Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2Q3_LEIIN

TriTrypDb:

LINF_270016500

Length:

206

Annotations

LeishMANIAdb annotations

This small family of proteins is restricted to kinetoplastids only.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	8
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4I2Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2Q3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.344
CLV_NRD_NRD_1	26	28	PF00675	0.392
CLV_PCSK_KEX2_1	140	142	PF00082	0.425
CLV_PCSK_KEX2_1	199	201	PF00082	0.368
CLV_PCSK_KEX2_1	25	27	PF00082	0.351
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.423
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.381
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.351
CLV_PCSK_SKI1_1	201	205	PF00082	0.448
CLV_PCSK_SKI1_1	29	33	PF00082	0.479
CLV_PCSK_SKI1_1	45	49	PF00082	0.361
CLV_PCSK_SKI1_1	93	97	PF00082	0.582
DEG_COP1_1	143	153	PF00400	0.570
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DOC_CDC14_PxL_1	165	173	PF14671	0.534
DOC_USP7_MATH_1	118	122	PF00917	0.477
DOC_USP7_UBL2_3	25	29	PF12436	0.659
DOC_USP7_UBL2_3	57	61	PF12436	0.553
LIG_14-3-3_CanoR_1	159	167	PF00244	0.540
LIG_14-3-3_CanoR_1	178	186	PF00244	0.681
LIG_14-3-3_CanoR_1	54	60	PF00244	0.539
LIG_FHA_1	144	150	PF00498	0.594
LIG_FHA_1	41	47	PF00498	0.514
LIG_FHA_2	168	174	PF00498	0.617
LIG_FHA_2	183	189	PF00498	0.672
LIG_FHA_2	19	25	PF00498	0.726
LIG_FHA_2	30	36	PF00498	0.589
LIG_LIR_Gen_1	101	111	PF02991	0.286
LIG_LIR_Gen_1	60	70	PF02991	0.541
LIG_LIR_Nem_3	101	106	PF02991	0.283
LIG_LIR_Nem_3	60	65	PF02991	0.500
LIG_LIR_Nem_3	68	73	PF02991	0.461
LIG_PCNA_yPIPBox_3	189	198	PF02747	0.545
LIG_Pex14_1	103	107	PF04695	0.335
LIG_Pex14_1	71	75	PF04695	0.300
LIG_Pex14_2	107	111	PF04695	0.335
LIG_Pex14_2	72	76	PF04695	0.404
LIG_PTB_Apo_2	64	71	PF02174	0.526
LIG_PTB_Phospho_1	64	70	PF10480	0.527
LIG_REV1ctd_RIR_1	94	102	PF16727	0.350
LIG_SH2_CRK	62	66	PF00017	0.493
LIG_SH2_NCK_1	165	169	PF00017	0.524
LIG_SH2_STAP1	37	41	PF00017	0.604
LIG_SH2_STAP1	62	66	PF00017	0.561
LIG_SH2_STAT5	110	113	PF00017	0.289
LIG_SH2_STAT5	153	156	PF00017	0.547
LIG_SH2_STAT5	197	200	PF00017	0.469
LIG_SH2_STAT5	75	78	PF00017	0.430
LIG_SH3_3	166	172	PF00018	0.626
LIG_TRFH_1	165	169	PF08558	0.522
LIG_TYR_ITIM	163	168	PF00017	0.512
MOD_CK1_1	9	15	PF00069	0.681
MOD_CK2_1	167	173	PF00069	0.616
MOD_CK2_1	29	35	PF00069	0.599
MOD_GlcNHglycan	100	103	PF01048	0.561
MOD_GlcNHglycan	62	65	PF01048	0.378
MOD_NEK2_1	48	53	PF00069	0.543
MOD_NEK2_1	80	85	PF00069	0.308
MOD_NEK2_1	96	101	PF00069	0.317
MOD_PIKK_1	158	164	PF00454	0.538
MOD_PIKK_1	29	35	PF00454	0.622
MOD_PKA_2	158	164	PF00069	0.538
MOD_PKA_2	53	59	PF00069	0.579
MOD_Plk_1	182	188	PF00069	0.644
MOD_Plk_4	119	125	PF00069	0.550
MOD_Plk_4	6	12	PF00069	0.653
MOD_SUMO_for_1	163	166	PF00179	0.529
MOD_SUMO_rev_2	135	142	PF00179	0.585
TRG_ENDOCYTIC_2	165	168	PF00928	0.560
TRG_ENDOCYTIC_2	62	65	PF00928	0.489
TRG_ENDOCYTIC_2	73	76	PF00928	0.254
TRG_ER_diArg_1	52	55	PF00400	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX1	Leptomonas seymouri	68%	100%
A0A0S4JB41	Bodo saltans	39%	100%
A0A1X0P566	Trypanosomatidae	51%	100%
A0A3S7X0K5	Leishmania donovani	99%	100%
A0A422N2U5	Trypanosoma rangeli	52%	100%
A4HFM5	Leishmania braziliensis	89%	100%
D0A5V5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AD79	Leishmania major	97%	100%
E9AZ03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%