S1-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2R8_LEIIN

TriTrypDb:

LINF_270018100

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2R8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.713
CLV_C14_Caspase3-7	70	74	PF00656	0.689
CLV_NRD_NRD_1	100	102	PF00675	0.455
CLV_NRD_NRD_1	5	7	PF00675	0.524
CLV_PCSK_SKI1_1	11	15	PF00082	0.475
CLV_PCSK_SKI1_1	146	150	PF00082	0.571
CLV_PCSK_SKI1_1	158	162	PF00082	0.547
CLV_PCSK_SKI1_1	215	219	PF00082	0.638
CLV_PCSK_SKI1_1	45	49	PF00082	0.422
DEG_APCC_DBOX_1	157	165	PF00400	0.686
DEG_SCF_FBW7_1	64	69	PF00400	0.577
DEG_SPOP_SBC_1	171	175	PF00917	0.637
DOC_MAPK_gen_1	101	111	PF00069	0.417
DOC_MAPK_MEF2A_6	102	111	PF00069	0.423
DOC_MAPK_MEF2A_6	27	36	PF00069	0.555
DOC_PP1_RVXF_1	103	109	PF00149	0.426
DOC_PP2B_LxvP_1	48	51	PF13499	0.522
DOC_USP7_MATH_1	66	70	PF00917	0.628
DOC_USP7_MATH_1	78	82	PF00917	0.713
DOC_USP7_MATH_1	83	87	PF00917	0.668
DOC_USP7_UBL2_3	7	11	PF12436	0.527
DOC_WW_Pin1_4	124	129	PF00397	0.456
DOC_WW_Pin1_4	35	40	PF00397	0.442
DOC_WW_Pin1_4	60	65	PF00397	0.680
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BIR_III_4	19	23	PF00653	0.519
LIG_Clathr_ClatBox_1	90	94	PF01394	0.506
LIG_FHA_1	172	178	PF00498	0.601
LIG_LIR_Apic_2	21	26	PF02991	0.476
LIG_LIR_LC3C_4	113	116	PF02991	0.228
LIG_PDZ_Class_3	236	241	PF00595	0.679
LIG_SH2_SRC	17	20	PF00017	0.562
LIG_SH2_STAP1	167	171	PF00017	0.674
LIG_SH2_STAT5	17	20	PF00017	0.558
LIG_SH3_3	206	212	PF00018	0.671
LIG_SH3_3	94	100	PF00018	0.437
LIG_SUMO_SIM_anti_2	113	119	PF11976	0.402
LIG_SUMO_SIM_par_1	113	119	PF11976	0.402
LIG_SUMO_SIM_par_1	89	94	PF11976	0.522
LIG_TRAF2_1	231	234	PF00917	0.615
MOD_CK1_1	124	130	PF00069	0.462
MOD_CK1_1	176	182	PF00069	0.673
MOD_CK1_1	58	64	PF00069	0.714
MOD_CK1_1	69	75	PF00069	0.708
MOD_CK2_1	199	205	PF00069	0.705
MOD_CK2_1	228	234	PF00069	0.614
MOD_Cter_Amidation	4	7	PF01082	0.533
MOD_GlcNHglycan	1	4	PF01048	0.574
MOD_GlcNHglycan	184	187	PF01048	0.661
MOD_GlcNHglycan	19	23	PF01048	0.449
MOD_GlcNHglycan	53	56	PF01048	0.638
MOD_GlcNHglycan	85	88	PF01048	0.703
MOD_GSK3_1	120	127	PF00069	0.552
MOD_GSK3_1	167	174	PF00069	0.609
MOD_GSK3_1	51	58	PF00069	0.582
MOD_GSK3_1	62	69	PF00069	0.643
MOD_NEK2_1	18	23	PF00069	0.514
MOD_PIKK_1	11	17	PF00454	0.615
MOD_PKA_2	187	193	PF00069	0.741
MOD_PKB_1	144	152	PF00069	0.507
MOD_Plk_4	173	179	PF00069	0.632
MOD_ProDKin_1	124	130	PF00069	0.454
MOD_ProDKin_1	35	41	PF00069	0.444
MOD_ProDKin_1	60	66	PF00069	0.678
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I4	Leptomonas seymouri	61%	96%
A0A1X0P448	Trypanosomatidae	36%	82%
A0A3Q8IEC6	Leishmania donovani	100%	100%
A0A3R7MDN0	Trypanosoma rangeli	44%	100%
A4HFP2	Leishmania braziliensis	80%	100%
D0A5X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AD95	Leishmania major	90%	100%
E9AZ20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5B8N2	Trypanosoma cruzi	42%	100%