Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2Q5_LEIIN

TriTrypDb:

LINF_270016700

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4I2Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.362
CLV_C14_Caspase3-7	202	206	PF00656	0.596
CLV_C14_Caspase3-7	95	99	PF00656	0.538
CLV_NRD_NRD_1	143	145	PF00675	0.601
CLV_NRD_NRD_1	175	177	PF00675	0.421
CLV_NRD_NRD_1	357	359	PF00675	0.470
CLV_NRD_NRD_1	370	372	PF00675	0.443
CLV_NRD_NRD_1	60	62	PF00675	0.637
CLV_PCSK_KEX2_1	143	145	PF00082	0.631
CLV_PCSK_KEX2_1	175	177	PF00082	0.421
CLV_PCSK_KEX2_1	200	202	PF00082	0.457
CLV_PCSK_KEX2_1	357	359	PF00082	0.470
CLV_PCSK_KEX2_1	370	372	PF00082	0.443
CLV_PCSK_KEX2_1	60	62	PF00082	0.637
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.438
CLV_PCSK_PC7_1	353	359	PF00082	0.412
CLV_PCSK_SKI1_1	243	247	PF00082	0.380
CLV_PCSK_SKI1_1	391	395	PF00082	0.417
DEG_APCC_DBOX_1	390	398	PF00400	0.583
DEG_COP1_1	35	42	PF00400	0.466
DEG_Nend_UBRbox_3	1	3	PF02207	0.518
DOC_CYCLIN_RxL_1	387	398	PF00134	0.586
DOC_MAPK_gen_1	58	68	PF00069	0.437
DOC_MAPK_HePTP_8	397	409	PF00069	0.321
DOC_MAPK_MEF2A_6	116	124	PF00069	0.396
DOC_MAPK_MEF2A_6	400	409	PF00069	0.300
DOC_MAPK_MEF2A_6	60	69	PF00069	0.432
DOC_PP1_RVXF_1	241	247	PF00149	0.582
DOC_PP1_RVXF_1	398	405	PF00149	0.351
DOC_PP4_FxxP_1	9	12	PF00568	0.499
DOC_USP7_MATH_1	130	134	PF00917	0.465
DOC_USP7_MATH_1	308	312	PF00917	0.692
DOC_USP7_MATH_1	318	322	PF00917	0.646
DOC_USP7_MATH_1	351	355	PF00917	0.703
DOC_USP7_MATH_1	366	370	PF00917	0.620
DOC_USP7_MATH_1	40	44	PF00917	0.572
DOC_USP7_MATH_1	92	96	PF00917	0.519
LIG_14-3-3_CanoR_1	144	154	PF00244	0.289
LIG_14-3-3_CanoR_1	81	86	PF00244	0.592
LIG_Actin_WH2_2	189	206	PF00022	0.580
LIG_Actin_WH2_2	400	418	PF00022	0.301
LIG_BIR_III_2	317	321	PF00653	0.672
LIG_BIR_III_4	129	133	PF00653	0.364
LIG_Clathr_ClatBox_1	254	258	PF01394	0.537
LIG_FHA_1	146	152	PF00498	0.272
LIG_FHA_1	188	194	PF00498	0.583
LIG_FHA_1	24	30	PF00498	0.525
LIG_FHA_1	281	287	PF00498	0.629
LIG_FHA_2	124	130	PF00498	0.365
LIG_FHA_2	260	266	PF00498	0.612
LIG_GBD_Chelix_1	402	410	PF00786	0.343
LIG_IRF3_LxIS_1	120	125	PF10401	0.436
LIG_LIR_Apic_2	8	12	PF02991	0.505
LIG_PCNA_yPIPBox_3	167	178	PF02747	0.638
LIG_SH2_CRK	344	348	PF00017	0.650
LIG_SH2_STAP1	263	267	PF00017	0.582
LIG_SH2_STAT5	155	158	PF00017	0.351
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.425
LIG_SUMO_SIM_anti_2	181	191	PF11976	0.577
LIG_SUMO_SIM_anti_2	381	389	PF11976	0.603
LIG_SUMO_SIM_par_1	160	165	PF11976	0.380
LIG_SUMO_SIM_par_1	181	191	PF11976	0.577
LIG_SUMO_SIM_par_1	392	398	PF11976	0.472
LIG_TRAF2_1	320	323	PF00917	0.666
LIG_TRAF2_1	35	38	PF00917	0.472
LIG_TYR_ITIM	153	158	PF00017	0.351
LIG_UBA3_1	218	225	PF00899	0.512
MOD_CK1_1	133	139	PF00069	0.457
MOD_CK1_1	365	371	PF00069	0.705
MOD_CK1_1	373	379	PF00069	0.657
MOD_CK1_1	381	387	PF00069	0.572
MOD_CK1_1	53	59	PF00069	0.565
MOD_CK2_1	162	168	PF00069	0.628
MOD_CK2_1	259	265	PF00069	0.605
MOD_CK2_1	32	38	PF00069	0.522
MOD_CK2_1	69	75	PF00069	0.399
MOD_GlcNHglycan	15	18	PF01048	0.749
MOD_GlcNHglycan	164	167	PF01048	0.478
MOD_GlcNHglycan	311	314	PF01048	0.465
MOD_GlcNHglycan	364	367	PF01048	0.602
MOD_GlcNHglycan	372	375	PF01048	0.592
MOD_GlcNHglycan	380	383	PF01048	0.511
MOD_GlcNHglycan	411	414	PF01048	0.327
MOD_GlcNHglycan	94	97	PF01048	0.734
MOD_GSK3_1	118	125	PF00069	0.485
MOD_GSK3_1	13	20	PF00069	0.556
MOD_GSK3_1	276	283	PF00069	0.672
MOD_GSK3_1	358	365	PF00069	0.695
MOD_GSK3_1	366	373	PF00069	0.649
MOD_GSK3_1	374	381	PF00069	0.603
MOD_GSK3_1	50	57	PF00069	0.589
MOD_GSK3_1	69	76	PF00069	0.469
MOD_N-GLC_1	233	238	PF02516	0.361
MOD_N-GLC_1	73	78	PF02516	0.693
MOD_N-GLC_1	92	97	PF02516	0.753
MOD_NEK2_1	122	127	PF00069	0.481
MOD_NEK2_1	187	192	PF00069	0.595
MOD_NEK2_2	40	45	PF00069	0.472
MOD_PIKK_1	205	211	PF00454	0.603
MOD_PKA_1	357	363	PF00069	0.755
MOD_PKA_1	370	376	PF00069	0.676
MOD_PKA_2	357	363	PF00069	0.712
MOD_PKA_2	370	376	PF00069	0.770
MOD_PKA_2	51	57	PF00069	0.519
MOD_PKA_2	80	86	PF00069	0.574
MOD_Plk_1	233	239	PF00069	0.523
MOD_Plk_1	50	56	PF00069	0.482
MOD_Plk_2-3	100	106	PF00069	0.522
MOD_Plk_4	118	124	PF00069	0.509
MOD_Plk_4	188	194	PF00069	0.579
MOD_Plk_4	277	283	PF00069	0.620
MOD_Plk_4	381	387	PF00069	0.665
MOD_SUMO_for_1	199	202	PF00179	0.595
MOD_SUMO_for_1	214	217	PF00179	0.525
MOD_SUMO_rev_2	360	366	PF00179	0.601
TRG_DiLeu_BaEn_1	181	186	PF01217	0.546
TRG_DiLeu_BaEn_2	250	256	PF01217	0.507
TRG_ENDOCYTIC_2	155	158	PF00928	0.351
TRG_ER_diArg_1	143	145	PF00400	0.428
TRG_ER_diArg_1	174	176	PF00400	0.620
TRG_ER_diArg_1	357	359	PF00400	0.680
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL1	Leptomonas seymouri	45%	98%
A0A3S7X0L7	Leishmania donovani	100%	100%
A4HFM7	Leishmania braziliensis	63%	100%
E9AD81	Leishmania major	89%	100%
E9AZ05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5AT52	Trypanosoma cruzi	26%	100%