Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2G9_LEIIN

TriTrypDb:

LINF_260029600

Length:

442

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2G9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.530
CLV_NRD_NRD_1	184	186	PF00675	0.516
CLV_NRD_NRD_1	207	209	PF00675	0.505
CLV_NRD_NRD_1	308	310	PF00675	0.503
CLV_NRD_NRD_1	51	53	PF00675	0.552
CLV_NRD_NRD_1	65	67	PF00675	0.516
CLV_NRD_NRD_1	96	98	PF00675	0.455
CLV_PCSK_FUR_1	182	186	PF00082	0.539
CLV_PCSK_FUR_1	306	310	PF00082	0.489
CLV_PCSK_KEX2_1	142	144	PF00082	0.565
CLV_PCSK_KEX2_1	184	186	PF00082	0.516
CLV_PCSK_KEX2_1	308	310	PF00082	0.490
CLV_PCSK_KEX2_1	51	53	PF00082	0.552
CLV_PCSK_KEX2_1	65	67	PF00082	0.522
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.565
CLV_PCSK_PC7_1	180	186	PF00082	0.517
CLV_PCSK_SKI1_1	139	143	PF00082	0.536
CLV_PCSK_SKI1_1	308	312	PF00082	0.487
CLV_PCSK_SKI1_1	98	102	PF00082	0.456
DEG_APCC_DBOX_1	210	218	PF00400	0.515
DEG_APCC_DBOX_1	361	369	PF00400	0.571
DEG_APCC_KENBOX_2	18	22	PF00400	0.575
DOC_CYCLIN_RxL_1	305	313	PF00134	0.569
DOC_MAPK_gen_1	409	418	PF00069	0.625
DOC_MAPK_gen_1	97	103	PF00069	0.525
DOC_MAPK_MEF2A_6	266	273	PF00069	0.421
DOC_PP1_RVXF_1	296	303	PF00149	0.334
DOC_PP4_FxxP_1	302	305	PF00568	0.438
DOC_USP7_MATH_1	134	138	PF00917	0.469
DOC_USP7_MATH_1	250	254	PF00917	0.548
DOC_USP7_MATH_1	319	323	PF00917	0.529
DOC_WW_Pin1_4	301	306	PF00397	0.501
LIG_14-3-3_CanoR_1	182	192	PF00244	0.542
LIG_14-3-3_CanoR_1	309	318	PF00244	0.537
LIG_Actin_WH2_2	248	264	PF00022	0.483
LIG_APCC_ABBA_1	361	366	PF00400	0.494
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	188	192	PF00533	0.619
LIG_CaM_IQ_9	167	182	PF13499	0.545
LIG_Clathr_ClatBox_1	242	246	PF01394	0.491
LIG_deltaCOP1_diTrp_1	125	131	PF00928	0.506
LIG_FHA_1	155	161	PF00498	0.468
LIG_FHA_1	22	28	PF00498	0.549
LIG_FHA_1	375	381	PF00498	0.557
LIG_FHA_1	86	92	PF00498	0.460
LIG_FHA_2	217	223	PF00498	0.485
LIG_FHA_2	330	336	PF00498	0.488
LIG_FHA_2	353	359	PF00498	0.495
LIG_FHA_2	39	45	PF00498	0.551
LIG_LIR_Apic_2	11	17	PF02991	0.414
LIG_LIR_Gen_1	125	134	PF02991	0.503
LIG_LIR_Gen_1	20	30	PF02991	0.543
LIG_LIR_Gen_1	229	237	PF02991	0.493
LIG_LIR_Gen_1	238	245	PF02991	0.462
LIG_LIR_Gen_1	267	276	PF02991	0.404
LIG_LIR_Gen_1	414	422	PF02991	0.590
LIG_LIR_Gen_1	74	83	PF02991	0.549
LIG_LIR_Gen_1	86	94	PF02991	0.433
LIG_LIR_Nem_3	110	115	PF02991	0.536
LIG_LIR_Nem_3	125	130	PF02991	0.435
LIG_LIR_Nem_3	20	25	PF02991	0.444
LIG_LIR_Nem_3	229	234	PF02991	0.512
LIG_LIR_Nem_3	238	244	PF02991	0.423
LIG_LIR_Nem_3	267	271	PF02991	0.396
LIG_LIR_Nem_3	274	279	PF02991	0.417
LIG_LIR_Nem_3	404	408	PF02991	0.569
LIG_LIR_Nem_3	414	418	PF02991	0.457
LIG_LIR_Nem_3	74	78	PF02991	0.586
LIG_LIR_Nem_3	86	90	PF02991	0.433
LIG_NRBOX	100	106	PF00104	0.473
LIG_NRBOX	306	312	PF00104	0.557
LIG_Pex14_1	127	131	PF04695	0.531
LIG_Pex14_2	192	196	PF04695	0.565
LIG_Pex14_2	226	230	PF04695	0.425
LIG_Pex14_2	90	94	PF04695	0.230
LIG_PTB_Apo_2	225	232	PF02174	0.534
LIG_PTB_Phospho_1	225	231	PF10480	0.530
LIG_RPA_C_Fungi	46	58	PF08784	0.544
LIG_SH2_CRK	14	18	PF00017	0.537
LIG_SH2_CRK	231	235	PF00017	0.550
LIG_SH2_CRK	276	280	PF00017	0.496
LIG_SH2_GRB2like	231	234	PF00017	0.546
LIG_SH2_NCK_1	231	235	PF00017	0.550
LIG_SH2_PTP2	415	418	PF00017	0.564
LIG_SH2_SRC	231	234	PF00017	0.486
LIG_SH2_STAP1	22	26	PF00017	0.493
LIG_SH2_STAT5	354	357	PF00017	0.486
LIG_SH2_STAT5	415	418	PF00017	0.588
LIG_SH2_STAT5	84	87	PF00017	0.498
LIG_SH3_3	432	438	PF00018	0.639
LIG_SUMO_SIM_par_1	113	119	PF11976	0.590
LIG_SUMO_SIM_par_1	23	28	PF11976	0.451
LIG_SUMO_SIM_par_1	269	275	PF11976	0.490
LIG_SUMO_SIM_par_1	29	34	PF11976	0.552
LIG_TRAF2_1	188	191	PF00917	0.550
LIG_TYR_ITIM	159	164	PF00017	0.435
LIG_UBA3_1	270	278	PF00899	0.513
LIG_UBA3_1	418	426	PF00899	0.604
LIG_WRC_WIRS_1	100	105	PF05994	0.521
MOD_CDK_SPK_2	301	306	PF00069	0.507
MOD_CDK_SPxxK_3	301	308	PF00069	0.469
MOD_CK1_1	133	139	PF00069	0.456
MOD_CK1_1	186	192	PF00069	0.596
MOD_CK1_1	352	358	PF00069	0.469
MOD_CK1_1	374	380	PF00069	0.449
MOD_CK2_1	184	190	PF00069	0.560
MOD_CK2_1	287	293	PF00069	0.420
MOD_CK2_1	329	335	PF00069	0.536
MOD_CK2_1	352	358	PF00069	0.467
MOD_CK2_1	38	44	PF00069	0.460
MOD_CK2_1	394	400	PF00069	0.620
MOD_CK2_1	73	79	PF00069	0.602
MOD_GlcNHglycan	132	135	PF01048	0.414
MOD_GlcNHglycan	147	150	PF01048	0.596
MOD_GlcNHglycan	312	315	PF01048	0.570
MOD_GlcNHglycan	69	72	PF01048	0.683
MOD_GlcNHglycan	75	78	PF01048	0.586
MOD_GSK3_1	126	133	PF00069	0.486
MOD_GSK3_1	150	157	PF00069	0.550
MOD_GSK3_1	310	317	PF00069	0.545
MOD_GSK3_1	371	378	PF00069	0.489
MOD_GSK3_1	407	414	PF00069	0.570
MOD_GSK3_1	67	74	PF00069	0.587
MOD_GSK3_1	99	106	PF00069	0.433
MOD_N-GLC_1	226	231	PF02516	0.548
MOD_NEK2_1	103	108	PF00069	0.491
MOD_NEK2_1	196	201	PF00069	0.496
MOD_NEK2_1	226	231	PF00069	0.398
MOD_NEK2_1	310	315	PF00069	0.498
MOD_NEK2_1	329	334	PF00069	0.502
MOD_NEK2_1	372	377	PF00069	0.486
MOD_NEK2_1	385	390	PF00069	0.561
MOD_NEK2_1	422	427	PF00069	0.568
MOD_NEK2_2	134	139	PF00069	0.521
MOD_PIKK_1	196	202	PF00454	0.480
MOD_PIKK_1	407	413	PF00454	0.588
MOD_PKA_1	184	190	PF00069	0.613
MOD_PKA_1	65	71	PF00069	0.675
MOD_PKA_2	145	151	PF00069	0.648
MOD_PKA_2	183	189	PF00069	0.554
MOD_PKA_2	210	216	PF00069	0.511
MOD_PKA_2	65	71	PF00069	0.606
MOD_PKB_1	182	190	PF00069	0.614
MOD_Plk_1	115	121	PF00069	0.532
MOD_Plk_1	134	140	PF00069	0.471
MOD_Plk_1	226	232	PF00069	0.532
MOD_Plk_1	352	358	PF00069	0.490
MOD_Plk_4	126	132	PF00069	0.467
MOD_Plk_4	21	27	PF00069	0.553
MOD_Plk_4	226	232	PF00069	0.423
MOD_Plk_4	376	382	PF00069	0.452
MOD_Plk_4	411	417	PF00069	0.622
MOD_Plk_4	99	105	PF00069	0.476
MOD_ProDKin_1	301	307	PF00069	0.500
MOD_SUMO_for_1	368	371	PF00179	0.572
MOD_SUMO_rev_2	106	115	PF00179	0.577
MOD_SUMO_rev_2	321	330	PF00179	0.577
MOD_SUMO_rev_2	34	41	PF00179	0.418
MOD_SUMO_rev_2	401	410	PF00179	0.540
TRG_DiLeu_BaEn_1	110	115	PF01217	0.516
TRG_DiLeu_BaEn_1	326	331	PF01217	0.360
TRG_DiLeu_BaEn_2	98	104	PF01217	0.527
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.308
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.573
TRG_ENDOCYTIC_2	161	164	PF00928	0.439
TRG_ENDOCYTIC_2	22	25	PF00928	0.477
TRG_ENDOCYTIC_2	231	234	PF00928	0.498
TRG_ENDOCYTIC_2	276	279	PF00928	0.452
TRG_ENDOCYTIC_2	415	418	PF00928	0.531
TRG_ER_diArg_1	183	185	PF00400	0.533
TRG_ER_diArg_1	305	308	PF00400	0.482
TRG_ER_diArg_1	64	66	PF00400	0.597
TRG_NES_CRM1_1	162	173	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM42	Leptomonas seymouri	63%	100%
A0A1X0P7I7	Trypanosomatidae	35%	92%
A0A1X0P7R8	Trypanosomatidae	26%	87%
A0A3Q8ID54	Leishmania donovani	99%	100%
A0A3R7LDN5	Trypanosoma rangeli	31%	95%
A0A422MV92	Trypanosoma rangeli	27%	92%
A4HF86	Leishmania braziliensis	76%	100%
C9ZX27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	95%
D0A343	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	91%
E9AYM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8V0	Leishmania major	92%	100%
V5ATI0	Trypanosoma cruzi	31%	100%