TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2J7_LEIIN

TriTrypDb:

LINF_270005000

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.543
CLV_NRD_NRD_1	35	37	PF00675	0.369
CLV_NRD_NRD_1	366	368	PF00675	0.469
CLV_PCSK_KEX2_1	134	136	PF00082	0.548
CLV_PCSK_KEX2_1	182	184	PF00082	0.457
CLV_PCSK_KEX2_1	200	202	PF00082	0.348
CLV_PCSK_KEX2_1	293	295	PF00082	0.384
CLV_PCSK_KEX2_1	35	37	PF00082	0.369
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.457
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.348
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.384
CLV_PCSK_SKI1_1	163	167	PF00082	0.376
CLV_PCSK_SKI1_1	189	193	PF00082	0.414
CLV_PCSK_SKI1_1	273	277	PF00082	0.450
CLV_PCSK_SKI1_1	35	39	PF00082	0.603
CLV_PCSK_SKI1_1	350	354	PF00082	0.376
CLV_PCSK_SKI1_1	367	371	PF00082	0.308
DEG_APCC_DBOX_1	254	262	PF00400	0.314
DEG_Nend_UBRbox_2	1	3	PF02207	0.461
DOC_CYCLIN_RxL_1	160	167	PF00134	0.447
DOC_CYCLIN_RxL_1	270	279	PF00134	0.456
DOC_MAPK_gen_1	365	374	PF00069	0.480
DOC_MAPK_MEF2A_6	365	374	PF00069	0.585
DOC_MAPK_MEF2A_6	4	11	PF00069	0.294
DOC_PP1_RVXF_1	271	278	PF00149	0.454
DOC_PP1_RVXF_1	292	299	PF00149	0.422
DOC_USP7_MATH_1	219	223	PF00917	0.445
DOC_USP7_UBL2_3	117	121	PF12436	0.424
DOC_USP7_UBL2_3	289	293	PF12436	0.416
DOC_WW_Pin1_4	189	194	PF00397	0.461
DOC_WW_Pin1_4	340	345	PF00397	0.326
LIG_14-3-3_CanoR_1	171	175	PF00244	0.568
LIG_APCC_ABBAyCdc20_2	88	94	PF00400	0.362
LIG_Clathr_ClatBox_1	274	278	PF01394	0.593
LIG_FHA_1	190	196	PF00498	0.579
LIG_FHA_1	21	27	PF00498	0.339
LIG_LIR_Gen_1	114	119	PF02991	0.449
LIG_LIR_Gen_1	194	203	PF02991	0.371
LIG_LIR_Gen_1	268	277	PF02991	0.396
LIG_LIR_Gen_1	44	53	PF02991	0.375
LIG_LIR_Nem_3	110	115	PF02991	0.348
LIG_LIR_Nem_3	194	199	PF02991	0.363
LIG_LIR_Nem_3	268	274	PF02991	0.386
LIG_LIR_Nem_3	39	45	PF02991	0.399
LIG_PDZ_Class_2	369	374	PF00595	0.489
LIG_PTB_Apo_2	86	93	PF02174	0.370
LIG_SH2_CRK	271	275	PF00017	0.476
LIG_SH2_NCK_1	205	209	PF00017	0.379
LIG_SH2_SRC	299	302	PF00017	0.474
LIG_SH2_STAP1	22	26	PF00017	0.331
LIG_SH2_STAT5	10	13	PF00017	0.327
LIG_SH2_STAT5	22	25	PF00017	0.425
LIG_SH2_STAT5	299	302	PF00017	0.470
LIG_SH2_STAT5	85	88	PF00017	0.310
LIG_SH3_3	237	243	PF00018	0.434
LIG_SH3_3	278	284	PF00018	0.444
LIG_SUMO_SIM_anti_2	123	131	PF11976	0.434
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.362
LIG_TRAF2_1	307	310	PF00917	0.434
LIG_TYR_ITIM	113	118	PF00017	0.361
LIG_TYR_ITIM	8	13	PF00017	0.264
LIG_UBA3_1	321	326	PF00899	0.319
MOD_CDK_SPxK_1	340	346	PF00069	0.321
MOD_CK2_1	117	123	PF00069	0.379
MOD_CK2_1	204	210	PF00069	0.441
MOD_Cter_Amidation	365	368	PF01082	0.419
MOD_GlcNHglycan	206	209	PF01048	0.461
MOD_GlcNHglycan	322	325	PF01048	0.434
MOD_GSK3_1	117	124	PF00069	0.494
MOD_N-GLC_1	121	126	PF02516	0.404
MOD_NEK2_1	11	16	PF00069	0.415
MOD_PIKK_1	100	106	PF00454	0.310
MOD_PKA_2	170	176	PF00069	0.383
MOD_Plk_4	125	131	PF00069	0.452
MOD_Plk_4	142	148	PF00069	0.376
MOD_ProDKin_1	189	195	PF00069	0.454
MOD_ProDKin_1	340	346	PF00069	0.321
MOD_SUMO_for_1	116	119	PF00179	0.413
MOD_SUMO_for_1	199	202	PF00179	0.383
MOD_SUMO_for_1	37	40	PF00179	0.397
TRG_DiLeu_BaEn_1	125	130	PF01217	0.398
TRG_DiLeu_BaEn_1	310	315	PF01217	0.295
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.446
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.284
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.326
TRG_DiLeu_LyEn_5	310	315	PF01217	0.312
TRG_ENDOCYTIC_2	10	13	PF00928	0.305
TRG_ENDOCYTIC_2	115	118	PF00928	0.362
TRG_ENDOCYTIC_2	22	25	PF00928	0.355
TRG_ENDOCYTIC_2	271	274	PF00928	0.400
TRG_ENDOCYTIC_2	46	49	PF00928	0.427
TRG_ER_diArg_1	133	135	PF00400	0.535
TRG_ER_diArg_1	35	37	PF00400	0.387
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I333	Leptomonas seymouri	75%	90%
A0A0S4IVD3	Bodo saltans	44%	81%
A0A1X0NPF3	Trypanosomatidae	60%	86%
A0A3Q8IPL3	Leishmania donovani	100%	100%
A4HFC1	Leishmania braziliensis	88%	100%
C9ZPM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	88%
E9ACX8	Leishmania major	96%	100%
E9AYQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BCK8	Trypanosoma cruzi	60%	88%