Conserved plasma membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2L5_LEIIN

TriTrypDb:

LINF_270007700

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I2L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.686
CLV_NRD_NRD_1	290	292	PF00675	0.561
CLV_NRD_NRD_1	93	95	PF00675	0.496
CLV_PCSK_KEX2_1	106	108	PF00082	0.394
CLV_PCSK_KEX2_1	93	95	PF00082	0.496
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.394
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.496
CLV_PCSK_SKI1_1	136	140	PF00082	0.425
CLV_PCSK_SKI1_1	213	217	PF00082	0.462
CLV_PCSK_SKI1_1	281	285	PF00082	0.484
DEG_Nend_Nbox_1	1	3	PF02207	0.441
DEG_SPOP_SBC_1	172	176	PF00917	0.787
DOC_CKS1_1	11	16	PF01111	0.322
DOC_PP4_FxxP_1	116	119	PF00568	0.635
DOC_USP7_MATH_1	173	177	PF00917	0.758
DOC_USP7_MATH_1	218	222	PF00917	0.704
DOC_USP7_MATH_1	248	252	PF00917	0.751
DOC_USP7_MATH_1	81	85	PF00917	0.462
DOC_WW_Pin1_4	10	15	PF00397	0.337
DOC_WW_Pin1_4	301	306	PF00397	0.740
LIG_14-3-3_CanoR_1	171	181	PF00244	0.698
LIG_14-3-3_CanoR_1	3	11	PF00244	0.441
LIG_BIR_III_4	269	273	PF00653	0.668
LIG_FHA_1	143	149	PF00498	0.720
LIG_FHA_1	188	194	PF00498	0.590
LIG_FHA_1	221	227	PF00498	0.653
LIG_FHA_1	250	256	PF00498	0.664
LIG_FHA_1	37	43	PF00498	0.354
LIG_FHA_1	77	83	PF00498	0.417
LIG_FHA_2	252	258	PF00498	0.635
LIG_Integrin_RGD_1	277	279	PF01839	0.495
LIG_IRF3_LxIS_1	146	151	PF10401	0.678
LIG_LIR_Gen_1	205	215	PF02991	0.636
LIG_LIR_Gen_1	257	267	PF02991	0.652
LIG_LIR_Nem_3	163	168	PF02991	0.723
LIG_LIR_Nem_3	205	211	PF02991	0.604
LIG_LIR_Nem_3	257	263	PF02991	0.601
LIG_SH2_CRK	165	169	PF00017	0.745
LIG_SH2_STAP1	208	212	PF00017	0.661
LIG_SH2_STAT5	238	241	PF00017	0.651
LIG_SH2_STAT5	46	49	PF00017	0.375
LIG_SH3_3	193	199	PF00018	0.601
LIG_SH3_3	8	14	PF00018	0.454
LIG_SH3_4	284	291	PF00018	0.725
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.441
LIG_SUMO_SIM_anti_2	174	184	PF11976	0.725
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.287
LIG_SUMO_SIM_par_1	144	151	PF11976	0.697
LIG_SUMO_SIM_par_1	194	200	PF11976	0.588
LIG_SUMO_SIM_par_1	223	231	PF11976	0.649
LIG_SUMO_SIM_par_1	316	322	PF11976	0.315
LIG_UBA3_1	211	216	PF00899	0.657
MOD_CK1_1	174	180	PF00069	0.732
MOD_CK1_1	200	206	PF00069	0.645
MOD_CK1_1	221	227	PF00069	0.663
MOD_CK1_1	251	257	PF00069	0.671
MOD_CK1_1	27	33	PF00069	0.468
MOD_CK1_1	293	299	PF00069	0.753
MOD_CK2_1	174	180	PF00069	0.760
MOD_CK2_1	253	259	PF00069	0.659
MOD_CK2_1	29	35	PF00069	0.470
MOD_CK2_1	293	299	PF00069	0.745
MOD_CK2_1	50	56	PF00069	0.416
MOD_Cter_Amidation	104	107	PF01082	0.498
MOD_GlcNHglycan	183	186	PF01048	0.419
MOD_GlcNHglycan	202	205	PF01048	0.418
MOD_GlcNHglycan	295	298	PF01048	0.518
MOD_GlcNHglycan	31	34	PF01048	0.648
MOD_GSK3_1	138	145	PF00069	0.646
MOD_GSK3_1	217	224	PF00069	0.621
MOD_GSK3_1	24	31	PF00069	0.410
MOD_GSK3_1	249	256	PF00069	0.646
MOD_GSK3_1	6	13	PF00069	0.332
MOD_GSK3_1	76	83	PF00069	0.339
MOD_N-GLC_1	142	147	PF02516	0.374
MOD_NEK2_1	148	153	PF00069	0.663
MOD_NEK2_1	181	186	PF00069	0.708
MOD_NEK2_1	202	207	PF00069	0.655
MOD_NEK2_1	4	9	PF00069	0.354
MOD_PKA_2	221	227	PF00069	0.608
MOD_PKA_2	273	279	PF00069	0.669
MOD_PKA_2	290	296	PF00069	0.749
MOD_Plk_1	142	148	PF00069	0.684
MOD_Plk_2-3	253	259	PF00069	0.677
MOD_Plk_2-3	50	56	PF00069	0.416
MOD_Plk_4	17	23	PF00069	0.386
MOD_Plk_4	197	203	PF00069	0.647
MOD_Plk_4	207	213	PF00069	0.577
MOD_ProDKin_1	10	16	PF00069	0.340
MOD_ProDKin_1	301	307	PF00069	0.736
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.689
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.707
TRG_ENDOCYTIC_2	165	168	PF00928	0.734
TRG_ENDOCYTIC_2	208	211	PF00928	0.564
TRG_NLS_MonoExtN_4	289	295	PF00514	0.716
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX16	Leptomonas seymouri	42%	95%
A0A3Q8IE36	Leishmania donovani	99%	100%
A4HFE5	Leishmania braziliensis	73%	100%
C9ZKW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	84%
E9AD03	Leishmania major	91%	100%
E9AYS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%