Putative nitrilase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative nitrilase

Gene product:

nitrilase - putative

Species:

Leishmania infantum

UniProt:

A4I2F5_LEIIN

TriTrypDb:

LINF_260028200

Length:

279

Annotations

Annotations by Jardim et al.

Oxidoreductase, nitrilase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I2F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2F5

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006107	oxaloacetate metabolic process	7	1
GO:0006520	amino acid metabolic process	3	1
GO:0006528	asparagine metabolic process	6	1
GO:0006541	glutamine metabolic process	6	1
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009064	glutamine family amino acid metabolic process	5	1
GO:0009066	aspartate family amino acid metabolic process	5	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0000257	nitrilase activity	5	7
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	12
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	12
GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	4	7
GO:0050152	omega-amidase activity	5	1
GO:0080061	indole-3-acetonitrile nitrilase activity	6	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.281
CLV_PCSK_KEX2_1	34	36	PF00082	0.325
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.348
CLV_PCSK_SKI1_1	24	28	PF00082	0.450
DEG_APCC_DBOX_1	268	276	PF00400	0.440
DEG_APCC_KENBOX_2	76	80	PF00400	0.285
DOC_MAPK_gen_1	34	41	PF00069	0.310
DOC_MAPK_MEF2A_6	151	158	PF00069	0.310
DOC_MAPK_RevD_3	263	279	PF00069	0.459
DOC_PP4_FxxP_1	46	49	PF00568	0.291

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H1	Leptomonas seymouri	80%	100%
A0A0S4ILR2	Bodo saltans	57%	98%
A0A140NCB4	Escherichia coli (strain B / BL21-DE3)	25%	100%
A0A140NDS5	Escherichia coli (strain B / BL21-DE3)	23%	100%
A0A1X0P8A8	Trypanosomatidae	73%	100%
A0A3S7X065	Leishmania donovani	100%	100%
A0A422P3W9	Trypanosoma rangeli	67%	100%
A4HF72	Leishmania braziliensis	88%	100%
C9ZX42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AYK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%

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