Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I2P0_LEIIN

TriTrypDb:

LINF_270014800

Length:

1035

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2P0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.651
CLV_C14_Caspase3-7	574	578	PF00656	0.540
CLV_C14_Caspase3-7	696	700	PF00656	0.501
CLV_C14_Caspase3-7	785	789	PF00656	0.564
CLV_C14_Caspase3-7	881	885	PF00656	0.462
CLV_NRD_NRD_1	284	286	PF00675	0.614
CLV_NRD_NRD_1	936	938	PF00675	0.654
CLV_NRD_NRD_1	986	988	PF00675	0.473
CLV_NRD_NRD_1	997	999	PF00675	0.380
CLV_PCSK_KEX2_1	284	286	PF00082	0.614
CLV_PCSK_KEX2_1	581	583	PF00082	0.595
CLV_PCSK_KEX2_1	848	850	PF00082	0.538
CLV_PCSK_KEX2_1	936	938	PF00082	0.660
CLV_PCSK_KEX2_1	986	988	PF00082	0.473
CLV_PCSK_KEX2_1	997	999	PF00082	0.380
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.614
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.529
CLV_PCSK_PC1ET2_1	848	850	PF00082	0.509
CLV_PCSK_SKI1_1	1027	1031	PF00082	0.502
CLV_PCSK_SKI1_1	182	186	PF00082	0.485
CLV_PCSK_SKI1_1	270	274	PF00082	0.374
CLV_PCSK_SKI1_1	706	710	PF00082	0.362
CLV_PCSK_SKI1_1	721	725	PF00082	0.406
CLV_PCSK_SKI1_1	848	852	PF00082	0.504
CLV_PCSK_SKI1_1	962	966	PF00082	0.376
CLV_PCSK_SKI1_1	987	991	PF00082	0.404
DEG_APCC_DBOX_1	177	185	PF00400	0.388
DEG_APCC_DBOX_1	269	277	PF00400	0.452
DEG_APCC_DBOX_1	705	713	PF00400	0.391
DEG_APCC_DBOX_1	871	879	PF00400	0.481
DEG_MDM2_SWIB_1	747	755	PF02201	0.532
DEG_Nend_UBRbox_3	1	3	PF02207	0.580
DEG_SPOP_SBC_1	346	350	PF00917	0.545
DEG_SPOP_SBC_1	430	434	PF00917	0.360
DEG_SPOP_SBC_1	685	689	PF00917	0.392
DOC_CKS1_1	53	58	PF01111	0.560
DOC_CKS1_1	796	801	PF01111	0.529
DOC_CYCLIN_RxL_1	1024	1034	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	22	25	PF00134	0.463
DOC_MAPK_gen_1	116	124	PF00069	0.469
DOC_MAPK_gen_1	633	643	PF00069	0.428
DOC_MAPK_MEF2A_6	636	643	PF00069	0.460
DOC_MAPK_MEF2A_6	834	843	PF00069	0.606
DOC_MAPK_NFAT4_5	636	644	PF00069	0.455
DOC_PP1_RVXF_1	119	126	PF00149	0.392
DOC_PP1_RVXF_1	464	471	PF00149	0.385
DOC_PP1_RVXF_1	960	966	PF00149	0.393
DOC_PP2B_LxvP_1	22	25	PF13499	0.490
DOC_PP2B_LxvP_1	566	569	PF13499	0.405
DOC_PP2B_LxvP_1	850	853	PF13499	0.508
DOC_PP4_FxxP_1	1022	1025	PF00568	0.415
DOC_PP4_FxxP_1	85	88	PF00568	0.585
DOC_USP7_MATH_1	162	166	PF00917	0.567
DOC_USP7_MATH_1	209	213	PF00917	0.360
DOC_USP7_MATH_1	346	350	PF00917	0.632
DOC_USP7_MATH_1	351	355	PF00917	0.624
DOC_USP7_MATH_1	395	399	PF00917	0.625
DOC_USP7_MATH_1	451	455	PF00917	0.472
DOC_USP7_MATH_1	527	531	PF00917	0.428
DOC_USP7_MATH_1	544	548	PF00917	0.689
DOC_USP7_MATH_1	674	678	PF00917	0.499
DOC_USP7_MATH_1	685	689	PF00917	0.482
DOC_USP7_MATH_1	698	702	PF00917	0.517
DOC_USP7_MATH_1	789	793	PF00917	0.537
DOC_USP7_MATH_1	805	809	PF00917	0.469
DOC_USP7_MATH_1	830	834	PF00917	0.621
DOC_USP7_MATH_1	917	921	PF00917	0.604
DOC_USP7_UBL2_3	656	660	PF12436	0.503
DOC_WW_Pin1_4	10	15	PF00397	0.522
DOC_WW_Pin1_4	105	110	PF00397	0.650
DOC_WW_Pin1_4	222	227	PF00397	0.473
DOC_WW_Pin1_4	331	336	PF00397	0.612
DOC_WW_Pin1_4	511	516	PF00397	0.504
DOC_WW_Pin1_4	52	57	PF00397	0.564
DOC_WW_Pin1_4	759	764	PF00397	0.708
DOC_WW_Pin1_4	795	800	PF00397	0.537
DOC_WW_Pin1_4	818	823	PF00397	0.612
DOC_WW_Pin1_4	828	833	PF00397	0.611
DOC_WW_Pin1_4	924	929	PF00397	0.513
LIG_14-3-3_CanoR_1	178	182	PF00244	0.419
LIG_14-3-3_CanoR_1	193	201	PF00244	0.399
LIG_14-3-3_CanoR_1	352	359	PF00244	0.621
LIG_14-3-3_CanoR_1	500	509	PF00244	0.455
LIG_14-3-3_CanoR_1	62	66	PF00244	0.600
LIG_14-3-3_CanoR_1	702	709	PF00244	0.443
LIG_14-3-3_CanoR_1	783	787	PF00244	0.544
LIG_14-3-3_CanoR_1	81	86	PF00244	0.452
LIG_14-3-3_CanoR_1	834	841	PF00244	0.555
LIG_14-3-3_CanoR_1	857	865	PF00244	0.527
LIG_14-3-3_CanoR_1	901	909	PF00244	0.514
LIG_14-3-3_CanoR_1	936	943	PF00244	0.725
LIG_14-3-3_CanoR_1	986	995	PF00244	0.432
LIG_BIR_III_2	788	792	PF00653	0.567
LIG_BIR_III_4	577	581	PF00653	0.553
LIG_BIR_III_4	991	995	PF00653	0.518
LIG_BRCT_BRCA1_1	254	258	PF00533	0.450
LIG_BRCT_BRCA1_1	81	85	PF00533	0.606
LIG_BRCT_BRCA1_1	820	824	PF00533	0.709
LIG_Clathr_ClatBox_1	838	842	PF01394	0.591
LIG_FHA_1	106	112	PF00498	0.611
LIG_FHA_1	127	133	PF00498	0.518
LIG_FHA_1	139	145	PF00498	0.342
LIG_FHA_1	202	208	PF00498	0.487
LIG_FHA_1	214	220	PF00498	0.270
LIG_FHA_1	245	251	PF00498	0.482
LIG_FHA_1	313	319	PF00498	0.398
LIG_FHA_1	332	338	PF00498	0.580
LIG_FHA_1	362	368	PF00498	0.496
LIG_FHA_1	378	384	PF00498	0.340
LIG_FHA_1	447	453	PF00498	0.443
LIG_FHA_1	474	480	PF00498	0.355
LIG_FHA_1	512	518	PF00498	0.441
LIG_FHA_1	607	613	PF00498	0.458
LIG_FHA_1	636	642	PF00498	0.491
LIG_FHA_1	68	74	PF00498	0.509
LIG_FHA_1	796	802	PF00498	0.531
LIG_FHA_1	856	862	PF00498	0.592
LIG_FHA_1	868	874	PF00498	0.401
LIG_FHA_1	925	931	PF00498	0.561
LIG_FHA_1	976	982	PF00498	0.414
LIG_FHA_2	154	160	PF00498	0.443
LIG_FHA_2	35	41	PF00498	0.670
LIG_FHA_2	423	429	PF00498	0.377
LIG_FHA_2	943	949	PF00498	0.501
LIG_Integrin_RGD_1	633	635	PF01839	0.471
LIG_KLC1_Yacidic_2	401	406	PF13176	0.497
LIG_LIR_Apic_2	1021	1025	PF02991	0.486
LIG_LIR_Apic_2	82	88	PF02991	0.577
LIG_LIR_Gen_1	152	163	PF02991	0.406
LIG_LIR_Gen_1	315	323	PF02991	0.457
LIG_LIR_Gen_1	44	53	PF02991	0.546
LIG_LIR_Gen_1	481	489	PF02991	0.404
LIG_LIR_Gen_1	516	527	PF02991	0.433
LIG_LIR_Nem_3	152	158	PF02991	0.374
LIG_LIR_Nem_3	315	320	PF02991	0.437
LIG_LIR_Nem_3	401	407	PF02991	0.508
LIG_LIR_Nem_3	44	50	PF02991	0.523
LIG_LIR_Nem_3	467	473	PF02991	0.475
LIG_LIR_Nem_3	481	485	PF02991	0.314
LIG_LIR_Nem_3	516	522	PF02991	0.405
LIG_LIR_Nem_3	898	902	PF02991	0.435
LIG_MYND_1	459	463	PF01753	0.380
LIG_Pex14_2	138	142	PF04695	0.373
LIG_Pex14_2	747	751	PF04695	0.515
LIG_Pex14_2	984	988	PF04695	0.392
LIG_SH2_CRK	47	51	PF00017	0.620
LIG_SH2_NCK_1	155	159	PF00017	0.439
LIG_SH2_PTP2	404	407	PF00017	0.513
LIG_SH2_SRC	404	407	PF00017	0.513
LIG_SH2_SRC	968	971	PF00017	0.457
LIG_SH2_STAP1	47	51	PF00017	0.544
LIG_SH2_STAP1	482	486	PF00017	0.389
LIG_SH2_STAT5	153	156	PF00017	0.372
LIG_SH2_STAT5	174	177	PF00017	0.553
LIG_SH2_STAT5	366	369	PF00017	0.409
LIG_SH2_STAT5	404	407	PF00017	0.513
LIG_SH2_STAT5	926	929	PF00017	0.512
LIG_SH2_STAT5	982	985	PF00017	0.460
LIG_SH3_2	279	284	PF14604	0.591
LIG_SH3_3	20	26	PF00018	0.468
LIG_SH3_3	273	279	PF00018	0.454
LIG_SH3_3	389	395	PF00018	0.564
LIG_SH3_3	457	463	PF00018	0.376
LIG_SH3_3	826	832	PF00018	0.533
LIG_SH3_4	656	663	PF00018	0.487
LIG_SUMO_SIM_anti_2	1007	1013	PF11976	0.389
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.376
LIG_SUMO_SIM_anti_2	800	805	PF11976	0.543
LIG_SUMO_SIM_par_1	329	334	PF11976	0.611
LIG_SUMO_SIM_par_1	378	384	PF11976	0.408
LIG_SUMO_SIM_par_1	474	481	PF11976	0.318
LIG_SUMO_SIM_par_1	600	605	PF11976	0.407
LIG_SUMO_SIM_par_1	677	684	PF11976	0.369
LIG_SUMO_SIM_par_1	687	696	PF11976	0.405
LIG_TRAF2_1	167	170	PF00917	0.412
LIG_UBA3_1	650	656	PF00899	0.358
LIG_WRC_WIRS_1	1019	1024	PF05994	0.475
LIG_WW_3	1024	1028	PF00397	0.446
MOD_CDC14_SPxK_1	831	834	PF00782	0.515
MOD_CDK_SPK_2	759	764	PF00069	0.551
MOD_CDK_SPK_2	924	929	PF00069	0.588
MOD_CDK_SPxK_1	828	834	PF00069	0.525
MOD_CDK_SPxxK_3	511	518	PF00069	0.462
MOD_CDK_SPxxK_3	52	59	PF00069	0.564
MOD_CK1_1	177	183	PF00069	0.542
MOD_CK1_1	252	258	PF00069	0.427
MOD_CK1_1	290	296	PF00069	0.654
MOD_CK1_1	341	347	PF00069	0.610
MOD_CK1_1	36	42	PF00069	0.658
MOD_CK1_1	360	366	PF00069	0.364
MOD_CK1_1	446	452	PF00069	0.490
MOD_CK1_1	478	484	PF00069	0.383
MOD_CK1_1	540	546	PF00069	0.619
MOD_CK1_1	701	707	PF00069	0.423
MOD_CK1_1	774	780	PF00069	0.485
MOD_CK1_1	833	839	PF00069	0.728
MOD_CK1_1	915	921	PF00069	0.682
MOD_CK2_1	112	118	PF00069	0.483
MOD_CK2_1	153	159	PF00069	0.441
MOD_CK2_1	162	168	PF00069	0.462
MOD_CK2_1	395	401	PF00069	0.574
MOD_CK2_1	484	490	PF00069	0.391
MOD_CK2_1	722	728	PF00069	0.521
MOD_CK2_1	738	744	PF00069	0.409
MOD_CK2_1	794	800	PF00069	0.412
MOD_CK2_1	942	948	PF00069	0.516
MOD_Cter_Amidation	579	582	PF01082	0.621
MOD_GlcNHglycan	1006	1009	PF01048	0.516
MOD_GlcNHglycan	105	108	PF01048	0.510
MOD_GlcNHglycan	159	163	PF01048	0.525
MOD_GlcNHglycan	190	193	PF01048	0.423
MOD_GlcNHglycan	326	329	PF01048	0.607
MOD_GlcNHglycan	349	352	PF01048	0.592
MOD_GlcNHglycan	353	356	PF01048	0.618
MOD_GlcNHglycan	372	375	PF01048	0.308
MOD_GlcNHglycan	387	390	PF01048	0.616
MOD_GlcNHglycan	398	401	PF01048	0.691
MOD_GlcNHglycan	416	419	PF01048	0.330
MOD_GlcNHglycan	445	448	PF01048	0.436
MOD_GlcNHglycan	486	489	PF01048	0.408
MOD_GlcNHglycan	539	542	PF01048	0.580
MOD_GlcNHglycan	615	618	PF01048	0.548
MOD_GlcNHglycan	67	70	PF01048	0.514
MOD_GlcNHglycan	709	712	PF01048	0.451
MOD_GlcNHglycan	756	759	PF01048	0.480
MOD_GlcNHglycan	766	769	PF01048	0.351
MOD_GlcNHglycan	807	810	PF01048	0.661
MOD_GlcNHglycan	81	84	PF01048	0.498
MOD_GlcNHglycan	824	827	PF01048	0.524
MOD_GlcNHglycan	913	917	PF01048	0.654
MOD_GlcNHglycan	938	941	PF01048	0.585
MOD_GSK3_1	149	156	PF00069	0.423
MOD_GSK3_1	158	165	PF00069	0.420
MOD_GSK3_1	176	183	PF00069	0.302
MOD_GSK3_1	188	195	PF00069	0.382
MOD_GSK3_1	203	210	PF00069	0.343
MOD_GSK3_1	340	347	PF00069	0.603
MOD_GSK3_1	357	364	PF00069	0.470
MOD_GSK3_1	366	373	PF00069	0.333
MOD_GSK3_1	442	449	PF00069	0.479
MOD_GSK3_1	469	476	PF00069	0.313
MOD_GSK3_1	540	547	PF00069	0.543
MOD_GSK3_1	57	64	PF00069	0.611
MOD_GSK3_1	590	597	PF00069	0.501
MOD_GSK3_1	722	729	PF00069	0.535
MOD_GSK3_1	743	750	PF00069	0.630
MOD_GSK3_1	77	84	PF00069	0.451
MOD_GSK3_1	818	825	PF00069	0.671
MOD_GSK3_1	851	858	PF00069	0.534
MOD_GSK3_1	908	915	PF00069	0.618
MOD_GSK3_1	931	938	PF00069	0.634
MOD_LATS_1	412	418	PF00433	0.373
MOD_N-GLC_1	323	328	PF02516	0.606
MOD_N-GLC_1	338	343	PF02516	0.506
MOD_N-GLC_1	674	679	PF02516	0.498
MOD_N-GLC_1	950	955	PF02516	0.436
MOD_NEK2_1	1	6	PF00069	0.516
MOD_NEK2_1	202	207	PF00069	0.559
MOD_NEK2_1	213	218	PF00069	0.302
MOD_NEK2_1	304	309	PF00069	0.432
MOD_NEK2_1	340	345	PF00069	0.606
MOD_NEK2_1	368	373	PF00069	0.421
MOD_NEK2_1	495	500	PF00069	0.480
MOD_NEK2_1	590	595	PF00069	0.681
MOD_NEK2_1	707	712	PF00069	0.456
MOD_NEK2_1	747	752	PF00069	0.516
MOD_NEK2_1	782	787	PF00069	0.532
MOD_NEK2_1	824	829	PF00069	0.676
MOD_NEK2_1	844	849	PF00069	0.544
MOD_NEK2_1	935	940	PF00069	0.667
MOD_NEK2_2	716	721	PF00069	0.453
MOD_PIKK_1	594	600	PF00454	0.490
MOD_PIKK_1	701	707	PF00454	0.498
MOD_PIKK_1	856	862	PF00454	0.574
MOD_PKA_1	936	942	PF00069	0.646
MOD_PKA_2	177	183	PF00069	0.417
MOD_PKA_2	192	198	PF00069	0.376
MOD_PKA_2	287	293	PF00069	0.695
MOD_PKA_2	324	330	PF00069	0.565
MOD_PKA_2	351	357	PF00069	0.621
MOD_PKA_2	437	443	PF00069	0.394
MOD_PKA_2	58	64	PF00069	0.640
MOD_PKA_2	701	707	PF00069	0.523
MOD_PKA_2	782	788	PF00069	0.544
MOD_PKA_2	833	839	PF00069	0.626
MOD_PKA_2	856	862	PF00069	0.536
MOD_PKA_2	900	906	PF00069	0.503
MOD_PKA_2	935	941	PF00069	0.788
MOD_Plk_1	202	208	PF00069	0.436
MOD_Plk_1	338	344	PF00069	0.584
MOD_Plk_1	360	366	PF00069	0.502
MOD_Plk_1	377	383	PF00069	0.301
MOD_Plk_1	743	749	PF00069	0.563
MOD_Plk_1	950	956	PF00069	0.483
MOD_Plk_4	1	7	PF00069	0.514
MOD_Plk_4	149	155	PF00069	0.481
MOD_Plk_4	182	188	PF00069	0.405
MOD_Plk_4	203	209	PF00069	0.423
MOD_Plk_4	213	219	PF00069	0.282
MOD_Plk_4	260	266	PF00069	0.427
MOD_Plk_4	287	293	PF00069	0.669
MOD_Plk_4	313	319	PF00069	0.464
MOD_Plk_4	361	367	PF00069	0.474
MOD_Plk_4	431	437	PF00069	0.394
MOD_Plk_4	637	643	PF00069	0.469
MOD_Plk_4	674	680	PF00069	0.380
MOD_Plk_4	686	692	PF00069	0.414
MOD_Plk_4	719	725	PF00069	0.551
MOD_Plk_4	733	739	PF00069	0.384
MOD_Plk_4	747	753	PF00069	0.483
MOD_Plk_4	774	780	PF00069	0.545
MOD_Plk_4	81	87	PF00069	0.579
MOD_ProDKin_1	10	16	PF00069	0.518
MOD_ProDKin_1	105	111	PF00069	0.634
MOD_ProDKin_1	222	228	PF00069	0.488
MOD_ProDKin_1	331	337	PF00069	0.614
MOD_ProDKin_1	511	517	PF00069	0.506
MOD_ProDKin_1	52	58	PF00069	0.562
MOD_ProDKin_1	759	765	PF00069	0.702
MOD_ProDKin_1	795	801	PF00069	0.535
MOD_ProDKin_1	818	824	PF00069	0.612
MOD_ProDKin_1	828	834	PF00069	0.612
MOD_ProDKin_1	924	930	PF00069	0.521
MOD_SUMO_for_1	550	553	PF00179	0.550
MOD_SUMO_rev_2	36	44	PF00179	0.596
MOD_SUMO_rev_2	574	583	PF00179	0.563
TRG_DiLeu_BaEn_1	118	123	PF01217	0.475
TRG_DiLeu_BaEn_1	203	208	PF01217	0.479
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.540
TRG_DiLeu_BaLyEn_6	846	851	PF01217	0.541
TRG_DiLeu_LyEn_5	118	123	PF01217	0.475
TRG_ENDOCYTIC_2	155	158	PF00928	0.355
TRG_ENDOCYTIC_2	404	407	PF00928	0.513
TRG_ENDOCYTIC_2	47	50	PF00928	0.530
TRG_ENDOCYTIC_2	482	485	PF00928	0.393
TRG_ER_diArg_1	872	875	PF00400	0.490
TRG_ER_diArg_1	935	937	PF00400	0.654
TRG_ER_diArg_1	986	988	PF00400	0.473
TRG_ER_diArg_1	997	999	PF00400	0.380
TRG_NLS_MonoExtC_3	283	288	PF00514	0.613
TRG_NLS_MonoExtN_4	282	289	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	1027	1031	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	997	1001	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ23	Leptomonas seymouri	38%	96%
A0A3S7X0K8	Leishmania donovani	99%	100%
A4HFK8	Leishmania braziliensis	69%	100%
E9AD63	Leishmania major	91%	100%
E9AYY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%