TSNAXIP1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2M0_LEIIN

TriTrypDb:

LINF_270008400

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4I2M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2M0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.599
CLV_C14_Caspase3-7	330	334	PF00656	0.513
CLV_NRD_NRD_1	12	14	PF00675	0.608
CLV_NRD_NRD_1	160	162	PF00675	0.555
CLV_NRD_NRD_1	192	194	PF00675	0.533
CLV_NRD_NRD_1	221	223	PF00675	0.669
CLV_NRD_NRD_1	32	34	PF00675	0.150
CLV_NRD_NRD_1	468	470	PF00675	0.478
CLV_NRD_NRD_1	622	624	PF00675	0.386
CLV_NRD_NRD_1	632	634	PF00675	0.324
CLV_PCSK_FUR_1	9	13	PF00082	0.610
CLV_PCSK_KEX2_1	11	13	PF00082	0.531
CLV_PCSK_KEX2_1	160	162	PF00082	0.555
CLV_PCSK_KEX2_1	221	223	PF00082	0.570
CLV_PCSK_KEX2_1	32	34	PF00082	0.322
CLV_PCSK_KEX2_1	467	469	PF00082	0.489
CLV_PCSK_KEX2_1	568	570	PF00082	0.584
CLV_PCSK_KEX2_1	622	624	PF00082	0.386
CLV_PCSK_KEX2_1	632	634	PF00082	0.324
CLV_PCSK_KEX2_1	91	93	PF00082	0.223
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.555
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.584
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.271
CLV_PCSK_PC7_1	464	470	PF00082	0.312
CLV_PCSK_SKI1_1	189	193	PF00082	0.615
CLV_PCSK_SKI1_1	448	452	PF00082	0.330
CLV_PCSK_SKI1_1	455	459	PF00082	0.338
CLV_PCSK_SKI1_1	487	491	PF00082	0.423
CLV_PCSK_SKI1_1	55	59	PF00082	0.267
CLV_PCSK_SKI1_1	69	73	PF00082	0.319
CLV_Separin_Metazoa	461	465	PF03568	0.293
DEG_APCC_DBOX_1	447	455	PF00400	0.405
DEG_MDM2_SWIB_1	542	550	PF02201	0.396
DEG_SPOP_SBC_1	4	8	PF00917	0.518
DOC_CYCLIN_RxL_1	379	389	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	384	390	PF00134	0.379
DOC_MAPK_gen_1	380	388	PF00069	0.440
DOC_MAPK_gen_1	467	475	PF00069	0.498
DOC_MAPK_gen_1	622	630	PF00069	0.355
DOC_MAPK_MEF2A_6	380	388	PF00069	0.475
DOC_PP2B_LxvP_1	384	387	PF13499	0.392
DOC_PP2B_PxIxI_1	602	608	PF00149	0.481
DOC_SPAK_OSR1_1	513	517	PF12202	0.481
DOC_USP7_MATH_1	16	20	PF00917	0.484
DOC_USP7_MATH_1	327	331	PF00917	0.670
DOC_USP7_MATH_1	4	8	PF00917	0.598
DOC_USP7_MATH_1	404	408	PF00917	0.576
DOC_USP7_MATH_1	43	47	PF00917	0.437
DOC_USP7_MATH_1	502	506	PF00917	0.383
DOC_WW_Pin1_4	631	636	PF00397	0.359
LIG_14-3-3_CanoR_1	205	209	PF00244	0.601
LIG_14-3-3_CanoR_1	221	226	PF00244	0.521
LIG_14-3-3_CanoR_1	245	250	PF00244	0.577
LIG_14-3-3_CanoR_1	329	333	PF00244	0.618
LIG_14-3-3_CanoR_1	382	387	PF00244	0.475
LIG_14-3-3_CanoR_1	513	517	PF00244	0.452
LIG_14-3-3_CanoR_1	569	575	PF00244	0.457
LIG_14-3-3_CanoR_1	622	631	PF00244	0.358
LIG_Actin_WH2_2	102	117	PF00022	0.413
LIG_Actin_WH2_2	458	476	PF00022	0.419
LIG_Actin_WH2_2	543	558	PF00022	0.491
LIG_APCC_ABBA_1	51	56	PF00400	0.376
LIG_BRCT_BRCA1_1	266	270	PF00533	0.542
LIG_Clathr_ClatBox_1	152	156	PF01394	0.505
LIG_CtBP_PxDLS_1	459	463	PF00389	0.450
LIG_CtBP_PxDLS_1	635	639	PF00389	0.469
LIG_EH1_1	268	276	PF00400	0.433
LIG_FHA_1	270	276	PF00498	0.619
LIG_FHA_1	354	360	PF00498	0.627
LIG_FHA_1	374	380	PF00498	0.498
LIG_FHA_1	387	393	PF00498	0.354
LIG_FHA_1	552	558	PF00498	0.337
LIG_FHA_1	576	582	PF00498	0.413
LIG_FHA_1	612	618	PF00498	0.435
LIG_FHA_1	624	630	PF00498	0.327
LIG_FHA_2	100	106	PF00498	0.419
LIG_FHA_2	142	148	PF00498	0.484
LIG_FHA_2	161	167	PF00498	0.627
LIG_LIR_Gen_1	224	231	PF02991	0.633
LIG_LIR_Gen_1	491	502	PF02991	0.371
LIG_LIR_Gen_1	535	542	PF02991	0.327
LIG_LIR_Gen_1	56	65	PF02991	0.292
LIG_LIR_Gen_1	590	599	PF02991	0.423
LIG_LIR_Nem_3	224	228	PF02991	0.586
LIG_LIR_Nem_3	491	497	PF02991	0.408
LIG_LIR_Nem_3	535	541	PF02991	0.375
LIG_LIR_Nem_3	56	61	PF02991	0.293
LIG_LIR_Nem_3	590	596	PF02991	0.425
LIG_LIR_Nem_3	66	71	PF02991	0.284
LIG_PDZ_Class_2	636	641	PF00595	0.515
LIG_Pex14_2	412	416	PF04695	0.432
LIG_Pex14_2	490	494	PF04695	0.407
LIG_Pex14_2	538	542	PF04695	0.385
LIG_Pex14_2	54	58	PF04695	0.388
LIG_Pex14_2	61	65	PF04695	0.334
LIG_SH2_CRK	593	597	PF00017	0.416
LIG_SH2_CRK	68	72	PF00017	0.325
LIG_SH2_NCK_1	225	229	PF00017	0.614
LIG_SH2_PTP2	595	598	PF00017	0.416
LIG_SH2_STAP1	266	270	PF00017	0.542
LIG_SH2_STAP1	79	83	PF00017	0.281
LIG_SH2_STAT5	38	41	PF00017	0.271
LIG_SH2_STAT5	537	540	PF00017	0.412
LIG_SH2_STAT5	593	596	PF00017	0.475
LIG_SH3_3	355	361	PF00018	0.578
LIG_SUMO_SIM_par_1	151	156	PF11976	0.555
LIG_SUMO_SIM_par_1	603	608	PF11976	0.533
LIG_TRAF2_1	131	134	PF00917	0.362
LIG_TRAF2_1	634	637	PF00917	0.422
LIG_UBA3_1	111	115	PF00899	0.413
LIG_UBA3_1	152	160	PF00899	0.563
LIG_WRC_WIRS_1	58	63	PF05994	0.358
MOD_CK1_1	151	157	PF00069	0.473
MOD_CK1_1	182	188	PF00069	0.620
MOD_CK1_1	317	323	PF00069	0.759
MOD_CK1_1	395	401	PF00069	0.494
MOD_CK1_1	476	482	PF00069	0.522
MOD_CK1_1	533	539	PF00069	0.452
MOD_CK1_1	597	603	PF00069	0.394
MOD_CK2_1	141	147	PF00069	0.466
MOD_CK2_1	160	166	PF00069	0.550
MOD_CK2_1	516	522	PF00069	0.538
MOD_CK2_1	605	611	PF00069	0.524
MOD_CK2_1	631	637	PF00069	0.403
MOD_CK2_1	99	105	PF00069	0.446
MOD_GlcNHglycan	129	132	PF01048	0.397
MOD_GlcNHglycan	180	184	PF01048	0.425
MOD_GlcNHglycan	316	319	PF01048	0.635
MOD_GlcNHglycan	479	482	PF01048	0.532
MOD_GlcNHglycan	570	573	PF01048	0.540
MOD_GlcNHglycan	606	610	PF01048	0.450
