LeishMANIAdb
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ATP-binding cassette protein subfamily D, member 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-binding cassette protein subfamily D, member 1
Gene product:
glycosomal transporter (GAT3) - putative
Species:
Leishmania infantum
UniProt:
A4I2N3_LEIIN
TriTrypDb:
LINF_270009800
Length:
688

Annotations

Annotations by Jardim et al.

Glycosome membrane, GAT3 glycosomal ATP-binding cassette D, member 1 ABCD1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005777 peroxisome 6 1
GO:0005778 peroxisomal membrane 6 1
GO:0020015 glycosome 7 1
GO:0020022 acidocalcisome 5 1
GO:0031090 organelle membrane 3 1
GO:0031903 microbody membrane 5 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A4I2N3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2N3

Function

Biological processes
Term Name Level Count
GO:0000038 very long-chain fatty acid metabolic process 5 1
GO:0006082 organic acid metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006631 fatty acid metabolic process 4 1
GO:0006635 fatty acid beta-oxidation 6 1
GO:0006810 transport 3 1
GO:0006869 lipid transport 5 1
GO:0006996 organelle organization 4 1
GO:0007031 peroxisome organization 5 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009062 fatty acid catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0015849 organic acid transport 5 1
GO:0015908 fatty acid transport 6 1
GO:0015909 long-chain fatty acid transport 7 1
GO:0015910 long-chain fatty acid import into peroxisome 5 1
GO:0015919 peroxisomal membrane transport 5 1
GO:0016042 lipid catabolic process 4 1
GO:0016043 cellular component organization 3 1
GO:0016054 organic acid catabolic process 4 1
GO:0019395 fatty acid oxidation 5 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0030258 lipid modification 4 1
GO:0032365 intracellular lipid transport 4 1
GO:0032787 monocarboxylic acid metabolic process 6 1
GO:0034440 lipid oxidation 5 1
GO:0042760 very long-chain fatty acid catabolic process 6 1
GO:0043436 oxoacid metabolic process 4 1
GO:0043574 peroxisomal transport 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044242 cellular lipid catabolic process 4 1
GO:0044248 cellular catabolic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044282 small molecule catabolic process 3 1
GO:0046395 carboxylic acid catabolic process 5 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0055085 transmembrane transport 2 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0072329 monocarboxylic acid catabolic process 6 1
GO:1901575 organic substance catabolic process 3 1
GO:1902001 fatty acid transmembrane transport 5 1
GO:1903825 organic acid transmembrane transport 3 1
GO:1905039 carboxylic acid transmembrane transport 4 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0005215 transporter activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0015399 primary active transmembrane transporter activity 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0022804 active transmembrane transporter activity 3 12
GO:0022857 transmembrane transporter activity 2 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0042626 ATPase-coupled transmembrane transporter activity 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140359 ABC-type transporter activity 3 12
GO:0140657 ATP-dependent activity 1 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0005319 lipid transporter activity 2 1
GO:0005324 long-chain fatty acid transporter activity 3 1
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 186 190 PF00656 0.256
CLV_NRD_NRD_1 174 176 PF00675 0.458
CLV_NRD_NRD_1 255 257 PF00675 0.249
CLV_NRD_NRD_1 276 278 PF00675 0.221
CLV_NRD_NRD_1 347 349 PF00675 0.593
CLV_NRD_NRD_1 635 637 PF00675 0.502
CLV_PCSK_KEX2_1 174 176 PF00082 0.455
CLV_PCSK_KEX2_1 255 257 PF00082 0.249
CLV_PCSK_KEX2_1 276 278 PF00082 0.221
CLV_PCSK_KEX2_1 347 349 PF00082 0.579
CLV_PCSK_KEX2_1 635 637 PF00082 0.526
CLV_PCSK_SKI1_1 102 106 PF00082 0.280
CLV_PCSK_SKI1_1 238 242 PF00082 0.405
CLV_PCSK_SKI1_1 276 280 PF00082 0.244
CLV_PCSK_SKI1_1 296 300 PF00082 0.272
CLV_PCSK_SKI1_1 508 512 PF00082 0.448
CLV_PCSK_SKI1_1 597 601 PF00082 0.485
CLV_PCSK_SKI1_1 78 82 PF00082 0.456
DOC_CDC14_PxL_1 216 224 PF14671 0.299
DOC_MAPK_gen_1 607 615 PF00069 0.275
DOC_MAPK_gen_1 670 677 PF00069 0.419
DOC_MAPK_MEF2A_6 102 109 PF00069 0.337
DOC_MAPK_MEF2A_6 135 144 PF00069 0.508
DOC_MAPK_MEF2A_6 353 362 PF00069 0.305
DOC_MAPK_MEF2A_6 439 446 PF00069 0.325
DOC_PP1_RVXF_1 595 601 PF00149 0.330
DOC_PP2B_LxvP_1 493 496 PF13499 0.266
DOC_PP4_FxxP_1 217 220 PF00568 0.233
DOC_PP4_FxxP_1 510 513 PF00568 0.215
DOC_USP7_MATH_1 30 34 PF00917 0.455
DOC_USP7_MATH_1 513 517 PF00917 0.258
DOC_WW_Pin1_4 346 351 PF00397 0.303
DOC_WW_Pin1_4 450 455 PF00397 0.308
DOC_WW_Pin1_4 509 514 PF00397 0.333
DOC_WW_Pin1_4 535 540 PF00397 0.369
DOC_WW_Pin1_4 608 613 PF00397 0.276
LIG_14-3-3_CanoR_1 167 173 PF00244 0.292
LIG_14-3-3_CanoR_1 542 551 PF00244 0.307
LIG_14-3-3_CanoR_1 592 596 PF00244 0.250
LIG_14-3-3_CanoR_1 640 645 PF00244 0.236
LIG_Actin_WH2_2 224 240 PF00022 0.320
LIG_Actin_WH2_2 295 312 PF00022 0.472
LIG_BRCT_BRCA1_1 168 172 PF00533 0.258
LIG_BRCT_BRCA1_1 32 36 PF00533 0.382
LIG_BRCT_BRCA1_1 463 467 PF00533 0.279
LIG_BRCT_BRCA1_1 505 509 PF00533 0.299
LIG_BRCT_BRCA1_1 91 95 PF00533 0.368
LIG_Clathr_ClatBox_1 443 447 PF01394 0.343
LIG_CSL_BTD_1 493 496 PF09270 0.258
LIG_eIF4E_1 359 365 PF01652 0.371
LIG_FHA_1 246 252 PF00498 0.458
LIG_FHA_1 278 284 PF00498 0.469
LIG_FHA_1 30 36 PF00498 0.385
LIG_FHA_1 438 444 PF00498 0.375
LIG_FHA_1 482 488 PF00498 0.244
LIG_FHA_1 536 542 PF00498 0.330
LIG_FHA_1 64 70 PF00498 0.427
LIG_FHA_1 653 659 PF00498 0.271
LIG_FHA_2 184 190 PF00498 0.246
LIG_FHA_2 521 527 PF00498 0.233
LIG_FHA_2 57 63 PF00498 0.396
LIG_FHA_2 624 630 PF00498 0.362
LIG_FHA_2 643 649 PF00498 0.182
LIG_GBD_Chelix_1 140 148 PF00786 0.422
LIG_IRF3_LxIS_1 298 305 PF10401 0.472
LIG_LIR_Apic_2 16 22 PF02991 0.513
LIG_LIR_Apic_2 516 520 PF02991 0.236
LIG_LIR_Gen_1 208 218 PF02991 0.212
LIG_LIR_Gen_1 327 338 PF02991 0.480
LIG_LIR_Gen_1 414 424 PF02991 0.429
LIG_LIR_Gen_1 470 478 PF02991 0.246
LIG_LIR_Gen_1 523 533 PF02991 0.297
LIG_LIR_Gen_1 92 103 PF02991 0.327
LIG_LIR_Nem_3 208 213 PF02991 0.229
LIG_LIR_Nem_3 327 333 PF02991 0.483
LIG_LIR_Nem_3 414 419 PF02991 0.414
LIG_LIR_Nem_3 440 444 PF02991 0.316
LIG_LIR_Nem_3 470 476 PF02991 0.246
LIG_LIR_Nem_3 523 528 PF02991 0.297
LIG_LIR_Nem_3 579 585 PF02991 0.241
LIG_LIR_Nem_3 92 98 PF02991 0.328
LIG_PCNA_yPIPBox_3 369 380 PF02747 0.338
LIG_Pex14_2 172 176 PF04695 0.258
LIG_Pex14_2 206 210 PF04695 0.212
LIG_Pex14_2 375 379 PF04695 0.321
LIG_Pex14_2 95 99 PF04695 0.276
LIG_SH2_CRK 177 181 PF00017 0.276
LIG_SH2_CRK 19 23 PF00017 0.627
LIG_SH2_CRK 416 420 PF00017 0.417
LIG_SH2_CRK 517 521 PF00017 0.258
LIG_SH2_GRB2like 282 285 PF00017 0.472
LIG_SH2_SRC 359 362 PF00017 0.347
LIG_SH2_STAP1 564 568 PF00017 0.317
LIG_SH2_STAT5 202 205 PF00017 0.254
LIG_SH2_STAT5 216 219 PF00017 0.221
LIG_SH2_STAT5 282 285 PF00017 0.541
LIG_SH2_STAT5 297 300 PF00017 0.441
LIG_SH2_STAT5 359 362 PF00017 0.292
LIG_SH2_STAT5 426 429 PF00017 0.372
LIG_SH3_3 417 423 PF00018 0.428
LIG_SH3_3 531 537 PF00018 0.257
LIG_SH3_3 668 674 PF00018 0.409
LIG_SUMO_SIM_anti_2 610 618 PF11976 0.273
LIG_SUMO_SIM_par_1 610 618 PF11976 0.242
LIG_SUMO_SIM_par_1 640 645 PF11976 0.288
LIG_TRFH_1 509 513 PF08558 0.330
LIG_TYR_ITIM 213 218 PF00017 0.233
LIG_TYR_ITSM 521 528 PF00017 0.330
LIG_UBA3_1 364 373 PF00899 0.375
LIG_UBA3_1 489 497 PF00899 0.330
LIG_UBA3_1 657 665 PF00899 0.383
LIG_UBA3_1 94 102 PF00899 0.321
LIG_WRC_WIRS_1 330 335 PF05994 0.348
MOD_CDK_SPxxK_3 346 353 PF00069 0.302
MOD_CDK_SPxxK_3 535 542 PF00069 0.272
MOD_CK1_1 13 19 PF00069 0.681
MOD_CK1_1 245 251 PF00069 0.337
MOD_CK1_1 328 334 PF00069 0.347
MOD_CK1_1 383 389 PF00069 0.295
MOD_CK1_1 461 467 PF00069 0.330
MOD_CK1_1 502 508 PF00069 0.317
MOD_CK1_1 583 589 PF00069 0.257
MOD_CK1_1 89 95 PF00069 0.331
MOD_CK2_1 187 193 PF00069 0.265
MOD_CK2_1 520 526 PF00069 0.233
MOD_GlcNHglycan 10 13 PF01048 0.411
MOD_GlcNHglycan 149 152 PF01048 0.190
MOD_GlcNHglycan 238 241 PF01048 0.337
MOD_GlcNHglycan 32 35 PF01048 0.308
MOD_GlcNHglycan 327 330 PF01048 0.263
MOD_GlcNHglycan 497 500 PF01048 0.496
MOD_GlcNHglycan 565 568 PF01048 0.540
MOD_GlcNHglycan 585 588 PF01048 0.324
MOD_GlcNHglycan 88 91 PF01048 0.526
MOD_GSK3_1 142 149 PF00069 0.320
MOD_GSK3_1 183 190 PF00069 0.240
MOD_GSK3_1 194 201 PF00069 0.228
MOD_GSK3_1 241 248 PF00069 0.394
MOD_GSK3_1 263 270 PF00069 0.487
MOD_GSK3_1 325 332 PF00069 0.492
MOD_GSK3_1 383 390 PF00069 0.300
MOD_GSK3_1 403 410 PF00069 0.227
MOD_GSK3_1 411 418 PF00069 0.455
MOD_GSK3_1 424 431 PF00069 0.470
MOD_GSK3_1 495 502 PF00069 0.301
MOD_GSK3_1 509 516 PF00069 0.244
MOD_GSK3_1 52 59 PF00069 0.442
MOD_GSK3_1 576 583 PF00069 0.258
MOD_GSK3_1 8 15 PF00069 0.606
MOD_LATS_1 409 415 PF00433 0.436
MOD_N-GLC_1 368 373 PF02516 0.501
MOD_N-GLC_1 461 466 PF02516 0.443
MOD_N-GLC_2 479 481 PF02516 0.458
MOD_NEK2_1 168 173 PF00069 0.330
MOD_NEK2_1 187 192 PF00069 0.330
MOD_NEK2_1 241 246 PF00069 0.407
MOD_NEK2_1 302 307 PF00069 0.530
MOD_NEK2_1 325 330 PF00069 0.431
MOD_NEK2_1 368 373 PF00069 0.300
MOD_NEK2_1 407 412 PF00069 0.404
MOD_NEK2_1 424 429 PF00069 0.481
MOD_NEK2_1 571 576 PF00069 0.303
MOD_NEK2_1 8 13 PF00069 0.685
MOD_NEK2_2 520 525 PF00069 0.299
MOD_PIKK_1 263 269 PF00454 0.530
MOD_PIKK_1 39 45 PF00454 0.481
MOD_PIKK_1 424 430 PF00454 0.439
MOD_PIKK_1 499 505 PF00454 0.317
MOD_PIKK_1 60 66 PF00454 0.465
MOD_PK_1 10 16 PF00069 0.607
MOD_PK_1 640 646 PF00069 0.286
MOD_PKA_2 166 172 PF00069 0.233
MOD_PKA_2 591 597 PF00069 0.264
MOD_PKA_2 86 92 PF00069 0.272
MOD_PKB_1 165 173 PF00069 0.272
MOD_Plk_1 302 308 PF00069 0.530
MOD_Plk_1 368 374 PF00069 0.287
MOD_Plk_1 380 386 PF00069 0.261
MOD_Plk_1 395 401 PF00069 0.285
MOD_Plk_1 461 467 PF00069 0.243
MOD_Plk_1 503 509 PF00069 0.247
MOD_Plk_1 576 582 PF00069 0.250
MOD_Plk_1 60 66 PF00069 0.402
MOD_Plk_1 617 623 PF00069 0.241
MOD_Plk_2-3 466 472 PF00069 0.295
MOD_Plk_2-3 618 624 PF00069 0.334
MOD_Plk_4 183 189 PF00069 0.256
MOD_Plk_4 329 335 PF00069 0.313
MOD_Plk_4 403 409 PF00069 0.394
MOD_Plk_4 482 488 PF00069 0.233
MOD_Plk_4 513 519 PF00069 0.238
MOD_Plk_4 520 526 PF00069 0.243
MOD_Plk_4 553 559 PF00069 0.244
MOD_Plk_4 618 624 PF00069 0.334
MOD_Plk_4 89 95 PF00069 0.359
MOD_ProDKin_1 346 352 PF00069 0.306
MOD_ProDKin_1 450 456 PF00069 0.312
MOD_ProDKin_1 509 515 PF00069 0.333
MOD_ProDKin_1 535 541 PF00069 0.369
MOD_ProDKin_1 608 614 PF00069 0.276
MOD_SUMO_for_1 444 447 PF00179 0.343
MOD_SUMO_rev_2 431 441 PF00179 0.332
TRG_ENDOCYTIC_2 177 180 PF00928 0.246
TRG_ENDOCYTIC_2 215 218 PF00928 0.233
TRG_ENDOCYTIC_2 275 278 PF00928 0.454
TRG_ENDOCYTIC_2 359 362 PF00928 0.292
TRG_ENDOCYTIC_2 416 419 PF00928 0.459
TRG_ENDOCYTIC_2 426 429 PF00928 0.372
TRG_ENDOCYTIC_2 5 8 PF00928 0.577
TRG_ENDOCYTIC_2 525 528 PF00928 0.295
TRG_ER_diArg_1 174 176 PF00400 0.251
TRG_ER_diArg_1 254 256 PF00400 0.449
TRG_ER_diArg_1 275 277 PF00400 0.421
TRG_ER_diArg_1 634 636 PF00400 0.319
TRG_ER_diArg_1 84 87 PF00400 0.330
TRG_NES_CRM1_1 324 339 PF08389 0.530
TRG_NES_CRM1_1 366 381 PF08389 0.302
TRG_NES_CRM1_1 540 555 PF08389 0.317

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1V4 Leptomonas seymouri 22% 80%
A0A0N1I6W7 Leptomonas seymouri 73% 100%
A0A0S4JRH8 Bodo saltans 39% 91%
A0A1X0P474 Trypanosomatidae 52% 100%
A0A3Q8ICD7 Leishmania donovani 24% 82%
A0A3Q8ICJ2 Leishmania donovani 100% 100%
A0A3R7KWF0 Trypanosoma rangeli 23% 100%
A0A3S7X6Y1 Leishmania donovani 21% 100%
A0A422NTH3 Trypanosoma rangeli 51% 100%
A4HFH3 Leishmania braziliensis 83% 100%
A4HJ32 Leishmania braziliensis 22% 100%
A4I6L1 Leishmania infantum 24% 82%
A4I948 Leishmania infantum 22% 100%
C9ZN63 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 21% 100%
D0A5P9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
D0A6C8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 21% 100%
D3ZHR2 Rattus norvegicus 24% 93%
E9AD24 Leishmania major 93% 100%
E9AYU9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B1K4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
F1RBC8 Danio rerio 22% 90%
O14678 Homo sapiens 24% 100%
O89016 Mus musculus 22% 100%
P16970 Rattus norvegicus 25% 100%
P28288 Homo sapiens 25% 100%
P33897 Homo sapiens 24% 92%
P34230 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 81%
P41909 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 79%
P48410 Mus musculus 24% 93%
P55096 Mus musculus 25% 100%
Q4Q402 Leishmania major 21% 100%
Q55774 Synechocystis sp. (strain PCC 6803 / Kazusa) 23% 100%
Q61285 Mus musculus 22% 93%
Q6NLC1 Arabidopsis thaliana 24% 97%
Q7JUN3 Drosophila melanogaster 24% 94%
Q8T8P3 Dictyostelium discoideum 21% 93%
Q9BHG2 Leishmania major 24% 100%
Q9QY44 Rattus norvegicus 22% 93%
Q9UBJ2 Homo sapiens 23% 93%
V5BXE1 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS