RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2H2_LEIIN

TriTrypDb:

LINF_260030100

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2H2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.571
CLV_NRD_NRD_1	117	119	PF00675	0.577
CLV_NRD_NRD_1	120	122	PF00675	0.539
CLV_NRD_NRD_1	124	126	PF00675	0.479
CLV_NRD_NRD_1	219	221	PF00675	0.731
CLV_NRD_NRD_1	72	74	PF00675	0.637
CLV_PCSK_FUR_1	216	220	PF00082	0.686
CLV_PCSK_KEX2_1	117	119	PF00082	0.563
CLV_PCSK_KEX2_1	124	126	PF00082	0.459
CLV_PCSK_KEX2_1	200	202	PF00082	0.642
CLV_PCSK_KEX2_1	218	220	PF00082	0.689
CLV_PCSK_KEX2_1	32	34	PF00082	0.567
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.642
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.567
CLV_PCSK_SKI1_1	125	129	PF00082	0.573
CLV_PCSK_SKI1_1	148	152	PF00082	0.523
CLV_PCSK_SKI1_1	158	162	PF00082	0.391
DEG_APCC_DBOX_1	124	132	PF00400	0.605
DEG_APCC_KENBOX_2	181	185	PF00400	0.519
DEG_SPOP_SBC_1	140	144	PF00917	0.568
DOC_USP7_MATH_1	140	144	PF00917	0.413
DOC_USP7_MATH_1	19	23	PF00917	0.573
DOC_USP7_MATH_2	105	111	PF00917	0.691
LIG_14-3-3_CanoR_1	52	58	PF00244	0.515
LIG_14-3-3_CanoR_1	79	85	PF00244	0.440
LIG_BIR_III_2	82	86	PF00653	0.575
LIG_CtBP_PxDLS_1	2	6	PF00389	0.541
LIG_FHA_1	10	16	PF00498	0.431
LIG_FHA_1	140	146	PF00498	0.586
LIG_FHA_1	70	76	PF00498	0.511
LIG_FHA_1	87	93	PF00498	0.681
LIG_FHA_2	107	113	PF00498	0.673
LIG_LIR_Gen_1	38	48	PF02991	0.537
LIG_LIR_Gen_1	67	75	PF02991	0.557
LIG_LIR_LC3C_4	44	49	PF02991	0.479
LIG_LIR_Nem_3	154	160	PF02991	0.586
LIG_LIR_Nem_3	38	43	PF02991	0.487
LIG_LIR_Nem_3	67	71	PF02991	0.501
LIG_NRBOX	26	32	PF00104	0.519
LIG_PCNA_yPIPBox_3	23	33	PF02747	0.561
LIG_SH2_CRK	157	161	PF00017	0.586
LIG_SH2_STAT5	14	17	PF00017	0.457
LIG_TRAF2_1	110	113	PF00917	0.660
LIG_TYR_ITIM	155	160	PF00017	0.586
LIG_UBA3_1	26	32	PF00899	0.486
MOD_CK1_1	53	59	PF00069	0.452
MOD_CK2_1	106	112	PF00069	0.697
MOD_CK2_1	140	146	PF00069	0.566
MOD_GlcNHglycan	133	136	PF01048	0.590
MOD_GlcNHglycan	166	169	PF01048	0.585
MOD_GlcNHglycan	204	208	PF01048	0.664
MOD_GlcNHglycan	97	100	PF01048	0.650
MOD_GSK3_1	55	62	PF00069	0.453
MOD_GSK3_1	9	16	PF00069	0.526
MOD_NEK2_1	106	111	PF00069	0.758
MOD_NEK2_1	139	144	PF00069	0.592
MOD_NEK2_1	9	14	PF00069	0.448
MOD_PIKK_1	19	25	PF00454	0.574
MOD_PIKK_1	191	197	PF00454	0.592
MOD_PKA_2	78	84	PF00069	0.435
MOD_Plk_1	140	146	PF00069	0.547
MOD_Plk_2-3	141	147	PF00069	0.570
MOD_Plk_4	64	70	PF00069	0.556
TRG_ENDOCYTIC_2	157	160	PF00928	0.587
TRG_ER_diArg_1	216	219	PF00400	0.731
TRG_NES_CRM1_1	4	17	PF08389	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L0	Leptomonas seymouri	65%	100%
A0A0S4JIP0	Bodo saltans	35%	100%
A0A1X0P7J1	Trypanosomatidae	42%	78%
A0A3S7X077	Leishmania donovani	100%	100%
A0A422P3P4	Trypanosoma rangeli	47%	87%
A4HF90	Leishmania braziliensis	81%	100%
C9ZX22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	91%
E9AYM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8U6	Leishmania major	92%	100%