Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2F9_LEIIN

TriTrypDb:

LINF_260028600

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2F9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.561
CLV_C14_Caspase3-7	263	267	PF00656	0.682
CLV_NRD_NRD_1	121	123	PF00675	0.475
CLV_NRD_NRD_1	129	131	PF00675	0.511
CLV_NRD_NRD_1	208	210	PF00675	0.692
CLV_NRD_NRD_1	221	223	PF00675	0.647
CLV_NRD_NRD_1	274	276	PF00675	0.637
CLV_NRD_NRD_1	37	39	PF00675	0.467
CLV_NRD_NRD_1	58	60	PF00675	0.570
CLV_NRD_NRD_1	78	80	PF00675	0.307
CLV_PCSK_FUR_1	38	42	PF00082	0.568
CLV_PCSK_KEX2_1	121	123	PF00082	0.479
CLV_PCSK_KEX2_1	129	131	PF00082	0.525
CLV_PCSK_KEX2_1	208	210	PF00082	0.692
CLV_PCSK_KEX2_1	40	42	PF00082	0.462
CLV_PCSK_KEX2_1	58	60	PF00082	0.328
CLV_PCSK_KEX2_1	78	80	PF00082	0.307
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.565
CLV_PCSK_SKI1_1	104	108	PF00082	0.503
CLV_PCSK_SKI1_1	129	133	PF00082	0.578
CLV_PCSK_SKI1_1	158	162	PF00082	0.793
CLV_PCSK_SKI1_1	208	212	PF00082	0.607
CLV_PCSK_SKI1_1	232	236	PF00082	0.647
CLV_PCSK_SKI1_1	239	243	PF00082	0.590
CLV_PCSK_SKI1_1	83	87	PF00082	0.507
CLV_Separin_Metazoa	75	79	PF03568	0.531
DEG_APCC_DBOX_1	242	250	PF00400	0.439
DOC_MAPK_DCC_7	193	202	PF00069	0.609
DOC_MAPK_gen_1	193	202	PF00069	0.609
DOC_MAPK_gen_1	222	229	PF00069	0.678
DOC_MAPK_MEF2A_6	193	202	PF00069	0.609
DOC_USP7_MATH_1	153	157	PF00917	0.708
DOC_USP7_MATH_1	169	173	PF00917	0.713
DOC_USP7_MATH_1	19	23	PF00917	0.481
DOC_USP7_MATH_1	198	202	PF00917	0.696
DOC_USP7_MATH_1	241	245	PF00917	0.516
DOC_USP7_UBL2_3	136	140	PF12436	0.629
DOC_USP7_UBL2_3	189	193	PF12436	0.617
DOC_WW_Pin1_4	161	166	PF00397	0.743
DOC_WW_Pin1_4	17	22	PF00397	0.457
DOC_WW_Pin1_4	57	62	PF00397	0.624
DOC_WW_Pin1_4	94	99	PF00397	0.587
LIG_14-3-3_CanoR_1	151	160	PF00244	0.705
LIG_14-3-3_CanoR_1	209	218	PF00244	0.648
LIG_14-3-3_CanoR_1	222	231	PF00244	0.679
LIG_14-3-3_CanoR_1	99	106	PF00244	0.511
LIG_FHA_1	105	111	PF00498	0.566
LIG_FHA_2	132	138	PF00498	0.636
LIG_FHA_2	233	239	PF00498	0.666
LIG_LIR_Apic_2	192	198	PF02991	0.551
LIG_LIR_Apic_2	216	221	PF02991	0.624
LIG_LIR_Nem_3	213	218	PF02991	0.639
LIG_PCNA_yPIPBox_3	25	39	PF02747	0.548
LIG_SH2_CRK	149	153	PF00017	0.701
LIG_SH2_CRK	18	22	PF00017	0.454
LIG_SH2_GRB2like	67	70	PF00017	0.473
LIG_SH2_NCK_1	18	22	PF00017	0.491
LIG_SH2_SRC	114	117	PF00017	0.576
LIG_SH2_SRC	147	150	PF00017	0.643
LIG_SH2_SRC	218	221	PF00017	0.620
LIG_SH2_STAP1	215	219	PF00017	0.653
LIG_SH2_STAT3	187	190	PF00017	0.608
