Sema domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2M4_LEIIN

TriTrypDb:

LINF_270008800

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4I2M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2M4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.574
CLV_PCSK_SKI1_1	134	138	PF00082	0.548
CLV_PCSK_SKI1_1	144	148	PF00082	0.447
CLV_PCSK_SKI1_1	33	37	PF00082	0.576
CLV_PCSK_SKI1_1	8	12	PF00082	0.610
DEG_Nend_UBRbox_3	1	3	PF02207	0.644
DEG_SPOP_SBC_1	94	98	PF00917	0.619
DOC_USP7_MATH_1	130	134	PF00917	0.630
DOC_USP7_MATH_1	185	189	PF00917	0.451
DOC_USP7_MATH_1	94	98	PF00917	0.567
LIG_14-3-3_CanoR_1	163	167	PF00244	0.572
LIG_BRCT_BRCA1_1	97	101	PF00533	0.528
LIG_FHA_1	72	78	PF00498	0.587
LIG_FHA_2	10	16	PF00498	0.582
LIG_FHA_2	145	151	PF00498	0.523
LIG_LIR_Apic_2	65	70	PF02991	0.718
LIG_LIR_Gen_1	14	22	PF02991	0.614
LIG_LIR_Nem_3	126	131	PF02991	0.462
LIG_LIR_Nem_3	14	20	PF02991	0.606
LIG_PCNA_yPIPBox_3	180	193	PF02747	0.520
LIG_PDZ_Class_2	189	194	PF00595	0.489
LIG_PTB_Apo_2	76	83	PF02174	0.593
LIG_PTB_Phospho_1	76	82	PF10480	0.467
LIG_Rb_LxCxE_1	31	49	PF01857	0.590
LIG_SH2_PTP2	17	20	PF00017	0.563
LIG_SH2_SRC	67	70	PF00017	0.512
LIG_SH2_STAT3	82	85	PF00017	0.521
LIG_SH2_STAT5	111	114	PF00017	0.532
LIG_SH2_STAT5	166	169	PF00017	0.509
LIG_SH2_STAT5	17	20	PF00017	0.563
LIG_SH2_STAT5	176	179	PF00017	0.456
LIG_SH2_STAT5	82	85	PF00017	0.579
LIG_SH3_4	56	63	PF00018	0.591
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.620
LIG_WRC_WIRS_1	72	77	PF05994	0.581
LIG_WRPW_2	128	131	PF00400	0.493
MOD_CK1_1	188	194	PF00069	0.517
MOD_CK2_1	144	150	PF00069	0.619
MOD_CK2_1	165	171	PF00069	0.554
MOD_CK2_1	63	69	PF00069	0.598
MOD_GlcNHglycan	101	104	PF01048	0.450
MOD_GlcNHglycan	89	92	PF01048	0.718
MOD_GSK3_1	116	123	PF00069	0.469
MOD_GSK3_1	16	23	PF00069	0.653
MOD_GSK3_1	89	96	PF00069	0.558
MOD_N-GLC_1	78	83	PF02516	0.462
MOD_NEK2_1	62	67	PF00069	0.602
MOD_NEK2_1	71	76	PF00069	0.620
MOD_PIKK_1	81	87	PF00454	0.550
MOD_PIKK_1	89	95	PF00454	0.556
MOD_PKA_1	144	150	PF00069	0.600
MOD_PKA_2	162	168	PF00069	0.545
MOD_Plk_1	78	84	PF00069	0.579
MOD_Plk_4	123	129	PF00069	0.552
MOD_Plk_4	188	194	PF00069	0.552
MOD_Plk_4	78	84	PF00069	0.544
MOD_SUMO_rev_2	126	136	PF00179	0.591
MOD_SUMO_rev_2	140	147	PF00179	0.510
MOD_SUMO_rev_2	49	58	PF00179	0.586
TRG_DiLeu_BaEn_1	31	36	PF01217	0.634
TRG_ENDOCYTIC_2	17	20	PF00928	0.563
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC1	Leptomonas seymouri	67%	99%
A0A0S4JRB9	Bodo saltans	28%	100%
A0A1X0P3W2	Trypanosomatidae	35%	95%
A0A3Q8ID94	Leishmania donovani	100%	100%
A0A3R7KLB2	Trypanosoma rangeli	30%	94%
A4HFG2	Leishmania braziliensis	87%	100%
D0A5N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
E9AD14	Leishmania major	97%	100%
E9AYT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%