LeishMANIAdb
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Putative ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATPase
Gene product:
ATPase - putative
Species:
Leishmania infantum
UniProt:
A4I2M3_LEIIN
TriTrypDb:
LINF_270008700
Length:
656

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I2M3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2M3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0005488 binding 1 13
GO:0005524 ATP binding 5 13
GO:0016462 pyrophosphatase activity 5 13
GO:0016787 hydrolase activity 2 13
GO:0016817 hydrolase activity, acting on acid anhydrides 3 13
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 13
GO:0016887 ATP hydrolysis activity 7 13
GO:0017076 purine nucleotide binding 4 13
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 13
GO:0030554 adenyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032559 adenyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 520 524 PF00656 0.308
CLV_NRD_NRD_1 112 114 PF00675 0.595
CLV_NRD_NRD_1 173 175 PF00675 0.502
CLV_NRD_NRD_1 286 288 PF00675 0.479
CLV_NRD_NRD_1 377 379 PF00675 0.546
CLV_NRD_NRD_1 483 485 PF00675 0.355
CLV_NRD_NRD_1 501 503 PF00675 0.259
CLV_NRD_NRD_1 53 55 PF00675 0.583
CLV_PCSK_FUR_1 481 485 PF00082 0.425
CLV_PCSK_KEX2_1 112 114 PF00082 0.595
CLV_PCSK_KEX2_1 173 175 PF00082 0.667
CLV_PCSK_KEX2_1 377 379 PF00082 0.546
CLV_PCSK_KEX2_1 483 485 PF00082 0.411
CLV_PCSK_KEX2_1 501 503 PF00082 0.170
CLV_PCSK_KEX2_1 53 55 PF00082 0.582
CLV_PCSK_KEX2_1 637 639 PF00082 0.365
CLV_PCSK_PC1ET2_1 637 639 PF00082 0.365
CLV_PCSK_SKI1_1 104 108 PF00082 0.437
CLV_PCSK_SKI1_1 147 151 PF00082 0.507
CLV_PCSK_SKI1_1 230 234 PF00082 0.499
CLV_PCSK_SKI1_1 342 346 PF00082 0.346
CLV_PCSK_SKI1_1 428 432 PF00082 0.320
CLV_PCSK_SKI1_1 476 480 PF00082 0.311
DEG_APCC_DBOX_1 229 237 PF00400 0.524
DEG_MDM2_SWIB_1 255 263 PF02201 0.507
DEG_Nend_Nbox_1 1 3 PF02207 0.493
DEG_SPOP_SBC_1 175 179 PF00917 0.700
DOC_ANK_TNKS_1 79 86 PF00023 0.381
DOC_CYCLIN_yCln2_LP_2 542 548 PF00134 0.425
DOC_MAPK_FxFP_2 334 337 PF00069 0.434
DOC_MAPK_gen_1 481 491 PF00069 0.347
DOC_MAPK_gen_1 549 559 PF00069 0.298
DOC_MAPK_gen_1 87 94 PF00069 0.538
DOC_MAPK_MEF2A_6 305 312 PF00069 0.386
DOC_MAPK_MEF2A_6 483 491 PF00069 0.329
DOC_MAPK_MEF2A_6 552 561 PF00069 0.306
DOC_MAPK_MEF2A_6 567 575 PF00069 0.354
DOC_PP1_RVXF_1 386 393 PF00149 0.442
DOC_PP1_RVXF_1 405 412 PF00149 0.416
DOC_PP2B_LxvP_1 318 321 PF13499 0.553
DOC_PP4_FxxP_1 334 337 PF00568 0.434
DOC_SPAK_OSR1_1 421 425 PF12202 0.473
DOC_USP7_MATH_1 159 163 PF00917 0.448
DOC_USP7_MATH_1 175 179 PF00917 0.504
DOC_USP7_MATH_1 205 209 PF00917 0.541
DOC_USP7_MATH_1 232 236 PF00917 0.464
DOC_USP7_MATH_1 303 307 PF00917 0.550
DOC_USP7_MATH_1 446 450 PF00917 0.350
DOC_USP7_MATH_1 71 75 PF00917 0.630
DOC_WW_Pin1_4 10 15 PF00397 0.449
DOC_WW_Pin1_4 247 252 PF00397 0.467
DOC_WW_Pin1_4 422 427 PF00397 0.482
