Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2N8_LEIIN

TriTrypDb:

LINF_270014600

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2N8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	596	600	PF00656	0.579
CLV_NRD_NRD_1	183	185	PF00675	0.482
CLV_NRD_NRD_1	571	573	PF00675	0.532
CLV_PCSK_KEX2_1	183	185	PF00082	0.493
CLV_PCSK_KEX2_1	571	573	PF00082	0.532
CLV_PCSK_KEX2_1	597	599	PF00082	0.524
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.524
CLV_PCSK_SKI1_1	18	22	PF00082	0.493
CLV_PCSK_SKI1_1	288	292	PF00082	0.507
CLV_PCSK_SKI1_1	331	335	PF00082	0.384
CLV_PCSK_SKI1_1	37	41	PF00082	0.284
CLV_PCSK_SKI1_1	387	391	PF00082	0.431
CLV_PCSK_SKI1_1	571	575	PF00082	0.529
CLV_PCSK_SKI1_1	64	68	PF00082	0.590
DEG_APCC_DBOX_1	168	176	PF00400	0.424
DOC_CDC14_PxL_1	324	332	PF14671	0.410
DOC_CYCLIN_RxL_1	132	141	PF00134	0.534
DOC_CYCLIN_RxL_1	328	338	PF00134	0.332
DOC_CYCLIN_yClb1_LxF_4	14	20	PF00134	0.553
DOC_MAPK_DCC_7	108	116	PF00069	0.530
DOC_MAPK_gen_1	234	244	PF00069	0.512
DOC_MAPK_gen_1	313	321	PF00069	0.368
DOC_MAPK_gen_1	597	603	PF00069	0.519
DOC_MAPK_gen_1	61	69	PF00069	0.595
DOC_MAPK_MEF2A_6	108	116	PF00069	0.673
DOC_MAPK_MEF2A_6	155	162	PF00069	0.541
DOC_MAPK_MEF2A_6	387	394	PF00069	0.426
DOC_MAPK_NFAT4_5	155	163	PF00069	0.538
DOC_MAPK_NFAT4_5	387	395	PF00069	0.468
DOC_PP1_SILK_1	284	289	PF00149	0.522
DOC_PP2B_LxvP_1	554	557	PF13499	0.424
DOC_PP4_FxxP_1	430	433	PF00568	0.500
DOC_PP4_FxxP_1	574	577	PF00568	0.533
DOC_USP7_MATH_1	282	286	PF00917	0.514
DOC_USP7_MATH_1	403	407	PF00917	0.627
DOC_USP7_MATH_1	5	9	PF00917	0.479
DOC_USP7_MATH_1	528	532	PF00917	0.630
DOC_USP7_MATH_1	587	591	PF00917	0.586
DOC_WW_Pin1_4	115	120	PF00397	0.688
DOC_WW_Pin1_4	486	491	PF00397	0.652
DOC_WW_Pin1_4	562	567	PF00397	0.475
LIG_14-3-3_CanoR_1	205	215	PF00244	0.628
LIG_14-3-3_CanoR_1	275	279	PF00244	0.523
LIG_14-3-3_CanoR_1	370	374	PF00244	0.542
LIG_14-3-3_CanoR_1	408	418	PF00244	0.528
LIG_14-3-3_CanoR_1	421	425	PF00244	0.373
LIG_14-3-3_CanoR_1	459	469	PF00244	0.450
LIG_14-3-3_CanoR_1	519	525	PF00244	0.603
LIG_Actin_WH2_1	13	30	PF00022	0.524
LIG_Actin_WH2_2	168	185	PF00022	0.441
LIG_Actin_WH2_2	219	236	PF00022	0.434
LIG_Actin_WH2_2	258	274	PF00022	0.536
LIG_Actin_WH2_2	283	301	PF00022	0.508
LIG_Actin_WH2_2	326	344	PF00022	0.444
LIG_Actin_WH2_2	351	369	PF00022	0.438
LIG_Actin_WH2_2	443	461	PF00022	0.452
LIG_Actin_WH2_2	5	20	PF00022	0.523
LIG_APCC_ABBA_1	427	432	PF00400	0.499
LIG_APCC_ABBA_1	448	453	PF00400	0.469
LIG_BIR_III_2	305	309	PF00653	0.520
LIG_BRCT_BRCA1_1	120	124	PF00533	0.563
LIG_Clathr_ClatBox_1	503	507	PF01394	0.350
LIG_FHA_1	190	196	PF00498	0.542
LIG_FHA_1	527	533	PF00498	0.515
LIG_FHA_1	589	595	PF00498	0.510
LIG_FHA_1	602	608	PF00498	0.360
LIG_FHA_2	234	240	PF00498	0.512
LIG_FHA_2	245	251	PF00498	0.487
LIG_FHA_2	370	376	PF00498	0.601
LIG_GBD_Chelix_1	354	362	PF00786	0.480
LIG_LIR_Apic_2	322	326	PF02991	0.484
LIG_LIR_Gen_1	239	245	PF02991	0.490
LIG_LIR_Gen_1	449	458	PF02991	0.488
LIG_LIR_Gen_1	45	53	PF02991	0.543
LIG_LIR_Gen_1	507	513	PF02991	0.415
LIG_LIR_Gen_1	548	558	PF02991	0.370
LIG_LIR_Nem_3	127	133	PF02991	0.490
LIG_LIR_Nem_3	219	223	PF02991	0.433
LIG_LIR_Nem_3	239	244	PF02991	0.403
LIG_LIR_Nem_3	305	310	PF02991	0.481
LIG_LIR_Nem_3	449	454	PF02991	0.467
LIG_LIR_Nem_3	45	49	PF02991	0.500
LIG_LIR_Nem_3	507	511	PF02991	0.386
LIG_LIR_Nem_3	548	553	PF02991	0.368
LIG_LIR_Nem_3	55	59	PF02991	0.499
LIG_LYPXL_yS_3	56	59	PF13949	0.534
LIG_NRBOX	329	335	PF00104	0.468
LIG_NRBOX	499	505	PF00104	0.391
LIG_Pex14_2	42	46	PF04695	0.491
LIG_REV1ctd_RIR_1	621	631	PF16727	0.537
LIG_SH2_PTP2	323	326	PF00017	0.509
LIG_SH2_SRC	323	326	PF00017	0.509
LIG_SH2_STAT3	104	107	PF00017	0.586
LIG_SH2_STAT3	294	297	PF00017	0.530
LIG_SH2_STAT5	323	326	PF00017	0.468
LIG_SH2_STAT5	508	511	PF00017	0.428
LIG_SH2_STAT5	550	553	PF00017	0.457
LIG_SH3_3	113	119	PF00018	0.710
LIG_SH3_3	322	328	PF00018	0.531
LIG_SH3_3	385	391	PF00018	0.523
LIG_SH3_3	611	617	PF00018	0.609
LIG_Sin3_3	156	163	PF02671	0.462
LIG_SUMO_SIM_anti_2	590	596	PF11976	0.575
LIG_SUMO_SIM_par_1	446	453	PF11976	0.431
LIG_SUMO_SIM_par_1	590	596	PF11976	0.499
LIG_TRAF2_1	210	213	PF00917	0.588
LIG_TYR_ITIM	128	133	PF00017	0.502
LIG_WRC_WIRS_1	241	246	PF05994	0.484
MOD_CK1_1	118	124	PF00069	0.602
MOD_CK1_1	188	194	PF00069	0.475
MOD_CK1_1	219	225	PF00069	0.463
MOD_CK1_1	254	260	PF00069	0.532
MOD_CK1_1	411	417	PF00069	0.546
MOD_CK1_1	419	425	PF00069	0.411
MOD_CK1_1	486	492	PF00069	0.571
MOD_CK1_1	523	529	PF00069	0.659
MOD_CK2_1	206	212	PF00069	0.630
MOD_CK2_1	369	375	PF00069	0.597
MOD_CK2_1	419	425	PF00069	0.381
MOD_CK2_1	449	455	PF00069	0.523
MOD_GlcNHglycan	108	111	PF01048	0.663
MOD_GlcNHglycan	120	123	PF01048	0.636
MOD_GlcNHglycan	147	150	PF01048	0.594
MOD_GlcNHglycan	187	190	PF01048	0.442
MOD_GlcNHglycan	209	212	PF01048	0.603
MOD_GlcNHglycan	335	338	PF01048	0.500
MOD_GlcNHglycan	500	503	PF01048	0.509
MOD_GlcNHglycan	578	581	PF01048	0.601
MOD_GlcNHglycan	584	587	PF01048	0.615
MOD_GlcNHglycan	64	67	PF01048	0.568
MOD_GSK3_1	185	192	PF00069	0.479
MOD_GSK3_1	240	247	PF00069	0.473
MOD_GSK3_1	329	336	PF00069	0.455
MOD_GSK3_1	356	363	PF00069	0.502
MOD_GSK3_1	403	410	PF00069	0.559
MOD_GSK3_1	416	423	PF00069	0.387
MOD_GSK3_1	435	442	PF00069	0.540
MOD_GSK3_1	519	526	PF00069	0.550
MOD_GSK3_1	558	565	PF00069	0.489
MOD_GSK3_1	67	74	PF00069	0.680
MOD_N-GLC_1	22	27	PF02516	0.454
MOD_N-GLC_1	435	440	PF02516	0.514
MOD_NEK2_1	126	131	PF00069	0.482
MOD_NEK2_1	206	211	PF00069	0.612
MOD_NEK2_1	233	238	PF00069	0.468
MOD_NEK2_1	244	249	PF00069	0.436
MOD_NEK2_1	271	276	PF00069	0.602
MOD_NEK2_1	356	361	PF00069	0.424
MOD_NEK2_1	520	525	PF00069	0.474
MOD_NEK2_1	609	614	PF00069	0.560
MOD_NEK2_2	216	221	PF00069	0.417
MOD_NEK2_2	528	533	PF00069	0.531
MOD_PIKK_1	512	518	PF00454	0.496
MOD_PIKK_1	523	529	PF00454	0.668
MOD_PK_1	627	633	PF00069	0.551
MOD_PKA_2	204	210	PF00069	0.594
MOD_PKA_2	233	239	PF00069	0.505
MOD_PKA_2	274	280	PF00069	0.547
MOD_PKA_2	341	347	PF00069	0.584
MOD_PKA_2	369	375	PF00069	0.597
MOD_PKA_2	407	413	PF00069	0.548
MOD_PKA_2	420	426	PF00069	0.364
MOD_PKA_2	439	445	PF00069	0.323
MOD_Plk_1	126	132	PF00069	0.492
MOD_Plk_1	22	28	PF00069	0.468
MOD_Plk_1	397	403	PF00069	0.542
MOD_Plk_1	71	77	PF00069	0.631
MOD_Plk_2-3	449	455	PF00069	0.455
MOD_Plk_4	22	28	PF00069	0.512
MOD_Plk_4	240	246	PF00069	0.466
MOD_Plk_4	260	266	PF00069	0.410
MOD_Plk_4	282	288	PF00069	0.484
MOD_Plk_4	329	335	PF00069	0.404
MOD_Plk_4	439	445	PF00069	0.518
MOD_Plk_4	609	615	PF00069	0.540
MOD_Plk_4	627	633	PF00069	0.462
MOD_ProDKin_1	115	121	PF00069	0.677
MOD_ProDKin_1	486	492	PF00069	0.646
MOD_ProDKin_1	562	568	PF00069	0.479
TRG_AP2beta_CARGO_1	239	248	PF09066	0.466
TRG_DiLeu_BaEn_1	453	458	PF01217	0.524
TRG_DiLeu_BaEn_1	7	12	PF01217	0.594
TRG_DiLeu_BaEn_2	47	53	PF01217	0.497
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.526
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.456
TRG_DiLeu_BaLyEn_6	443	448	PF01217	0.475
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.563
TRG_ENDOCYTIC_2	130	133	PF00928	0.455
TRG_ENDOCYTIC_2	508	511	PF00928	0.421
TRG_ENDOCYTIC_2	550	553	PF00928	0.393
TRG_ENDOCYTIC_2	56	59	PF00928	0.465
TRG_ER_diArg_1	169	172	PF00400	0.500
TRG_ER_diArg_1	182	184	PF00400	0.434
TRG_ER_diArg_1	570	572	PF00400	0.530
TRG_NES_CRM1_1	161	174	PF08389	0.369
TRG_NES_CRM1_1	225	239	PF08389	0.437
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	571	575	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC39	Leptomonas seymouri	47%	73%
A0A1X0P545	Trypanosomatidae	29%	73%
A0A3R7KBK6	Trypanosoma rangeli	27%	77%
A0A3S7X0J4	Leishmania donovani	100%	74%
A4HFK6	Leishmania braziliensis	79%	100%
D0A5T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	76%
E9AD61	Leishmania major	92%	100%
E9AYY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BE63	Trypanosoma cruzi	29%	76%