Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2N0_LEIIN

TriTrypDb:

LINF_270009500

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2N0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.602
CLV_C14_Caspase3-7	449	453	PF00656	0.427
CLV_C14_Caspase3-7	526	530	PF00656	0.626
CLV_NRD_NRD_1	141	143	PF00675	0.586
CLV_NRD_NRD_1	169	171	PF00675	0.650
CLV_NRD_NRD_1	324	326	PF00675	0.553
CLV_NRD_NRD_1	549	551	PF00675	0.608
CLV_PCSK_KEX2_1	128	130	PF00082	0.562
CLV_PCSK_KEX2_1	141	143	PF00082	0.519
CLV_PCSK_KEX2_1	171	173	PF00082	0.649
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.562
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.685
CLV_PCSK_SKI1_1	142	146	PF00082	0.439
CLV_PCSK_SKI1_1	253	257	PF00082	0.531
CLV_PCSK_SKI1_1	38	42	PF00082	0.429
CLV_PCSK_SKI1_1	399	403	PF00082	0.507
CLV_PCSK_SKI1_1	445	449	PF00082	0.569
CLV_PCSK_SKI1_1	49	53	PF00082	0.427
CLV_PCSK_SKI1_1	538	542	PF00082	0.618
CLV_PCSK_SKI1_1	78	82	PF00082	0.452
DEG_APCC_DBOX_1	312	320	PF00400	0.447
DOC_CKS1_1	379	384	PF01111	0.432
DOC_CYCLIN_RxL_1	107	120	PF00134	0.470
DOC_CYCLIN_RxL_1	249	257	PF00134	0.573
DOC_MAPK_gen_1	128	135	PF00069	0.497
DOC_MAPK_gen_1	33	43	PF00069	0.481
DOC_MAPK_MEF2A_6	313	320	PF00069	0.470
DOC_PP1_RVXF_1	76	83	PF00149	0.476
DOC_PP1_SILK_1	137	142	PF00149	0.487
DOC_PP2B_LxvP_1	12	15	PF13499	0.482
DOC_PP4_FxxP_1	3	6	PF00568	0.507
DOC_PP4_FxxP_1	379	382	PF00568	0.363
DOC_USP7_MATH_1	101	105	PF00917	0.516
DOC_USP7_MATH_1	192	196	PF00917	0.651
DOC_USP7_MATH_1	238	242	PF00917	0.595
DOC_USP7_MATH_1	293	297	PF00917	0.579
DOC_USP7_MATH_1	343	347	PF00917	0.550
DOC_USP7_MATH_1	478	482	PF00917	0.638
DOC_USP7_MATH_1	503	507	PF00917	0.447
DOC_USP7_UBL2_3	538	542	PF12436	0.493
DOC_WW_Pin1_4	1	6	PF00397	0.615
DOC_WW_Pin1_4	217	222	PF00397	0.530
DOC_WW_Pin1_4	232	237	PF00397	0.579
DOC_WW_Pin1_4	318	323	PF00397	0.450
DOC_WW_Pin1_4	364	369	PF00397	0.566
DOC_WW_Pin1_4	378	383	PF00397	0.287
DOC_WW_Pin1_4	508	513	PF00397	0.624
LIG_14-3-3_CanoR_1	399	408	PF00244	0.552
LIG_14-3-3_CanoR_1	502	512	PF00244	0.508
LIG_Actin_WH2_2	287	305	PF00022	0.540
LIG_APCC_ABBA_1	41	46	PF00400	0.466
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	320	324	PF00533	0.475
LIG_BRCT_BRCA1_2	320	326	PF00533	0.476
LIG_Clathr_ClatBox_1	185	189	PF01394	0.710
LIG_CtBP_PxDLS_1	15	19	PF00389	0.607
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.413
LIG_EH_1	414	418	PF12763	0.409
LIG_EH1_1	206	214	PF00400	0.536
LIG_FHA_1	217	223	PF00498	0.471
LIG_FHA_1	379	385	PF00498	0.499
LIG_FHA_1	400	406	PF00498	0.442
LIG_FHA_2	153	159	PF00498	0.586
LIG_FHA_2	206	212	PF00498	0.481
LIG_FHA_2	392	398	PF00498	0.536
LIG_FHA_2	512	518	PF00498	0.412
LIG_LIR_Apic_2	2	6	PF02991	0.510
LIG_LIR_Gen_1	264	272	PF02991	0.459
LIG_LIR_Gen_1	473	478	PF02991	0.559
LIG_LIR_Nem_3	264	268	PF02991	0.493
LIG_LIR_Nem_3	321	327	PF02991	0.483
LIG_LIR_Nem_3	411	417	PF02991	0.497
LIG_LIR_Nem_3	473	477	PF02991	0.651
LIG_MYND_1	11	15	PF01753	0.533
LIG_MYND_1	147	151	PF01753	0.576
LIG_NBox_RRM_1	500	510	PF00076	0.582
LIG_NRBOX	224	230	PF00104	0.537
LIG_NRBOX	315	321	PF00104	0.471
LIG_RPA_C_Fungi	497	509	PF08784	0.287
LIG_SH2_CRK	265	269	PF00017	0.508
LIG_SH2_SRC	93	96	PF00017	0.457
LIG_SH2_STAP1	533	537	PF00017	0.582
LIG_SH2_STAP1	93	97	PF00017	0.454
LIG_SH2_STAT3	164	167	PF00017	0.732
LIG_SH2_STAT5	435	438	PF00017	0.577
LIG_SH3_3	356	362	PF00018	0.552
LIG_SH3_3	472	478	PF00018	0.750
LIG_SUMO_SIM_par_1	10	17	PF11976	0.575
LIG_SUMO_SIM_par_1	223	230	PF11976	0.558
LIG_TRAF2_1	45	48	PF00917	0.556
LIG_WRC_WIRS_1	327	332	PF05994	0.489
MOD_CDK_SPK_2	318	323	PF00069	0.450
MOD_CDK_SPxK_1	364	370	PF00069	0.598
MOD_CDK_SPxxK_3	217	224	PF00069	0.538
MOD_CDK_SPxxK_3	318	325	PF00069	0.458
MOD_CDK_SPxxK_3	508	515	PF00069	0.549
MOD_CK1_1	241	247	PF00069	0.601
MOD_CK1_1	296	302	PF00069	0.570
MOD_CK1_1	476	482	PF00069	0.670
MOD_CK1_1	511	517	PF00069	0.628
MOD_CK2_1	152	158	PF00069	0.573
MOD_CK2_1	343	349	PF00069	0.567
MOD_CK2_1	391	397	PF00069	0.508
MOD_CK2_1	42	48	PF00069	0.548
MOD_CK2_1	511	517	PF00069	0.584
MOD_Cter_Amidation	548	551	PF01082	0.580
MOD_GlcNHglycan	23	26	PF01048	0.493
MOD_GlcNHglycan	240	243	PF01048	0.653
MOD_GlcNHglycan	245	248	PF01048	0.494
MOD_GlcNHglycan	295	298	PF01048	0.559
MOD_GlcNHglycan	338	341	PF01048	0.570
MOD_GlcNHglycan	426	429	PF01048	0.476
MOD_GlcNHglycan	467	470	PF01048	0.736
MOD_GlcNHglycan	505	508	PF01048	0.532
MOD_GSK3_1	1	8	PF00069	0.620
MOD_GSK3_1	203	210	PF00069	0.486
MOD_GSK3_1	216	223	PF00069	0.490
MOD_GSK3_1	227	234	PF00069	0.500
MOD_GSK3_1	292	299	PF00069	0.563
MOD_GSK3_1	420	427	PF00069	0.539
MOD_GSK3_1	461	468	PF00069	0.650
MOD_GSK3_1	473	480	PF00069	0.613
MOD_LATS_1	67	73	PF00433	0.556
MOD_N-GLC_1	122	127	PF02516	0.523
MOD_N-GLC_1	399	404	PF02516	0.297
MOD_N-GLC_2	37	39	PF02516	0.607
MOD_NEK2_1	152	157	PF00069	0.542
MOD_PIKK_1	227	233	PF00454	0.621
MOD_PIKK_1	478	484	PF00454	0.696
MOD_PIKK_1	5	11	PF00454	0.617
MOD_PKA_1	170	176	PF00069	0.722
MOD_PKA_2	32	38	PF00069	0.639
MOD_PKA_2	489	495	PF00069	0.657
MOD_PKB_1	443	451	PF00069	0.615
MOD_Plk_1	122	128	PF00069	0.569
MOD_Plk_1	142	148	PF00069	0.325
MOD_Plk_2-3	391	397	PF00069	0.351
MOD_Plk_4	180	186	PF00069	0.636
MOD_Plk_4	264	270	PF00069	0.481
MOD_Plk_4	306	312	PF00069	0.379
MOD_Plk_4	370	376	PF00069	0.479
MOD_ProDKin_1	1	7	PF00069	0.610
MOD_ProDKin_1	217	223	PF00069	0.527
MOD_ProDKin_1	232	238	PF00069	0.578
MOD_ProDKin_1	318	324	PF00069	0.460
MOD_ProDKin_1	364	370	PF00069	0.565
MOD_ProDKin_1	378	384	PF00069	0.263
MOD_ProDKin_1	508	514	PF00069	0.627
MOD_SUMO_for_1	51	54	PF00179	0.588
MOD_SUMO_rev_2	195	205	PF00179	0.548
TRG_DiLeu_BaEn_1	315	320	PF01217	0.427
TRG_DiLeu_BaEn_1	442	447	PF01217	0.524
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.531
TRG_ENDOCYTIC_2	102	105	PF00928	0.470
TRG_ENDOCYTIC_2	265	268	PF00928	0.446
TRG_ENDOCYTIC_2	533	536	PF00928	0.591
TRG_ER_diArg_1	140	142	PF00400	0.580
TRG_ER_diArg_1	169	172	PF00400	0.720
TRG_NLS_MonoExtC_3	169	174	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKI5	Leptomonas seymouri	55%	99%
A0A1X0P429	Trypanosomatidae	25%	100%
A0A3R7MVK8	Trypanosoma rangeli	28%	100%
A0A3S7X0E6	Leishmania donovani	99%	100%
A4HFG8	Leishmania braziliensis	79%	100%
D0A5P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
E9AD21	Leishmania major	92%	99%
E9AYU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DP58	Trypanosoma cruzi	27%	100%