LeishMANIAdb
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CAAX prenyl protease

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CAAX prenyl protease
Gene product:
CAAX prenyl protease 1 - putative
Species:
Leishmania infantum
UniProt:
A4I2K0_LEIIN
TriTrypDb:
LINF_270005300
Length:
427

Annotations

Annotations by Jardim et al.

Proteases, CAAX prenyl protease 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005789 endoplasmic reticulum membrane 4 10
GO:0016020 membrane 2 10
GO:0031090 organelle membrane 3 10
GO:0110165 cellular anatomical entity 1 10
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I2K0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2K0

Function

Biological processes
TermNameLevelCount
GO:0006508 proteolysis 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0016485 protein processing 5 11
GO:0019538 protein metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044238 primary metabolic process 2 11
GO:0051604 protein maturation 4 11
GO:0071586 CAAX-box protein processing 6 11
GO:0071704 organic substance metabolic process 2 11
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 11
GO:0004175 endopeptidase activity 4 11
GO:0004222 metalloendopeptidase activity 5 11
GO:0005488 binding 1 11
GO:0008233 peptidase activity 3 11
GO:0008237 metallopeptidase activity 4 11
GO:0016787 hydrolase activity 2 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_MEL_PAP_1 173 179 PF00089 0.231
CLV_NRD_NRD_1 245 247 PF00675 0.174
CLV_NRD_NRD_1 31 33 PF00675 0.266
CLV_NRD_NRD_1 362 364 PF00675 0.268
CLV_NRD_NRD_1 43 45 PF00675 0.233
CLV_PCSK_FUR_1 29 33 PF00082 0.306
CLV_PCSK_KEX2_1 245 247 PF00082 0.172
CLV_PCSK_KEX2_1 261 263 PF00082 0.136
CLV_PCSK_KEX2_1 31 33 PF00082 0.266
CLV_PCSK_KEX2_1 321 323 PF00082 0.458
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PC87 Leptomonas seymouri 60% 100%
A0A0S4J5R2 Bodo saltans 47% 100%
A0A1X0P508 Trypanosomatidae 47% 100%
A0A3S7X0A9 Leishmania donovani 100% 100%
A4HFC3 Leishmania braziliensis 76% 100%
C9ZYC0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9ACY1 Leishmania major 96% 100%
E9AYQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O75844 Homo sapiens 34% 90%
P40769 Bacillus subtilis (strain 168) 27% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS