S5A_REDUCTASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1295) - putative

Species:

Leishmania infantum

UniProt:

A4I2P4_LEIIN

TriTrypDb:

LINF_270015500

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4I2P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.227
CLV_NRD_NRD_1	72	74	PF00675	0.473
CLV_PCSK_KEX2_1	104	106	PF00082	0.227
CLV_PCSK_KEX2_1	72	74	PF00082	0.448
CLV_PCSK_SKI1_1	167	171	PF00082	0.479
CLV_PCSK_SKI1_1	299	303	PF00082	0.287
DEG_Nend_UBRbox_2	1	3	PF02207	0.411
DOC_CKS1_1	160	165	PF01111	0.230
DOC_CKS1_1	197	202	PF01111	0.448
DOC_PP1_RVXF_1	95	101	PF00149	0.299
DOC_USP7_MATH_1	236	240	PF00917	0.345
DOC_USP7_MATH_1	75	79	PF00917	0.324
DOC_WW_Pin1_4	126	131	PF00397	0.484
DOC_WW_Pin1_4	159	164	PF00397	0.279
DOC_WW_Pin1_4	196	201	PF00397	0.494
DOC_WW_Pin1_4	283	288	PF00397	0.460
LIG_14-3-3_CanoR_1	97	101	PF00244	0.427
LIG_APCC_ABBA_1	221	226	PF00400	0.451
LIG_Clathr_ClatBox_1	178	182	PF01394	0.358
LIG_deltaCOP1_diTrp_1	113	123	PF00928	0.426
LIG_deltaCOP1_diTrp_1	186	192	PF00928	0.494
LIG_FHA_1	120	126	PF00498	0.464
LIG_FHA_1	144	150	PF00498	0.272
LIG_FHA_1	151	157	PF00498	0.251
LIG_FHA_1	168	174	PF00498	0.276
LIG_FHA_1	24	30	PF00498	0.359
LIG_FHA_1	262	268	PF00498	0.303
LIG_FHA_1	284	290	PF00498	0.467
LIG_FHA_1	81	87	PF00498	0.421
LIG_FHA_2	163	169	PF00498	0.288
LIG_FHA_2	181	187	PF00498	0.147
LIG_LIR_Gen_1	114	125	PF02991	0.374
LIG_LIR_Gen_1	134	144	PF02991	0.356
LIG_LIR_Gen_1	168	179	PF02991	0.330
LIG_LIR_Gen_1	228	237	PF02991	0.272
LIG_LIR_Gen_1	38	44	PF02991	0.500
LIG_LIR_Gen_1	46	54	PF02991	0.254
LIG_LIR_Gen_1	55	61	PF02991	0.266
LIG_LIR_Gen_1	99	108	PF02991	0.469
LIG_LIR_Nem_3	114	120	PF02991	0.390
LIG_LIR_Nem_3	122	126	PF02991	0.427
LIG_LIR_Nem_3	134	139	PF02991	0.264
LIG_LIR_Nem_3	168	174	PF02991	0.349
LIG_LIR_Nem_3	228	233	PF02991	0.274
LIG_LIR_Nem_3	38	43	PF02991	0.503
LIG_LIR_Nem_3	44	50	PF02991	0.423
LIG_LIR_Nem_3	55	59	PF02991	0.249
LIG_LIR_Nem_3	85	90	PF02991	0.383
LIG_LIR_Nem_3	99	103	PF02991	0.401
LIG_MYND_1	287	291	PF01753	0.468
LIG_Pex14_1	56	60	PF04695	0.299
LIG_Pex14_2	139	143	PF04695	0.349
LIG_REV1ctd_RIR_1	100	109	PF16727	0.494
LIG_SH2_CRK	282	286	PF00017	0.494
LIG_SH2_STAP1	217	221	PF00017	0.451
LIG_SH2_STAT3	61	64	PF00017	0.345
LIG_SH2_STAT5	119	122	PF00017	0.451
LIG_SH2_STAT5	205	208	PF00017	0.494
