Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2L9_LEIIN

TriTrypDb:

LINF_270008300

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I2L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2L9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.644
CLV_NRD_NRD_1	232	234	PF00675	0.554
CLV_NRD_NRD_1	344	346	PF00675	0.496
CLV_NRD_NRD_1	365	367	PF00675	0.486
CLV_NRD_NRD_1	375	377	PF00675	0.397
CLV_NRD_NRD_1	413	415	PF00675	0.721
CLV_NRD_NRD_1	464	466	PF00675	0.699
CLV_NRD_NRD_1	468	470	PF00675	0.643
CLV_NRD_NRD_1	475	477	PF00675	0.541
CLV_NRD_NRD_1	486	488	PF00675	0.377
CLV_PCSK_FUR_1	462	466	PF00082	0.680
CLV_PCSK_KEX2_1	2	4	PF00082	0.644
CLV_PCSK_KEX2_1	232	234	PF00082	0.554
CLV_PCSK_KEX2_1	343	345	PF00082	0.500
CLV_PCSK_KEX2_1	365	367	PF00082	0.488
CLV_PCSK_KEX2_1	375	377	PF00082	0.399
CLV_PCSK_KEX2_1	413	415	PF00082	0.721
CLV_PCSK_KEX2_1	464	466	PF00082	0.699
CLV_PCSK_KEX2_1	468	470	PF00082	0.643
CLV_PCSK_KEX2_1	475	477	PF00082	0.541
CLV_PCSK_KEX2_1	485	487	PF00082	0.387
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.488
CLV_PCSK_PC7_1	340	346	PF00082	0.446
CLV_PCSK_PC7_1	464	470	PF00082	0.657
CLV_PCSK_SKI1_1	344	348	PF00082	0.424
CLV_PCSK_SKI1_1	375	379	PF00082	0.491
CLV_PCSK_SKI1_1	469	473	PF00082	0.713
DEG_Nend_UBRbox_1	1	4	PF02207	0.648
DEG_SPOP_SBC_1	125	129	PF00917	0.510
DOC_CKS1_1	261	266	PF01111	0.673
DOC_CYCLIN_RxL_1	340	351	PF00134	0.472
DOC_CYCLIN_RxL_1	372	382	PF00134	0.565
DOC_MAPK_gen_1	340	350	PF00069	0.484
DOC_MAPK_gen_1	365	373	PF00069	0.541
DOC_MAPK_gen_1	462	472	PF00069	0.704
DOC_MAPK_gen_1	81	90	PF00069	0.551
DOC_MAPK_MEF2A_6	343	350	PF00069	0.486
DOC_MAPK_NFAT4_5	343	351	PF00069	0.516
DOC_MAPK_RevD_3	217	233	PF00069	0.553
DOC_PP1_RVXF_1	79	86	PF00149	0.309
DOC_PP2B_LxvP_1	252	255	PF13499	0.639
DOC_PP4_FxxP_1	441	444	PF00568	0.555
DOC_PP4_FxxP_1	97	100	PF00568	0.524
DOC_USP7_MATH_1	10	14	PF00917	0.680
DOC_USP7_MATH_1	125	129	PF00917	0.464
DOC_USP7_MATH_1	158	162	PF00917	0.517
DOC_USP7_MATH_1	186	190	PF00917	0.636
DOC_USP7_MATH_1	28	32	PF00917	0.519
DOC_USP7_MATH_1	43	47	PF00917	0.596
DOC_USP7_MATH_1	79	83	PF00917	0.571
DOC_USP7_UBL2_3	479	483	PF12436	0.500
DOC_WW_Pin1_4	260	265	PF00397	0.680
DOC_WW_Pin1_4	385	390	PF00397	0.569
DOC_WW_Pin1_4	448	453	PF00397	0.649
DOC_WW_Pin1_4	98	103	PF00397	0.558
LIG_14-3-3_CanoR_1	115	121	PF00244	0.588
LIG_14-3-3_CanoR_1	166	170	PF00244	0.433
LIG_14-3-3_CanoR_1	195	202	PF00244	0.653
LIG_14-3-3_CanoR_1	303	312	PF00244	0.541
LIG_14-3-3_CanoR_1	343	349	PF00244	0.486
LIG_14-3-3_CanoR_1	403	407	PF00244	0.594
LIG_14-3-3_CanoR_1	91	97	PF00244	0.472
