Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2J1_LEIIN

TriTrypDb:

LINF_260032400

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2J1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.524
CLV_NRD_NRD_1	27	29	PF00675	0.478
CLV_NRD_NRD_1	341	343	PF00675	0.587
CLV_NRD_NRD_1	367	369	PF00675	0.497
CLV_NRD_NRD_1	434	436	PF00675	0.525
CLV_NRD_NRD_1	547	549	PF00675	0.522
CLV_PCSK_KEX2_1	160	162	PF00082	0.620
CLV_PCSK_KEX2_1	27	29	PF00082	0.541
CLV_PCSK_KEX2_1	341	343	PF00082	0.587
CLV_PCSK_KEX2_1	367	369	PF00082	0.574
CLV_PCSK_KEX2_1	547	549	PF00082	0.522
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.620
CLV_PCSK_SKI1_1	212	216	PF00082	0.534
CLV_PCSK_SKI1_1	95	99	PF00082	0.578
DEG_APCC_DBOX_1	547	555	PF00400	0.476
DEG_APCC_DBOX_1	94	102	PF00400	0.455
DEG_SPOP_SBC_1	56	60	PF00917	0.554
DOC_CKS1_1	541	546	PF01111	0.631
DOC_MAPK_gen_1	476	485	PF00069	0.658
DOC_MAPK_MEF2A_6	476	485	PF00069	0.674
DOC_MAPK_MEF2A_6	68	75	PF00069	0.548
DOC_MAPK_MEF2A_6	77	84	PF00069	0.489
DOC_PP1_RVXF_1	566	572	PF00149	0.409
DOC_PP2B_LxvP_1	459	462	PF13499	0.609
DOC_PP4_FxxP_1	383	386	PF00568	0.353
DOC_PP4_FxxP_1	532	535	PF00568	0.334
DOC_USP7_MATH_1	124	128	PF00917	0.758
DOC_USP7_MATH_1	139	143	PF00917	0.796
DOC_USP7_MATH_1	234	238	PF00917	0.629
DOC_USP7_MATH_1	270	274	PF00917	0.685
DOC_USP7_MATH_1	275	279	PF00917	0.663
DOC_USP7_MATH_1	312	316	PF00917	0.564
DOC_USP7_MATH_1	370	374	PF00917	0.435
DOC_USP7_MATH_1	406	410	PF00917	0.504
DOC_USP7_MATH_1	466	470	PF00917	0.613
DOC_USP7_MATH_1	502	506	PF00917	0.592
DOC_USP7_MATH_1	56	60	PF00917	0.690
DOC_USP7_MATH_2	544	550	PF00917	0.458
DOC_USP7_UBL2_3	190	194	PF12436	0.421
DOC_WW_Pin1_4	239	244	PF00397	0.725
DOC_WW_Pin1_4	296	301	PF00397	0.517
DOC_WW_Pin1_4	306	311	PF00397	0.525
DOC_WW_Pin1_4	32	37	PF00397	0.474
DOC_WW_Pin1_4	448	453	PF00397	0.426
DOC_WW_Pin1_4	488	493	PF00397	0.658
DOC_WW_Pin1_4	540	545	PF00397	0.628
DOC_WW_Pin1_4	61	66	PF00397	0.496
LIG_14-3-3_CanoR_1	212	217	PF00244	0.504
LIG_14-3-3_CanoR_1	235	239	PF00244	0.609
LIG_14-3-3_CanoR_1	313	320	PF00244	0.747
LIG_14-3-3_CanoR_1	430	435	PF00244	0.642
LIG_14-3-3_CanoR_1	441	450	PF00244	0.611
LIG_Actin_WH2_2	90	108	PF00022	0.449
LIG_APCC_ABBA_1	460	465	PF00400	0.476
LIG_FHA_1	247	253	PF00498	0.809
LIG_FHA_1	317	323	PF00498	0.685
LIG_FHA_1	33	39	PF00498	0.460
LIG_FHA_1	380	386	PF00498	0.361
LIG_FHA_1	429	435	PF00498	0.636
LIG_FHA_1	465	471	PF00498	0.496
LIG_FHA_1	493	499	PF00498	0.516
LIG_FHA_1	529	535	PF00498	0.338
LIG_FHA_2	121	127	PF00498	0.778
LIG_FHA_2	166	172	PF00498	0.595
LIG_FHA_2	201	207	PF00498	0.462
LIG_FHA_2	541	547	PF00498	0.446
LIG_FHA_2	6	12	PF00498	0.558
LIG_FXI_DFP_1	218	222	PF00024	0.486
LIG_GBD_Chelix_1	38	46	PF00786	0.510
LIG_Integrin_isoDGR_2	210	212	PF01839	0.533
LIG_IRF3_LxIS_1	74	81	PF10401	0.500
LIG_LIR_Apic_2	382	386	PF02991	0.353
LIG_LIR_Apic_2	531	535	PF02991	0.334
LIG_LIR_Apic_2	539	544	PF02991	0.426
LIG_LIR_Gen_1	215	226	PF02991	0.420
LIG_LIR_Gen_1	409	419	PF02991	0.412
LIG_LIR_Nem_3	171	177	PF02991	0.423
LIG_LIR_Nem_3	20	26	PF02991	0.531
LIG_LIR_Nem_3	215	221	PF02991	0.415
LIG_LIR_Nem_3	409	414	PF02991	0.392
LIG_LIR_Nem_3	468	474	PF02991	0.504
LIG_LIR_Nem_3	505	511	PF02991	0.454
LIG_LYPXL_yS_3	508	511	PF13949	0.378
LIG_LYPXL_yS_3	579	582	PF13949	0.448
LIG_PCNA_yPIPBox_3	194	208	PF02747	0.513
LIG_PROFILIN_1	149	155	PF00235	0.539
LIG_SH2_NCK_1	541	545	PF00017	0.546
LIG_SH2_SRC	463	466	PF00017	0.561
LIG_SH2_STAT5	100	103	PF00017	0.568
LIG_SH2_STAT5	224	227	PF00017	0.396
LIG_SH2_STAT5	471	474	PF00017	0.552
LIG_SH2_STAT5	484	487	PF00017	0.481
LIG_SH2_STAT5	499	502	PF00017	0.276
LIG_SH3_3	144	150	PF00018	0.790
LIG_SH3_3	194	200	PF00018	0.377
LIG_SH3_3	238	244	PF00018	0.587
LIG_SH3_3	319	325	PF00018	0.678
LIG_SH3_3	559	565	PF00018	0.485
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.433
LIG_TRAF2_1	203	206	PF00917	0.462
LIG_TRAF2_1	462	465	PF00917	0.578
LIG_TRAF2_1	543	546	PF00917	0.439
LIG_TRAF2_2	562	567	PF00917	0.408
LIG_UBA3_1	480	486	PF00899	0.572
LIG_WRC_WIRS_1	356	361	PF05994	0.502
MOD_CDK_SPxxK_3	306	313	PF00069	0.597
MOD_CDK_SPxxK_3	540	547	PF00069	0.459
MOD_CDK_SPxxK_3	61	68	PF00069	0.585
MOD_CK1_1	127	133	PF00069	0.727
MOD_CK1_1	159	165	PF00069	0.514
MOD_CK1_1	242	248	PF00069	0.713
MOD_CK1_1	278	284	PF00069	0.657
MOD_CK1_1	34	40	PF00069	0.509
MOD_CK1_1	417	423	PF00069	0.436
MOD_CK1_1	453	459	PF00069	0.604
MOD_CK1_1	523	529	PF00069	0.464
MOD_CK1_1	533	539	PF00069	0.412
MOD_CK1_1	59	65	PF00069	0.549
MOD_CK2_1	120	126	PF00069	0.701
MOD_CK2_1	139	145	PF00069	0.524
MOD_CK2_1	200	206	PF00069	0.521
MOD_CK2_1	5	11	PF00069	0.545
MOD_CK2_1	533	539	PF00069	0.395
MOD_CK2_1	540	546	PF00069	0.403
MOD_CK2_1	61	67	PF00069	0.458
MOD_GlcNHglycan	130	133	PF01048	0.651
MOD_GlcNHglycan	372	375	PF01048	0.549
MOD_GlcNHglycan	424	427	PF01048	0.624
MOD_GlcNHglycan	500	503	PF01048	0.447
MOD_GlcNHglycan	504	507	PF01048	0.587
MOD_GlcNHglycan	522	525	PF01048	0.366
MOD_GlcNHglycan	548	551	PF01048	0.575
MOD_GlcNHglycan	557	560	PF01048	0.503
MOD_GSK3_1	120	127	PF00069	0.653
MOD_GSK3_1	239	246	PF00069	0.673
MOD_GSK3_1	270	277	PF00069	0.638
MOD_GSK3_1	292	299	PF00069	0.571
MOD_GSK3_1	312	319	PF00069	0.625
MOD_GSK3_1	34	41	PF00069	0.594
MOD_GSK3_1	446	453	PF00069	0.517
MOD_GSK3_1	488	495	PF00069	0.538
MOD_GSK3_1	498	505	PF00069	0.364
MOD_GSK3_1	51	58	PF00069	0.332
MOD_GSK3_1	530	537	PF00069	0.477
MOD_GSK3_1	7	14	PF00069	0.547
MOD_N-GLC_1	200	205	PF02516	0.516
MOD_N-GLC_1	31	36	PF02516	0.571
MOD_N-GLC_1	406	411	PF02516	0.487
MOD_N-GLC_2	118	120	PF02516	0.630
MOD_NEK2_1	165	170	PF00069	0.442
MOD_NEK2_1	379	384	PF00069	0.386
MOD_NEK2_1	414	419	PF00069	0.558
MOD_NEK2_1	498	503	PF00069	0.447
MOD_NEK2_1	55	60	PF00069	0.561
MOD_NEK2_1	78	83	PF00069	0.450
MOD_NEK2_2	466	471	PF00069	0.476
MOD_PIKK_1	108	114	PF00454	0.666
MOD_PIKK_1	234	240	PF00454	0.599
MOD_PK_1	430	436	PF00069	0.487
MOD_PKA_2	234	240	PF00069	0.584
MOD_PKA_2	292	298	PF00069	0.639
MOD_PKA_2	312	318	PF00069	0.546
MOD_PKA_2	340	346	PF00069	0.747
MOD_PKA_2	546	552	PF00069	0.577
MOD_Plk_1	293	299	PF00069	0.662
MOD_Plk_1	354	360	PF00069	0.610
MOD_Plk_1	50	56	PF00069	0.441
MOD_Plk_1	69	75	PF00069	0.527
MOD_Plk_2-3	355	361	PF00069	0.510
MOD_Plk_2-3	507	513	PF00069	0.514
MOD_Plk_4	278	284	PF00069	0.710
MOD_Plk_4	293	299	PF00069	0.568
MOD_Plk_4	318	324	PF00069	0.708
MOD_Plk_4	38	44	PF00069	0.450
MOD_Plk_4	466	472	PF00069	0.468
MOD_Plk_4	69	75	PF00069	0.584
MOD_ProDKin_1	239	245	PF00069	0.725
MOD_ProDKin_1	296	302	PF00069	0.516
MOD_ProDKin_1	306	312	PF00069	0.520
MOD_ProDKin_1	32	38	PF00069	0.463
MOD_ProDKin_1	448	454	PF00069	0.427
MOD_ProDKin_1	488	494	PF00069	0.651
MOD_ProDKin_1	540	546	PF00069	0.622
MOD_ProDKin_1	61	67	PF00069	0.489
MOD_SUMO_rev_2	512	520	PF00179	0.510
MOD_SUMO_rev_2	9	15	PF00179	0.603
TRG_DiLeu_BaEn_1	410	415	PF01217	0.382
TRG_DiLeu_BaEn_1	70	75	PF01217	0.476
TRG_DiLeu_LyEn_5	410	415	PF01217	0.382
TRG_ENDOCYTIC_2	218	221	PF00928	0.367
TRG_ENDOCYTIC_2	508	511	PF00928	0.445
TRG_ENDOCYTIC_2	579	582	PF00928	0.448
TRG_ER_diArg_1	26	28	PF00400	0.466
TRG_ER_diArg_1	341	344	PF00400	0.581
TRG_ER_diArg_1	366	368	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I848	Leptomonas seymouri	56%	100%
A0A1X0P7D0	Trypanosomatidae	32%	100%
A0A3R7MCE3	Trypanosoma rangeli	35%	100%
A0A3S7X099	Leishmania donovani	100%	100%
A4HFA9	Leishmania braziliensis	79%	100%
C9ZWZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AYP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8S6	Leishmania major	94%	100%
V5B7P2	Trypanosoma cruzi	35%	100%