF12436	0.501
DOC_USP7_UBL2_3	7	11	PF12436	0.567
DOC_WW_Pin1_4	101	106	PF00397	0.696
DOC_WW_Pin1_4	209	214	PF00397	0.756
DOC_WW_Pin1_4	216	221	PF00397	0.752
DOC_WW_Pin1_4	571	576	PF00397	0.489
DOC_WW_Pin1_4	577	582	PF00397	0.478
DOC_WW_Pin1_4	594	599	PF00397	0.517
DOC_WW_Pin1_4	625	630	PF00397	0.501
LIG_14-3-3_CanoR_1	251	258	PF00244	0.655
LIG_14-3-3_CanoR_1	318	323	PF00244	0.532
LIG_14-3-3_CanoR_1	434	438	PF00244	0.501
LIG_Actin_WH2_2	392	410	PF00022	0.547
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BRCT_BRCA1_1	537	541	PF00533	0.501
LIG_CtBP_PxDLS_1	108	112	PF00389	0.591
LIG_FHA_1	199	205	PF00498	0.802
LIG_FHA_1	219	225	PF00498	0.652
LIG_FHA_1	318	324	PF00498	0.490
LIG_FHA_1	394	400	PF00498	0.465
LIG_FHA_1	426	432	PF00498	0.503
LIG_FHA_1	480	486	PF00498	0.501
LIG_FHA_1	643	649	PF00498	0.552
LIG_FHA_1	658	664	PF00498	0.519
LIG_FHA_2	117	123	PF00498	0.576
LIG_FHA_2	143	149	PF00498	0.477
LIG_FHA_2	245	251	PF00498	0.635
LIG_FHA_2	332	338	PF00498	0.537
LIG_LIR_Apic_2	592	598	PF02991	0.560
LIG_LIR_Gen_1	333	344	PF02991	0.416
LIG_LIR_Gen_1	631	640	PF02991	0.548
LIG_LIR_Nem_3	311	316	PF02991	0.416
LIG_LIR_Nem_3	333	339	PF02991	0.428
LIG_LIR_Nem_3	410	414	PF02991	0.485
LIG_LIR_Nem_3	439	443	PF02991	0.560
LIG_LIR_Nem_3	482	486	PF02991	0.504
LIG_LIR_Nem_3	536	542	PF02991	0.527
LIG_MYND_1	582	586	PF01753	0.570
LIG_SH2_CRK	483	487	PF00017	0.501
LIG_SH2_CRK	539	543	PF00017	0.560
LIG_SH2_CRK	578	582	PF00017	0.445
LIG_SH2_PTP2	440	443	PF00017	0.560
LIG_SH2_STAT5	422	425	PF00017	0.525
LIG_SH2_STAT5	440	443	PF00017	0.525
LIG_SH2_STAT5	623	626	PF00017	0.501
LIG_SH2_STAT5	632	635	PF00017	0.501
LIG_SH3_3	102	108	PF00018	0.677
LIG_SH3_3	279	285	PF00018	0.581
LIG_SH3_3	372	378	PF00018	0.539
LIG_SUMO_SIM_anti_2	289	295	PF11976	0.456
LIG_SUMO_SIM_anti_2	381	388	PF11976	0.434
LIG_SUMO_SIM_par_1	106	113	PF11976	0.591
LIG_SUMO_SIM_par_1	221	228	PF11976	0.662
LIG_SUMO_SIM_par_1	320	327	PF11976	0.602
LIG_SUMO_SIM_par_1	398	404	PF11976	0.444
LIG_SUMO_SIM_par_1	455	461	PF11976	0.501
LIG_TRAF2_1	247	250	PF00917	0.635
LIG_TRFH_1	625	629	PF08558	0.501
LIG_TYR_ITIM	438	443	PF00017	0.560
LIG_TYR_ITIM	481	486	PF00017	0.501
LIG_UBA3_1	399	408	PF00899	0.541
MOD_CDK_SPxK_1	594	600	PF00069	0.560
MOD_CK1_1	104	110	PF00069	0.754
MOD_CK1_1	165	171	PF00069	0.651
MOD_CK1_1	193	199	PF00069	0.667
MOD_CK1_1	2	8	PF00069	0.506
MOD_CK1_1	209	215	PF00069	0.597
MOD_CK1_1	317	323	PF00069	0.494
MOD_CK1_1	410	416	PF00069	0.409
MOD_CK1_1	425	431	PF00069	0.501
MOD_CK1_1	618	624	PF00069	0.542
MOD_CK2_1	116	122	PF00069	0.725
MOD_CK2_1	132	138	PF00069	0.545
MOD_CK2_1	142	148	PF00069	0.508
MOD_CK2_1	165	171	PF00069	0.595
MOD_CK2_1	17	23	PF00069	0.419
MOD_CK2_1	2	8	PF00069	0.506
MOD_CK2_1	244	250	PF00069	0.627
MOD_CK2_1	324	330	PF00069	0.564
MOD_CK2_1	331	337	PF00069	0.509
MOD_CK2_1	410	416	PF00069	0.409
MOD_CK2_1	433	439	PF00069	0.501
MOD_GlcNHglycan	112	115	PF01048	0.665
MOD_GlcNHglycan	134	137	PF01048	0.655
MOD_GlcNHglycan	140	143	PF01048	0.663
MOD_GlcNHglycan	192	195	PF01048	0.662
MOD_GlcNHglycan	196	199	PF01048	0.718
MOD_GlcNHglycan	208	211	PF01048	0.566
MOD_GlcNHglycan	231	234	PF01048	0.652
MOD_GlcNHglycan	238	241	PF01048	0.690
MOD_GlcNHglycan	253	256	PF01048	0.638
MOD_GlcNHglycan	302	305	PF01048	0.478
MOD_GlcNHglycan	310	313	PF01048	0.422
MOD_GlcNHglycan	352	356	PF01048	0.413
MOD_GlcNHglycan	460	463	PF01048	0.318
MOD_GlcNHglycan	475	478	PF01048	0.255
MOD_GlcNHglycan	503	506	PF01048	0.358
MOD_GlcNHglycan	591	594	PF01048	0.331
MOD_GlcNHglycan	607	610	PF01048	0.265
MOD_GlcNHglycan	618	621	PF01048	0.328
MOD_GlcNHglycan	645	648	PF01048	0.424
MOD_GlcNHglycan	92	95	PF01048	0.674
MOD_GSK3_1	103	110	PF00069	0.707
MOD_GSK3_1	112	119	PF00069	0.647
MOD_GSK3_1	138	145	PF00069	0.671
MOD_GSK3_1	190	197	PF00069	0.637
MOD_GSK3_1	208	215	PF00069	0.755
MOD_GSK3_1	218	225	PF00069	0.652
MOD_GSK3_1	314	321	PF00069	0.473
MOD_GSK3_1	421	428	PF00069	0.501
MOD_GSK3_1	484	491	PF00069	0.525
MOD_GSK3_1	565	572	PF00069	0.541
MOD_GSK3_1	614	621	PF00069	0.515
MOD_N-GLC_1	228	233	PF02516	0.678
MOD_NEK2_1	407	412	PF00069	0.451
MOD_NEK2_1	432	437	PF00069	0.501
MOD_NEK2_1	501	506	PF00069	0.525
MOD_NEK2_1	535	540	PF00069	0.501
MOD_NEK2_1	589	594	PF00069	0.591
MOD_NEK2_1	605	610	PF00069	0.397
MOD_NEK2_1	616	621	PF00069	0.564
MOD_NEK2_1	643	648	PF00069	0.548
MOD_PIKK_1	124	130	PF00454	0.573
MOD_PIKK_1	142	148	PF00454	0.382
MOD_PIKK_1	658	664	PF00454	0.601
MOD_PKA_2	317	323	PF00069	0.499
MOD_PKA_2	433	439	PF00069	0.501
MOD_PKA_2	589	595	PF00069	0.548
MOD_PKA_2	657	663	PF00069	0.604
MOD_PKB_1	349	357	PF00069	0.420
MOD_Plk_1	331	337	PF00069	0.509
MOD_Plk_1	393	399	PF00069	0.451
MOD_Plk_1	416	422	PF00069	0.511
MOD_Plk_1	658	664	PF00069	0.601
MOD_Plk_4	318	324	PF00069	0.531
MOD_Plk_4	378	384	PF00069	0.617
MOD_Plk_4	410	416	PF00069	0.409
MOD_Plk_4	425	431	PF00069	0.501
MOD_Plk_4	433	439	PF00069	0.501
MOD_Plk_4	488	494	PF00069	0.501
MOD_Plk_4	628	634	PF00069	0.516
MOD_ProDKin_1	101	107	PF00069	0.696
MOD_ProDKin_1	209	215	PF00069	0.757
MOD_ProDKin_1	216	222	PF00069	0.752
MOD_ProDKin_1	571	577	PF00069	0.489
MOD_ProDKin_1	582	588	PF00069	0.472
MOD_ProDKin_1	594	600	PF00069	0.501
MOD_ProDKin_1	625	631	PF00069	0.501
MOD_SUMO_rev_2	401	410	PF00179	0.494
MOD_SUMO_rev_2	75	84	PF00179	0.393
TRG_DiLeu_BaEn_1	289	294	PF01217	0.499
TRG_DiLeu_BaEn_1	295	300	PF01217	0.525
TRG_DiLeu_BaEn_2	536	542	PF01217	0.501
TRG_ENDOCYTIC_2	440	443	PF00928	0.560
TRG_ENDOCYTIC_2	483	486	PF00928	0.501
TRG_ENDOCYTIC_2	539	542	PF00928	0.560
TRG_ENDOCYTIC_2	632	635	PF00928	0.510
TRG_ER_diArg_1	347	349	PF00400	0.468
TRG_ER_diArg_1	365	367	PF00400	0.296
TRG_NLS_Bipartite_1	150	165	PF00514	0.607
TRG_NLS_MonoExtN_4	158	165	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D4	Leptomonas seymouri	67%	99%
A0A1X0P4F2	Trypanosomatidae	43%	100%
A0A3Q8IE91	Leishmania donovani	100%	100%
A4HFP5	Leishmania braziliensis	87%	100%
D0A5X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AD99	Leishmania major	93%	100%
E9AZ24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%