Kinetoplast-associated protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4I2L3_LEIIN

TriTrypDb:

Length:

660

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Annotations by Jardim et al.

Kinetoplastid proteins, Kinetoplast-associated -like (Fragment)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I2L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.562
CLV_NRD_NRD_1	657	659	PF00675	0.495
CLV_PCSK_KEX2_1	3	5	PF00082	0.562
CLV_PCSK_KEX2_1	657	659	PF00082	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.549
DOC_USP7_MATH_1	24	28	PF00917	0.614
LIG_FHA_2	17	23	PF00498	0.515
MOD_CK2_1	16	22	PF00069	0.503
MOD_GlcNHglycan	26	29	PF01048	0.525
MOD_N-GLC_1	16	21	PF02516	0.505
MOD_N-GLC_1	9	14	PF02516	0.523
MOD_Plk_1	16	22	PF00069	0.511
TRG_ER_diArg_1	657	659	PF00400	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJE1	Leishmania donovani	49%	71%
A4HFE2	Leishmania braziliensis	88%	100%
A4HFE3	Leishmania braziliensis	85%	100%
E9AD01	Leishmania major	92%	100%
Q4Q548	Leishmania major	46%	74%