Putative syntaxin binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sec1/Munc18 related protein - putative

Species:

Leishmania infantum

UniProt:

A4I2F3_LEIIN

TriTrypDb:

LINF_260028000

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1
GO:0030141	secretory granule	8	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0099503	secretory vesicle	7	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I2F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2F3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0006886	intracellular protein transport	4	1
GO:0006904	vesicle docking involved in exocytosis	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0140029	exocytic process	2	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	541	545	PF00656	0.320
CLV_NRD_NRD_1	143	145	PF00675	0.368
CLV_NRD_NRD_1	393	395	PF00675	0.295
CLV_NRD_NRD_1	458	460	PF00675	0.266
CLV_NRD_NRD_1	564	566	PF00675	0.409
CLV_NRD_NRD_1	63	65	PF00675	0.433
CLV_NRD_NRD_1	648	650	PF00675	0.324
CLV_NRD_NRD_1	689	691	PF00675	0.331
CLV_PCSK_KEX2_1	143	145	PF00082	0.368
CLV_PCSK_KEX2_1	393	395	PF00082	0.319
CLV_PCSK_KEX2_1	458	460	PF00082	0.457
CLV_PCSK_KEX2_1	564	566	PF00082	0.426
CLV_PCSK_KEX2_1	63	65	PF00082	0.460
CLV_PCSK_KEX2_1	648	650	PF00082	0.365
CLV_PCSK_KEX2_1	688	690	PF00082	0.331
CLV_PCSK_SKI1_1	185	189	PF00082	0.380
CLV_PCSK_SKI1_1	459	463	PF00082	0.338
CLV_PCSK_SKI1_1	484	488	PF00082	0.305
CLV_PCSK_SKI1_1	503	507	PF00082	0.412
CLV_PCSK_SKI1_1	58	62	PF00082	0.531
CLV_PCSK_SKI1_1	64	68	PF00082	0.330
CLV_PCSK_SKI1_1	642	646	PF00082	0.425
CLV_PCSK_SKI1_1	648	652	PF00082	0.378
CLV_PCSK_SKI1_1	682	686	PF00082	0.309
CLV_PCSK_SKI1_1	690	694	PF00082	0.270
DEG_APCC_DBOX_1	481	489	PF00400	0.255
DEG_APCC_DBOX_1	63	71	PF00400	0.390
DEG_APCC_DBOX_1	689	697	PF00400	0.299
DEG_Nend_UBRbox_1	1	4	PF02207	0.603
DEG_SPOP_SBC_1	30	34	PF00917	0.514
DEG_SPOP_SBC_1	616	620	PF00917	0.198
DOC_CKS1_1	725	730	PF01111	0.387
DOC_MAPK_DCC_7	212	220	PF00069	0.387
DOC_MAPK_gen_1	185	194	PF00069	0.311
DOC_MAPK_gen_1	363	371	PF00069	0.331
DOC_MAPK_gen_1	482	490	PF00069	0.274
DOC_MAPK_gen_1	686	695	PF00069	0.330
DOC_MAPK_MEF2A_6	185	194	PF00069	0.334
DOC_MAPK_MEF2A_6	212	220	PF00069	0.387
DOC_MAPK_MEF2A_6	424	431	PF00069	0.267
DOC_MAPK_MEF2A_6	470	479	PF00069	0.302
DOC_MAPK_MEF2A_6	482	490	PF00069	0.204
DOC_MAPK_MEF2A_6	686	695	PF00069	0.334
DOC_MAPK_NFAT4_5	482	490	PF00069	0.255
DOC_MAPK_NFAT4_5	688	696	PF00069	0.331
DOC_PP1_RVXF_1	688	695	PF00149	0.255
DOC_PP2B_LxvP_1	119	122	PF13499	0.414
DOC_PP2B_LxvP_1	213	216	PF13499	0.305
DOC_PP4_FxxP_1	194	197	PF00568	0.255
DOC_USP7_MATH_1	18	22	PF00917	0.522
DOC_USP7_MATH_1	270	274	PF00917	0.343
DOC_USP7_MATH_1	346	350	PF00917	0.226
DOC_USP7_MATH_1	473	477	PF00917	0.387
DOC_USP7_MATH_1	558	562	PF00917	0.261
DOC_USP7_MATH_1	563	567	PF00917	0.265
DOC_USP7_MATH_1	615	619	PF00917	0.335
DOC_USP7_UBL2_3	682	686	PF12436	0.450
DOC_WW_Pin1_4	14	19	PF00397	0.599
DOC_WW_Pin1_4	2	7	PF00397	0.764
DOC_WW_Pin1_4	284	289	PF00397	0.310
DOC_WW_Pin1_4	294	299	PF00397	0.392
DOC_WW_Pin1_4	577	582	PF00397	0.420
DOC_WW_Pin1_4	724	729	PF00397	0.387
LIG_14-3-3_CanoR_1	13	18	PF00244	0.576
LIG_14-3-3_CanoR_1	234	239	PF00244	0.264
LIG_14-3-3_CanoR_1	281	288	PF00244	0.397
LIG_14-3-3_CanoR_1	470	478	PF00244	0.422
LIG_14-3-3_CanoR_1	564	568	PF00244	0.404
LIG_14-3-3_CanoR_1	630	634	PF00244	0.423
LIG_14-3-3_CanoR_1	730	736	PF00244	0.331
LIG_Actin_WH2_2	638	654	PF00022	0.387
LIG_APCC_ABBA_1	204	209	PF00400	0.331
LIG_APCC_ABBA_1	425	430	PF00400	0.255
LIG_APCC_ABBAyCdc20_2	424	430	PF00400	0.255
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.432
LIG_BRCT_BRCA1_1	198	202	PF00533	0.387
LIG_BRCT_BRCA1_1	236	240	PF00533	0.387
LIG_Clathr_ClatBox_1	191	195	PF01394	0.362
LIG_Clathr_ClatBox_1	300	304	PF01394	0.274
LIG_Clathr_ClatBox_1	326	330	PF01394	0.274
LIG_deltaCOP1_diTrp_1	356	366	PF00928	0.260
LIG_DLG_GKlike_1	637	645	PF00625	0.283
LIG_FHA_1	231	237	PF00498	0.397
LIG_FHA_1	470	476	PF00498	0.288
LIG_FHA_1	527	533	PF00498	0.289
LIG_FHA_1	672	678	PF00498	0.338
LIG_FHA_1	711	717	PF00498	0.302
LIG_FHA_1	721	727	PF00498	0.273
LIG_FHA_2	112	118	PF00498	0.274
LIG_FHA_2	184	190	PF00498	0.387
LIG_FHA_2	539	545	PF00498	0.283
LIG_FHA_2	698	704	PF00498	0.255
LIG_LIR_Apic_2	193	197	PF02991	0.274
LIG_LIR_Gen_1	304	314	PF02991	0.255
LIG_LIR_Gen_1	316	327	PF02991	0.255
LIG_LIR_Gen_1	463	473	PF02991	0.299
LIG_LIR_Gen_1	521	526	PF02991	0.401
LIG_LIR_Gen_1	83	90	PF02991	0.445
LIG_LIR_Nem_3	237	242	PF02991	0.334
LIG_LIR_Nem_3	304	310	PF02991	0.255
LIG_LIR_Nem_3	316	322	PF02991	0.255
LIG_LIR_Nem_3	356	362	PF02991	0.255
LIG_LIR_Nem_3	463	468	PF02991	0.305
LIG_LIR_Nem_3	521	525	PF02991	0.425
LIG_LIR_Nem_3	623	629	PF02991	0.325
LIG_LIR_Nem_3	662	666	PF02991	0.283
LIG_LIR_Nem_3	700	704	PF02991	0.348
LIG_LIR_Nem_3	83	89	PF02991	0.374
