LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Kinetoplast-associated protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Kinetoplast-associated protein-like protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4I2L3_LEIIN
TriTrypDb:
Length:
660

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Annotations by Jardim et al.

Kinetoplastid proteins, Kinetoplast-associated -like (Fragment)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1
Previous1Next

Expansion

Sequence features

A4I2L3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2L3

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 3 5 PF00675 0.562
CLV_NRD_NRD_1 657 659 PF00675 0.495
CLV_PCSK_KEX2_1 3 5 PF00082 0.562
CLV_PCSK_KEX2_1 657 659 PF00082 0.494
DEG_Nend_UBRbox_3 1 3 PF02207 0.549
DOC_USP7_MATH_1 24 28 PF00917 0.614
LIG_FHA_2 17 23 PF00498 0.515
MOD_CK2_1 16 22 PF00069 0.503
MOD_GlcNHglycan 26 29 PF01048 0.525
MOD_N-GLC_1 16 21 PF02516 0.505
Previous12Next

Homologs

ProteinTaxonomySequence identityCoverage
A0A3Q8IJE1 Leishmania donovani 49% 71%
A4HFE2 Leishmania braziliensis 88% 100%
A4HFE3 Leishmania braziliensis 85% 100%
E9AD01 Leishmania major 92% 100%
Q4Q548 Leishmania major 46% 74%
Previous1Next

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS