Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4I2J0_LEIIN

TriTrypDb:

LINF_260031100

Length:

480

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Annotations by Jardim et al.

Phosphatase, Serine/threonine- phosphatase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005955	calcineurin complex	3	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A4I2J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2J0

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	14
GO:0009987	cellular process	1	14
GO:0019722	calcium-mediated signaling	5	14
GO:0019932	second-messenger-mediated signaling	4	14
GO:0035556	intracellular signal transduction	3	14
GO:0050789	regulation of biological process	2	14
GO:0050794	regulation of cellular process	3	14
GO:0065007	biological regulation	1	14
GO:0097720	calcineurin-mediated signaling	6	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004721	phosphoprotein phosphatase activity	3	14
GO:0004722	protein serine/threonine phosphatase activity	4	14
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	5	14
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005516	calmodulin binding	3	12
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0016791	phosphatase activity	5	14
GO:0017018	myosin phosphatase activity	5	14
GO:0033192	calmodulin-dependent protein phosphatase activity	6	14
GO:0042578	phosphoric ester hydrolase activity	4	14
GO:0140096	catalytic activity, acting on a protein	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.544
CLV_PCSK_KEX2_1	153	155	PF00082	0.345
CLV_PCSK_KEX2_1	197	199	PF00082	0.392
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.345
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.392
CLV_PCSK_SKI1_1	102	106	PF00082	0.345
CLV_PCSK_SKI1_1	144	148	PF00082	0.277
CLV_PCSK_SKI1_1	154	158	PF00082	0.252
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DEG_SPOP_SBC_1	18	22	PF00917	0.363
DOC_MAPK_MEF2A_6	112	121	PF00069	0.312
DOC_PP2B_LxvP_1	238	241	PF13499	0.287
DOC_PP4_FxxP_1	208	211	PF00568	0.287
DOC_PP4_FxxP_1	296	299	PF00568	0.252
DOC_USP7_MATH_1	167	171	PF00917	0.371
DOC_USP7_MATH_1	18	22	PF00917	0.468
DOC_USP7_UBL2_3	283	287	PF12436	0.477
DOC_USP7_UBL2_3	401	405	PF12436	0.482
DOC_WW_Pin1_4	190	195	PF00397	0.243
DOC_WW_Pin1_4	324	329	PF00397	0.377
DOC_WW_Pin1_4	379	384	PF00397	0.573
LIG_14-3-3_CanoR_1	144	150	PF00244	0.283
LIG_14-3-3_CanoR_1	198	205	PF00244	0.287
LIG_14-3-3_CanoR_1	245	250	PF00244	0.236
LIG_14-3-3_CanoR_1	322	328	PF00244	0.310
LIG_14-3-3_CanoR_1	414	420	PF00244	0.597
LIG_Actin_WH2_2	181	199	PF00022	0.392
LIG_BRCT_BRCA1_1	21	25	PF00533	0.403
LIG_BRCT_BRCA1_1	342	346	PF00533	0.323
LIG_BRCT_BRCA1_1	412	416	PF00533	0.579
LIG_EH1_1	114	122	PF00400	0.392
LIG_FHA_1	339	345	PF00498	0.402
LIG_FHA_1	354	360	PF00498	0.444
LIG_FHA_2	416	422	PF00498	0.468
LIG_Integrin_isoDGR_2	466	468	PF01839	0.336
LIG_LIR_Apic_2	219	225	PF02991	0.236
LIG_LIR_Apic_2	341	345	PF02991	0.404
LIG_LIR_Gen_1	170	180	PF02991	0.313
LIG_LIR_Gen_1	183	192	PF02991	0.310
LIG_LIR_Gen_1	413	421	PF02991	0.581
LIG_LIR_Nem_3	147	152	PF02991	0.280
LIG_LIR_Nem_3	170	175	PF02991	0.296
LIG_LIR_Nem_3	183	188	PF02991	0.288
LIG_LIR_Nem_3	276	282	PF02991	0.325
LIG_LIR_Nem_3	413	419	PF02991	0.521
LIG_NRBOX	87	93	PF00104	0.234
LIG_Pex14_1	342	346	PF04695	0.323
LIG_Pex14_2	336	340	PF04695	0.329
LIG_PTB_Apo_2	179	186	PF02174	0.268
LIG_SH2_CRK	165	169	PF00017	0.229
LIG_SH2_GRB2like	149	152	PF00017	0.268
LIG_SH2_GRB2like	251	254	PF00017	0.287
LIG_SH2_GRB2like	305	308	PF00017	0.291
LIG_SH2_NCK_1	251	255	PF00017	0.379
LIG_SH2_PTP2	103	106	PF00017	0.287
LIG_SH2_SRC	249	252	PF00017	0.392
LIG_SH2_STAP1	160	164	PF00017	0.256
LIG_SH2_STAP1	251	255	PF00017	0.311
LIG_SH2_STAP1	305	309	PF00017	0.306
LIG_SH2_STAT5	103	106	PF00017	0.238
LIG_SH2_STAT5	109	112	PF00017	0.251
LIG_SH2_STAT5	149	152	PF00017	0.268
LIG_SH2_STAT5	249	252	PF00017	0.326
LIG_SH2_STAT5	301	304	PF00017	0.331
LIG_SH2_STAT5	332	335	PF00017	0.339
LIG_SH3_1	6	12	PF00018	0.593
LIG_SH3_3	355	361	PF00018	0.558
LIG_SH3_3	440	446	PF00018	0.548
LIG_SH3_3	6	12	PF00018	0.444
LIG_SUMO_SIM_anti_2	118	124	PF11976	0.252
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.305
LIG_SUMO_SIM_par_1	348	356	PF11976	0.323
LIG_UBA3_1	120	127	PF00899	0.293
MOD_CDK_SPxxK_3	190	197	PF00069	0.252
MOD_CK2_1	390	396	PF00069	0.499
MOD_CK2_1	415	421	PF00069	0.492
MOD_GlcNHglycan	169	172	PF01048	0.345
MOD_GlcNHglycan	21	24	PF01048	0.491
MOD_GlcNHglycan	213	216	PF01048	0.242
MOD_GlcNHglycan	26	30	PF01048	0.516
MOD_GlcNHglycan	296	299	PF01048	0.258
MOD_GlcNHglycan	463	466	PF01048	0.322
MOD_GSK3_1	140	147	PF00069	0.261
MOD_GSK3_1	241	248	PF00069	0.369
MOD_GSK3_1	375	382	PF00069	0.634
MOD_GSK3_1	386	393	PF00069	0.623
MOD_N-GLC_1	241	246	PF02516	0.392
MOD_N-GLC_1	324	329	PF02516	0.371
MOD_N-GLC_2	300	302	PF02516	0.266
MOD_NEK2_1	19	24	PF00069	0.482
MOD_NEK2_1	25	30	PF00069	0.503
MOD_NEK2_1	340	345	PF00069	0.323
MOD_NEK2_1	415	420	PF00069	0.499
MOD_NEK2_1	71	76	PF00069	0.379
MOD_PIKK_1	53	59	PF00454	0.288
MOD_PIKK_1	96	102	PF00454	0.302
MOD_PK_1	390	396	PF00069	0.387
MOD_PKA_1	197	203	PF00069	0.287
MOD_PKA_2	197	203	PF00069	0.287
MOD_PKA_2	410	416	PF00069	0.591
MOD_Plk_4	130	136	PF00069	0.348
MOD_Plk_4	145	151	PF00069	0.154
MOD_Plk_4	245	251	PF00069	0.268
MOD_Plk_4	390	396	PF00069	0.468
MOD_Plk_4	50	56	PF00069	0.326
MOD_Plk_4	71	77	PF00069	0.234
MOD_ProDKin_1	190	196	PF00069	0.243
MOD_ProDKin_1	324	330	PF00069	0.376
MOD_ProDKin_1	379	385	PF00069	0.573
MOD_SUMO_for_1	152	155	PF00179	0.287
MOD_SUMO_rev_2	193	199	PF00179	0.287
MOD_SUMO_rev_2	343	352	PF00179	0.379
TRG_DiLeu_BaEn_1	118	123	PF01217	0.287
TRG_DiLeu_BaEn_1	261	266	PF01217	0.312
TRG_DiLeu_BaEn_1	366	371	PF01217	0.643
TRG_ENDOCYTIC_2	103	106	PF00928	0.296
TRG_ENDOCYTIC_2	149	152	PF00928	0.267
TRG_ENDOCYTIC_2	165	168	PF00928	0.165
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y2	Leptomonas seymouri	76%	88%
A0A0N1ILH2	Leptomonas seymouri	39%	100%
A0A0N1PD03	Leptomonas seymouri	26%	100%
A0A0S4IIW0	Bodo saltans	46%	100%
A0A0S4J1J1	Bodo saltans	33%	100%
A0A0S4JDD1	Bodo saltans	52%	100%
A0A0S4JKZ6	Bodo saltans	59%	97%
A0A0S4KLF4	Bodo saltans	26%	100%
A0A1X0NMS7	Trypanosomatidae	25%	100%
A0A1X0P6J3	Trypanosomatidae	53%	100%
A0A1X0P7H9	Trypanosomatidae	59%	100%
A0A1X0P7Q5	Trypanosomatidae	44%	100%
A0A1X0P9R6	Trypanosomatidae	30%	100%
A0A3Q8I8M6	Leishmania donovani	30%	100%
A0A3Q8ID20	Leishmania donovani	100%	100%
A0A3R7M399	Trypanosoma rangeli	30%	100%
A0A3R7MBA3	Trypanosoma rangeli	56%	100%
A0A3S5H6K2	Leishmania donovani	25%	100%
A0A3S5H6T9	Leishmania donovani	35%	100%
A0A3S5H7Q6	Leishmania donovani	36%	100%
A0A3S7WZ39	Leishmania donovani	36%	100%
A0A3S7XAY3	Leishmania donovani	39%	100%
A0A422N1U7	Trypanosoma rangeli	27%	80%
A0A422N9D5	Trypanosoma rangeli	45%	100%
A4H6S0	Leishmania braziliensis	25%	100%
A4H7Z3	Leishmania braziliensis	34%	100%
A4HF98	Leishmania braziliensis	78%	100%
A4HJQ1	Leishmania braziliensis	35%	100%
A4HP65	Leishmania braziliensis	38%	100%
A4HV49	Leishmania infantum	25%	100%
A4HVT0	Leishmania infantum	30%	100%
A4HWC1	Leishmania infantum	35%	100%
A4I1H6	Leishmania infantum	36%	100%
A4I768	Leishmania infantum	36%	100%
A4IDH0	Leishmania infantum	39%	100%
C9ZM48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZQD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZX13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
D0A358	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A366	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	75%
E9ANT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9APH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AQ21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AXL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AYN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B262	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
O14829	Homo sapiens	26%	74%
O35655	Mus musculus	26%	74%
O42773	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	45%	75%
O74789	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P14747	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	79%
P16298	Homo sapiens	50%	92%
P20651	Rattus norvegicus	49%	91%
P23287	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	87%
P48452	Bos taurus	51%	92%
P48453	Mus musculus	49%	91%
P48454	Homo sapiens	49%	94%
P48455	Mus musculus	47%	94%
P48456	Drosophila melanogaster	48%	77%
P48457	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	46%	87%
P63328	Mus musculus	51%	92%
P63329	Rattus norvegicus	51%	92%
Q05681	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	48%	86%
Q08209	Homo sapiens	51%	92%
Q0G819	Caenorhabditis elegans	48%	89%
Q12705	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	87%
Q27889	Drosophila melanogaster	48%	84%
Q4Q1M5	Leishmania major	38%	100%
Q4Q5Z8	Leishmania major	36%	100%
Q4Q8T8	Leishmania major	94%	100%
Q4Q9W1	Leishmania major	36%	100%
Q4QFG0	Leishmania major	35%	100%
Q4QG03	Leishmania major	29%	100%
Q4QGT8	Leishmania major	25%	100%
Q4WUR1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	48%	90%
Q7YSW8	Dictyostelium discoideum	45%	77%
Q9FN02	Arabidopsis thaliana	34%	100%
Q9VXF1	Drosophila melanogaster	48%	82%
V5B3V2	Trypanosoma cruzi	52%	100%
V5BBR3	Trypanosoma cruzi	47%	100%
V5BBS3	Trypanosoma cruzi	27%	80%
V5BQD7	Trypanosoma cruzi	31%	100%