MOD_GSK3_1	114	121	PF00069	0.313
MOD_GSK3_1	382	389	PF00069	0.497
MOD_GSK3_1	473	480	PF00069	0.511
MOD_GSK3_1	512	519	PF00069	0.502
MOD_GSK3_1	533	540	PF00069	0.454
MOD_GSK3_1	607	614	PF00069	0.511
MOD_N-GLC_1	118	123	PF02516	0.413
MOD_NEK2_1	114	119	PF00069	0.413
MOD_NEK2_1	244	249	PF00069	0.737
MOD_NEK2_1	373	378	PF00069	0.520
MOD_NEK2_1	392	397	PF00069	0.419
MOD_NEK2_1	434	439	PF00069	0.529
MOD_NEK2_1	473	478	PF00069	0.530
MOD_NEK2_1	512	517	PF00069	0.525
MOD_NEK2_1	624	629	PF00069	0.395
MOD_NEK2_2	537	542	PF00069	0.396
MOD_PIKK_1	196	202	PF00454	0.591
MOD_PIKK_1	308	314	PF00454	0.709
MOD_PIKK_1	416	422	PF00454	0.525
MOD_PIKK_1	597	603	PF00454	0.344
MOD_PIKK_1	97	103	PF00454	0.413
MOD_PKA_1	160	166	PF00069	0.551
MOD_PKA_1	221	227	PF00069	0.577
MOD_PKA_1	290	296	PF00069	0.576
MOD_PKA_1	568	574	PF00069	0.431
MOD_PKA_2	160	166	PF00069	0.530
MOD_PKA_2	204	210	PF00069	0.592
MOD_PKA_2	221	227	PF00069	0.533
MOD_PKA_2	244	250	PF00069	0.659
MOD_PKA_2	328	334	PF00069	0.598
MOD_PKA_2	473	479	PF00069	0.473
MOD_PKA_2	512	518	PF00069	0.392
MOD_PKA_2	568	574	PF00069	0.431
MOD_PKA_2	624	630	PF00069	0.390
MOD_Plk_1	118	124	PF00069	0.413
MOD_Plk_1	404	410	PF00069	0.613
MOD_Plk_1	502	508	PF00069	0.385
MOD_Plk_1	533	539	PF00069	0.454
MOD_Plk_2-3	99	105	PF00069	0.374
MOD_Plk_4	148	154	PF00069	0.490
MOD_Plk_4	392	398	PF00069	0.430
MOD_Plk_4	533	539	PF00069	0.440
MOD_Plk_4	57	63	PF00069	0.365
MOD_Plk_4	591	597	PF00069	0.501
MOD_Plk_4	624	630	PF00069	0.385
MOD_Plk_4	70	76	PF00069	0.218
MOD_ProDKin_1	631	637	PF00069	0.372
MOD_SUMO_rev_2	66	71	PF00179	0.483
TRG_DiLeu_BaEn_2	367	373	PF01217	0.539
TRG_DiLeu_BaEn_2	533	539	PF01217	0.428
TRG_ENDOCYTIC_2	225	228	PF00928	0.644
TRG_ENDOCYTIC_2	593	596	PF00928	0.418
TRG_ENDOCYTIC_2	68	71	PF00928	0.282
TRG_ER_diArg_1	220	222	PF00400	0.673
TRG_ER_diArg_1	31	33	PF00400	0.300
TRG_ER_diArg_1	467	469	PF00400	0.495
TRG_ER_diArg_1	517	520	PF00400	0.459
TRG_ER_diArg_1	621	623	PF00400	0.400
TRG_ER_diArg_1	631	633	PF00400	0.383
TRG_ER_diArg_1	9	12	PF00400	0.610
TRG_NES_CRM1_1	545	559	PF08389	0.310
TRG_NES_CRM1_1	85	99	PF08389	0.430
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY0	Leptomonas seymouri	58%	84%
A0A1X0ND09	Trypanosomatidae	33%	93%
A0A3S7X0D8	Leishmania donovani	99%	87%
A0A422NTD8	Trypanosoma rangeli	33%	85%
A4HFF1	Leishmania braziliensis	81%	100%
D0A5N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	87%
E9AD10	Leishmania major	95%	100%
E9AYT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DP68	Trypanosoma cruzi	33%	86%