Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I2I9_LEIIN

TriTrypDb:

LINF_260031000

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.575
CLV_C14_Caspase3-7	464	468	PF00656	0.613
CLV_NRD_NRD_1	105	107	PF00675	0.678
CLV_NRD_NRD_1	381	383	PF00675	0.646
CLV_NRD_NRD_1	40	42	PF00675	0.409
CLV_NRD_NRD_1	448	450	PF00675	0.614
CLV_NRD_NRD_1	81	83	PF00675	0.432
CLV_PCSK_FUR_1	275	279	PF00082	0.395
CLV_PCSK_KEX2_1	277	279	PF00082	0.465
CLV_PCSK_KEX2_1	352	354	PF00082	0.505
CLV_PCSK_KEX2_1	40	42	PF00082	0.409
CLV_PCSK_KEX2_1	448	450	PF00082	0.628
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.465
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.505
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.675
CLV_PCSK_SKI1_1	106	110	PF00082	0.674
CLV_PCSK_SKI1_1	352	356	PF00082	0.512
CLV_PCSK_SKI1_1	393	397	PF00082	0.690
CLV_PCSK_SKI1_1	401	405	PF00082	0.709
CLV_PCSK_SKI1_1	8	12	PF00082	0.507
DEG_MDM2_SWIB_1	227	235	PF02201	0.408
DEG_Nend_UBRbox_2	1	3	PF02207	0.415
DEG_SCF_FBW7_2	366	372	PF00400	0.486
DEG_SPOP_SBC_1	112	116	PF00917	0.638
DEG_SPOP_SBC_1	411	415	PF00917	0.659
DOC_CKS1_1	29	34	PF01111	0.481
DOC_CKS1_1	366	371	PF01111	0.479
DOC_MAPK_FxFP_2	280	283	PF00069	0.339
DOC_MAPK_gen_1	233	241	PF00069	0.411
DOC_MAPK_gen_1	40	46	PF00069	0.400
DOC_PP4_FxxP_1	280	283	PF00568	0.339
DOC_PP4_FxxP_1	76	79	PF00568	0.460
DOC_USP7_MATH_1	120	124	PF00917	0.757
DOC_USP7_MATH_1	142	146	PF00917	0.543
DOC_USP7_MATH_1	184	188	PF00917	0.461
DOC_USP7_MATH_1	254	258	PF00917	0.418
DOC_USP7_MATH_1	39	43	PF00917	0.442
DOC_USP7_MATH_1	472	476	PF00917	0.654
DOC_USP7_UBL2_3	128	132	PF12436	0.610
DOC_USP7_UBL2_3	404	408	PF12436	0.783
DOC_WW_Pin1_4	188	193	PF00397	0.575
DOC_WW_Pin1_4	28	33	PF00397	0.473
DOC_WW_Pin1_4	365	370	PF00397	0.537
DOC_WW_Pin1_4	403	408	PF00397	0.681
DOC_WW_Pin1_4	412	417	PF00397	0.702
DOC_WW_Pin1_4	430	435	PF00397	0.546
LIG_14-3-3_CanoR_1	221	227	PF00244	0.499
LIG_14-3-3_CanoR_1	382	390	PF00244	0.645
LIG_14-3-3_CanoR_1	40	44	PF00244	0.611
LIG_14-3-3_CanoR_1	401	407	PF00244	0.487
LIG_14-3-3_CanoR_1	451	458	PF00244	0.616
LIG_Actin_WH2_2	42	58	PF00022	0.350
LIG_BRCT_BRCA1_1	256	260	PF00533	0.429
LIG_FHA_1	441	447	PF00498	0.631
LIG_FHA_2	156	162	PF00498	0.607
LIG_FHA_2	180	186	PF00498	0.464
LIG_FHA_2	327	333	PF00498	0.534
LIG_FHA_2	99	105	PF00498	0.564
LIG_LIR_Apic_2	74	79	PF02991	0.460
LIG_LIR_Gen_1	171	180	PF02991	0.489
LIG_LIR_Gen_1	42	50	PF02991	0.450
LIG_LIR_Gen_1	63	73	PF02991	0.360
LIG_LIR_Nem_3	171	177	PF02991	0.491
LIG_LIR_Nem_3	265	270	PF02991	0.435
LIG_LIR_Nem_3	42	46	PF02991	0.452
LIG_LIR_Nem_3	478	484	PF02991	0.463
LIG_LIR_Nem_3	63	69	PF02991	0.360
LIG_LIR_Nem_3	71	76	PF02991	0.370
LIG_LYPXL_SIV_4	283	291	PF13949	0.333
LIG_PCNA_PIPBox_1	195	204	PF02747	0.406
LIG_PCNA_yPIPBox_3	190	202	PF02747	0.426
LIG_Pex14_2	227	231	PF04695	0.415
LIG_SH2_CRK	267	271	PF00017	0.452
LIG_SH2_CRK	43	47	PF00017	0.422
LIG_SH2_NCK_1	267	271	PF00017	0.423
LIG_SH2_SRC	484	487	PF00017	0.569
LIG_SH2_STAP1	224	228	PF00017	0.348
LIG_SH2_STAP1	262	266	PF00017	0.355
LIG_SH3_3	136	142	PF00018	0.581
LIG_SH3_3	204	210	PF00018	0.370
LIG_SH3_3	26	32	PF00018	0.441
LIG_SH3_3	280	286	PF00018	0.316
LIG_SH3_3	422	428	PF00018	0.759
LIG_SH3_3	46	52	PF00018	0.262
LIG_TRAF2_1	296	299	PF00917	0.433
MOD_CDK_SPK_2	403	408	PF00069	0.631
MOD_CK1_1	114	120	PF00069	0.604
MOD_CK1_1	164	170	PF00069	0.573
MOD_CK1_1	381	387	PF00069	0.592
MOD_CK1_1	456	462	PF00069	0.632
MOD_CK1_1	474	480	PF00069	0.432
MOD_CK1_1	97	103	PF00069	0.503
MOD_CK2_1	149	155	PF00069	0.687
MOD_CK2_1	179	185	PF00069	0.469
MOD_CK2_1	211	217	PF00069	0.503
MOD_CK2_1	307	313	PF00069	0.554
MOD_CK2_1	326	332	PF00069	0.348
MOD_CK2_1	456	462	PF00069	0.596
MOD_CK2_1	463	469	PF00069	0.592
MOD_CK2_1	68	74	PF00069	0.323
MOD_CK2_1	90	96	PF00069	0.541
MOD_Cter_Amidation	104	107	PF01082	0.628
MOD_Cter_Amidation	231	234	PF01082	0.346
MOD_Cter_Amidation	439	442	PF01082	0.735
MOD_GlcNHglycan	120	123	PF01048	0.728
MOD_GlcNHglycan	144	147	PF01048	0.654
MOD_GlcNHglycan	256	259	PF01048	0.433
MOD_GlcNHglycan	375	378	PF01048	0.527
MOD_GlcNHglycan	421	424	PF01048	0.792
MOD_GlcNHglycan	443	446	PF01048	0.607
MOD_GlcNHglycan	70	73	PF01048	0.332
MOD_GSK3_1	111	118	PF00069	0.739
MOD_GSK3_1	149	156	PF00069	0.654
MOD_GSK3_1	184	191	PF00069	0.499
MOD_GSK3_1	262	269	PF00069	0.391
MOD_GSK3_1	378	385	PF00069	0.600
MOD_GSK3_1	399	406	PF00069	0.670
MOD_GSK3_1	412	419	PF00069	0.700
MOD_GSK3_1	430	437	PF00069	0.532
MOD_GSK3_1	461	468	PF00069	0.626
MOD_GSK3_1	471	478	PF00069	0.651
MOD_GSK3_1	90	97	PF00069	0.541
MOD_LATS_1	351	357	PF00433	0.490
MOD_N-GLC_1	188	193	PF02516	0.637
MOD_NEK2_1	266	271	PF00069	0.450
MOD_NEK2_1	337	342	PF00069	0.459
MOD_NEK2_1	373	378	PF00069	0.607
MOD_NEK2_2	222	227	PF00069	0.445
MOD_NEK2_2	262	267	PF00069	0.349
MOD_PIKK_1	120	126	PF00454	0.639
MOD_PIKK_1	285	291	PF00454	0.360
MOD_PKA_1	382	388	PF00069	0.637
MOD_PKA_1	441	447	PF00069	0.688
MOD_PKA_2	118	124	PF00069	0.687
MOD_PKA_2	378	384	PF00069	0.690
MOD_PKA_2	39	45	PF00069	0.466
MOD_PKA_2	97	103	PF00069	0.555
MOD_PKB_1	449	457	PF00069	0.630
MOD_Plk_1	164	170	PF00069	0.576
MOD_Plk_1	262	268	PF00069	0.355
MOD_Plk_1	461	467	PF00069	0.658
MOD_Plk_1	475	481	PF00069	0.660
MOD_Plk_2-3	149	155	PF00069	0.643
MOD_Plk_2-3	463	469	PF00069	0.567
MOD_Plk_4	222	228	PF00069	0.358
MOD_Plk_4	262	268	PF00069	0.355
MOD_Plk_4	6	12	PF00069	0.398
MOD_ProDKin_1	188	194	PF00069	0.572
MOD_ProDKin_1	28	34	PF00069	0.468
MOD_ProDKin_1	365	371	PF00069	0.545
MOD_ProDKin_1	403	409	PF00069	0.680
MOD_ProDKin_1	412	418	PF00069	0.703
MOD_ProDKin_1	430	436	PF00069	0.547
MOD_SUMO_rev_2	164	173	PF00179	0.514
MOD_SUMO_rev_2	74	81	PF00179	0.490
TRG_DiLeu_BaEn_1	332	337	PF01217	0.419
TRG_DiLeu_BaEn_4	344	350	PF01217	0.438
TRG_ENDOCYTIC_2	224	227	PF00928	0.346
TRG_ENDOCYTIC_2	267	270	PF00928	0.433
TRG_ENDOCYTIC_2	284	287	PF00928	0.240
TRG_ENDOCYTIC_2	43	46	PF00928	0.394
TRG_NLS_Bipartite_1	127	144	PF00514	0.597
TRG_NLS_MonoCore_2	139	144	PF00514	0.644
TRG_NLS_MonoCore_2	447	452	PF00514	0.633
TRG_NLS_MonoExtC_3	448	453	PF00514	0.648
TRG_NLS_MonoExtN_4	137	144	PF00514	0.723
TRG_NLS_MonoExtN_4	448	454	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P789	Trypanosomatidae	43%	100%
A0A3R7KYR3	Trypanosoma rangeli	41%	100%
A0A3S7X087	Leishmania donovani	100%	100%
A4HF97	Leishmania braziliensis	70%	96%
C9ZX14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AYN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8T9	Leishmania major	91%	100%