WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2R5_LEIIN

TriTrypDb:

LINF_270017800

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2R5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.722
CLV_PCSK_KEX2_1	105	107	PF00082	0.722
DEG_SCF_FBW7_1	275	281	PF00400	0.756
DEG_SCF_FBW7_1	482	488	PF00400	0.678
DEG_SIAH_1	527	535	PF03145	0.665
DEG_SPOP_SBC_1	252	256	PF00917	0.644
DOC_ANK_TNKS_1	564	571	PF00023	0.790
DOC_CKS1_1	275	280	PF01111	0.780
DOC_CKS1_1	482	487	PF01111	0.781
DOC_PP1_RVXF_1	2	9	PF00149	0.678
DOC_PP2B_LxvP_1	259	262	PF13499	0.629
DOC_PP2B_LxvP_1	499	502	PF13499	0.607
DOC_PP2B_LxvP_1	571	574	PF13499	0.775
DOC_USP7_MATH_1	317	321	PF00917	0.727
DOC_USP7_MATH_1	334	338	PF00917	0.624
DOC_USP7_MATH_1	378	382	PF00917	0.748
DOC_USP7_MATH_1	405	409	PF00917	0.722
DOC_USP7_MATH_1	433	437	PF00917	0.684
DOC_USP7_MATH_1	441	445	PF00917	0.609
DOC_USP7_MATH_1	450	454	PF00917	0.537
DOC_USP7_MATH_1	476	480	PF00917	0.847
DOC_USP7_MATH_1	483	487	PF00917	0.701
DOC_USP7_MATH_1	58	62	PF00917	0.779
DOC_WW_Pin1_4	212	217	PF00397	0.725
DOC_WW_Pin1_4	244	249	PF00397	0.666
DOC_WW_Pin1_4	253	258	PF00397	0.681
DOC_WW_Pin1_4	274	279	PF00397	0.721
DOC_WW_Pin1_4	336	341	PF00397	0.823
DOC_WW_Pin1_4	366	371	PF00397	0.728
DOC_WW_Pin1_4	374	379	PF00397	0.719
DOC_WW_Pin1_4	389	394	PF00397	0.666
DOC_WW_Pin1_4	398	403	PF00397	0.687
DOC_WW_Pin1_4	410	415	PF00397	0.643
DOC_WW_Pin1_4	417	422	PF00397	0.529
DOC_WW_Pin1_4	481	486	PF00397	0.785
DOC_WW_Pin1_4	578	583	PF00397	0.790
LIG_14-3-3_CanoR_1	156	160	PF00244	0.654
LIG_14-3-3_CanoR_1	44	50	PF00244	0.753
LIG_14-3-3_CanoR_1	90	99	PF00244	0.640
LIG_AP2alpha_2	111	113	PF02296	0.788
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BIR_III_2	457	461	PF00653	0.744
LIG_BRCT_BRCA1_1	436	440	PF00533	0.753
LIG_eIF4E_1	274	280	PF01652	0.603
LIG_EVH1_1	274	278	PF00568	0.808
LIG_EVH1_1	571	575	PF00568	0.774
LIG_EVH1_2	573	577	PF00568	0.784
LIG_FHA_1	275	281	PF00498	0.737
LIG_FHA_1	323	329	PF00498	0.719
LIG_FHA_1	342	348	PF00498	0.506
LIG_FHA_1	46	52	PF00498	0.807
LIG_FHA_1	472	478	PF00498	0.837
LIG_FHA_1	486	492	PF00498	0.566
LIG_IBAR_NPY_1	507	509	PF08397	0.768
LIG_LIR_Apic_2	215	221	PF02991	0.723
LIG_LIR_Apic_2	272	276	PF02991	0.703
LIG_LIR_Apic_2	292	297	PF02991	0.527
LIG_LIR_Apic_2	408	414	PF02991	0.837
LIG_LIR_Apic_2	506	512	PF02991	0.840
LIG_LIR_Gen_1	170	178	PF02991	0.712
LIG_LIR_Nem_3	144	150	PF02991	0.687
LIG_LIR_Nem_3	170	175	PF02991	0.708
LIG_LIR_Nem_3	576	580	PF02991	0.815
LIG_LIR_Nem_3	73	77	PF02991	0.696
LIG_MYND_1	257	261	PF01753	0.636
LIG_PTAP_UEV_1	547	552	PF05743	0.664
LIG_SH2_CRK	294	298	PF00017	0.743
LIG_SH2_CRK	390	394	PF00017	0.813
LIG_SH2_CRK	411	415	PF00017	0.843
LIG_SH2_CRK	509	513	PF00017	0.838
LIG_SH2_GRB2like	99	102	PF00017	0.670
LIG_SH2_NCK_1	218	222	PF00017	0.814
LIG_SH2_NCK_1	390	394	PF00017	0.813
LIG_SH2_SRC	218	221	PF00017	0.736
LIG_SH2_SRC	314	317	PF00017	0.824
LIG_SH2_SRC	509	512	PF00017	0.840
LIG_SH2_SRC	544	547	PF00017	0.641
LIG_SH2_STAP1	150	154	PF00017	0.672
LIG_SH2_STAT3	150	153	PF00017	0.672
LIG_SH2_STAT5	223	226	PF00017	0.820
LIG_SH2_STAT5	314	317	PF00017	0.824
LIG_SH3_1	187	193	PF00018	0.751
LIG_SH3_3	185	191	PF00018	0.827
LIG_SH3_3	272	278	PF00018	0.647
LIG_SH3_3	301	307	PF00018	0.768
LIG_SH3_3	313	319	PF00018	0.670
LIG_SH3_3	354	360	PF00018	0.686
LIG_SH3_3	364	370	PF00018	0.650
LIG_SH3_3	396	402	PF00018	0.663
LIG_SH3_3	477	483	PF00018	0.713
LIG_SH3_3	498	504	PF00018	0.731
LIG_SH3_3	525	531	PF00018	0.836
LIG_SH3_3	545	551	PF00018	0.513
LIG_SH3_3	569	575	PF00018	0.788
LIG_SH3_3	576	582	PF00018	0.702
LIG_WRC_WIRS_1	553	558	PF05994	0.848
LIG_WRPW_2	577	580	PF00400	0.819
MOD_CK1_1	260	266	PF00069	0.742
MOD_CK1_1	281	287	PF00069	0.816
MOD_CK1_1	322	328	PF00069	0.750
MOD_CK1_1	339	345	PF00069	0.544
MOD_CK1_1	428	434	PF00069	0.732
MOD_CK1_1	436	442	PF00069	0.663
MOD_CK1_1	45	51	PF00069	0.754
MOD_CK1_1	486	492	PF00069	0.729
MOD_CK1_1	549	555	PF00069	0.831
MOD_CK2_1	76	82	PF00069	0.601
MOD_GlcNHglycan	21	24	PF01048	0.646
MOD_GlcNHglycan	230	233	PF01048	0.718
MOD_GlcNHglycan	25	29	PF01048	0.715
MOD_GlcNHglycan	262	265	PF01048	0.728
MOD_GlcNHglycan	285	288	PF01048	0.819
MOD_GlcNHglycan	31	34	PF01048	0.538
MOD_GlcNHglycan	336	339	PF01048	0.685
MOD_GlcNHglycan	425	428	PF01048	0.846
MOD_GlcNHglycan	430	433	PF01048	0.768
MOD_GlcNHglycan	443	446	PF01048	0.525
MOD_GlcNHglycan	452	455	PF01048	0.683
MOD_GlcNHglycan	548	551	PF01048	0.793
MOD_GlcNHglycan	559	562	PF01048	0.691
MOD_GlcNHglycan	566	569	PF01048	0.579
MOD_GlcNHglycan	62	65	PF01048	0.794
MOD_GlcNHglycan	74	77	PF01048	0.620
MOD_GlcNHglycan	78	81	PF01048	0.508
MOD_GSK3_1	253	260	PF00069	0.802
MOD_GSK3_1	265	272	PF00069	0.691
MOD_GSK3_1	274	281	PF00069	0.596
MOD_GSK3_1	285	292	PF00069	0.593
MOD_GSK3_1	317	324	PF00069	0.673
MOD_GSK3_1	334	341	PF00069	0.673
MOD_GSK3_1	374	381	PF00069	0.730
MOD_GSK3_1	38	45	PF00069	0.820
MOD_GSK3_1	472	479	PF00069	0.762
MOD_GSK3_1	481	488	PF00069	0.621
MOD_GSK3_1	513	520	PF00069	0.724
MOD_GSK3_1	552	559	PF00069	0.810
MOD_GSK3_1	72	79	PF00069	0.755
MOD_GSK3_1	90	97	PF00069	0.572
MOD_LATS_1	423	429	PF00433	0.637
MOD_N-GLC_1	42	47	PF02516	0.830
MOD_N-GLC_1	423	428	PF02516	0.786
MOD_NEK2_1	279	284	PF00069	0.675
MOD_NEK2_1	299	304	PF00069	0.572
MOD_NEK2_1	365	370	PF00069	0.745
MOD_NEK2_1	38	43	PF00069	0.819
MOD_NEK2_1	415	420	PF00069	0.741
MOD_NEK2_1	556	561	PF00069	0.764
MOD_PIKK_1	210	216	PF00454	0.734
MOD_PIKK_1	265	271	PF00454	0.618
MOD_PIKK_1	299	305	PF00454	0.780
MOD_PIKK_1	38	44	PF00454	0.820
MOD_PIKK_1	382	388	PF00454	0.824
MOD_PIKK_1	405	411	PF00454	0.816
MOD_PIKK_1	415	421	PF00454	0.679
MOD_PIKK_1	483	489	PF00454	0.699
MOD_PIKK_1	94	100	PF00454	0.730
MOD_PKA_1	106	112	PF00069	0.721
MOD_PKA_2	106	112	PF00069	0.721
MOD_PKA_2	155	161	PF00069	0.671
MOD_PKA_2	19	25	PF00069	0.618
MOD_PKA_2	564	570	PF00069	0.834
MOD_Plk_1	42	48	PF00069	0.751
MOD_Plk_4	269	275	PF00069	0.754
MOD_Plk_4	486	492	PF00069	0.686
MOD_ProDKin_1	212	218	PF00069	0.729
MOD_ProDKin_1	244	250	PF00069	0.667
MOD_ProDKin_1	253	259	PF00069	0.682
MOD_ProDKin_1	274	280	PF00069	0.723
MOD_ProDKin_1	336	342	PF00069	0.821
MOD_ProDKin_1	366	372	PF00069	0.725
MOD_ProDKin_1	374	380	PF00069	0.716
MOD_ProDKin_1	389	395	PF00069	0.665
MOD_ProDKin_1	398	404	PF00069	0.688
MOD_ProDKin_1	410	416	PF00069	0.643
MOD_ProDKin_1	417	423	PF00069	0.531
MOD_ProDKin_1	481	487	PF00069	0.784
MOD_SUMO_for_1	537	540	PF00179	0.777
MOD_SUMO_rev_2	79	85	PF00179	0.620
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.841
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.602
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.497
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.726
TRG_ENDOCYTIC_2	172	175	PF00928	0.719
TRG_ER_diArg_1	104	107	PF00400	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IPV7	Leishmania donovani	99%	100%
A4HFN9	Leishmania braziliensis	62%	96%
E9AD92	Leishmania major	89%	100%
E9AZ17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%