LIG_SH2_STAT5	54	57	PF00017	0.308
LIG_SH2_STAT5	61	64	PF00017	0.289
LIG_SH3_3	157	163	PF00018	0.284
LIG_SH3_3	194	200	PF00018	0.448
LIG_SUMO_SIM_par_1	257	264	PF11976	0.275
LIG_TYR_ITIM	52	57	PF00017	0.336
LIG_UBA3_1	301	306	PF00899	0.520
LIG_WRC_WIRS_1	140	145	PF05994	0.270
MOD_CK1_1	292	298	PF00069	0.565
MOD_CK1_1	82	88	PF00069	0.362
MOD_CK2_1	162	168	PF00069	0.305
MOD_CMANNOS	147	150	PF00535	0.299
MOD_CMANNOS	247	250	PF00535	0.358
MOD_GlcNHglycan	18	21	PF01048	0.321
MOD_GlcNHglycan	250	253	PF01048	0.385
MOD_GlcNHglycan	296	299	PF01048	0.261
MOD_GlcNHglycan	4	7	PF01048	0.553
MOD_GSK3_1	12	19	PF00069	0.329
MOD_GSK3_1	139	146	PF00069	0.316
MOD_GSK3_1	236	243	PF00069	0.276
MOD_GSK3_1	261	268	PF00069	0.294
MOD_GSK3_1	289	296	PF00069	0.526
MOD_GSK3_1	75	82	PF00069	0.304
MOD_N-GLC_1	38	43	PF02516	0.227
MOD_NEK2_1	139	144	PF00069	0.307
MOD_NEK2_1	16	21	PF00069	0.285
MOD_NEK2_1	209	214	PF00069	0.433
MOD_NEK2_1	215	220	PF00069	0.419
MOD_NEK2_1	23	28	PF00069	0.299
MOD_NEK2_1	261	266	PF00069	0.342
MOD_NEK2_1	293	298	PF00069	0.498
MOD_NEK2_1	89	94	PF00069	0.365
MOD_PK_1	45	51	PF00069	0.264
MOD_PKA_2	96	102	PF00069	0.264
MOD_Plk_1	167	173	PF00069	0.266
MOD_Plk_1	225	231	PF00069	0.358
MOD_Plk_1	38	44	PF00069	0.427
MOD_Plk_2-3	38	44	PF00069	0.484
MOD_Plk_4	143	149	PF00069	0.318
MOD_Plk_4	18	24	PF00069	0.365
MOD_Plk_4	225	231	PF00069	0.301
MOD_Plk_4	289	295	PF00069	0.581
MOD_Plk_4	38	44	PF00069	0.372
MOD_Plk_4	52	58	PF00069	0.358
MOD_Plk_4	82	88	PF00069	0.331
MOD_ProDKin_1	126	132	PF00069	0.484
MOD_ProDKin_1	159	165	PF00069	0.279
MOD_ProDKin_1	196	202	PF00069	0.494
MOD_ProDKin_1	283	289	PF00069	0.459
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.157
TRG_ENDOCYTIC_2	282	285	PF00928	0.494
TRG_ENDOCYTIC_2	40	43	PF00928	0.451
TRG_ENDOCYTIC_2	54	57	PF00928	0.416
TRG_ER_diArg_1	103	105	PF00400	0.451
TRG_ER_diArg_1	71	73	PF00400	0.248
TRG_ER_diLys_1	305	308	PF00400	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU3	Leptomonas seymouri	67%	99%
A0A0S4JVU4	Bodo saltans	43%	91%
A0A1X0P416	Trypanosomatidae	48%	97%
A0A3S7X0J3	Leishmania donovani	99%	100%
A4HFL5	Leishmania braziliensis	77%	100%
E9AD69	Leishmania major	94%	100%
E9AYZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O74507	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	90%