DNA topoisomerase (ATP-hydrolyzing)

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2H7_LEIIN

TriTrypDb:

LINF_260031300

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2H7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.442
CLV_NRD_NRD_1	59	61	PF00675	0.496
CLV_PCSK_SKI1_1	45	49	PF00082	0.528
CLV_Separin_Metazoa	8	12	PF03568	0.580
DOC_MAPK_gen_1	57	66	PF00069	0.482
DOC_MAPK_gen_1	72	82	PF00069	0.579
DOC_MAPK_MEF2A_6	60	68	PF00069	0.623
DOC_USP7_MATH_1	10	14	PF00917	0.545
DOC_USP7_UBL2_3	57	61	PF12436	0.610
LIG_14-3-3_CanoR_1	60	68	PF00244	0.606
LIG_FHA_1	2	8	PF00498	0.489
LIG_FHA_1	60	66	PF00498	0.608
LIG_SH2_STAT3	90	93	PF00017	0.702
LIG_SH2_STAT5	24	27	PF00017	0.506
LIG_SH2_STAT5	86	89	PF00017	0.642
LIG_SH2_STAT5	90	93	PF00017	0.637
LIG_SH3_3	4	10	PF00018	0.585
MOD_CK1_1	70	76	PF00069	0.542
MOD_GlcNHglycan	71	75	PF01048	0.647
MOD_NEK2_1	1	6	PF00069	0.633
MOD_PKA_2	10	16	PF00069	0.548
MOD_PKA_2	59	65	PF00069	0.606
MOD_Plk_4	10	16	PF00069	0.553
MOD_SUMO_for_1	5	8	PF00179	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM40	Leptomonas seymouri	54%	100%
A0A3S7X089	Leishmania donovani	100%	100%
C9ZX11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AYN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q8T6	Leishmania major	94%	100%