LIG_14-3-3_CanoR_1 147 152 PF00244 0.452
LIG_14-3-3_CanoR_1 391 398 PF00244 0.466
LIG_14-3-3_CanoR_1 513 519 PF00244 0.298
LIG_14-3-3_CanoR_1 53 62 PF00244 0.516
LIG_14-3-3_CanoR_1 622 630 PF00244 0.458
LIG_Actin_WH2_2 282 299 PF00022 0.434
LIG_Actin_WH2_2 461 478 PF00022 0.311
LIG_APCC_ABBA_1 606 611 PF00400 0.511
LIG_BRCT_BRCA1_1 245 249 PF00533 0.536
LIG_BRCT_BRCA1_1 251 255 PF00533 0.556
LIG_BRCT_BRCA1_1 56 60 PF00533 0.538
LIG_Clathr_ClatBox_1 455 459 PF01394 0.425
LIG_eIF4E_1 155 161 PF01652 0.435
LIG_FHA_1 193 199 PF00498 0.445
LIG_FHA_1 237 243 PF00498 0.552
LIG_FHA_1 260 266 PF00498 0.470
LIG_FHA_1 32 38 PF00498 0.612
LIG_FHA_1 439 445 PF00498 0.311
LIG_FHA_1 580 586 PF00498 0.490
LIG_FHA_1 624 630 PF00498 0.435
LIG_FHA_1 63 69 PF00498 0.420
LIG_FHA_2 100 106 PF00498 0.518
LIG_FHA_2 266 272 PF00498 0.514
LIG_FHA_2 366 372 PF00498 0.498
LIG_FHA_2 518 524 PF00498 0.311
LIG_FHA_2 561 567 PF00498 0.452
LIG_FHA_2 576 582 PF00498 0.284
LIG_FHA_2 637 643 PF00498 0.474
LIG_LIR_Gen_1 450 461 PF02991 0.314
LIG_LIR_Gen_1 523 533 PF02991 0.446
LIG_LIR_LC3C_4 262 267 PF02991 0.438
LIG_LIR_Nem_3 141 146 PF02991 0.472
LIG_LIR_Nem_3 450 456 PF02991 0.316
LIG_LIR_Nem_3 523 528 PF02991 0.446
LIG_NBox_RRM_1 336 346 PF00076 0.298
LIG_NRBOX 197 203 PF00104 0.526
LIG_NRBOX 514 520 PF00104 0.311
LIG_NRBOX 570 576 PF00104 0.491
LIG_Pex14_1 245 249 PF04695 0.536
LIG_Pex14_2 255 259 PF04695 0.535
LIG_Pex14_2 330 334 PF04695 0.435
LIG_SH2_CRK 155 159 PF00017 0.465
LIG_SH2_CRK 433 437 PF00017 0.298
LIG_SH2_PTP2 130 133 PF00017 0.413
LIG_SH2_SRC 457 460 PF00017 0.326
LIG_SH2_STAP1 641 645 PF00017 0.467
LIG_SH2_STAT3 628 631 PF00017 0.522
LIG_SH2_STAT5 101 104 PF00017 0.436
LIG_SH2_STAT5 130 133 PF00017 0.380
LIG_SH2_STAT5 144 147 PF00017 0.389
LIG_SH2_STAT5 25 28 PF00017 0.524
LIG_SH2_STAT5 335 338 PF00017 0.429
LIG_SH2_STAT5 457 460 PF00017 0.318
LIG_SH2_STAT5 467 470 PF00017 0.326
LIG_SH2_STAT5 474 477 PF00017 0.311
LIG_SH2_STAT5 628 631 PF00017 0.501
LIG_SH3_3 105 111 PF00018 0.532
LIG_SH3_3 554 560 PF00018 0.303
LIG_SH3_3 78 84 PF00018 0.453
LIG_SUMO_SIM_anti_2 262 269 PF11976 0.429
LIG_SUMO_SIM_anti_2 306 311 PF11976 0.363
LIG_SUMO_SIM_anti_2 493 499 PF11976 0.326
LIG_SUMO_SIM_par_1 262 269 PF11976 0.505
LIG_TRAF2_1 254 257 PF00917 0.429
LIG_UBA3_1 198 207 PF00899 0.502
LIG_UBA3_1 605 610 PF00899 0.511
LIG_WW_3 425 429 PF00397 0.429
MOD_CDK_SPxK_1 422 428 PF00069 0.478
MOD_CK1_1 247 253 PF00069 0.495
MOD_CK1_1 72 78 PF00069 0.503
MOD_CK2_1 247 253 PF00069 0.548
MOD_CK2_1 265 271 PF00069 0.481
MOD_CK2_1 365 371 PF00069 0.479
MOD_CK2_1 72 78 PF00069 0.605
MOD_CK2_1 99 105 PF00069 0.491
MOD_Cter_Amidation 499 502 PF01082 0.326
MOD_GlcNHglycan 161 164 PF01048 0.486
MOD_GlcNHglycan 352 355 PF01048 0.544
MOD_GlcNHglycan 358 361 PF01048 0.434
MOD_GlcNHglycan 459 462 PF01048 0.318
MOD_GlcNHglycan 464 467 PF01048 0.302
MOD_GlcNHglycan 503 506 PF01048 0.420
MOD_GlcNHglycan 592 595 PF01048 0.411
MOD_GlcNHglycan 611 614 PF01048 0.461
MOD_GlcNHglycan 633 636 PF01048 0.505
MOD_GlcNHglycan 74 77 PF01048 0.584
MOD_GSK3_1 232 239 PF00069 0.501
MOD_GSK3_1 243 250 PF00069 0.473
MOD_GSK3_1 31 38 PF00069 0.578
MOD_GSK3_1 365 372 PF00069 0.448
MOD_GSK3_1 513 520 PF00069 0.311
MOD_GSK3_1 575 582 PF00069 0.425
MOD_GSK3_1 586 593 PF00069 0.295
MOD_GSK3_1 6 13 PF00069 0.548
MOD_GSK3_1 636 643 PF00069 0.483
MOD_LATS_1 511 517 PF00433 0.393
MOD_N-GLC_1 451 456 PF02516 0.370
MOD_N-GLC_1 6 11 PF02516 0.465
MOD_NEK2_1 243 248 PF00069 0.497
MOD_NEK2_1 310 315 PF00069 0.312
MOD_NEK2_1 33 38 PF00069 0.612
MOD_NEK2_1 345 350 PF00069 0.457
MOD_NEK2_1 41 46 PF00069 0.496
MOD_NEK2_1 514 519 PF00069 0.311
MOD_NEK2_1 575 580 PF00069 0.392
MOD_NEK2_1 609 614 PF00069 0.521
MOD_NEK2_1 62 67 PF00069 0.524
MOD_NEK2_1 636 641 PF00069 0.465
MOD_NEK2_1 99 104 PF00069 0.497
MOD_NEK2_2 142 147 PF00069 0.515
MOD_NEK2_2 244 249 PF00069 0.385
MOD_PIKK_1 54 60 PF00454 0.571
MOD_PKA_1 501 507 PF00069 0.408
MOD_PKA_2 390 396 PF00069 0.465
MOD_PKA_2 501 507 PF00069 0.345
MOD_PKA_2 566 572 PF00069 0.493
MOD_PKA_2 621 627 PF00069 0.528
MOD_Plk_1 104 110 PF00069 0.502
MOD_Plk_1 205 211 PF00069 0.533
MOD_Plk_1 41 47 PF00069 0.547
MOD_Plk_1 451 457 PF00069 0.393
MOD_Plk_1 641 647 PF00069 0.519
MOD_Plk_4 238 244 PF00069 0.500
MOD_Plk_4 259 265 PF00069 0.506
MOD_Plk_4 380 386 PF00069 0.621
MOD_Plk_4 439 445 PF00069 0.298
MOD_Plk_4 459 465 PF00069 0.116
MOD_Plk_4 514 520 PF00069 0.310
MOD_Plk_4 566 572 PF00069 0.452
MOD_ProDKin_1 10 16 PF00069 0.443
MOD_ProDKin_1 247 253 PF00069 0.474
MOD_ProDKin_1 422 428 PF00069 0.478
MOD_SUMO_rev_2 590 600 PF00179 0.508
TRG_DiLeu_BaEn_1 194 199 PF01217 0.514
TRG_DiLeu_BaEn_1 510 515 PF01217 0.425
TRG_DiLeu_LyEn_5 510 515 PF01217 0.425
TRG_ENDOCYTIC_2 130 133 PF00928 0.395
TRG_ENDOCYTIC_2 155 158 PF00928 0.480
TRG_ER_diArg_1 111 113 PF00400 0.604
TRG_ER_diArg_1 166 169 PF00400 0.533
TRG_ER_diArg_1 377 379 PF00400 0.596
TRG_ER_diArg_1 481 484 PF00400 0.425
TRG_ER_diArg_1 501 503 PF00400 0.116
TRG_ER_diArg_1 53 55 PF00400 0.589
TRG_Pf-PMV_PEXEL_1 287 292 PF00026 0.434
TRG_Pf-PMV_PEXEL_1 473 477 PF00026 0.326
TRG_Pf-PMV_PEXEL_1 583 587 PF00026 0.527

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYP0 Leptomonas seymouri 67% 97%
A0A0S4JUV1 Bodo saltans 40% 100%
A0A0S4KLG9 Bodo saltans 30% 100%
A0A1X0P3W8 Trypanosomatidae 44% 100%
A0A3R7L6R6 Trypanosoma rangeli 44% 98%
A0A3S7X0E5 Leishmania donovani 100% 100%
A4HFG1 Leishmania braziliensis 86% 100%
D0A5N6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AD13 Leishmania major 92% 100%
E9AYT8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O74941 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 70%
V5BSQ8 Trypanosoma cruzi 42% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS