Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I2G0_LEIIN

TriTrypDb:

LINF_260028700

Length:

729

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	8
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:1990904	ribonucleoprotein complex	2	8
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4I2G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2G0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	3
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	2
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0030515	snoRNA binding	5	1
GO:0034511	U3 snoRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0003824	catalytic activity	1	1
GO:0004672	protein kinase activity	3	1
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.698
CLV_C14_Caspase3-7	41	45	PF00656	0.549
CLV_C14_Caspase3-7	437	441	PF00656	0.689
CLV_C14_Caspase3-7	492	496	PF00656	0.616
CLV_C14_Caspase3-7	552	556	PF00656	0.662
CLV_C14_Caspase3-7	593	597	PF00656	0.696
CLV_NRD_NRD_1	151	153	PF00675	0.528
CLV_NRD_NRD_1	302	304	PF00675	0.660
CLV_NRD_NRD_1	314	316	PF00675	0.587
CLV_NRD_NRD_1	411	413	PF00675	0.625
CLV_NRD_NRD_1	541	543	PF00675	0.609
CLV_NRD_NRD_1	545	547	PF00675	0.641
CLV_NRD_NRD_1	58	60	PF00675	0.506
CLV_NRD_NRD_1	617	619	PF00675	0.763
CLV_PCSK_FUR_1	222	226	PF00082	0.683
CLV_PCSK_KEX2_1	151	153	PF00082	0.528
CLV_PCSK_KEX2_1	224	226	PF00082	0.709
CLV_PCSK_KEX2_1	314	316	PF00082	0.716
CLV_PCSK_KEX2_1	411	413	PF00082	0.625
CLV_PCSK_KEX2_1	541	543	PF00082	0.625
CLV_PCSK_KEX2_1	545	547	PF00082	0.629
CLV_PCSK_KEX2_1	58	60	PF00082	0.506
CLV_PCSK_KEX2_1	617	619	PF00082	0.750
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.709
CLV_PCSK_PC7_1	541	547	PF00082	0.705
CLV_PCSK_SKI1_1	134	138	PF00082	0.578
CLV_PCSK_SKI1_1	246	250	PF00082	0.664
CLV_PCSK_SKI1_1	403	407	PF00082	0.754
CLV_PCSK_SKI1_1	491	495	PF00082	0.516
CLV_PCSK_SKI1_1	514	518	PF00082	0.644
CLV_PCSK_SKI1_1	531	535	PF00082	0.632
CLV_PCSK_SKI1_1	59	63	PF00082	0.425
CLV_PCSK_SKI1_1	623	627	PF00082	0.585
DEG_SPOP_SBC_1	108	112	PF00917	0.592
DEG_SPOP_SBC_1	681	685	PF00917	0.548
DOC_CKS1_1	426	431	PF01111	0.538
DOC_MAPK_gen_1	312	321	PF00069	0.735
DOC_MAPK_gen_1	491	499	PF00069	0.630
DOC_MAPK_MEF2A_6	312	321	PF00069	0.735
DOC_MAPK_RevD_3	209	225	PF00069	0.615
DOC_PP1_RVXF_1	387	393	PF00149	0.631
DOC_PP2B_LxvP_1	406	409	PF13499	0.762
DOC_PP2B_LxvP_1	47	50	PF13499	0.612
DOC_PP4_FxxP_1	210	213	PF00568	0.514
DOC_SPAK_OSR1_1	100	104	PF12202	0.506
DOC_USP7_MATH_1	213	217	PF00917	0.586
DOC_USP7_MATH_1	344	348	PF00917	0.742
DOC_USP7_MATH_1	401	405	PF00917	0.677
DOC_USP7_MATH_1	415	419	PF00917	0.545
DOC_USP7_MATH_1	485	489	PF00917	0.618
DOC_USP7_MATH_1	50	54	PF00917	0.590
DOC_USP7_MATH_1	693	697	PF00917	0.573
DOC_USP7_MATH_1	698	702	PF00917	0.573
DOC_USP7_MATH_1	711	715	PF00917	0.365
DOC_USP7_UBL2_3	403	407	PF12436	0.706
DOC_USP7_UBL2_3	494	498	PF12436	0.571
DOC_USP7_UBL2_3	517	521	PF12436	0.655
DOC_WW_Pin1_4	370	375	PF00397	0.732
DOC_WW_Pin1_4	376	381	PF00397	0.709
DOC_WW_Pin1_4	425	430	PF00397	0.578
DOC_WW_Pin1_4	665	670	PF00397	0.569
DOC_WW_Pin1_4	92	97	PF00397	0.654
LIG_14-3-3_CanoR_1	102	108	PF00244	0.565
LIG_14-3-3_CanoR_1	151	156	PF00244	0.524
LIG_14-3-3_CanoR_1	314	318	PF00244	0.609
LIG_14-3-3_CanoR_1	473	479	PF00244	0.536
LIG_14-3-3_CanoR_1	58	67	PF00244	0.560
LIG_14-3-3_CanoR_1	617	623	PF00244	0.706
LIG_14-3-3_CanoR_1	630	634	PF00244	0.444
LIG_14-3-3_CanoR_1	647	655	PF00244	0.396
LIG_Actin_WH2_2	479	496	PF00022	0.619
LIG_Actin_WH2_2	504	519	PF00022	0.634
LIG_APCC_ABBA_1	248	253	PF00400	0.688
LIG_BIR_III_4	348	352	PF00653	0.703
LIG_BIR_III_4	360	364	PF00653	0.550
LIG_BRCT_BRCA1_1	382	386	PF00533	0.647
LIG_BRCT_BRCA1_1	447	451	PF00533	0.519
LIG_CaM_IQ_9	390	405	PF13499	0.638
LIG_EH1_1	114	122	PF00400	0.594
LIG_FHA_1	108	114	PF00498	0.501
LIG_FHA_1	179	185	PF00498	0.548
LIG_FHA_1	201	207	PF00498	0.499
LIG_FHA_1	272	278	PF00498	0.431
LIG_FHA_1	336	342	PF00498	0.762
LIG_FHA_1	420	426	PF00498	0.467
LIG_FHA_1	60	66	PF00498	0.432
LIG_FHA_1	683	689	PF00498	0.643
LIG_FHA_1	72	78	PF00498	0.473
LIG_FHA_2	143	149	PF00498	0.557
LIG_FHA_2	490	496	PF00498	0.563
LIG_FHA_2	83	89	PF00498	0.464
LIG_LIR_Apic_2	207	213	PF02991	0.506
LIG_LIR_Gen_1	37	47	PF02991	0.615
LIG_LIR_Gen_1	675	682	PF02991	0.642
LIG_LIR_Nem_3	621	625	PF02991	0.680
LIG_LIR_Nem_3	675	680	PF02991	0.573
LIG_LIR_Nem_3	80	86	PF02991	0.565
LIG_PCNA_PIPBox_1	652	661	PF02747	0.516
LIG_PCNA_TLS_4	630	637	PF02747	0.637
LIG_PTB_Apo_2	676	683	PF02174	0.632
LIG_PTB_Phospho_1	676	682	PF10480	0.636
LIG_RPA_C_Fungi	53	65	PF08784	0.522
LIG_SH2_CRK	706	710	PF00017	0.573
LIG_SH2_NCK_1	251	255	PF00017	0.732
LIG_SH2_NCK_1	500	504	PF00017	0.623
LIG_SH2_NCK_1	706	710	PF00017	0.573
LIG_SH2_SRC	251	254	PF00017	0.724
LIG_SH2_STAP1	500	504	PF00017	0.585
LIG_SH2_STAP1	706	710	PF00017	0.573
LIG_SH2_STAT3	710	713	PF00017	0.580
LIG_SH2_STAT5	13	16	PF00017	0.650
LIG_SH2_STAT5	186	189	PF00017	0.473
LIG_SH2_STAT5	474	477	PF00017	0.471
LIG_SH2_STAT5	500	503	PF00017	0.574
LIG_SH2_STAT5	682	685	PF00017	0.613
LIG_SH3_1	224	230	PF00018	0.739
LIG_SH3_2	613	618	PF14604	0.607
LIG_SH3_3	209	215	PF00018	0.585
LIG_SH3_3	224	230	PF00018	0.492
LIG_SH3_3	420	426	PF00018	0.543
LIG_SH3_3	610	616	PF00018	0.696
LIG_SUMO_SIM_anti_2	143	148	PF11976	0.589
LIG_SUMO_SIM_par_1	62	68	PF11976	0.521
LIG_SxIP_EBH_1	211	225	PF03271	0.621
LIG_TRAF2_1	362	365	PF00917	0.708
LIG_TRAF2_1	537	540	PF00917	0.601
LIG_TRAF2_1	549	552	PF00917	0.618
LIG_TRAF2_1	565	568	PF00917	0.530
LIG_TRAF2_1	569	572	PF00917	0.711
LIG_TRAF2_1	580	583	PF00917	0.590
LIG_TRAF2_1	638	641	PF00917	0.634
LIG_TRAF2_1	85	88	PF00917	0.538
LIG_UBA3_1	659	667	PF00899	0.356
LIG_WW_3	614	618	PF00397	0.601
MOD_CDK_SPxxK_3	665	672	PF00069	0.638
MOD_CK1_1	232	238	PF00069	0.699
MOD_CK1_1	3	9	PF00069	0.537
MOD_CK1_1	306	312	PF00069	0.533
MOD_CK1_1	372	378	PF00069	0.726
MOD_CK1_1	433	439	PF00069	0.718
MOD_CK1_1	696	702	PF00069	0.616
MOD_CK1_1	716	722	PF00069	0.264
MOD_CK1_1	94	100	PF00069	0.729
MOD_CK2_1	142	148	PF00069	0.508
MOD_CK2_1	265	271	PF00069	0.569
MOD_CK2_1	551	557	PF00069	0.644
MOD_CK2_1	567	573	PF00069	0.705
MOD_CK2_1	65	71	PF00069	0.458
MOD_CK2_1	82	88	PF00069	0.483
MOD_GlcNHglycan	126	129	PF01048	0.540
MOD_GlcNHglycan	172	175	PF01048	0.487
MOD_GlcNHglycan	191	194	PF01048	0.314
MOD_GlcNHglycan	258	261	PF01048	0.708
MOD_GlcNHglycan	403	406	PF01048	0.656
MOD_GlcNHglycan	417	420	PF01048	0.507
MOD_GlcNHglycan	432	435	PF01048	0.436
MOD_GlcNHglycan	436	439	PF01048	0.477
MOD_GlcNHglycan	445	448	PF01048	0.481
MOD_GlcNHglycan	67	70	PF01048	0.510
MOD_GlcNHglycan	691	694	PF01048	0.625
MOD_GlcNHglycan	698	701	PF01048	0.516
MOD_GSK3_1	103	110	PF00069	0.430
MOD_GSK3_1	200	207	PF00069	0.588
MOD_GSK3_1	229	236	PF00069	0.707
MOD_GSK3_1	261	268	PF00069	0.584
MOD_GSK3_1	303	310	PF00069	0.638
MOD_GSK3_1	372	379	PF00069	0.741
MOD_GSK3_1	397	404	PF00069	0.686
MOD_GSK3_1	415	422	PF00069	0.511
MOD_GSK3_1	430	437	PF00069	0.527
MOD_GSK3_1	485	492	PF00069	0.623
MOD_GSK3_1	567	574	PF00069	0.678
MOD_GSK3_1	689	696	PF00069	0.639
MOD_GSK3_1	709	716	PF00069	0.539
MOD_GSK3_1	73	80	PF00069	0.534
MOD_GSK3_1	91	98	PF00069	0.598
MOD_LATS_1	57	63	PF00433	0.408
MOD_N-GLC_1	140	145	PF02516	0.590
MOD_N-GLC_1	170	175	PF02516	0.501
MOD_NEK2_1	107	112	PF00069	0.473
MOD_NEK2_1	233	238	PF00069	0.794
MOD_NEK2_1	335	340	PF00069	0.695
MOD_NEK2_1	430	435	PF00069	0.645
MOD_NEK2_1	77	82	PF00069	0.450
MOD_NEK2_2	50	55	PF00069	0.521
MOD_NEK2_2	504	509	PF00069	0.509
MOD_PIKK_1	709	715	PF00454	0.552
MOD_PKA_1	151	157	PF00069	0.376
MOD_PKA_1	303	309	PF00069	0.631
MOD_PKA_1	623	629	PF00069	0.550
MOD_PKA_2	103	109	PF00069	0.533
MOD_PKA_2	150	156	PF00069	0.532
MOD_PKA_2	3	9	PF00069	0.591
MOD_PKA_2	307	313	PF00069	0.709
MOD_PKA_2	472	478	PF00069	0.492
MOD_PKA_2	544	550	PF00069	0.500
MOD_PKA_2	629	635	PF00069	0.576
MOD_PKA_2	646	652	PF00069	0.400
MOD_Plk_1	335	341	PF00069	0.768
MOD_Plk_2-3	32	38	PF00069	0.454
MOD_Plk_2-3	551	557	PF00069	0.780
MOD_Plk_2-3	567	573	PF00069	0.648
MOD_Plk_4	103	109	PF00069	0.556
MOD_Plk_4	142	148	PF00069	0.585
MOD_Plk_4	172	178	PF00069	0.480
MOD_Plk_4	445	451	PF00069	0.475
MOD_Plk_4	50	56	PF00069	0.463
MOD_Plk_4	698	704	PF00069	0.656
MOD_ProDKin_1	370	376	PF00069	0.733
MOD_ProDKin_1	425	431	PF00069	0.577
MOD_ProDKin_1	665	671	PF00069	0.569
MOD_ProDKin_1	92	98	PF00069	0.652
MOD_SUMO_rev_2	243	248	PF00179	0.595
MOD_SUMO_rev_2	37	45	PF00179	0.532
MOD_SUMO_rev_2	383	390	PF00179	0.615
MOD_SUMO_rev_2	512	519	PF00179	0.641
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.587
TRG_ENDOCYTIC_2	39	42	PF00928	0.618
TRG_ENDOCYTIC_2	706	709	PF00928	0.586
TRG_ER_diArg_1	101	104	PF00400	0.666
TRG_ER_diArg_1	411	413	PF00400	0.547
TRG_ER_diArg_1	616	618	PF00400	0.760
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	465	470	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDU6	Leishmania donovani	100%	99%
A0A422P3R9	Trypanosoma rangeli	25%	100%
A4HF77	Leishmania braziliensis	79%	100%
E9AYL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8V9	Leishmania major	94%	100%
V5ATI5	Trypanosoma cruzi	25%	100%