Formin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Formin-like protein

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2Q4_LEIIN

TriTrypDb:

LINF_270016600

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2Q4

PDB structure(s): 7am2_BK

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.710
CLV_C14_Caspase3-7	524	528	PF00656	0.584
CLV_C14_Caspase3-7	666	670	PF00656	0.411
CLV_NRD_NRD_1	208	210	PF00675	0.462
CLV_NRD_NRD_1	621	623	PF00675	0.506
CLV_NRD_NRD_1	662	664	PF00675	0.415
CLV_NRD_NRD_1	693	695	PF00675	0.553
CLV_NRD_NRD_1	832	834	PF00675	0.480
CLV_PCSK_FUR_1	501	505	PF00082	0.575
CLV_PCSK_KEX2_1	208	210	PF00082	0.517
CLV_PCSK_KEX2_1	503	505	PF00082	0.468
CLV_PCSK_KEX2_1	621	623	PF00082	0.467
CLV_PCSK_KEX2_1	662	664	PF00082	0.415
CLV_PCSK_KEX2_1	692	694	PF00082	0.566
CLV_PCSK_KEX2_1	832	834	PF00082	0.435
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.512
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.612
CLV_PCSK_PC7_1	828	834	PF00082	0.441
CLV_PCSK_SKI1_1	195	199	PF00082	0.503
CLV_PCSK_SKI1_1	238	242	PF00082	0.544
CLV_PCSK_SKI1_1	331	335	PF00082	0.504
CLV_PCSK_SKI1_1	668	672	PF00082	0.447
CLV_PCSK_SKI1_1	693	697	PF00082	0.479
CLV_PCSK_SKI1_1	712	716	PF00082	0.207
CLV_PCSK_SKI1_1	800	804	PF00082	0.454
CLV_PCSK_SKI1_1	835	839	PF00082	0.458
CLV_PCSK_SKI1_1	85	89	PF00082	0.657
DEG_APCC_DBOX_1	330	338	PF00400	0.537
DEG_APCC_DBOX_1	711	719	PF00400	0.451
DEG_Nend_UBRbox_1	1	4	PF02207	0.663
DEG_SCF_FBW7_2	874	881	PF00400	0.573
DEG_SPOP_SBC_1	23	27	PF00917	0.748
DEG_SPOP_SBC_1	462	466	PF00917	0.623
DEG_SPOP_SBC_1	776	780	PF00917	0.624
DOC_ANK_TNKS_1	845	852	PF00023	0.441
DOC_CKS1_1	866	871	PF01111	0.463
DOC_CKS1_1	875	880	PF01111	0.447
DOC_CYCLIN_RxL_1	326	338	PF00134	0.553
DOC_CYCLIN_yClb1_LxF_4	229	235	PF00134	0.496
DOC_MAPK_gen_1	192	202	PF00069	0.511
DOC_MAPK_gen_1	429	439	PF00069	0.447
DOC_MAPK_gen_1	665	673	PF00069	0.472
DOC_MAPK_MEF2A_6	165	172	PF00069	0.592
DOC_MAPK_MEF2A_6	432	439	PF00069	0.502
DOC_MAPK_MEF2A_6	475	483	PF00069	0.620
DOC_MAPK_MEF2A_6	746	753	PF00069	0.410
DOC_MAPK_NFAT4_5	432	440	PF00069	0.499
DOC_PP1_RVXF_1	414	420	PF00149	0.533
DOC_PP1_RVXF_1	860	867	PF00149	0.575
DOC_PP4_FxxP_1	57	60	PF00568	0.491
DOC_PP4_FxxP_1	866	869	PF00568	0.606
DOC_USP7_MATH_1	18	22	PF00917	0.784
DOC_USP7_MATH_1	23	27	PF00917	0.642
DOC_USP7_MATH_1	34	38	PF00917	0.691
DOC_USP7_MATH_1	463	467	PF00917	0.697
DOC_USP7_MATH_1	776	780	PF00917	0.622
DOC_USP7_MATH_1	856	860	PF00917	0.525
DOC_USP7_MATH_1	94	98	PF00917	0.798
DOC_USP7_MATH_2	47	53	PF00917	0.634
DOC_WW_Pin1_4	137	142	PF00397	0.711
DOC_WW_Pin1_4	275	280	PF00397	0.474
DOC_WW_Pin1_4	397	402	PF00397	0.537
