Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

JmjC domain - hydroxylase - putative

Species:

Leishmania infantum

UniProt:

A4I2R6_LEIIN

TriTrypDb:

LINF_270017900

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I2R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2R6

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0006449	regulation of translational termination	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0018126	protein hydroxylation	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043243	positive regulation of protein-containing complex disassembly	6	1
GO:0043244	regulation of protein-containing complex disassembly	5	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045727	positive regulation of translation	7	1
GO:0045905	positive regulation of translational termination	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0051213	dioxygenase activity	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.523
CLV_C14_Caspase3-7	194	198	PF00656	0.347
CLV_C14_Caspase3-7	408	412	PF00656	0.308
CLV_C14_Caspase3-7	447	451	PF00656	0.487
CLV_NRD_NRD_1	416	418	PF00675	0.346
CLV_NRD_NRD_1	47	49	PF00675	0.396
CLV_NRD_NRD_1	88	90	PF00675	0.578
CLV_PCSK_KEX2_1	416	418	PF00082	0.346
CLV_PCSK_KEX2_1	46	48	PF00082	0.460
CLV_PCSK_KEX2_1	484	486	PF00082	0.650
CLV_PCSK_KEX2_1	88	90	PF00082	0.578
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.453
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.650
CLV_PCSK_SKI1_1	295	299	PF00082	0.308
CLV_PCSK_SKI1_1	382	386	PF00082	0.329
DEG_Nend_Nbox_1	1	3	PF02207	0.438
DEG_SPOP_SBC_1	122	126	PF00917	0.339
DEG_SPOP_SBC_1	158	162	PF00917	0.490
DOC_CKS1_1	288	293	PF01111	0.505
DOC_PP2B_PxIxI_1	291	297	PF00149	0.437
DOC_PP4_FxxP_1	288	291	PF00568	0.514
DOC_USP7_MATH_1	123	127	PF00917	0.553
DOC_USP7_MATH_1	148	152	PF00917	0.392
DOC_USP7_MATH_1	163	167	PF00917	0.469
DOC_USP7_MATH_1	242	246	PF00917	0.468
DOC_USP7_MATH_1	68	72	PF00917	0.521
DOC_WW_Pin1_4	128	133	PF00397	0.617
DOC_WW_Pin1_4	244	249	PF00397	0.416
DOC_WW_Pin1_4	287	292	PF00397	0.505
DOC_WW_Pin1_4	78	83	PF00397	0.675
LIG_14-3-3_CanoR_1	392	400	PF00244	0.381
LIG_BIR_III_4	33	37	PF00653	0.347
LIG_BRCT_BRCA1_1	257	261	PF00533	0.514
LIG_DCNL_PONY_1	1	4	PF03556	0.433
LIG_deltaCOP1_diTrp_1	194	199	PF00928	0.299
LIG_deltaCOP1_diTrp_1	266	271	PF00928	0.422
LIG_EH1_1	377	385	PF00400	0.354
LIG_eIF4E_1	279	285	PF01652	0.519
LIG_EVH1_1	288	292	PF00568	0.522
LIG_FHA_1	109	115	PF00498	0.338
LIG_FHA_1	153	159	PF00498	0.532
LIG_FHA_1	325	331	PF00498	0.576
LIG_FHA_1	365	371	PF00498	0.399
LIG_FHA_1	375	381	PF00498	0.345
LIG_FHA_1	433	439	PF00498	0.489
LIG_FHA_1	70	76	PF00498	0.612
LIG_FHA_2	177	183	PF00498	0.356
LIG_FHA_2	288	294	PF00498	0.456
LIG_FHA_2	296	302	PF00498	0.413
LIG_FHA_2	74	80	PF00498	0.541
LIG_FHA_2	93	99	PF00498	0.696
LIG_LIR_Apic_2	182	188	PF02991	0.371
LIG_LIR_Apic_2	266	272	PF02991	0.422
LIG_LIR_Gen_1	234	243	PF02991	0.249
LIG_LIR_Gen_1	430	438	PF02991	0.439
LIG_LIR_Gen_1	475	481	PF02991	0.492
LIG_LIR_Nem_3	234	240	PF02991	0.253
LIG_LIR_Nem_3	245	249	PF02991	0.433
LIG_LIR_Nem_3	252	257	PF02991	0.477
LIG_LIR_Nem_3	282	288	PF02991	0.458
LIG_LIR_Nem_3	329	334	PF02991	0.423
LIG_LIR_Nem_3	412	418	PF02991	0.437
LIG_LIR_Nem_3	475	480	PF02991	0.493
LIG_LIR_Nem_3	8	14	PF02991	0.328
LIG_Pex14_1	195	199	PF04695	0.296
LIG_Pex14_1	374	378	PF04695	0.425
LIG_Pex14_2	314	318	PF04695	0.371
LIG_SH2_CRK	185	189	PF00017	0.363
LIG_SH2_CRK	320	324	PF00017	0.479
LIG_SH2_PTP2	239	242	PF00017	0.397
LIG_SH2_STAP1	257	261	PF00017	0.422
LIG_SH2_STAP1	477	481	PF00017	0.492
LIG_SH2_STAT5	139	142	PF00017	0.300
LIG_SH2_STAT5	239	242	PF00017	0.401
LIG_SH2_STAT5	270	273	PF00017	0.443
LIG_SH2_STAT5	279	282	PF00017	0.465
LIG_SH3_3	129	135	PF00018	0.417
LIG_SH3_3	18	24	PF00018	0.324
LIG_SH3_3	283	289	PF00018	0.527
LIG_SH3_3	303	309	PF00018	0.415
LIG_SH3_3	310	316	PF00018	0.414
LIG_SH3_3	349	355	PF00018	0.683
LIG_SH3_3	62	68	PF00018	0.453
LIG_SUMO_SIM_anti_2	401	409	PF11976	0.403
LIG_TRAF2_1	103	106	PF00917	0.472
LIG_TRFH_1	285	289	PF08558	0.456
LIG_WRC_WIRS_1	196	201	PF05994	0.367
MOD_CDK_SPxxK_3	78	85	PF00069	0.570
MOD_CK1_1	162	168	PF00069	0.537
MOD_CK1_1	174	180	PF00069	0.348
MOD_CK1_1	396	402	PF00069	0.462
MOD_CK1_1	430	436	PF00069	0.389
MOD_CK1_1	77	83	PF00069	0.675
MOD_CK2_1	295	301	PF00069	0.272
MOD_GlcNHglycan	125	128	PF01048	0.498
MOD_GlcNHglycan	161	164	PF01048	0.566
MOD_GlcNHglycan	176	179	PF01048	0.455
MOD_GlcNHglycan	33	37	PF01048	0.440
MOD_GlcNHglycan	362	365	PF01048	0.550
MOD_GlcNHglycan	411	414	PF01048	0.519
MOD_GlcNHglycan	446	449	PF01048	0.437
MOD_GSK3_1	117	124	PF00069	0.439
MOD_GSK3_1	148	155	PF00069	0.350
MOD_GSK3_1	158	165	PF00069	0.416
MOD_GSK3_1	217	224	PF00069	0.430
MOD_GSK3_1	253	260	PF00069	0.283
MOD_GSK3_1	360	367	PF00069	0.501
MOD_GSK3_1	69	76	PF00069	0.507
MOD_N-GLC_1	324	329	PF02516	0.353
MOD_N-GLC_1	424	429	PF02516	0.471
MOD_N-GLC_2	262	264	PF02516	0.283
MOD_N-GLC_2	29	31	PF02516	0.449
MOD_N-GLC_2	373	375	PF02516	0.283
MOD_NEK2_1	149	154	PF00069	0.420
MOD_NEK2_1	211	216	PF00069	0.654
MOD_NEK2_1	366	371	PF00069	0.267
MOD_NEK2_1	4	9	PF00069	0.486
MOD_NEK2_2	432	437	PF00069	0.308
MOD_PIKK_1	221	227	PF00454	0.371
MOD_PIKK_1	57	63	PF00454	0.427
MOD_PKA_2	174	180	PF00069	0.483
MOD_PKA_2	409	415	PF00069	0.454
MOD_Plk_1	427	433	PF00069	0.369
MOD_ProDKin_1	128	134	PF00069	0.614
MOD_ProDKin_1	244	250	PF00069	0.255
MOD_ProDKin_1	287	293	PF00069	0.379
MOD_ProDKin_1	78	84	PF00069	0.670
MOD_SUMO_rev_2	476	486	PF00179	0.371
TRG_DiLeu_BaEn_1	401	406	PF01217	0.505
TRG_DiLeu_BaEn_1	476	481	PF01217	0.374
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.253
TRG_ENDOCYTIC_2	11	14	PF00928	0.415
TRG_ENDOCYTIC_2	251	254	PF00928	0.421
TRG_ENDOCYTIC_2	320	323	PF00928	0.342
TRG_ENDOCYTIC_2	477	480	PF00928	0.494
TRG_ER_diArg_1	415	417	PF00400	0.337
TRG_ER_diArg_1	47	49	PF00400	0.454
TRG_NES_CRM1_1	293	303	PF08389	0.392
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I519	Leptomonas seymouri	51%	93%
A0A0S4JI40	Bodo saltans	31%	99%
A0A1X0P4A9	Trypanosomatidae	37%	100%
A0A3R7LP24	Trypanosoma rangeli	41%	100%
A0A3S7X0M0	Leishmania donovani	100%	100%
A4HFP0	Leishmania braziliensis	76%	100%
D0A5X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AD93	Leishmania major	91%	100%
E9AZ18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q08BY5	Danio rerio	26%	100%
Q67ZB6	Arabidopsis thaliana	25%	100%
V5BD54	Trypanosoma cruzi	40%	100%