LIG_SH2_STAT5	187	190	PF00017	0.605
LIG_SH2_STAT5	224	227	PF00017	0.648
LIG_SH2_STAT5	67	70	PF00017	0.471
LIG_SH3_3	252	258	PF00018	0.592
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.570
LIG_TRAF2_1	261	264	PF00917	0.657
LIG_TRAF2_1	46	49	PF00917	0.533
LIG_TYR_ITIM	31	36	PF00017	0.567
MOD_CDK_SPK_2	161	166	PF00069	0.743
MOD_CDK_SPK_2	94	99	PF00069	0.656
MOD_CK1_1	164	170	PF00069	0.791
MOD_CK2_1	232	238	PF00069	0.607
MOD_CK2_1	241	247	PF00069	0.579
MOD_CK2_1	99	105	PF00069	0.524
MOD_GlcNHglycan	155	158	PF01048	0.723
MOD_GlcNHglycan	166	169	PF01048	0.705
MOD_GlcNHglycan	171	174	PF01048	0.630
MOD_GlcNHglycan	55	58	PF01048	0.615
MOD_GSK3_1	100	107	PF00069	0.538
MOD_GSK3_1	160	167	PF00069	0.744
MOD_GSK3_1	19	26	PF00069	0.482
MOD_GSK3_1	237	244	PF00069	0.643
MOD_GSK3_1	53	60	PF00069	0.596
MOD_N-GLC_1	24	29	PF02516	0.536
MOD_N-GLC_2	186	188	PF02516	0.533
MOD_N-GLC_2	69	71	PF02516	0.506
MOD_NEK2_1	210	215	PF00069	0.622
MOD_NEK2_1	23	28	PF00069	0.477
MOD_NEK2_1	271	276	PF00069	0.686
MOD_PIKK_1	210	216	PF00454	0.650
MOD_PK_1	196	202	PF00069	0.622
MOD_PKA_1	142	148	PF00069	0.686
MOD_PKA_1	222	228	PF00069	0.674
MOD_PKA_2	250	256	PF00069	0.644
MOD_PKA_2	271	277	PF00069	0.672
MOD_PKB_1	230	238	PF00069	0.563
MOD_Plk_1	225	231	PF00069	0.684
MOD_Plk_1	237	243	PF00069	0.593
MOD_Plk_1	24	30	PF00069	0.542
MOD_Plk_4	142	148	PF00069	0.686
MOD_Plk_4	19	25	PF00069	0.482
MOD_ProDKin_1	161	167	PF00069	0.743
MOD_ProDKin_1	17	23	PF00069	0.450
MOD_ProDKin_1	57	63	PF00069	0.621
MOD_ProDKin_1	94	100	PF00069	0.585
MOD_SUMO_for_1	141	144	PF00179	0.662
TRG_DiLeu_BaEn_3	95	101	PF01217	0.579
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.696
TRG_ENDOCYTIC_2	149	152	PF00928	0.707
TRG_ENDOCYTIC_2	224	227	PF00928	0.648
TRG_ENDOCYTIC_2	33	36	PF00928	0.554
TRG_ER_diArg_1	120	122	PF00400	0.498
TRG_ER_diArg_1	128	130	PF00400	0.525
TRG_ER_diArg_1	208	210	PF00400	0.692
TRG_ER_diArg_1	229	232	PF00400	0.730
TRG_ER_diArg_1	242	245	PF00400	0.496
TRG_ER_diArg_1	77	79	PF00400	0.463
TRG_NLS_MonoExtN_4	272	279	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P3	Leptomonas seymouri	65%	100%
A0A1X0P7J6	Trypanosomatidae	35%	100%
A0A3R7NVA4	Trypanosoma rangeli	32%	100%
A0A3S7X062	Leishmania donovani	100%	100%
A4HF76	Leishmania braziliensis	85%	100%
C9ZX38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AYL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8W0	Leishmania major	96%	100%
V5D9J1	Trypanosoma cruzi	33%	100%