DOC_WW_Pin1_4	475	480	PF00397	0.623
DOC_WW_Pin1_4	582	587	PF00397	0.447
DOC_WW_Pin1_4	772	777	PF00397	0.599
DOC_WW_Pin1_4	785	790	PF00397	0.570
DOC_WW_Pin1_4	865	870	PF00397	0.458
DOC_WW_Pin1_4	874	879	PF00397	0.442
LIG_14-3-3_CanoR_1	195	200	PF00244	0.511
LIG_14-3-3_CanoR_1	244	249	PF00244	0.491
LIG_14-3-3_CanoR_1	35	39	PF00244	0.630
LIG_14-3-3_CanoR_1	516	520	PF00244	0.468
LIG_14-3-3_CanoR_1	693	701	PF00244	0.538
LIG_14-3-3_CanoR_1	800	808	PF00244	0.494
LIG_Actin_WH2_2	228	243	PF00022	0.472
LIG_Actin_WH2_2	650	667	PF00022	0.505
LIG_Actin_WH2_2	787	802	PF00022	0.444
LIG_BRCT_BRCA1_1	221	225	PF00533	0.394
LIG_BRCT_BRCA1_1	50	54	PF00533	0.592
LIG_BRCT_BRCA1_1	64	68	PF00533	0.606
LIG_deltaCOP1_diTrp_1	226	234	PF00928	0.537
LIG_deltaCOP1_diTrp_1	408	414	PF00928	0.502
LIG_EH1_1	623	631	PF00400	0.545
LIG_eIF4E_1	219	225	PF01652	0.508
LIG_eIF4E_1	730	736	PF01652	0.385
LIG_FHA_1	131	137	PF00498	0.747
LIG_FHA_1	194	200	PF00498	0.463
LIG_FHA_1	213	219	PF00498	0.466
LIG_FHA_1	327	333	PF00498	0.532
LIG_FHA_1	463	469	PF00498	0.739
LIG_FHA_1	476	482	PF00498	0.586
LIG_FHA_1	537	543	PF00498	0.496
LIG_FHA_1	598	604	PF00498	0.546
LIG_FHA_1	717	723	PF00498	0.533
LIG_FHA_1	786	792	PF00498	0.536
LIG_FHA_2	196	202	PF00498	0.478
LIG_FHA_2	264	270	PF00498	0.448
LIG_FHA_2	727	733	PF00498	0.444
LIG_LIR_Apic_2	313	317	PF02991	0.522
LIG_LIR_Gen_1	114	123	PF02991	0.669
LIG_LIR_Gen_1	253	263	PF02991	0.410
LIG_LIR_Gen_1	431	442	PF02991	0.431
LIG_LIR_Gen_1	494	502	PF02991	0.481
LIG_LIR_Gen_1	558	568	PF02991	0.444
LIG_LIR_Nem_3	114	120	PF02991	0.668
LIG_LIR_Nem_3	253	259	PF02991	0.410
LIG_LIR_Nem_3	37	41	PF02991	0.588
LIG_LIR_Nem_3	431	437	PF02991	0.424
LIG_LIR_Nem_3	494	499	PF02991	0.449
LIG_LIR_Nem_3	51	57	PF02991	0.470
LIG_LIR_Nem_3	584	590	PF02991	0.626
LIG_LIR_Nem_3	65	71	PF02991	0.477
LIG_NRBOX	402	408	PF00104	0.449
LIG_NRBOX	432	438	PF00104	0.447
LIG_NRBOX	447	453	PF00104	0.352
LIG_PCNA_yPIPBox_3	177	187	PF02747	0.494
LIG_PCNA_yPIPBox_3	208	218	PF02747	0.544
LIG_Pex14_2	373	377	PF04695	0.585
LIG_PROFILIN_1	8	14	PF00235	0.652
LIG_RPA_C_Fungi	518	530	PF08784	0.380
LIG_SH2_CRK	38	42	PF00017	0.536
LIG_SH2_CRK	434	438	PF00017	0.495
LIG_SH2_CRK	876	880	PF00017	0.455
LIG_SH2_PTP2	614	617	PF00017	0.525
LIG_SH2_STAT5	246	249	PF00017	0.432
LIG_SH2_STAT5	301	304	PF00017	0.539
LIG_SH2_STAT5	314	317	PF00017	0.581
LIG_SH2_STAT5	614	617	PF00017	0.487
LIG_SH2_STAT5	723	726	PF00017	0.422
LIG_SH2_STAT5	730	733	PF00017	0.357
LIG_SH2_STAT5	743	746	PF00017	0.369
LIG_SH2_STAT5	867	870	PF00017	0.479
LIG_SH2_STAT5	876	879	PF00017	0.452
LIG_SH3_3	138	144	PF00018	0.715
LIG_SH3_3	302	308	PF00018	0.554
LIG_SH3_3	360	366	PF00018	0.734
LIG_SH3_3	583	589	PF00018	0.669
LIG_SH3_3	6	12	PF00018	0.755
LIG_SH3_3	805	811	PF00018	0.613
LIG_SH3_3	866	872	PF00018	0.477
LIG_SH3_3	885	891	PF00018	0.481
LIG_Sin3_3	288	295	PF02671	0.468
LIG_SUMO_SIM_anti_2	378	387	PF11976	0.481
LIG_SUMO_SIM_par_1	168	174	PF11976	0.535
LIG_TRFH_1	301	305	PF08558	0.572
LIG_TYR_ITIM	36	41	PF00017	0.549
LIG_TYR_ITIM	402	407	PF00017	0.404
LIG_TYR_ITIM	874	879	PF00017	0.452
LIG_UBA3_1	541	548	PF00899	0.416
LIG_UBA3_1	790	797	PF00899	0.410
LIG_Vh1_VBS_1	643	661	PF01044	0.386
LIG_WW_3	92	96	PF00397	0.774
MOD_CK1_1	121	127	PF00069	0.746
MOD_CK1_1	132	138	PF00069	0.741
MOD_CK1_1	21	27	PF00069	0.802
MOD_CK1_1	250	256	PF00069	0.434
MOD_CK1_1	37	43	PF00069	0.589
MOD_CK1_1	464	470	PF00069	0.715
MOD_CK1_1	497	503	PF00069	0.528
MOD_CK1_1	544	550	PF00069	0.569
MOD_CK1_1	648	654	PF00069	0.419
MOD_CK1_1	758	764	PF00069	0.466
MOD_CK1_1	775	781	PF00069	0.487
MOD_CK1_1	793	799	PF00069	0.466
MOD_CK1_1	97	103	PF00069	0.823
MOD_CK2_1	207	213	PF00069	0.416
MOD_CK2_1	220	226	PF00069	0.382
MOD_CK2_1	263	269	PF00069	0.481
MOD_CK2_1	419	425	PF00069	0.528
MOD_CK2_1	534	540	PF00069	0.435
MOD_CMANNOS	411	414	PF00535	0.505
MOD_Cter_Amidation	619	622	PF01082	0.589
MOD_DYRK1A_RPxSP_1	582	586	PF00069	0.446
MOD_GlcNHglycan	113	116	PF01048	0.686
MOD_GlcNHglycan	119	123	PF01048	0.703
MOD_GlcNHglycan	30	33	PF01048	0.769
MOD_GlcNHglycan	323	326	PF01048	0.497
MOD_GlcNHglycan	342	345	PF01048	0.352
MOD_GlcNHglycan	389	392	PF01048	0.451
MOD_GlcNHglycan	421	424	PF01048	0.528
MOD_GlcNHglycan	496	499	PF01048	0.489
MOD_GlcNHglycan	536	539	PF01048	0.427
MOD_GlcNHglycan	548	551	PF01048	0.401
MOD_GlcNHglycan	592	595	PF01048	0.623
MOD_GlcNHglycan	647	650	PF01048	0.426
MOD_GlcNHglycan	665	668	PF01048	0.312
MOD_GlcNHglycan	779	782	PF01048	0.605
MOD_GlcNHglycan	96	99	PF01048	0.745
MOD_GSK3_1	118	125	PF00069	0.658
MOD_GSK3_1	130	137	PF00069	0.695
MOD_GSK3_1	18	25	PF00069	0.776
MOD_GSK3_1	242	249	PF00069	0.482
MOD_GSK3_1	321	328	PF00069	0.427
MOD_GSK3_1	367	374	PF00069	0.648
MOD_GSK3_1	37	44	PF00069	0.651
MOD_GSK3_1	458	465	PF00069	0.731
MOD_GSK3_1	475	482	PF00069	0.381
MOD_GSK3_1	483	490	PF00069	0.486
MOD_GSK3_1	546	553	PF00069	0.566
MOD_GSK3_1	644	651	PF00069	0.356
MOD_GSK3_1	752	759	PF00069	0.426
MOD_GSK3_1	772	779	PF00069	0.329
MOD_N-GLC_1	320	325	PF02516	0.497
MOD_N-GLC_1	345	350	PF02516	0.610
MOD_N-GLC_1	784	789	PF02516	0.609
MOD_NEK2_1	131	136	PF00069	0.762
MOD_NEK2_1	202	207	PF00069	0.403
MOD_NEK2_1	263	268	PF00069	0.464
MOD_NEK2_1	340	345	PF00069	0.533
MOD_NEK2_1	412	417	PF00069	0.545
MOD_NEK2_1	419	424	PF00069	0.474
MOD_NEK2_1	483	488	PF00069	0.578
MOD_NEK2_1	515	520	PF00069	0.502
MOD_NEK2_1	534	539	PF00069	0.223
MOD_NEK2_1	541	546	PF00069	0.406
MOD_NEK2_1	590	595	PF00069	0.579
MOD_NEK2_1	644	649	PF00069	0.358
MOD_NEK2_1	671	676	PF00069	0.351
MOD_NEK2_1	736	741	PF00069	0.381
MOD_NEK2_1	790	795	PF00069	0.457
MOD_NEK2_2	766	771	PF00069	0.529
MOD_PIKK_1	485	491	PF00454	0.605
MOD_PIKK_1	850	856	PF00454	0.552
MOD_PIKK_1	97	103	PF00454	0.774
MOD_PKA_1	693	699	PF00069	0.568
MOD_PKA_2	207	213	PF00069	0.563
MOD_PKA_2	321	327	PF00069	0.489
MOD_PKA_2	34	40	PF00069	0.660
MOD_PKA_2	371	377	PF00069	0.541
MOD_PKA_2	412	418	PF00069	0.561
MOD_PKA_2	515	521	PF00069	0.491
MOD_PKA_2	693	699	PF00069	0.509
MOD_PKA_2	94	100	PF00069	0.748
MOD_Plk_1	175	181	PF00069	0.433
MOD_Plk_1	212	218	PF00069	0.513
MOD_Plk_1	219	225	PF00069	0.508
MOD_Plk_1	62	68	PF00069	0.564
MOD_Plk_2-3	220	226	PF00069	0.529
MOD_Plk_2-3	375	381	PF00069	0.507
MOD_Plk_2-3	726	732	PF00069	0.433
MOD_Plk_4	195	201	PF00069	0.511
MOD_Plk_4	220	226	PF00069	0.464
MOD_Plk_4	263	269	PF00069	0.399
MOD_Plk_4	41	47	PF00069	0.607
MOD_Plk_4	467	473	PF00069	0.677
MOD_Plk_4	752	758	PF00069	0.432
MOD_Plk_4	815	821	PF00069	0.564
MOD_ProDKin_1	137	143	PF00069	0.710
MOD_ProDKin_1	275	281	PF00069	0.465
MOD_ProDKin_1	397	403	PF00069	0.532
MOD_ProDKin_1	475	481	PF00069	0.608
MOD_ProDKin_1	582	588	PF00069	0.442
MOD_ProDKin_1	772	778	PF00069	0.592
MOD_ProDKin_1	785	791	PF00069	0.563
MOD_ProDKin_1	865	871	PF00069	0.459
MOD_ProDKin_1	874	880	PF00069	0.447
MOD_SUMO_rev_2	390	399	PF00179	0.563
TRG_DiLeu_BaEn_1	277	282	PF01217	0.532
TRG_DiLeu_BaEn_1	640	645	PF01217	0.468
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.508
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.531
TRG_DiLeu_BaLyEn_6	786	791	PF01217	0.431
TRG_ENDOCYTIC_2	38	41	PF00928	0.541
TRG_ENDOCYTIC_2	404	407	PF00928	0.405
TRG_ENDOCYTIC_2	434	437	PF00928	0.441
TRG_ENDOCYTIC_2	614	617	PF00928	0.575
TRG_ENDOCYTIC_2	876	879	PF00928	0.446
TRG_ER_diArg_1	621	623	PF00400	0.497
TRG_ER_diArg_1	662	665	PF00400	0.428
TRG_ER_diArg_1	71	74	PF00400	0.547
TRG_ER_diArg_1	825	828	PF00400	0.453
TRG_ER_diArg_1	83	86	PF00400	0.525
TRG_ER_diArg_1	831	833	PF00400	0.441
TRG_NES_CRM1_1	284	296	PF08389	0.469
TRG_NES_CRM1_1	431	445	PF08389	0.519
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I525	Leptomonas seymouri	67%	95%
A0A0S4JJP4	Bodo saltans	27%	100%
A0A1X0P5I8	Trypanosomatidae	40%	100%
A0A3S7X0L4	Leishmania donovani	100%	100%
A0A422N2Z0	Trypanosoma rangeli	42%	100%
A4HFM6	Leishmania braziliensis	86%	100%
D0A5V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AD80	Leishmania major	96%	100%
E9AZ04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B8L6	Trypanosoma cruzi	41%	100%