LeishMANIAdb
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CAAX prenyl protease

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CAAX prenyl protease
Gene product:
CAAX prenyl protease 1 - putative
Species:
Leishmania infantum
UniProt:
A4I2K0_LEIIN
TriTrypDb:
LINF_270005300
Length:
427

Annotations

Annotations by Jardim et al.

Proteases, CAAX prenyl protease 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 10
GO:0016020 membrane 2 10
GO:0031090 organelle membrane 3 10
GO:0110165 cellular anatomical entity 1 10

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I2K0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2K0

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0016485 protein processing 5 11
GO:0019538 protein metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044238 primary metabolic process 2 11
GO:0051604 protein maturation 4 11
GO:0071586 CAAX-box protein processing 6 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004175 endopeptidase activity 4 11
GO:0004222 metalloendopeptidase activity 5 11
GO:0005488 binding 1 11
GO:0008233 peptidase activity 3 11
GO:0008237 metallopeptidase activity 4 11
GO:0016787 hydrolase activity 2 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0140096 catalytic activity, acting on a protein 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 173 179 PF00089 0.231
CLV_NRD_NRD_1 245 247 PF00675 0.174
CLV_NRD_NRD_1 31 33 PF00675 0.266
CLV_NRD_NRD_1 362 364 PF00675 0.268
CLV_NRD_NRD_1 43 45 PF00675 0.233
CLV_PCSK_FUR_1 29 33 PF00082 0.306
CLV_PCSK_KEX2_1 245 247 PF00082 0.172
CLV_PCSK_KEX2_1 261 263 PF00082 0.136
CLV_PCSK_KEX2_1 31 33 PF00082 0.266
CLV_PCSK_KEX2_1 321 323 PF00082 0.458
CLV_PCSK_KEX2_1 362 364 PF00082 0.322
CLV_PCSK_KEX2_1 425 427 PF00082 0.345
CLV_PCSK_PC1ET2_1 261 263 PF00082 0.174
CLV_PCSK_PC1ET2_1 321 323 PF00082 0.458
CLV_PCSK_PC1ET2_1 425 427 PF00082 0.345
CLV_PCSK_SKI1_1 153 157 PF00082 0.169
CLV_PCSK_SKI1_1 236 240 PF00082 0.250
CLV_PCSK_SKI1_1 262 266 PF00082 0.174
CLV_PCSK_SKI1_1 382 386 PF00082 0.227
CLV_PCSK_SKI1_1 45 49 PF00082 0.279
DEG_APCC_KENBOX_2 389 393 PF00400 0.416
DOC_CYCLIN_RxL_1 149 160 PF00134 0.391
DOC_CYCLIN_RxL_1 377 389 PF00134 0.466
DOC_CYCLIN_yCln2_LP_2 121 127 PF00134 0.266
DOC_CYCLIN_yCln2_LP_2 161 167 PF00134 0.324
DOC_CYCLIN_yCln2_LP_2 83 89 PF00134 0.324
DOC_MAPK_DCC_7 158 167 PF00069 0.236
DOC_MAPK_gen_1 382 388 PF00069 0.368
DOC_MAPK_MEF2A_6 10 18 PF00069 0.198
DOC_MAPK_MEF2A_6 153 161 PF00069 0.374
DOC_MAPK_MEF2A_6 180 189 PF00069 0.242
DOC_MAPK_MEF2A_6 292 300 PF00069 0.512
DOC_MAPK_RevD_3 16 32 PF00069 0.198
DOC_PP1_RVXF_1 166 173 PF00149 0.198
DOC_PP1_RVXF_1 313 320 PF00149 0.231
DOC_PP2B_LxvP_1 121 124 PF13499 0.266
DOC_PP2B_LxvP_1 198 201 PF13499 0.369
DOC_PP2B_LxvP_1 83 86 PF13499 0.268
DOC_PP4_FxxP_1 345 348 PF00568 0.191
DOC_SPAK_OSR1_1 370 374 PF12202 0.458
DOC_USP7_MATH_1 12 16 PF00917 0.182
DOC_USP7_UBL2_3 149 153 PF12436 0.377
DOC_WW_Pin1_4 1 6 PF00397 0.358
DOC_WW_Pin1_4 209 214 PF00397 0.403
DOC_WW_Pin1_4 394 399 PF00397 0.405
LIG_14-3-3_CanoR_1 158 162 PF00244 0.266
LIG_14-3-3_CanoR_1 245 253 PF00244 0.391
LIG_14-3-3_CanoR_1 393 397 PF00244 0.391
LIG_14-3-3_CanoR_1 96 104 PF00244 0.255
LIG_Actin_WH2_2 144 160 PF00022 0.407
LIG_Actin_WH2_2 220 238 PF00022 0.416
LIG_APCC_ABBA_1 338 343 PF00400 0.341
LIG_BIR_II_1 1 5 PF00653 0.283
LIG_Clathr_ClatBox_1 316 320 PF01394 0.232
LIG_eIF4E_1 221 227 PF01652 0.368
LIG_FHA_1 143 149 PF00498 0.473
LIG_FHA_1 152 158 PF00498 0.432
LIG_FHA_2 141 147 PF00498 0.374
LIG_FHA_2 210 216 PF00498 0.542
LIG_FHA_2 266 272 PF00498 0.391
LIG_FHA_2 46 52 PF00498 0.426
LIG_GBD_Chelix_1 300 308 PF00786 0.198
LIG_LIR_Apic_2 343 348 PF02991 0.321
LIG_LIR_Gen_1 126 133 PF02991 0.394
LIG_LIR_Gen_1 23 33 PF02991 0.380
LIG_LIR_Gen_1 399 410 PF02991 0.374
LIG_LIR_Gen_1 63 71 PF02991 0.418
LIG_LIR_LC3C_4 190 195 PF02991 0.182
LIG_LIR_Nem_3 122 128 PF02991 0.203
LIG_LIR_Nem_3 179 184 PF02991 0.174
LIG_LIR_Nem_3 218 224 PF02991 0.379
LIG_LIR_Nem_3 23 28 PF02991 0.207
LIG_LIR_Nem_3 343 349 PF02991 0.286
LIG_LIR_Nem_3 350 355 PF02991 0.243
LIG_LIR_Nem_3 399 405 PF02991 0.416
LIG_LIR_Nem_3 63 68 PF02991 0.394
LIG_PCNA_yPIPBox_3 166 180 PF02747 0.232
LIG_Pex14_2 127 131 PF04695 0.326
LIG_Pex14_2 177 181 PF04695 0.162
LIG_Pex14_2 341 345 PF04695 0.231
LIG_SH2_CRK 266 270 PF00017 0.362
LIG_SH2_CRK 402 406 PF00017 0.391
LIG_SH2_GRB2like 128 131 PF00017 0.391
LIG_SH2_GRB2like 297 300 PF00017 0.198
LIG_SH2_NCK_1 407 411 PF00017 0.374
LIG_SH2_PTP2 297 300 PF00017 0.198
LIG_SH2_STAP1 108 112 PF00017 0.271
LIG_SH2_STAP1 266 270 PF00017 0.362
LIG_SH2_STAT3 163 166 PF00017 0.232
LIG_SH2_STAT5 184 187 PF00017 0.191
LIG_SH2_STAT5 25 28 PF00017 0.241
LIG_SH2_STAT5 253 256 PF00017 0.389
LIG_SH2_STAT5 297 300 PF00017 0.198
LIG_SH2_STAT5 359 362 PF00017 0.384
LIG_SH2_STAT5 407 410 PF00017 0.416
LIG_SH2_STAT5 42 45 PF00017 0.362
LIG_SH2_STAT5 91 94 PF00017 0.324
LIG_SH3_3 200 206 PF00018 0.198
LIG_SUMO_SIM_anti_2 115 122 PF11976 0.198
LIG_SUMO_SIM_anti_2 190 195 PF11976 0.232
LIG_SUMO_SIM_anti_2 275 285 PF11976 0.326
LIG_SUMO_SIM_par_1 384 389 PF11976 0.368
LIG_TRAF2_1 48 51 PF00917 0.426
LIG_TYR_ITIM 264 269 PF00017 0.362
LIG_TYR_ITSM 217 224 PF00017 0.326
LIG_UBA3_1 161 168 PF00899 0.198
LIG_UBA3_1 385 390 PF00899 0.395
LIG_WRC_WIRS_1 349 354 PF05994 0.340
MOD_CK1_1 244 250 PF00069 0.362
MOD_CK1_1 63 69 PF00069 0.418
MOD_CK1_1 98 104 PF00069 0.335
MOD_CK2_1 123 129 PF00069 0.256
MOD_CK2_1 140 146 PF00069 0.305
MOD_CK2_1 265 271 PF00069 0.440
MOD_CK2_1 45 51 PF00069 0.400
MOD_GlcNHglycan 402 405 PF01048 0.191
MOD_GSK3_1 225 232 PF00069 0.491
MOD_GSK3_1 98 105 PF00069 0.193
MOD_N-GLC_1 33 38 PF02516 0.168
MOD_NEK2_1 157 162 PF00069 0.258
MOD_NEK2_1 187 192 PF00069 0.194
MOD_NEK2_1 265 270 PF00069 0.367
MOD_NEK2_1 308 313 PF00069 0.294
MOD_NEK2_1 371 376 PF00069 0.399
MOD_NEK2_1 405 410 PF00069 0.400
MOD_NEK2_1 74 79 PF00069 0.361
MOD_NEK2_2 216 221 PF00069 0.442
MOD_PKA_2 157 163 PF00069 0.266
MOD_PKA_2 244 250 PF00069 0.374
MOD_PKA_2 392 398 PF00069 0.368
MOD_PKA_2 95 101 PF00069 0.224
MOD_Plk_1 216 222 PF00069 0.413
MOD_Plk_1 229 235 PF00069 0.475
MOD_Plk_1 276 282 PF00069 0.350
MOD_Plk_1 60 66 PF00069 0.404
MOD_Plk_4 151 157 PF00069 0.397
MOD_Plk_4 187 193 PF00069 0.237
MOD_Plk_4 199 205 PF00069 0.147
MOD_Plk_4 216 222 PF00069 0.425
MOD_Plk_4 265 271 PF00069 0.362
MOD_Plk_4 276 282 PF00069 0.369
MOD_Plk_4 348 354 PF00069 0.303
MOD_Plk_4 38 44 PF00069 0.462
MOD_ProDKin_1 1 7 PF00069 0.352
MOD_ProDKin_1 209 215 PF00069 0.406
MOD_ProDKin_1 394 400 PF00069 0.405
TRG_ENDOCYTIC_2 128 131 PF00928 0.374
TRG_ENDOCYTIC_2 184 187 PF00928 0.204
TRG_ENDOCYTIC_2 221 224 PF00928 0.434
TRG_ENDOCYTIC_2 25 28 PF00928 0.375
TRG_ENDOCYTIC_2 266 269 PF00928 0.368
TRG_ENDOCYTIC_2 297 300 PF00928 0.345
TRG_ENDOCYTIC_2 324 327 PF00928 0.174
TRG_ENDOCYTIC_2 346 349 PF00928 0.232
TRG_ENDOCYTIC_2 402 405 PF00928 0.416
TRG_ENDOCYTIC_2 90 93 PF00928 0.265
TRG_ER_diArg_1 28 31 PF00400 0.489
TRG_ER_diLys_1 424 427 PF00400 0.476
TRG_NES_CRM1_1 122 135 PF08389 0.140
TRG_NES_CRM1_1 230 242 PF08389 0.391

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC87 Leptomonas seymouri 60% 100%
A0A0S4J5R2 Bodo saltans 47% 100%
A0A1X0P508 Trypanosomatidae 47% 100%
A0A3S7X0A9 Leishmania donovani 100% 100%
A4HFC3 Leishmania braziliensis 76% 100%
C9ZYC0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9ACY1 Leishmania major 96% 100%
E9AYQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O75844 Homo sapiens 34% 90%
P40769 Bacillus subtilis (strain 168) 27% 100%
P47154 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 94%
Q10071 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 90%
Q3Y6B8 Taenia solium 32% 90%
Q54FH7 Dictyostelium discoideum 35% 100%
Q6EPN8 Oryza sativa subsp. japonica 39% 100%
Q80W54 Mus musculus 33% 90%
Q8RX88 Arabidopsis thaliana 40% 100%
Q9XVE5 Caenorhabditis elegans 32% 97%
V5DQF4 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS