This 4-TM protein belongs to broad Eukaryotic family of primarily ER-associated proteins. This family also encompasses the human Emopamil-binding protein and intracellular sigma receptors.. Might be a sterol isomerase.. Localization: ER (by homology)
Sterol metabolism/biosynthesis, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase probable Uncharacterized
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 9 |
| NetGPI | no | yes: 0, no: 9 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 8 |
| GO:0110165 | cellular anatomical entity | 1 | 8 |
Related structures:
AlphaFold database: A4I2R0
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 58 | 60 | PF00675 | 0.582 |
| CLV_PCSK_KEX2_1 | 58 | 60 | PF00082 | 0.538 |
| CLV_PCSK_SKI1_1 | 111 | 115 | PF00082 | 0.365 |
| DEG_SIAH_1 | 39 | 47 | PF03145 | 0.435 |
| DOC_CYCLIN_yClb5_NLxxxL_5 | 33 | 41 | PF00134 | 0.400 |
| DOC_CYCLIN_yCln2_LP_2 | 139 | 145 | PF00134 | 0.485 |
| DOC_MAPK_DCC_7 | 135 | 145 | PF00069 | 0.336 |
| DOC_MAPK_MEF2A_6 | 99 | 106 | PF00069 | 0.410 |
| DOC_PP1_RVXF_1 | 9 | 15 | PF00149 | 0.591 |
| DOC_PP2B_LxvP_1 | 139 | 142 | PF13499 | 0.485 |
| DOC_USP7_MATH_1 | 162 | 166 | PF00917 | 0.599 |
| DOC_USP7_MATH_1 | 174 | 178 | PF00917 | 0.646 |
| LIG_14-3-3_CanoR_1 | 128 | 133 | PF00244 | 0.413 |
| LIG_14-3-3_CanoR_1 | 31 | 36 | PF00244 | 0.433 |
| LIG_AP2alpha_2 | 65 | 67 | PF02296 | 0.319 |
| LIG_FHA_1 | 135 | 141 | PF00498 | 0.391 |
| LIG_FHA_2 | 129 | 135 | PF00498 | 0.407 |
| LIG_GBD_Chelix_1 | 79 | 87 | PF00786 | 0.346 |
| LIG_HP1_1 | 19 | 23 | PF01393 | 0.429 |
| LIG_LIR_Gen_1 | 112 | 121 | PF02991 | 0.441 |
| LIG_LIR_Gen_1 | 144 | 154 | PF02991 | 0.349 |
| LIG_LIR_Gen_1 | 64 | 74 | PF02991 | 0.342 |
| LIG_LIR_Nem_3 | 108 | 113 | PF02991 | 0.368 |
| LIG_LIR_Nem_3 | 144 | 149 | PF02991 | 0.366 |
| LIG_LIR_Nem_3 | 64 | 70 | PF02991 | 0.344 |
| LIG_LIR_Nem_3 | 72 | 76 | PF02991 | 0.320 |
| LIG_SH2_CRK | 110 | 114 | PF00017 | 0.369 |
| LIG_SH2_STAP1 | 56 | 60 | PF00017 | 0.333 |
| LIG_SH2_STAT3 | 180 | 183 | PF00017 | 0.623 |
| LIG_SH2_STAT5 | 115 | 118 | PF00017 | 0.357 |
| LIG_SH3_3 | 13 | 19 | PF00018 | 0.353 |
| LIG_SH3_3 | 32 | 38 | PF00018 | 0.382 |
| LIG_SUMO_SIM_par_1 | 116 | 122 | PF11976 | 0.499 |
| LIG_SUMO_SIM_par_1 | 18 | 24 | PF11976 | 0.339 |
| LIG_SUMO_SIM_par_1 | 86 | 92 | PF11976 | 0.433 |
| LIG_TYR_ITIM | 113 | 118 | PF00017 | 0.447 |
| LIG_TYR_ITSM | 106 | 113 | PF00017 | 0.369 |
| LIG_UBA3_1 | 106 | 111 | PF00899 | 0.501 |
| LIG_UBA3_1 | 117 | 125 | PF00899 | 0.378 |
| LIG_UBA3_1 | 26 | 33 | PF00899 | 0.490 |
| MOD_CK2_1 | 128 | 134 | PF00069 | 0.445 |
| MOD_Cter_Amidation | 192 | 195 | PF01082 | 0.580 |
| MOD_GSK3_1 | 105 | 112 | PF00069 | 0.359 |
| MOD_GSK3_1 | 124 | 131 | PF00069 | 0.348 |
| MOD_GSK3_1 | 162 | 169 | PF00069 | 0.594 |
| MOD_GSK3_1 | 27 | 34 | PF00069 | 0.443 |
| MOD_LATS_1 | 126 | 132 | PF00433 | 0.331 |
| MOD_NEK2_1 | 109 | 114 | PF00069 | 0.349 |
| MOD_NEK2_1 | 27 | 32 | PF00069 | 0.439 |
| MOD_NEK2_1 | 83 | 88 | PF00069 | 0.454 |
| MOD_NEK2_2 | 105 | 110 | PF00069 | 0.405 |
| MOD_PIKK_1 | 174 | 180 | PF00454 | 0.757 |
| MOD_PK_1 | 31 | 37 | PF00069 | 0.450 |
| MOD_Plk_4 | 105 | 111 | PF00069 | 0.348 |
| MOD_Plk_4 | 134 | 140 | PF00069 | 0.315 |
| MOD_Plk_4 | 141 | 147 | PF00069 | 0.308 |
| MOD_Plk_4 | 148 | 154 | PF00069 | 0.280 |
| MOD_Plk_4 | 69 | 75 | PF00069 | 0.303 |
| MOD_Plk_4 | 83 | 89 | PF00069 | 0.341 |
| TRG_DiLeu_BaLyEn_6 | 4 | 9 | PF01217 | 0.567 |
| TRG_ENDOCYTIC_2 | 110 | 113 | PF00928 | 0.350 |
| TRG_ENDOCYTIC_2 | 115 | 118 | PF00928 | 0.337 |
| TRG_ENDOCYTIC_2 | 49 | 52 | PF00928 | 0.337 |
| TRG_ER_diArg_1 | 58 | 60 | PF00400 | 0.363 |
| TRG_ER_diLys_1 | 194 | 197 | PF00400 | 0.769 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I830 | Leptomonas seymouri | 48% | 98% |
| A0A0S4JB23 | Bodo saltans | 43% | 100% |
| A0A1X0P436 | Trypanosomatidae | 55% | 100% |
| A0A3Q8IGA5 | Leishmania donovani | 99% | 100% |
| A4HFN3 | Leishmania braziliensis | 77% | 100% |
| D0A5W3 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 50% | 100% |
| E9AD87 | Leishmania major | 92% | 100% |
| E9AZ11 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 84% | 100% |