Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2H3_LEIIN

TriTrypDb:

LINF_260030200

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I2H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.521
CLV_NRD_NRD_1	287	289	PF00675	0.733
CLV_NRD_NRD_1	385	387	PF00675	0.621
CLV_NRD_NRD_1	46	48	PF00675	0.595
CLV_NRD_NRD_1	5	7	PF00675	0.546
CLV_NRD_NRD_1	89	91	PF00675	0.546
CLV_NRD_NRD_1	93	95	PF00675	0.540
CLV_PCSK_FUR_1	14	18	PF00082	0.480
CLV_PCSK_KEX2_1	16	18	PF00082	0.521
CLV_PCSK_KEX2_1	174	176	PF00082	0.650
CLV_PCSK_KEX2_1	287	289	PF00082	0.729
CLV_PCSK_KEX2_1	45	47	PF00082	0.589
CLV_PCSK_KEX2_1	5	7	PF00082	0.546
CLV_PCSK_KEX2_1	89	91	PF00082	0.512
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.631
CLV_PCSK_SKI1_1	223	227	PF00082	0.629
CLV_PCSK_SKI1_1	330	334	PF00082	0.621
CLV_PCSK_SKI1_1	377	381	PF00082	0.517
CLV_PCSK_SKI1_1	6	10	PF00082	0.525
DEG_COP1_1	405	413	PF00400	0.385
DEG_Nend_UBRbox_1	1	4	PF02207	0.604
DEG_SPOP_SBC_1	22	26	PF00917	0.765
DOC_AGCK_PIF_1	138	143	PF00069	0.359
DOC_CKS1_1	322	327	PF01111	0.472
DOC_CYCLIN_RxL_1	326	336	PF00134	0.429
DOC_MAPK_FxFP_2	158	161	PF00069	0.483
DOC_MAPK_gen_1	103	111	PF00069	0.656
DOC_MAPK_gen_1	14	22	PF00069	0.732
DOC_MAPK_gen_1	174	180	PF00069	0.418
DOC_MAPK_gen_1	2	11	PF00069	0.693
DOC_MAPK_gen_1	205	213	PF00069	0.315
DOC_MAPK_gen_1	257	265	PF00069	0.532
DOC_MAPK_MEF2A_6	115	124	PF00069	0.542
DOC_MAPK_MEF2A_6	207	215	PF00069	0.293
DOC_PP4_FxxP_1	158	161	PF00568	0.483
DOC_USP7_MATH_1	308	312	PF00917	0.489
DOC_USP7_MATH_1	55	59	PF00917	0.745
DOC_USP7_UBL2_3	170	174	PF12436	0.337
DOC_USP7_UBL2_3	326	330	PF12436	0.389
DOC_WW_Pin1_4	147	152	PF00397	0.489
DOC_WW_Pin1_4	321	326	PF00397	0.538
DOC_WW_Pin1_4	39	44	PF00397	0.743
LIG_14-3-3_CanoR_1	115	121	PF00244	0.640
LIG_14-3-3_CanoR_1	14	20	PF00244	0.700
LIG_14-3-3_CanoR_1	153	157	PF00244	0.469
LIG_14-3-3_CanoR_1	175	179	PF00244	0.459
LIG_14-3-3_CanoR_1	260	264	PF00244	0.543
LIG_14-3-3_CanoR_1	295	305	PF00244	0.531
LIG_14-3-3_CanoR_1	334	338	PF00244	0.394
LIG_14-3-3_CanoR_1	89	93	PF00244	0.728
LIG_Actin_WH2_2	372	388	PF00022	0.444
LIG_BRCT_BRCA1_1	154	158	PF00533	0.521
LIG_BRCT_BRCA1_1	23	27	PF00533	0.668
LIG_BRCT_BRCA1_1	261	265	PF00533	0.540
LIG_Clathr_ClatBox_1	234	238	PF01394	0.457
LIG_CORNRBOX	213	221	PF00104	0.254
LIG_FHA_1	119	125	PF00498	0.366
LIG_FHA_1	140	146	PF00498	0.389
LIG_FHA_1	175	181	PF00498	0.474
LIG_FHA_1	229	235	PF00498	0.415
LIG_FHA_1	327	333	PF00498	0.480
LIG_FHA_1	405	411	PF00498	0.417
LIG_FHA_2	315	321	PF00498	0.551
LIG_FHA_2	403	409	PF00498	0.465
LIG_LIR_Apic_2	155	161	PF02991	0.496
LIG_LIR_Gen_1	139	149	PF02991	0.432
LIG_LIR_Gen_1	353	362	PF02991	0.449
LIG_LIR_Gen_1	418	428	PF02991	0.397
LIG_LIR_Nem_3	139	144	PF02991	0.431
LIG_LIR_Nem_3	155	160	PF02991	0.385
LIG_LIR_Nem_3	353	357	PF02991	0.431
LIG_LIR_Nem_3	418	424	PF02991	0.389
LIG_MLH1_MIPbox_1	154	158	PF16413	0.521
LIG_PCNA_yPIPBox_3	214	225	PF02747	0.419
LIG_PCNA_yPIPBox_3	377	389	PF02747	0.355
LIG_PTB_Apo_2	151	158	PF02174	0.424
LIG_SH2_CRK	141	145	PF00017	0.440
LIG_SH2_CRK	371	375	PF00017	0.399
LIG_SH2_SRC	371	374	PF00017	0.370
LIG_SH2_STAP1	141	145	PF00017	0.397
LIG_SH2_STAP1	314	318	PF00017	0.511
LIG_SH2_STAP1	354	358	PF00017	0.356
LIG_SH2_STAP1	371	375	PF00017	0.457
LIG_SH2_STAP1	389	393	PF00017	0.293
LIG_SH2_STAP1	435	439	PF00017	0.415
LIG_SH2_STAT5	123	126	PF00017	0.448
LIG_SH2_STAT5	137	140	PF00017	0.336
LIG_SH2_STAT5	141	144	PF00017	0.247
LIG_SH2_STAT5	227	230	PF00017	0.348
LIG_SH2_STAT5	373	376	PF00017	0.397
LIG_SH2_STAT5	437	440	PF00017	0.444
LIG_SH3_2	325	330	PF14604	0.508
LIG_SH3_3	319	325	PF00018	0.565
LIG_SUMO_SIM_anti_2	177	182	PF11976	0.458
LIG_SUMO_SIM_par_1	18	26	PF11976	0.716
LIG_SUMO_SIM_par_1	231	238	PF11976	0.383
LIG_TRAF2_1	83	86	PF00917	0.779
LIG_TYR_ITSM	137	144	PF00017	0.497
LIG_WW_3	42	46	PF00397	0.578
MOD_CDC14_SPxK_1	150	153	PF00782	0.647
MOD_CDK_SPK_2	321	326	PF00069	0.517
MOD_CDK_SPxK_1	147	153	PF00069	0.629
MOD_CDK_SPxK_1	39	45	PF00069	0.574
MOD_CDK_SPxxK_3	39	46	PF00069	0.674
MOD_CK1_1	21	27	PF00069	0.646
MOD_CK1_1	233	239	PF00069	0.541
MOD_CK1_1	259	265	PF00069	0.622
MOD_CK1_1	281	287	PF00069	0.726
MOD_CK1_1	309	315	PF00069	0.696
MOD_CK1_1	38	44	PF00069	0.627
MOD_CK2_1	314	320	PF00069	0.671
MOD_CK2_1	402	408	PF00069	0.598
MOD_CMANNOS	289	292	PF00535	0.668
MOD_GlcNHglycan	106	109	PF01048	0.727
MOD_GlcNHglycan	112	115	PF01048	0.587
MOD_GlcNHglycan	306	309	PF01048	0.613
MOD_GlcNHglycan	311	314	PF01048	0.594
MOD_GlcNHglycan	38	41	PF01048	0.656
MOD_GlcNHglycan	382	385	PF01048	0.602
MOD_GlcNHglycan	399	402	PF01048	0.379
MOD_GlcNHglycan	50	53	PF01048	0.786
MOD_GSK3_1	139	146	PF00069	0.427
MOD_GSK3_1	18	25	PF00069	0.720
MOD_GSK3_1	277	284	PF00069	0.687
MOD_GSK3_1	304	311	PF00069	0.672
MOD_GSK3_1	35	42	PF00069	0.572
MOD_N-GLC_1	147	152	PF02516	0.620
MOD_NEK2_1	104	109	PF00069	0.657
MOD_NEK2_1	125	130	PF00069	0.351
MOD_NEK2_1	304	309	PF00069	0.643
MOD_NEK2_1	332	337	PF00069	0.464
MOD_NEK2_1	339	344	PF00069	0.527
MOD_NEK2_1	375	380	PF00069	0.510
MOD_NEK2_2	152	157	PF00069	0.552
MOD_NEK2_2	88	93	PF00069	0.683
MOD_PIKK_1	282	288	PF00454	0.751
MOD_PKA_1	174	180	PF00069	0.634
MOD_PKA_2	104	110	PF00069	0.602
MOD_PKA_2	15	21	PF00069	0.693
MOD_PKA_2	152	158	PF00069	0.617
MOD_PKA_2	174	180	PF00069	0.569
MOD_PKA_2	259	265	PF00069	0.718
MOD_PKA_2	278	284	PF00069	0.438
MOD_PKA_2	333	339	PF00069	0.524
MOD_PKA_2	88	94	PF00069	0.775
MOD_Plk_2-3	402	408	PF00069	0.500
MOD_Plk_4	118	124	PF00069	0.333
MOD_Plk_4	139	145	PF00069	0.455
MOD_Plk_4	152	158	PF00069	0.566
MOD_Plk_4	216	222	PF00069	0.486
MOD_Plk_4	230	236	PF00069	0.415
MOD_ProDKin_1	147	153	PF00069	0.629
MOD_ProDKin_1	321	327	PF00069	0.676
MOD_ProDKin_1	39	45	PF00069	0.697
MOD_SUMO_rev_2	163	172	PF00179	0.533
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.547
TRG_ENDOCYTIC_2	141	144	PF00928	0.557
TRG_ENDOCYTIC_2	246	249	PF00928	0.550
TRG_ENDOCYTIC_2	354	357	PF00928	0.578
TRG_ENDOCYTIC_2	371	374	PF00928	0.516
TRG_ER_diArg_1	14	17	PF00400	0.642
TRG_ER_diArg_1	287	289	PF00400	0.682
TRG_ER_diArg_1	337	340	PF00400	0.453
TRG_ER_diArg_1	44	47	PF00400	0.665
TRG_ER_diArg_1	88	90	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV3	Leptomonas seymouri	49%	100%
A0A1X0P8N3	Trypanosomatidae	25%	100%
A0A3S7X083	Leishmania donovani	99%	100%
A4HF91	Leishmania braziliensis	68%	100%
C9ZX21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AYM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4Q8U5	Leishmania major	84%	100%