LIG_Actin_WH2_2	150	168	PF00022	0.530
LIG_BIR_III_2	250	254	PF00653	0.587
LIG_BRCT_BRCA1_1	127	131	PF00533	0.460
LIG_BRCT_BRCA1_1	308	312	PF00533	0.516
LIG_BRCT_BRCA1_1	81	85	PF00533	0.309
LIG_FHA_1	202	208	PF00498	0.680
LIG_FHA_1	256	262	PF00498	0.766
LIG_FHA_1	296	302	PF00498	0.458
LIG_FHA_1	345	351	PF00498	0.427
LIG_FHA_1	395	401	PF00498	0.524
LIG_FHA_1	472	478	PF00498	0.576
LIG_FHA_1	52	58	PF00498	0.553
LIG_FHA_2	101	107	PF00498	0.650
LIG_FHA_2	195	201	PF00498	0.660
LIG_FHA_2	261	267	PF00498	0.699
LIG_FHA_2	319	325	PF00498	0.491
LIG_FHA_2	330	336	PF00498	0.611
LIG_LIR_Apic_2	439	444	PF02991	0.544
LIG_LIR_Apic_2	448	452	PF02991	0.578
LIG_LIR_Apic_2	95	100	PF02991	0.515
LIG_LIR_Gen_1	128	139	PF02991	0.537
LIG_LIR_Gen_1	390	400	PF02991	0.540
LIG_LIR_Gen_1	82	93	PF02991	0.463
LIG_LIR_Nem_3	167	172	PF02991	0.371
LIG_LIR_Nem_3	390	395	PF02991	0.474
LIG_LIR_Nem_3	82	88	PF02991	0.537
LIG_LRP6_Inhibitor_1	477	483	PF00058	0.551
LIG_MYND_1	385	389	PF01753	0.501
LIG_NBox_RRM_1	313	323	PF00076	0.524
LIG_PCNA_yPIPBox_3	214	223	PF02747	0.507
LIG_REV1ctd_RIR_1	310	319	PF16727	0.519
LIG_SH2_CRK	169	173	PF00017	0.498
LIG_SH2_SRC	333	336	PF00017	0.627
LIG_SH2_STAP1	126	130	PF00017	0.522
LIG_SH2_STAP1	333	337	PF00017	0.595
LIG_SH2_STAP1	424	428	PF00017	0.585
LIG_SH2_STAT3	304	307	PF00017	0.522
LIG_SH2_STAT5	126	129	PF00017	0.461
LIG_SH2_STAT5	304	307	PF00017	0.522
LIG_SH2_STAT5	363	366	PF00017	0.533
LIG_SH2_STAT5	481	484	PF00017	0.493
LIG_SH3_3	324	330	PF00018	0.573
LIG_SH3_CIN85_PxpxPR_1	452	457	PF14604	0.729
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.461
LIG_SUMO_SIM_anti_2	370	375	PF11976	0.515
LIG_SUMO_SIM_par_1	429	434	PF11976	0.672
LIG_TRAF2_1	208	211	PF00917	0.718
LIG_TRAF2_1	332	335	PF00917	0.645
LIG_TYR_ITIM	157	162	PF00017	0.537
LIG_UBA3_1	419	427	PF00899	0.608
LIG_UBA3_1	89	98	PF00899	0.426
MOD_CDK_SPK_2	452	457	PF00069	0.706
MOD_CK1_1	108	114	PF00069	0.700
MOD_CK1_1	121	127	PF00069	0.441
MOD_CK1_1	190	196	PF00069	0.691
MOD_CK1_1	29	35	PF00069	0.590
MOD_CK1_1	409	415	PF00069	0.721
MOD_CK2_1	116	122	PF00069	0.523
MOD_CK2_1	178	184	PF00069	0.515
MOD_CK2_1	194	200	PF00069	0.568
MOD_CK2_1	318	324	PF00069	0.507
MOD_CK2_1	329	335	PF00069	0.614
MOD_GlcNHglycan	12	15	PF01048	0.721
MOD_GlcNHglycan	122	126	PF01048	0.484
MOD_GlcNHglycan	128	131	PF01048	0.474
MOD_GlcNHglycan	172	175	PF01048	0.452
MOD_GlcNHglycan	22	25	PF01048	0.649
MOD_GlcNHglycan	27	31	PF01048	0.546
MOD_GlcNHglycan	308	311	PF01048	0.553
MOD_GlcNHglycan	334	338	PF01048	0.571
MOD_GlcNHglycan	350	353	PF01048	0.356
MOD_GlcNHglycan	45	48	PF01048	0.271
MOD_GSK3_1	10	17	PF00069	0.607
MOD_GSK3_1	105	112	PF00069	0.733
MOD_GSK3_1	121	128	PF00069	0.410
MOD_GSK3_1	186	193	PF00069	0.645
MOD_GSK3_1	26	33	PF00069	0.536
MOD_GSK3_1	295	302	PF00069	0.445
MOD_GSK3_1	329	336	PF00069	0.622
MOD_GSK3_1	344	351	PF00069	0.346
MOD_GSK3_1	379	386	PF00069	0.554
MOD_GSK3_1	402	409	PF00069	0.626
MOD_GSK3_1	448	455	PF00069	0.758
MOD_GSK3_1	471	478	PF00069	0.592
MOD_NEK2_1	165	170	PF00069	0.479
MOD_NEK2_1	178	183	PF00069	0.558
MOD_NEK2_1	234	239	PF00069	0.437
MOD_NEK2_1	26	31	PF00069	0.600
MOD_NEK2_1	348	353	PF00069	0.485
MOD_NEK2_2	394	399	PF00069	0.536
MOD_NEK2_2	64	69	PF00069	0.391
MOD_NEK2_2	79	84	PF00069	0.477
MOD_NEK2_2	92	97	PF00069	0.301
MOD_PIKK_1	303	309	PF00454	0.514
MOD_PIKK_1	406	412	PF00454	0.621
MOD_PK_1	429	435	PF00069	0.642
MOD_PKA_1	344	350	PF00069	0.438
MOD_PKA_1	464	470	PF00069	0.678
MOD_PKA_1	475	481	PF00069	0.531
MOD_PKA_2	10	16	PF00069	0.682
MOD_PKA_2	165	171	PF00069	0.504
MOD_PKA_2	194	200	PF00069	0.691
MOD_PKA_2	267	273	PF00069	0.629
MOD_PKA_2	344	350	PF00069	0.452
MOD_PKA_2	402	408	PF00069	0.598
MOD_PKA_2	464	470	PF00069	0.678
MOD_PKA_2	475	481	PF00069	0.531
MOD_PKB_1	462	470	PF00069	0.566
MOD_Plk_1	105	111	PF00069	0.736
MOD_Plk_1	121	127	PF00069	0.356
MOD_Plk_1	209	215	PF00069	0.710
MOD_Plk_1	64	70	PF00069	0.336
MOD_Plk_2-3	105	111	PF00069	0.719
MOD_Plk_2-3	329	335	PF00069	0.647
MOD_Plk_4	318	324	PF00069	0.474
MOD_ProDKin_1	260	266	PF00069	0.677
MOD_ProDKin_1	385	391	PF00069	0.561
MOD_ProDKin_1	448	454	PF00069	0.650
MOD_ProDKin_1	98	104	PF00069	0.576
MOD_SUMO_rev_2	439	448	PF00179	0.689
TRG_DiLeu_BaEn_2	271	277	PF01217	0.553
TRG_DiLeu_BaEn_2	436	442	PF01217	0.554
TRG_ENDOCYTIC_2	159	162	PF00928	0.453
TRG_ENDOCYTIC_2	169	172	PF00928	0.323
TRG_ER_diArg_1	1	3	PF00400	0.651
TRG_ER_diArg_1	231	233	PF00400	0.472
TRG_ER_diArg_1	343	345	PF00400	0.567
TRG_ER_diArg_1	364	366	PF00400	0.467
TRG_ER_diArg_1	374	376	PF00400	0.410
TRG_ER_diArg_1	413	415	PF00400	0.721
TRG_ER_diArg_1	461	464	PF00400	0.711
TRG_ER_diArg_1	468	470	PF00400	0.638
TRG_ER_diArg_1	475	477	PF00400	0.536
TRG_NLS_Bipartite_1	468	489	PF00514	0.603
TRG_NLS_MonoCore_2	484	489	PF00514	0.509
TRG_NLS_MonoExtN_4	483	489	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S3	Leptomonas seymouri	59%	100%
A0A1X0P4N9	Trypanosomatidae	34%	100%
A0A3R7KSE1	Trypanosoma rangeli	35%	100%
A0A3S7X0E2	Leishmania donovani	99%	100%
A4HFF0	Leishmania braziliensis	80%	100%
D0A5N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AD09	Leishmania major	93%	100%
E9AYT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BSR3	Trypanosoma cruzi	34%	100%