This small membrane protein has a very long, basic N-terminus that might indicate a putative mitochondrial transit signal.. The protein is conserved in all KInetoplastids, but not seen outside this group.
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 10 |
| NetGPI | no | yes: 0, no: 10 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 8 |
| GO:0110165 | cellular anatomical entity | 1 | 8 |
Related structures:
AlphaFold database: A4I2Q6
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 130 | 132 | PF00675 | 0.544 |
| CLV_NRD_NRD_1 | 134 | 136 | PF00675 | 0.551 |
| CLV_NRD_NRD_1 | 18 | 20 | PF00675 | 0.451 |
| CLV_NRD_NRD_1 | 21 | 23 | PF00675 | 0.462 |
| CLV_NRD_NRD_1 | 3 | 5 | PF00675 | 0.440 |
| CLV_PCSK_FUR_1 | 131 | 135 | PF00082 | 0.587 |
| CLV_PCSK_FUR_1 | 18 | 22 | PF00082 | 0.429 |
| CLV_PCSK_KEX2_1 | 130 | 132 | PF00082 | 0.546 |
| CLV_PCSK_KEX2_1 | 133 | 135 | PF00082 | 0.554 |
| CLV_PCSK_KEX2_1 | 18 | 20 | PF00082 | 0.450 |
| CLV_PCSK_KEX2_1 | 21 | 23 | PF00082 | 0.464 |
| CLV_PCSK_KEX2_1 | 3 | 5 | PF00082 | 0.440 |
| CLV_PCSK_PC1ET2_1 | 20 | 22 | PF00082 | 0.443 |
| CLV_PCSK_PC7_1 | 130 | 136 | PF00082 | 0.578 |
| CLV_Separin_Metazoa | 10 | 14 | PF03568 | 0.657 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.627 |
| DOC_MAPK_gen_1 | 111 | 120 | PF00069 | 0.376 |
| DOC_MAPK_gen_1 | 3 | 11 | PF00069 | 0.644 |
| DOC_MAPK_MEF2A_6 | 114 | 122 | PF00069 | 0.407 |
| DOC_PP2B_LxvP_1 | 9 | 12 | PF13499 | 0.680 |
| LIG_14-3-3_CanoR_1 | 68 | 73 | PF00244 | 0.592 |
| LIG_FHA_2 | 94 | 100 | PF00498 | 0.439 |
| LIG_Integrin_RGD_1 | 114 | 116 | PF01839 | 0.552 |
| LIG_LIR_Gen_1 | 105 | 113 | PF02991 | 0.449 |
| LIG_LIR_Nem_3 | 105 | 110 | PF02991 | 0.419 |
| LIG_LIR_Nem_3 | 119 | 125 | PF02991 | 0.290 |
| LIG_LIR_Nem_3 | 81 | 86 | PF02991 | 0.294 |
| LIG_REV1ctd_RIR_1 | 90 | 98 | PF16727 | 0.543 |
| LIG_SH2_CRK | 107 | 111 | PF00017 | 0.352 |
| LIG_SH2_STAT3 | 50 | 53 | PF00017 | 0.637 |
| LIG_SH2_STAT5 | 107 | 110 | PF00017 | 0.401 |
| LIG_SH2_STAT5 | 50 | 53 | PF00017 | 0.543 |
| LIG_SH2_STAT5 | 86 | 89 | PF00017 | 0.284 |
| LIG_SH2_STAT5 | 95 | 98 | PF00017 | 0.341 |
| LIG_SH3_2 | 57 | 62 | PF14604 | 0.613 |
| LIG_SH3_3 | 35 | 41 | PF00018 | 0.765 |
| LIG_SH3_3 | 54 | 60 | PF00018 | 0.536 |
| LIG_SH3_3 | 8 | 14 | PF00018 | 0.695 |
| LIG_TYR_ITSM | 103 | 110 | PF00017 | 0.453 |
| MOD_CK2_1 | 4 | 10 | PF00069 | 0.548 |
| MOD_CK2_1 | 93 | 99 | PF00069 | 0.364 |
| MOD_Cter_Amidation | 128 | 131 | PF01082 | 0.591 |
| MOD_GlcNHglycan | 45 | 48 | PF01048 | 0.403 |
| MOD_PIKK_1 | 102 | 108 | PF00454 | 0.455 |
| MOD_PKA_2 | 67 | 73 | PF00069 | 0.614 |
| MOD_Plk_4 | 105 | 111 | PF00069 | 0.369 |
| MOD_Plk_4 | 79 | 85 | PF00069 | 0.339 |
| TRG_DiLeu_BaLyEn_6 | 135 | 140 | PF01217 | 0.401 |
| TRG_ENDOCYTIC_2 | 107 | 110 | PF00928 | 0.271 |
| TRG_ENDOCYTIC_2 | 89 | 92 | PF00928 | 0.351 |
| TRG_ER_diArg_1 | 130 | 133 | PF00400 | 0.362 |
| TRG_ER_diArg_1 | 18 | 21 | PF00400 | 0.626 |
| TRG_ER_diArg_1 | 2 | 4 | PF00400 | 0.643 |
| TRG_ER_diArg_1 | 55 | 58 | PF00400 | 0.550 |
| TRG_NLS_Bipartite_1 | 3 | 24 | PF00514 | 0.662 |
| TRG_NLS_MonoCore_2 | 18 | 23 | PF00514 | 0.652 |
| TRG_NLS_MonoExtC_3 | 19 | 24 | PF00514 | 0.727 |
| TRG_NLS_MonoExtN_4 | 18 | 24 | PF00514 | 0.660 |
| TRG_Pf-PMV_PEXEL_1 | 138 | 143 | PF00026 | 0.600 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1HZT6 | Leptomonas seymouri | 75% | 100% |
| A0A0S4JFD9 | Bodo saltans | 48% | 100% |
| A0A1X0P4W3 | Trypanosomatidae | 52% | 100% |
| A0A3S7X0M9 | Leishmania donovani | 100% | 100% |
| A0A422MWH1 | Trypanosoma rangeli | 57% | 100% |
| A4HFM8 | Leishmania braziliensis | 87% | 100% |
| D0A5V7 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 55% | 100% |
| E9AD82 | Leishmania major | 96% | 100% |
| E9AZ06 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |