LeishMANIAdb
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Ribokinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribokinase
Gene product:
ribokinase - putative
Species:
Leishmania infantum
UniProt:
A4I2M8_LEIIN
TriTrypDb:
LINF_270009300
Length:
329

Annotations

Annotations by Jardim et al.

Pentose Phosphate Pathway, ribokinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005737 cytoplasm 2 11
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1

Expansion

Sequence features

A4I2M8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2M8

PDB structure(s): 6a8a_A , 6a8a_B , 6a8b_A , 6a8b_B , 6a8c_A , 6a8c_B

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 12
GO:0005996 monosaccharide metabolic process 3 12
GO:0006014 D-ribose metabolic process 5 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0016052 carbohydrate catabolic process 4 12
GO:0019303 D-ribose catabolic process 6 12
GO:0019321 pentose metabolic process 4 12
GO:0019323 pentose catabolic process 5 12
GO:0044238 primary metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0044282 small molecule catabolic process 3 12
GO:0046365 monosaccharide catabolic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901575 organic substance catabolic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004747 ribokinase activity 5 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0019200 carbohydrate kinase activity 5 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 77 81 PF00656 0.504
CLV_NRD_NRD_1 310 312 PF00675 0.314
CLV_PCSK_KEX2_1 299 301 PF00082 0.297
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.315
CLV_PCSK_SKI1_1 197 201 PF00082 0.301
CLV_PCSK_SKI1_1 266 270 PF00082 0.352
CLV_PCSK_SKI1_1 292 296 PF00082 0.365
CLV_Separin_Metazoa 135 139 PF03568 0.584
DOC_CYCLIN_RxL_1 289 296 PF00134 0.584
DOC_MAPK_DCC_7 197 205 PF00069 0.527
DOC_MAPK_MEF2A_6 197 205 PF00069 0.527
DOC_PP2B_PxIxI_1 15 21 PF00149 0.449
DOC_USP7_MATH_1 201 205 PF00917 0.524
DOC_USP7_MATH_1 319 323 PF00917 0.625
DOC_USP7_MATH_1 70 74 PF00917 0.506
DOC_WW_Pin1_4 130 135 PF00397 0.565
LIG_14-3-3_CanoR_1 100 110 PF00244 0.558
LIG_14-3-3_CanoR_1 176 182 PF00244 0.490
LIG_14-3-3_CanoR_1 5 14 PF00244 0.411
LIG_AP_GAE_1 225 231 PF02883 0.431
LIG_BRCT_BRCA1_1 43 47 PF00533 0.485
LIG_BRCT_BRCA1_2 43 49 PF00533 0.490
LIG_eIF4E_1 14 20 PF01652 0.459
LIG_FHA_1 131 137 PF00498 0.513
LIG_FHA_2 163 169 PF00498 0.479
LIG_FHA_2 220 226 PF00498 0.487
LIG_FHA_2 75 81 PF00498 0.565
LIG_HP1_1 201 205 PF01393 0.556
LIG_LIR_Apic_2 317 321 PF02991 0.522
LIG_LIR_Gen_1 141 152 PF02991 0.490
LIG_LIR_Gen_1 225 234 PF02991 0.525
LIG_LIR_LC3C_4 17 21 PF02991 0.563
LIG_LIR_Nem_3 141 147 PF02991 0.479
LIG_LIR_Nem_3 225 231 PF02991 0.566
LIG_LIR_Nem_3 23 28 PF02991 0.479
LIG_PCNA_yPIPBox_3 232 243 PF02747 0.580
LIG_Pex14_2 47 51 PF04695 0.479
LIG_SH2_PTP2 202 205 PF00017 0.520
LIG_SH2_SRC 31 34 PF00017 0.516
LIG_SH2_STAP1 144 148 PF00017 0.584
LIG_SH2_STAT5 154 157 PF00017 0.520
LIG_SH2_STAT5 179 182 PF00017 0.479
LIG_SH2_STAT5 202 205 PF00017 0.508
LIG_SH2_STAT5 28 31 PF00017 0.465
LIG_SH2_STAT5 286 289 PF00017 0.541
LIG_SH2_STAT5 84 87 PF00017 0.479
LIG_SH3_3 120 126 PF00018 0.479
LIG_SH3_3 195 201 PF00018 0.495
LIG_SUMO_SIM_anti_2 17 23 PF11976 0.501
LIG_SUMO_SIM_par_1 109 115 PF11976 0.584
LIG_SUMO_SIM_par_1 17 23 PF11976 0.500
LIG_TYR_ITIM 200 205 PF00017 0.520
MOD_CK1_1 226 232 PF00069 0.478
MOD_CK2_1 115 121 PF00069 0.491
MOD_CK2_1 166 172 PF00069 0.592
MOD_CK2_1 219 225 PF00069 0.495
MOD_GlcNHglycan 183 186 PF01048 0.295
MOD_GlcNHglycan 225 228 PF01048 0.274
MOD_GSK3_1 126 133 PF00069 0.490
MOD_GSK3_1 162 169 PF00069 0.585
MOD_GSK3_1 177 184 PF00069 0.502
MOD_GSK3_1 219 226 PF00069 0.519
MOD_GSK3_1 307 314 PF00069 0.518
MOD_GSK3_1 70 77 PF00069 0.539
MOD_GSK3_1 98 105 PF00069 0.550
MOD_N-GLC_1 126 131 PF02516 0.279
MOD_N-GLC_2 302 304 PF02516 0.290
MOD_NEK2_1 112 117 PF00069 0.434
MOD_NEK2_1 280 285 PF00069 0.494
MOD_NEK2_1 98 103 PF00069 0.524
MOD_NEK2_2 177 182 PF00069 0.479
MOD_NEK2_2 201 206 PF00069 0.527
MOD_PIKK_1 311 317 PF00454 0.479
MOD_PKA_1 311 317 PF00069 0.490
MOD_Plk_1 211 217 PF00069 0.475
MOD_Plk_4 177 183 PF00069 0.478
MOD_Plk_4 201 207 PF00069 0.478
MOD_Plk_4 211 217 PF00069 0.477
MOD_Plk_4 280 286 PF00069 0.513
MOD_Plk_4 70 76 PF00069 0.492
MOD_ProDKin_1 130 136 PF00069 0.565
TRG_ENDOCYTIC_2 144 147 PF00928 0.490
TRG_ENDOCYTIC_2 179 182 PF00928 0.479
TRG_ENDOCYTIC_2 202 205 PF00928 0.520
TRG_Pf-PMV_PEXEL_1 292 296 PF00026 0.320

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H2WZY4 Staphylococcus aureus (strain COL) 32% 100%
A0A0N0P5S6 Leptomonas seymouri 79% 100%
A0A0S4JY74 Bodo saltans 57% 99%
A0A1X0P4P4 Trypanosomatidae 65% 98%
A0A3R7NMP1 Trypanosoma rangeli 67% 100%
A0A3S7X0F5 Leishmania donovani 100% 100%
A0A422P4V2 Trypanosoma rangeli 28% 96%
A1A6H3 Arabidopsis thaliana 28% 87%
A1AFX4 Escherichia coli O1:K1 / APEC 24% 69%
A1AV12 Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1) 25% 67%
A2WXV8 Oryza sativa subsp. indica 27% 100%
A3MZC0 Actinobacillus pleuropneumoniae serotype 5b (strain L20) 23% 69%
A4HFG6 Leishmania braziliensis 90% 100%
A4HI44 Leishmania braziliensis 27% 100%
A5UCC3 Haemophilus influenzae (strain PittEE) 23% 69%
A5UEH8 Haemophilus influenzae (strain PittGG) 23% 69%
A6Q4Z6 Nitratiruptor sp. (strain SB155-2) 25% 71%
A7HUC7 Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) 24% 67%
A7MP93 Cronobacter sakazakii (strain ATCC BAA-894) 24% 69%
A7ZE26 Campylobacter concisus (strain 13826) 25% 70%
A7ZRT3 Escherichia coli O139:H28 (strain E24377A / ETEC) 24% 69%
A8A4K6 Escherichia coli O9:H4 (strain HS) 24% 69%
A8FZZ3 Shewanella sediminis (strain HAW-EB3) 22% 69%
A9N5X8 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 23% 69%
B1IRR4 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 24% 69%
B1LF43 Escherichia coli (strain SMS-3-5 / SECEC) 24% 69%
B1XG57 Escherichia coli (strain K12 / DH10B) 24% 69%
B2U1F7 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 24% 69%
B3E5M9 Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) 26% 67%
B4EW46 Proteus mirabilis (strain HI4320) 25% 69%
B4T670 Salmonella newport (strain SL254) 23% 69%
B4TI51 Salmonella heidelberg (strain SL476) 23% 69%
B4TVT4 Salmonella schwarzengrund (strain CVM19633) 23% 69%
B5BG11 Salmonella paratyphi A (strain AKU_12601) 23% 69%
B5EEZ1 Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem) 26% 68%
B5F696 Salmonella agona (strain SL483) 23% 69%
B5FHT5 Salmonella dublin (strain CT_02021853) 24% 69%
B5QZ36 Salmonella enteritidis PT4 (strain P125109) 23% 69%
B5REF8 Salmonella gallinarum (strain 287/91 / NCTC 13346) 23% 69%
B5YR91 Escherichia coli O157:H7 (strain EC4115 / EHEC) 24% 69%
B6I423 Escherichia coli (strain SE11) 24% 69%
B7LGY7 Escherichia coli (strain 55989 / EAEC) 24% 69%
B7LQC9 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 24% 69%
B7LZK1 Escherichia coli O8 (strain IAI1) 24% 69%
B7MAC8 Escherichia coli O45:K1 (strain S88 / ExPEC) 24% 69%
B7N0K1 Escherichia coli O81 (strain ED1a) 24% 69%
B7ND40 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 24% 69%
B7NJR5 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 24% 69%
B7UIW0 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 24% 69%
B8CVJ1 Shewanella piezotolerans (strain WP3 / JCM 13877) 22% 69%
C0PYX3 Salmonella paratyphi C (strain RKS4594) 23% 69%
C4ZQW9 Escherichia coli (strain K12 / MC4100 / BW2952) 24% 69%
C9ZQQ3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 95%
C9ZQQ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 95%
D0A5P3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 99%
E9AD19 Leishmania major 95% 100%
E9AYU4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O05074 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 23% 69%
O27587 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 26% 100%
O29891 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 26% 100%
O60116 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 100%
O82616 Arabidopsis thaliana 26% 100%
O93919 Schizophyllum commune 25% 96%
P0A9J6 Escherichia coli (strain K12) 37% 100%
P0A9J7 Escherichia coli O157:H7 37% 100%
P22824 Vibrio alginolyticus 27% 100%
P25332 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 99%
P32143 Escherichia coli (strain K12) 30% 100%
P33020 Escherichia coli (strain K12) 26% 91%
P36945 Bacillus subtilis (strain 168) 33% 100%
P37829 Solanum tuberosum 29% 100%
P44330 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 24% 100%
P44331 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 37% 100%
P45416 Dickeya dadantii (strain 3937) 22% 100%
P47143 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 97%
P50053 Homo sapiens 23% 100%
P57168 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 22% 100%
P76658 Escherichia coli (strain K12) 24% 69%
P77493 Escherichia coli (strain K12) 25% 100%
P78825 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 97%
P97328 Mus musculus 22% 100%
Q02974 Rattus norvegicus 23% 100%
Q07Y78 Shewanella frigidimarina (strain NCIMB 400) 23% 69%
Q0JGZ6 Oryza sativa subsp. japonica 27% 100%
Q0T0L1 Shigella flexneri serotype 5b (strain 8401) 24% 69%
Q0TD55 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 24% 69%
Q1R6S9 Escherichia coli (strain UTI89 / UPEC) 24% 69%
Q30T22 Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) 24% 69%
Q31WY3 Shigella boydii serotype 4 (strain Sb227) 24% 69%
Q32BR2 Shigella dysenteriae serotype 1 (strain Sd197) 24% 69%
Q3YXJ0 Shigella sonnei (strain Ss046) 24% 69%
Q42896 Solanum lycopersicum 29% 100%
Q48P39 Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) 24% 69%
Q4QKN8 Haemophilus influenzae (strain 86-028NP) 23% 69%
Q4ZZ15 Pseudomonas syringae pv. syringae (strain B728a) 25% 69%
Q53W83 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 28% 100%
Q54UQ4 Dictyostelium discoideum 32% 100%
Q57JQ9 Salmonella choleraesuis (strain SC-B67) 23% 69%
Q5JDG9 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 26% 100%
Q5PC86 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 23% 69%
Q5RD71 Pongo abelii 23% 100%
Q6XZ78 Zea mays 27% 98%
Q6XZ79 Zea mays 27% 100%
Q74BF6 Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) 26% 67%
Q7AAQ7 Escherichia coli O157:H7 24% 69%
Q7CPR9 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 23% 69%
Q7N0C3 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 24% 69%
Q7UBI8 Shigella flexneri 24% 69%
Q7VFZ3 Helicobacter hepaticus (strain ATCC 51449 / 3B1) 25% 68%
Q7VQQ6 Blochmannia floridanus 22% 69%
Q7XJ81 Solanum habrochaites 29% 100%
Q87VF4 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) 24% 69%
Q8FDH5 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 24% 69%
Q8R1Q9 Mus musculus 42% 100%
Q8XEW9 Salmonella typhi 23% 69%
Q8ZKR2 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 26% 100%
Q97U29 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 23% 100%
Q9CF42 Lactococcus lactis subsp. lactis (strain IL1403) 31% 100%
Q9H477 Homo sapiens 42% 100%
Q9K6K1 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 35% 100%
Q9LNE3 Arabidopsis thaliana 29% 100%
Q9LNE4 Arabidopsis thaliana 29% 95%
Q9LZG0 Arabidopsis thaliana 25% 95%
Q9M1B9 Arabidopsis thaliana 29% 100%
Q9SF85 Arabidopsis thaliana 26% 96%
Q9SID0 Arabidopsis thaliana 30% 100%
V5B941 Trypanosoma cruzi 26% 95%
V5BXE5 Trypanosoma cruzi 67% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS