LeishMANIAdb
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Pep3_Vps18 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Pep3_Vps18 domain-containing protein
Gene product:
Pep3/Vps18/deep orange family/Region in Clathrin and VPS/Vacuolar sorting protein 39 domain 2 - putative
Species:
Leishmania infantum
UniProt:
A4I2P5_LEIIN
TriTrypDb:
LINF_270015400
Length:
1091

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 11
GO:0005768 endosome 7 1
GO:0030897 HOPS complex 3 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0098796 membrane protein complex 2 1
GO:0099023 vesicle tethering complex 2 1

Expansion

Sequence features

A4I2P5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2P5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 10
GO:0006886 intracellular protein transport 4 10
GO:0008104 protein localization 4 10
GO:0009987 cellular process 1 10
GO:0015031 protein transport 4 10
GO:0016192 vesicle-mediated transport 4 9
GO:0033036 macromolecule localization 2 10
GO:0045184 establishment of protein localization 3 10
GO:0046907 intracellular transport 3 10
GO:0051179 localization 1 10
GO:0051234 establishment of localization 2 10
GO:0051641 cellular localization 2 10
GO:0051649 establishment of localization in cell 3 10
GO:0070727 cellular macromolecule localization 3 10
GO:0071702 organic substance transport 4 10
GO:0071705 nitrogen compound transport 4 10
GO:0006904 vesicle docking involved in exocytosis 3 1
GO:0006996 organelle organization 4 1
GO:0007032 endosome organization 6 1
GO:0007033 vacuole organization 5 1
GO:0016043 cellular component organization 3 1
GO:0016050 vesicle organization 5 1
GO:0022406 membrane docking 2 1
GO:0048278 vesicle docking 4 1
GO:0048284 organelle fusion 5 1
GO:0051640 organelle localization 2 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0140029 exocytic process 2 1
GO:0140056 organelle localization by membrane tethering 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0030674 protein-macromolecule adaptor activity 2 1
GO:0060090 molecular adaptor activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 33 37 PF00656 0.590
CLV_C14_Caspase3-7 367 371 PF00656 0.438
CLV_C14_Caspase3-7 58 62 PF00656 0.504
CLV_C14_Caspase3-7 757 761 PF00656 0.565
CLV_C14_Caspase3-7 91 95 PF00656 0.470
CLV_NRD_NRD_1 1083 1085 PF00675 0.486
CLV_NRD_NRD_1 466 468 PF00675 0.382
CLV_NRD_NRD_1 505 507 PF00675 0.323
CLV_NRD_NRD_1 52 54 PF00675 0.510
CLV_NRD_NRD_1 853 855 PF00675 0.753
CLV_NRD_NRD_1 936 938 PF00675 0.428
CLV_PCSK_KEX2_1 466 468 PF00082 0.419
CLV_PCSK_KEX2_1 507 509 PF00082 0.322
CLV_PCSK_KEX2_1 52 54 PF00082 0.510
CLV_PCSK_KEX2_1 853 855 PF00082 0.753
CLV_PCSK_KEX2_1 963 965 PF00082 0.419
CLV_PCSK_PC1ET2_1 507 509 PF00082 0.340
CLV_PCSK_PC1ET2_1 963 965 PF00082 0.419
CLV_PCSK_SKI1_1 1005 1009 PF00082 0.360
CLV_PCSK_SKI1_1 205 209 PF00082 0.561
CLV_PCSK_SKI1_1 290 294 PF00082 0.532
CLV_PCSK_SKI1_1 332 336 PF00082 0.560
CLV_PCSK_SKI1_1 378 382 PF00082 0.401
CLV_PCSK_SKI1_1 466 470 PF00082 0.344
CLV_PCSK_SKI1_1 490 494 PF00082 0.356
CLV_PCSK_SKI1_1 515 519 PF00082 0.447
CLV_PCSK_SKI1_1 570 574 PF00082 0.386
CLV_PCSK_SKI1_1 626 630 PF00082 0.486
CLV_PCSK_SKI1_1 66 70 PF00082 0.500
CLV_PCSK_SKI1_1 725 729 PF00082 0.462
CLV_PCSK_SKI1_1 874 878 PF00082 0.559
DEG_APCC_DBOX_1 472 480 PF00400 0.453
DEG_APCC_DBOX_1 65 73 PF00400 0.567
DEG_COP1_1 337 348 PF00400 0.615
DEG_SPOP_SBC_1 194 198 PF00917 0.475
DEG_SPOP_SBC_1 248 252 PF00917 0.530
DOC_CYCLIN_RxL_1 623 633 PF00134 0.528
DOC_CYCLIN_RxL_1 729 742 PF00134 0.556
DOC_CYCLIN_RxL_1 999 1012 PF00134 0.346
DOC_CYCLIN_yCln2_LP_2 16 22 PF00134 0.574
DOC_MAPK_DCC_7 732 741 PF00069 0.564
DOC_MAPK_FxFP_2 1015 1018 PF00069 0.391
DOC_MAPK_gen_1 269 277 PF00069 0.534
DOC_MAPK_gen_1 495 503 PF00069 0.239
DOC_MAPK_gen_1 52 59 PF00069 0.506
DOC_MAPK_gen_1 640 649 PF00069 0.549
DOC_MAPK_gen_1 729 739 PF00069 0.563
DOC_MAPK_gen_1 937 944 PF00069 0.453
DOC_MAPK_HePTP_8 639 651 PF00069 0.441
DOC_MAPK_MEF2A_6 497 505 PF00069 0.239
DOC_MAPK_MEF2A_6 642 651 PF00069 0.518
DOC_MAPK_MEF2A_6 732 741 PF00069 0.564
DOC_PP1_RVXF_1 221 228 PF00149 0.439
DOC_PP1_RVXF_1 330 336 PF00149 0.577
DOC_PP1_RVXF_1 438 444 PF00149 0.306
DOC_PP1_RVXF_1 513 519 PF00149 0.475
DOC_PP2B_LxvP_1 847 850 PF13499 0.578
DOC_PP4_FxxP_1 1015 1018 PF00568 0.391
DOC_PP4_FxxP_1 429 432 PF00568 0.453
DOC_PP4_FxxP_1 80 83 PF00568 0.361
DOC_USP7_MATH_1 139 143 PF00917 0.520
DOC_USP7_MATH_1 151 155 PF00917 0.591
DOC_USP7_MATH_1 221 225 PF00917 0.421
DOC_USP7_MATH_1 248 252 PF00917 0.528
DOC_USP7_MATH_1 262 266 PF00917 0.525
DOC_USP7_MATH_1 341 345 PF00917 0.739
DOC_USP7_MATH_1 412 416 PF00917 0.439
DOC_USP7_MATH_1 6 10 PF00917 0.547
DOC_USP7_MATH_1 868 872 PF00917 0.727
DOC_USP7_MATH_1 910 914 PF00917 0.571
DOC_WW_Pin1_4 1009 1014 PF00397 0.353
DOC_WW_Pin1_4 195 200 PF00397 0.563
DOC_WW_Pin1_4 211 216 PF00397 0.491
DOC_WW_Pin1_4 415 420 PF00397 0.421
DOC_WW_Pin1_4 427 432 PF00397 0.421
DOC_WW_Pin1_4 446 451 PF00397 0.406
LIG_14-3-3_CanoR_1 271 276 PF00244 0.540
LIG_14-3-3_CanoR_1 336 341 PF00244 0.634
LIG_AP2alpha_2 444 446 PF02296 0.322
LIG_APCC_ABBA_1 20 25 PF00400 0.535
LIG_APCC_ABBA_1 836 841 PF00400 0.306
LIG_BIR_II_1 1 5 PF00653 0.678
LIG_BIR_III_3 1 5 PF00653 0.687
LIG_BIR_III_4 370 374 PF00653 0.513
LIG_BRCT_BRCA1_1 184 188 PF00533 0.501
LIG_BRCT_BRCA1_1 216 220 PF00533 0.588
LIG_BRCT_BRCA1_1 223 227 PF00533 0.358
LIG_DLG_GKlike_1 1032 1039 PF00625 0.435
LIG_EH1_1 763 771 PF00400 0.489
LIG_FHA_1 108 114 PF00498 0.531
LIG_FHA_1 265 271 PF00498 0.478
LIG_FHA_1 272 278 PF00498 0.483
LIG_FHA_1 322 328 PF00498 0.544
LIG_FHA_1 335 341 PF00498 0.599
LIG_FHA_1 428 434 PF00498 0.379
LIG_FHA_1 569 575 PF00498 0.449
LIG_FHA_1 669 675 PF00498 0.424
LIG_FHA_1 706 712 PF00498 0.422
LIG_FHA_1 718 724 PF00498 0.323
LIG_FHA_1 825 831 PF00498 0.426
LIG_FHA_1 84 90 PF00498 0.492
LIG_FHA_1 842 848 PF00498 0.296
LIG_FHA_1 930 936 PF00498 0.426
LIG_FHA_2 89 95 PF00498 0.468
LIG_FHA_2 967 973 PF00498 0.423
LIG_FHA_2 974 980 PF00498 0.422
LIG_Integrin_isoDGR_2 288 290 PF01839 0.522
LIG_LIR_Apic_2 1012 1018 PF02991 0.414
LIG_LIR_Apic_2 415 419 PF02991 0.428
LIG_LIR_Apic_2 427 432 PF02991 0.263
LIG_LIR_Gen_1 174 181 PF02991 0.475
LIG_LIR_Gen_1 393 402 PF02991 0.306
LIG_LIR_Gen_1 474 485 PF02991 0.404
LIG_LIR_Gen_1 552 561 PF02991 0.385
LIG_LIR_Gen_1 575 586 PF02991 0.500
LIG_LIR_Gen_1 596 607 PF02991 0.483
LIG_LIR_Gen_1 621 632 PF02991 0.527
LIG_LIR_Gen_1 706 712 PF02991 0.480
LIG_LIR_Gen_1 86 92 PF02991 0.435
LIG_LIR_Nem_3 1011 1017 PF02991 0.305
LIG_LIR_Nem_3 174 178 PF02991 0.490
LIG_LIR_Nem_3 393 398 PF02991 0.303
LIG_LIR_Nem_3 474 480 PF02991 0.373
LIG_LIR_Nem_3 552 557 PF02991 0.377
LIG_LIR_Nem_3 575 581 PF02991 0.393
LIG_LIR_Nem_3 596 602 PF02991 0.480
LIG_LIR_Nem_3 621 627 PF02991 0.536
LIG_LIR_Nem_3 706 710 PF02991 0.378
LIG_LIR_Nem_3 747 751 PF02991 0.463
LIG_LIR_Nem_3 86 90 PF02991 0.457
LIG_LIR_Nem_3 946 951 PF02991 0.420
LIG_LIR_Nem_3 954 959 PF02991 0.372
LIG_LIR_Nem_3 989 994 PF02991 0.393
LIG_PCNA_PIPBox_1 1036 1045 PF02747 0.510
LIG_PCNA_yPIPBox_3 44 56 PF02747 0.435
LIG_PCNA_yPIPBox_3 893 903 PF02747 0.517
LIG_Rb_pABgroove_1 312 320 PF01858 0.402
LIG_SH2_CRK 558 562 PF00017 0.366
LIG_SH2_NCK_1 298 302 PF00017 0.470
LIG_SH2_PTP2 788 791 PF00017 0.410
LIG_SH2_PTP2 87 90 PF00017 0.430
LIG_SH2_SRC 848 851 PF00017 0.497
LIG_SH2_STAP1 645 649 PF00017 0.459
LIG_SH2_STAP1 751 755 PF00017 0.526
LIG_SH2_STAP1 815 819 PF00017 0.336
LIG_SH2_STAT3 959 962 PF00017 0.453
LIG_SH2_STAT5 1014 1017 PF00017 0.354
LIG_SH2_STAT5 177 180 PF00017 0.437
LIG_SH2_STAT5 305 308 PF00017 0.481
LIG_SH2_STAT5 673 676 PF00017 0.358
LIG_SH2_STAT5 788 791 PF00017 0.270
LIG_SH2_STAT5 87 90 PF00017 0.465
LIG_SH2_STAT5 955 958 PF00017 0.379
LIG_SH2_STAT5 993 996 PF00017 0.306
LIG_SH3_1 428 434 PF00018 0.453
LIG_SH3_3 1075 1081 PF00018 0.527
LIG_SH3_3 16 22 PF00018 0.577
LIG_SH3_3 24 30 PF00018 0.534
LIG_SH3_3 396 402 PF00018 0.441
LIG_SH3_3 428 434 PF00018 0.426
LIG_SH3_3 70 76 PF00018 0.475
LIG_SUMO_SIM_par_1 1074 1079 PF11976 0.415
LIG_SUMO_SIM_par_1 235 241 PF11976 0.456
LIG_SUMO_SIM_par_1 715 721 PF11976 0.484
LIG_SUMO_SIM_par_1 765 771 PF11976 0.465
LIG_UBA3_1 598 606 PF00899 0.479
LIG_UBA3_1 723 729 PF00899 0.508
LIG_WRC_WIRS_1 745 750 PF05994 0.518
LIG_WW_2 431 434 PF00397 0.453
MOD_CDC14_SPxK_1 198 201 PF00782 0.358
MOD_CDK_SPxK_1 195 201 PF00069 0.353
MOD_CK1_1 160 166 PF00069 0.651
MOD_CK1_1 195 201 PF00069 0.506
MOD_CK1_1 211 217 PF00069 0.526
MOD_CK1_1 344 350 PF00069 0.690
MOD_CK1_1 415 421 PF00069 0.402
MOD_CK2_1 1028 1034 PF00069 0.431
MOD_CK2_1 336 342 PF00069 0.645
MOD_CK2_1 344 350 PF00069 0.708
MOD_CK2_1 627 633 PF00069 0.413
MOD_CK2_1 751 757 PF00069 0.480
MOD_CK2_1 8 14 PF00069 0.672
MOD_CK2_1 857 863 PF00069 0.646
MOD_CK2_1 90 96 PF00069 0.440
MOD_CK2_1 966 972 PF00069 0.415
MOD_GlcNHglycan 152 156 PF01048 0.641
MOD_GlcNHglycan 159 162 PF01048 0.711
MOD_GlcNHglycan 184 187 PF01048 0.462
MOD_GlcNHglycan 264 267 PF01048 0.536
MOD_GlcNHglycan 280 283 PF01048 0.428
MOD_GlcNHglycan 308 311 PF01048 0.452
MOD_GlcNHglycan 383 386 PF01048 0.387
MOD_GlcNHglycan 53 56 PF01048 0.501
MOD_GlcNHglycan 616 619 PF01048 0.564
MOD_GlcNHglycan 659 662 PF01048 0.534
MOD_GlcNHglycan 780 783 PF01048 0.428
MOD_GlcNHglycan 857 860 PF01048 0.654
MOD_GlcNHglycan 925 928 PF01048 0.362
MOD_GSK3_1 1003 1010 PF00069 0.394
MOD_GSK3_1 1028 1035 PF00069 0.527
MOD_GSK3_1 157 164 PF00069 0.754
MOD_GSK3_1 25 32 PF00069 0.565
MOD_GSK3_1 336 343 PF00069 0.710
MOD_GSK3_1 446 453 PF00069 0.397
MOD_GSK3_1 560 567 PF00069 0.450
MOD_GSK3_1 580 587 PF00069 0.275
MOD_GSK3_1 610 617 PF00069 0.499
MOD_GSK3_1 95 102 PF00069 0.448
MOD_N-GLC_2 525 527 PF02516 0.430
MOD_NEK2_1 1007 1012 PF00069 0.343
MOD_NEK2_1 107 112 PF00069 0.543
MOD_NEK2_1 208 213 PF00069 0.533
MOD_NEK2_1 227 232 PF00069 0.221
MOD_NEK2_1 237 242 PF00069 0.353
MOD_NEK2_1 334 339 PF00069 0.581
MOD_NEK2_1 469 474 PF00069 0.425
MOD_NEK2_1 51 56 PF00069 0.446
MOD_NEK2_1 560 565 PF00069 0.392
MOD_NEK2_1 580 585 PF00069 0.243
MOD_NEK2_1 627 632 PF00069 0.413
MOD_NEK2_1 668 673 PF00069 0.533
MOD_NEK2_1 68 73 PF00069 0.390
MOD_NEK2_1 804 809 PF00069 0.322
MOD_NEK2_1 810 815 PF00069 0.322
MOD_NEK2_2 883 888 PF00069 0.517
MOD_PIKK_1 123 129 PF00454 0.667
MOD_PIKK_1 161 167 PF00454 0.667
MOD_PIKK_1 269 275 PF00454 0.562
MOD_PIKK_1 31 37 PF00454 0.576
MOD_PIKK_1 519 525 PF00454 0.525
MOD_PIKK_1 966 972 PF00454 0.371
MOD_PIKK_1 994 1000 PF00454 0.411
MOD_PK_1 336 342 PF00069 0.625
MOD_PKA_2 294 300 PF00069 0.514
MOD_PKA_2 335 341 PF00069 0.598
MOD_PKA_2 51 57 PF00069 0.457
MOD_PKA_2 564 570 PF00069 0.487
MOD_Plk_1 1085 1091 PF00069 0.494
MOD_Plk_1 173 179 PF00069 0.528
MOD_Plk_1 341 347 PF00069 0.713
MOD_Plk_1 356 362 PF00069 0.496
MOD_Plk_1 705 711 PF00069 0.462
MOD_Plk_1 751 757 PF00069 0.533
MOD_Plk_1 863 869 PF00069 0.662
MOD_Plk_1 883 889 PF00069 0.515
MOD_Plk_1 95 101 PF00069 0.515
MOD_Plk_4 118 124 PF00069 0.473
MOD_Plk_4 301 307 PF00069 0.449
MOD_Plk_4 594 600 PF00069 0.479
MOD_Plk_4 706 712 PF00069 0.431
MOD_Plk_4 744 750 PF00069 0.479
MOD_Plk_4 805 811 PF00069 0.388
MOD_Plk_4 83 89 PF00069 0.473
MOD_ProDKin_1 1009 1015 PF00069 0.353
MOD_ProDKin_1 195 201 PF00069 0.566
MOD_ProDKin_1 211 217 PF00069 0.487
MOD_ProDKin_1 415 421 PF00069 0.421
MOD_ProDKin_1 427 433 PF00069 0.421
MOD_ProDKin_1 446 452 PF00069 0.406
MOD_SUMO_rev_2 866 876 PF00179 0.643
TRG_DiLeu_BaEn_1 174 179 PF01217 0.435
TRG_DiLeu_BaEn_1 329 334 PF01217 0.568
TRG_DiLeu_BaEn_1 64 69 PF01217 0.574
TRG_DiLeu_BaEn_1 940 945 PF01217 0.375
TRG_DiLeu_BaLyEn_6 647 652 PF01217 0.406
TRG_DiLeu_BaLyEn_6 787 792 PF01217 0.375
TRG_DiLeu_LyEn_5 329 334 PF01217 0.568
TRG_ENDOCYTIC_2 558 561 PF00928 0.360
TRG_ENDOCYTIC_2 645 648 PF00928 0.394
TRG_ENDOCYTIC_2 788 791 PF00928 0.301
TRG_ENDOCYTIC_2 833 836 PF00928 0.306
TRG_ENDOCYTIC_2 87 90 PF00928 0.412
TRG_ER_diArg_1 440 443 PF00400 0.340
TRG_ER_diArg_1 466 468 PF00400 0.426
TRG_ER_diArg_1 505 508 PF00400 0.306
TRG_ER_diArg_1 51 53 PF00400 0.500
TRG_ER_FFAT_1 950 961 PF00635 0.426
TRG_NES_CRM1_1 594 608 PF08389 0.427
TRG_NES_CRM1_1 934 947 PF08389 0.367
TRG_NLS_MonoExtC_3 505 511 PF00514 0.426
TRG_Pf-PMV_PEXEL_1 1005 1009 PF00026 0.373
TRG_Pf-PMV_PEXEL_1 1041 1045 PF00026 0.568
TRG_Pf-PMV_PEXEL_1 650 654 PF00026 0.429
TRG_Pf-PMV_PEXEL_1 725 730 PF00026 0.514
TRG_Pf-PMV_PEXEL_1 735 740 PF00026 0.561
TRG_Pf-PMV_PEXEL_1 790 794 PF00026 0.438
TRG_Pf-PMV_PEXEL_1 937 941 PF00026 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAX5 Leptomonas seymouri 63% 99%
A0A0S4JVP2 Bodo saltans 30% 100%
A0A1X0P439 Trypanosomatidae 35% 98%
A0A3R7NS00 Trypanosoma rangeli 36% 100%
A0A3S7X0J6 Leishmania donovani 100% 100%
A4HFL4 Leishmania braziliensis 82% 99%
D0A5Q6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 99%
E9AD68 Leishmania major 96% 100%
E9AYZ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
F4IDS7 Arabidopsis thaliana 23% 100%
P59015 Danio rerio 23% 100%
V5BE49 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS