Protein kinase

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4I2I8_LEIIN

TriTrypDb:

LINF_260030900

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 456

Expansion

Sequence features

A4I2I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2I8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.365
CLV_NRD_NRD_1	25	27	PF00675	0.351
CLV_NRD_NRD_1	29	31	PF00675	0.349
CLV_NRD_NRD_1	366	368	PF00675	0.346
CLV_NRD_NRD_1	64	66	PF00675	0.272
CLV_PCSK_KEX2_1	162	164	PF00082	0.322
CLV_PCSK_KEX2_1	224	226	PF00082	0.358
CLV_PCSK_KEX2_1	25	27	PF00082	0.387
CLV_PCSK_KEX2_1	29	31	PF00082	0.394
CLV_PCSK_KEX2_1	366	368	PF00082	0.342
CLV_PCSK_KEX2_1	60	62	PF00082	0.369
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.330
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.332
CLV_PCSK_PC7_1	25	31	PF00082	0.403
CLV_PCSK_SKI1_1	102	106	PF00082	0.433
CLV_PCSK_SKI1_1	163	167	PF00082	0.314
CLV_PCSK_SKI1_1	265	269	PF00082	0.284
CLV_PCSK_SKI1_1	427	431	PF00082	0.571
CLV_PCSK_SKI1_1	61	65	PF00082	0.291
DEG_APCC_DBOX_1	162	170	PF00400	0.283
DEG_APCC_DBOX_1	207	215	PF00400	0.403
DEG_APCC_DBOX_1	68	76	PF00400	0.428
DEG_APCC_KENBOX_2	404	408	PF00400	0.345
DOC_CKS1_1	278	283	PF01111	0.403
DOC_CKS1_1	462	467	PF01111	0.626
DOC_CKS1_1	6	11	PF01111	0.540
DOC_CKS1_1	98	103	PF01111	0.520
DOC_MAPK_gen_1	265	274	PF00069	0.255
DOC_MAPK_MEF2A_6	208	215	PF00069	0.403
DOC_USP7_MATH_1	352	356	PF00917	0.345
DOC_USP7_UBL2_3	167	171	PF12436	0.257
DOC_WW_Pin1_4	277	282	PF00397	0.403
DOC_WW_Pin1_4	461	466	PF00397	0.543
DOC_WW_Pin1_4	5	10	PF00397	0.555
DOC_WW_Pin1_4	87	92	PF00397	0.493
DOC_WW_Pin1_4	97	102	PF00397	0.542
LIG_14-3-3_CanoR_1	354	359	PF00244	0.339
LIG_14-3-3_CanoR_1	475	479	PF00244	0.598
LIG_14-3-3_CanoR_1	77	81	PF00244	0.522
LIG_APCC_ABBAyCdc20_2	260	266	PF00400	0.255
LIG_BIR_II_1	1	5	PF00653	0.605
LIG_BRCT_BRCA1_1	354	358	PF00533	0.345
LIG_BRCT_BRCA1_2	354	360	PF00533	0.345
LIG_EH_1	406	410	PF12763	0.291
LIG_FHA_1	1	7	PF00498	0.607
LIG_FHA_1	103	109	PF00498	0.502
LIG_FHA_1	240	246	PF00498	0.296
LIG_FHA_1	278	284	PF00498	0.383
LIG_FHA_1	370	376	PF00498	0.452
LIG_FHA_2	205	211	PF00498	0.345
LIG_FHA_2	433	439	PF00498	0.606
LIG_FHA_2	88	94	PF00498	0.404
LIG_LIR_Apic_2	275	281	PF02991	0.403
LIG_LIR_Apic_2	305	311	PF02991	0.284
LIG_LIR_Apic_2	97	101	PF02991	0.522
LIG_LIR_Gen_1	355	365	PF02991	0.336
LIG_LIR_Gen_1	400	409	PF02991	0.438
LIG_LIR_Gen_1	438	447	PF02991	0.479
LIG_LIR_Gen_1	90	99	PF02991	0.422
LIG_LIR_Nem_3	146	150	PF02991	0.392
LIG_LIR_Nem_3	296	302	PF02991	0.403
LIG_LIR_Nem_3	400	404	PF02991	0.438
LIG_LIR_Nem_3	438	442	PF02991	0.480
LIG_LIR_Nem_3	90	95	PF02991	0.456
LIG_MAD2	188	196	PF02301	0.332
LIG_PDZ_Class_2	476	481	PF00595	0.521
LIG_Pex14_1	468	472	PF04695	0.613
LIG_Pex14_2	147	151	PF04695	0.380
LIG_Pex14_2	31	35	PF04695	0.328
LIG_Pex14_2	76	80	PF04695	0.514
LIG_SH2_CRK	126	130	PF00017	0.475
LIG_SH2_CRK	278	282	PF00017	0.360
LIG_SH2_CRK	401	405	PF00017	0.345
LIG_SH2_NCK_1	126	130	PF00017	0.460
LIG_SH2_NCK_1	308	312	PF00017	0.383
LIG_SH2_NCK_1	393	397	PF00017	0.345
LIG_SH2_SRC	393	396	PF00017	0.291
LIG_SH2_STAP1	177	181	PF00017	0.345
LIG_SH2_STAT3	59	62	PF00017	0.345
LIG_SH2_STAT5	177	180	PF00017	0.403
LIG_SH2_STAT5	255	258	PF00017	0.255
LIG_SH2_STAT5	300	303	PF00017	0.288
LIG_SH2_STAT5	345	348	PF00017	0.363
LIG_SH2_STAT5	472	475	PF00017	0.617
LIG_SH2_STAT5	48	51	PF00017	0.394
LIG_SH2_STAT5	98	101	PF00017	0.523
LIG_SH3_3	190	196	PF00018	0.345
LIG_SH3_3	455	461	PF00018	0.649
LIG_SUMO_SIM_anti_2	209	216	PF11976	0.328
LIG_SUMO_SIM_par_1	209	216	PF11976	0.271
LIG_TRAF2_1	236	239	PF00917	0.291
LIG_TRAF2_2	395	400	PF00917	0.345
LIG_TYR_ITIM	342	347	PF00017	0.268
LIG_UBA3_1	165	171	PF00899	0.345
LIG_WRC_WIRS_1	133	138	PF05994	0.381
MOD_CDK_SPK_2	97	102	PF00069	0.526
MOD_CDK_SPxK_1	461	467	PF00069	0.627
MOD_CK1_1	110	116	PF00069	0.354
MOD_CK1_1	170	176	PF00069	0.298
MOD_CK1_1	97	103	PF00069	0.440
MOD_CK2_1	432	438	PF00069	0.573
MOD_CK2_1	87	93	PF00069	0.386
MOD_Cter_Amidation	23	26	PF01082	0.403
MOD_Cter_Amidation	27	30	PF01082	0.403
MOD_GlcNHglycan	154	159	PF01048	0.426
MOD_GlcNHglycan	22	25	PF01048	0.354
MOD_GlcNHglycan	250	253	PF01048	0.197
MOD_GlcNHglycan	274	277	PF01048	0.408
MOD_GlcNHglycan	347	350	PF01048	0.318
MOD_GSK3_1	272	279	PF00069	0.288
MOD_GSK3_1	438	445	PF00069	0.620
MOD_N-GLC_1	173	178	PF02516	0.403
MOD_N-GLC_2	68	70	PF02516	0.268
MOD_NEK2_1	107	112	PF00069	0.383
MOD_NEK2_1	125	130	PF00069	0.439
MOD_NEK2_1	175	180	PF00069	0.332
MOD_NEK2_1	20	25	PF00069	0.411
MOD_NEK2_1	76	81	PF00069	0.520
MOD_NEK2_2	327	332	PF00069	0.403
MOD_NEK2_2	54	59	PF00069	0.388
MOD_PKA_2	143	149	PF00069	0.409
MOD_PKA_2	474	480	PF00069	0.616
MOD_PKA_2	76	82	PF00069	0.565
MOD_Plk_1	173	179	PF00069	0.398
MOD_Plk_2-3	438	444	PF00069	0.571
MOD_Plk_4	110	116	PF00069	0.472
MOD_Plk_4	132	138	PF00069	0.340
MOD_Plk_4	146	152	PF00069	0.321
MOD_Plk_4	54	60	PF00069	0.388
MOD_ProDKin_1	277	283	PF00069	0.403
MOD_ProDKin_1	461	467	PF00069	0.543
MOD_ProDKin_1	5	11	PF00069	0.545
MOD_ProDKin_1	87	93	PF00069	0.497
MOD_ProDKin_1	97	103	PF00069	0.537
MOD_SUMO_for_1	151	154	PF00179	0.345
MOD_SUMO_rev_2	154	164	PF00179	0.291
TRG_DiLeu_BaEn_1	455	460	PF01217	0.612
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.561
TRG_ENDOCYTIC_2	126	129	PF00928	0.361
TRG_ENDOCYTIC_2	344	347	PF00928	0.287
TRG_ENDOCYTIC_2	401	404	PF00928	0.345
TRG_ER_diArg_1	29	31	PF00400	0.413
TRG_ER_diArg_1	353	356	PF00400	0.369
TRG_ER_diArg_1	365	367	PF00400	0.348
TRG_ER_diArg_1	69	72	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N5	Leptomonas seymouri	27%	100%
A0A0N0P7K3	Leptomonas seymouri	67%	100%
A0A0S4JH92	Bodo saltans	39%	97%
A0A0S4JPZ7	Bodo saltans	26%	100%
A0A0S4JQP0	Bodo saltans	42%	98%
A0A0S4KKJ1	Bodo saltans	24%	76%
A0A0S4KMV7	Bodo saltans	27%	100%
A0A1X0P022	Trypanosomatidae	24%	75%
A0A1X0P5U3	Trypanosomatidae	25%	94%
A0A1X0P834	Trypanosomatidae	46%	100%
A0A3Q8IFW0	Leishmania donovani	27%	100%
A0A3Q8IHA5	Leishmania donovani	100%	100%
A0A3R7MPF2	Trypanosoma rangeli	25%	74%
A0A3S5H5G0	Leishmania donovani	26%	100%
A0A422N3U8	Trypanosoma rangeli	27%	67%
A0A422P3P9	Trypanosoma rangeli	48%	97%
A0AAR7	Lotus japonicus	26%	93%
A4H459	Leishmania braziliensis	28%	100%
A4HF96	Leishmania braziliensis	89%	100%
A4HJW2	Leishmania braziliensis	27%	100%
A4HP12	Leishmania braziliensis	27%	94%
A4HSE2	Leishmania infantum	26%	100%
A4I7C4	Leishmania infantum	26%	100%
C9ZLF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	76%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZSU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	76%
C9ZUU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	73%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	96%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AYN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O14305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O61267	Drosophila melanogaster	26%	100%
O96017	Homo sapiens	28%	89%
P28867	Mus musculus	25%	71%
P34947	Homo sapiens	28%	82%
P43249	Bos taurus	28%	82%
Q0VD22	Bos taurus	29%	99%
Q4Q5T9	Leishmania major	28%	100%
Q4Q8U0	Leishmania major	97%	100%
Q4QJJ0	Leishmania major	27%	100%
Q60823	Mus musculus	27%	100%
Q6IP76	Xenopus laevis	26%	99%
Q6PA14	Xenopus laevis	26%	99%
Q8INB9	Drosophila melanogaster	26%	79%
Q8MYF1	Dictyostelium discoideum	26%	100%
Q9CAH1	Arabidopsis thaliana	27%	100%
Q9FZ36	Arabidopsis thaliana	25%	74%
Q9SIQ7	Arabidopsis thaliana	28%	83%
Q9SN43	Arabidopsis thaliana	27%	98%
Q9ZSA2	Arabidopsis thaliana	27%	91%
V5BC57	Trypanosoma cruzi	48%	97%
V5BHW8	Trypanosoma cruzi	26%	76%
V5BL06	Trypanosoma cruzi	27%	74%
V5C234	Trypanosoma cruzi	25%	88%