LIG_MLH1_MIPbox_1	236	240	PF16413	0.387
LIG_NRBOX	484	490	PF00104	0.278
LIG_PCNA_yPIPBox_3	317	327	PF02747	0.255
LIG_Pex14_2	629	633	PF04695	0.283
LIG_PTB_Apo_2	328	335	PF02174	0.274
LIG_PTB_Apo_2	604	611	PF02174	0.299
LIG_PTB_Phospho_1	328	334	PF10480	0.274
LIG_PTB_Phospho_1	604	610	PF10480	0.299
LIG_SH2_CRK	319	323	PF00017	0.264
LIG_SH2_CRK	465	469	PF00017	0.387
LIG_SH2_CRK	86	90	PF00017	0.334
LIG_SH2_GRB2like	465	468	PF00017	0.283
LIG_SH2_NCK_1	708	712	PF00017	0.283
LIG_SH2_SRC	465	468	PF00017	0.283
LIG_SH2_SRC	708	711	PF00017	0.299
LIG_SH2_STAP1	334	338	PF00017	0.334
LIG_SH2_STAT3	358	361	PF00017	0.299
LIG_SH2_STAT3	439	442	PF00017	0.299
LIG_SH2_STAT3	605	608	PF00017	0.331
LIG_SH2_STAT5	133	136	PF00017	0.288
LIG_SH2_STAT5	610	613	PF00017	0.330
LIG_SH3_3	119	125	PF00018	0.300
LIG_SH3_3	472	478	PF00018	0.334
LIG_SUMO_SIM_anti_2	295	304	PF11976	0.283
LIG_SUMO_SIM_par_1	295	304	PF11976	0.266
LIG_TRAF2_1	137	140	PF00917	0.387
LIG_TRAF2_1	342	345	PF00917	0.331
LIG_TYR_ITIM	699	704	PF00017	0.331
MOD_CDK_SPxK_1	724	730	PF00069	0.387
MOD_CK1_1	164	170	PF00069	0.331
MOD_CK1_1	21	27	PF00069	0.702
MOD_CK1_1	28	34	PF00069	0.697
MOD_CK1_1	284	290	PF00069	0.361
MOD_CK1_1	619	625	PF00069	0.329
MOD_CK1_1	724	730	PF00069	0.387
MOD_CK2_1	111	117	PF00069	0.274
MOD_CK2_1	162	168	PF00069	0.222
MOD_CK2_1	339	345	PF00069	0.352
MOD_CK2_1	697	703	PF00069	0.255
MOD_Cter_Amidation	456	459	PF01082	0.263
MOD_Cter_Amidation	55	58	PF01082	0.612
MOD_GlcNHglycan	128	131	PF01048	0.387
MOD_GlcNHglycan	220	223	PF01048	0.387
MOD_GlcNHglycan	23	26	PF01048	0.755
MOD_GlcNHglycan	28	31	PF01048	0.704
MOD_GlcNHglycan	283	286	PF01048	0.447
MOD_GlcNHglycan	33	36	PF01048	0.647
MOD_GlcNHglycan	341	344	PF01048	0.402
MOD_GlcNHglycan	396	399	PF01048	0.409
MOD_GlcNHglycan	409	412	PF01048	0.278
MOD_GlcNHglycan	41	44	PF01048	0.664
MOD_GlcNHglycan	577	580	PF01048	0.419
MOD_GlcNHglycan	597	600	PF01048	0.164
MOD_GSK3_1	14	21	PF00069	0.706
MOD_GSK3_1	160	167	PF00069	0.394
MOD_GSK3_1	226	233	PF00069	0.318
MOD_GSK3_1	234	241	PF00069	0.273
MOD_GSK3_1	25	32	PF00069	0.708
MOD_GSK3_1	272	279	PF00069	0.423
MOD_GSK3_1	280	287	PF00069	0.450
MOD_GSK3_1	469	476	PF00069	0.309
MOD_GSK3_1	492	499	PF00069	0.279
MOD_GSK3_1	520	527	PF00069	0.441
MOD_GSK3_1	615	622	PF00069	0.334
MOD_GSK3_1	720	727	PF00069	0.387
MOD_GSK3_1	730	737	PF00069	0.387
MOD_N-GLC_1	14	19	PF02516	0.566
MOD_N-GLC_1	569	574	PF02516	0.384
MOD_N-GLC_1	595	600	PF02516	0.465
MOD_N-GLC_2	203	205	PF02516	0.283
MOD_NEK2_1	161	166	PF00069	0.343
MOD_NEK2_1	280	285	PF00069	0.408
MOD_NEK2_1	518	523	PF00069	0.361
MOD_NEK2_1	524	529	PF00069	0.323
MOD_NEK2_1	569	574	PF00069	0.356
MOD_NEK2_1	629	634	PF00069	0.283
MOD_NEK2_1	731	736	PF00069	0.283
MOD_NEK2_2	183	188	PF00069	0.331
MOD_NEK2_2	423	428	PF00069	0.255
MOD_NEK2_2	563	568	PF00069	0.283
MOD_PIKK_1	252	258	PF00454	0.468
MOD_PIKK_1	511	517	PF00454	0.455
MOD_PK_1	234	240	PF00069	0.288
MOD_PK_1	556	562	PF00069	0.259
MOD_PKA_2	280	286	PF00069	0.331
MOD_PKA_2	469	475	PF00069	0.321
MOD_PKA_2	563	569	PF00069	0.409
MOD_PKA_2	629	635	PF00069	0.311
MOD_Plk_1	138	144	PF00069	0.294
MOD_Plk_1	303	309	PF00069	0.299
MOD_Plk_1	315	321	PF00069	0.288
MOD_Plk_1	334	340	PF00069	0.296
MOD_Plk_1	473	479	PF00069	0.312
MOD_Plk_4	111	117	PF00069	0.289
MOD_Plk_4	196	202	PF00069	0.299
MOD_Plk_4	234	240	PF00069	0.289
MOD_Plk_4	377	383	PF00069	0.314
MOD_Plk_4	721	727	PF00069	0.255
MOD_ProDKin_1	14	20	PF00069	0.599
MOD_ProDKin_1	2	8	PF00069	0.766
MOD_ProDKin_1	284	290	PF00069	0.310
MOD_ProDKin_1	294	300	PF00069	0.392
MOD_ProDKin_1	577	583	PF00069	0.420
MOD_ProDKin_1	724	730	PF00069	0.387
MOD_SUMO_rev_2	497	504	PF00179	0.368
MOD_SUMO_rev_2	676	684	PF00179	0.259
TRG_DiLeu_BaEn_1	296	301	PF01217	0.387
TRG_DiLeu_BaEn_1	500	505	PF01217	0.387
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.283
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.377
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.263
TRG_ENDOCYTIC_2	319	322	PF00928	0.255
TRG_ENDOCYTIC_2	465	468	PF00928	0.387
TRG_ENDOCYTIC_2	610	613	PF00928	0.255
TRG_ENDOCYTIC_2	701	704	PF00928	0.397
TRG_ENDOCYTIC_2	86	89	PF00928	0.397
TRG_ER_diArg_1	142	144	PF00400	0.368
TRG_ER_diArg_1	392	394	PF00400	0.259
TRG_ER_diArg_1	458	460	PF00400	0.440
TRG_ER_diArg_1	481	484	PF00400	0.283
TRG_ER_diArg_1	688	690	PF00400	0.387
TRG_NES_CRM1_1	182	195	PF08389	0.307
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUY7	Leptomonas seymouri	64%	100%
A0A1X0P7K8	Trypanosomatidae	40%	100%
A0A3Q8ID43	Leishmania donovani	100%	100%
A0A3R7MWF2	Trypanosoma rangeli	39%	100%
A4HF70	Leishmania braziliensis	77%	100%
C9ZX51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AYK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8W6	Leishmania major	95%	100%
Q54QC8	Dictyostelium discoideum	24%	100%
Q9C5P7	Arabidopsis thaliana	24%	100%
V5AUI0	Trypanosoma cruzi	40%	100%