Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2F2_LEIIN

TriTrypDb:

LINF_260027900

Length:

825

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2F2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	538	542	PF00656	0.639
CLV_NRD_NRD_1	346	348	PF00675	0.765
CLV_NRD_NRD_1	392	394	PF00675	0.752
CLV_NRD_NRD_1	505	507	PF00675	0.654
CLV_NRD_NRD_1	663	665	PF00675	0.763
CLV_NRD_NRD_1	73	75	PF00675	0.626
CLV_PCSK_FUR_1	630	634	PF00082	0.641
CLV_PCSK_FUR_1	70	74	PF00082	0.444
CLV_PCSK_KEX2_1	345	347	PF00082	0.799
CLV_PCSK_KEX2_1	489	491	PF00082	0.610
CLV_PCSK_KEX2_1	504	506	PF00082	0.648
CLV_PCSK_KEX2_1	632	634	PF00082	0.629
CLV_PCSK_KEX2_1	662	664	PF00082	0.736
CLV_PCSK_KEX2_1	72	74	PF00082	0.670
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.610
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.647
CLV_PCSK_PC7_1	485	491	PF00082	0.592
CLV_PCSK_SKI1_1	30	34	PF00082	0.607
CLV_PCSK_SKI1_1	451	455	PF00082	0.775
CLV_PCSK_SKI1_1	465	469	PF00082	0.644
CLV_PCSK_SKI1_1	530	534	PF00082	0.729
CLV_PCSK_SKI1_1	571	575	PF00082	0.615
CLV_PCSK_SKI1_1	633	637	PF00082	0.634
CLV_PCSK_SKI1_1	746	750	PF00082	0.626
CLV_PCSK_SKI1_1	786	790	PF00082	0.599
DEG_COP1_1	686	694	PF00400	0.754
DEG_SPOP_SBC_1	16	20	PF00917	0.706
DOC_CDC14_PxL_1	688	696	PF14671	0.631
DOC_CYCLIN_RxL_1	70	81	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.728
DOC_CYCLIN_yCln2_LP_2	553	559	PF00134	0.664
DOC_MAPK_gen_1	451	460	PF00069	0.704
DOC_MAPK_gen_1	489	497	PF00069	0.642
DOC_MAPK_gen_1	630	638	PF00069	0.607
DOC_MAPK_gen_1	70	78	PF00069	0.529
DOC_PP2B_LxvP_1	138	141	PF13499	0.631
DOC_PP2B_LxvP_1	680	683	PF13499	0.612
DOC_PP4_FxxP_1	477	480	PF00568	0.736
DOC_USP7_MATH_1	117	121	PF00917	0.735
DOC_USP7_MATH_1	133	137	PF00917	0.675
DOC_USP7_MATH_1	264	268	PF00917	0.603
DOC_USP7_MATH_1	508	512	PF00917	0.729
DOC_USP7_MATH_1	579	583	PF00917	0.728
DOC_USP7_UBL2_3	786	790	PF12436	0.618
DOC_WW_Pin1_4	289	294	PF00397	0.742
DOC_WW_Pin1_4	460	465	PF00397	0.744
DOC_WW_Pin1_4	545	550	PF00397	0.709
DOC_WW_Pin1_4	738	743	PF00397	0.731
LIG_14-3-3_CanoR_1	171	177	PF00244	0.691
LIG_14-3-3_CanoR_1	362	366	PF00244	0.627
LIG_14-3-3_CanoR_1	444	453	PF00244	0.765
LIG_14-3-3_CanoR_1	485	489	PF00244	0.584
LIG_14-3-3_CanoR_1	490	497	PF00244	0.624
LIG_14-3-3_CanoR_1	530	535	PF00244	0.726
LIG_14-3-3_CanoR_1	571	576	PF00244	0.653
LIG_14-3-3_CanoR_1	662	670	PF00244	0.684
LIG_14-3-3_CanoR_1	798	807	PF00244	0.581
LIG_BIR_II_1	1	5	PF00653	0.723
LIG_BIR_III_4	395	399	PF00653	0.587
LIG_BRCT_BRCA1_1	135	139	PF00533	0.762
LIG_BRCT_BRCA1_1	455	459	PF00533	0.638
LIG_Clathr_ClatBox_1	494	498	PF01394	0.775
LIG_eIF4E_1	183	189	PF01652	0.663
LIG_FHA_1	108	114	PF00498	0.612
LIG_FHA_1	133	139	PF00498	0.683
LIG_FHA_1	156	162	PF00498	0.710
LIG_FHA_1	17	23	PF00498	0.663
LIG_FHA_1	183	189	PF00498	0.632
LIG_FHA_1	202	208	PF00498	0.589
LIG_FHA_1	702	708	PF00498	0.735
LIG_FHA_1	739	745	PF00498	0.704
LIG_FHA_1	769	775	PF00498	0.686
LIG_FHA_2	19	25	PF00498	0.630
LIG_FHA_2	362	368	PF00498	0.676
LIG_FHA_2	417	423	PF00498	0.724
LIG_FHA_2	536	542	PF00498	0.714
LIG_FHA_2	614	620	PF00498	0.612
LIG_LIR_Apic_2	475	480	PF02991	0.739
LIG_LIR_Apic_2	771	776	PF02991	0.693
LIG_LIR_Gen_1	170	181	PF02991	0.686
LIG_LIR_Gen_1	190	201	PF02991	0.361
LIG_LIR_Gen_1	728	738	PF02991	0.636
LIG_LIR_Gen_1	801	812	PF02991	0.684
LIG_LIR_Nem_3	170	176	PF02991	0.690
LIG_LIR_Nem_3	190	196	PF02991	0.368
LIG_LIR_Nem_3	197	202	PF02991	0.507
LIG_LIR_Nem_3	475	481	PF02991	0.610
LIG_LIR_Nem_3	623	627	PF02991	0.620
LIG_LIR_Nem_3	728	734	PF02991	0.665
LIG_LIR_Nem_3	801	807	PF02991	0.631
LIG_LIR_Nem_3	818	824	PF02991	0.489
LIG_LYPXL_yS_3	481	484	PF13949	0.700
LIG_MAD2	369	377	PF02301	0.743
LIG_PTAP_UEV_1	808	813	PF05743	0.629
LIG_PTB_Apo_2	49	56	PF02174	0.631
LIG_SH2_CRK	328	332	PF00017	0.671
LIG_SH2_NCK_1	193	197	PF00017	0.671
LIG_SH2_NCK_1	363	367	PF00017	0.648
LIG_SH2_PTP2	173	176	PF00017	0.686
LIG_SH2_PTP2	374	377	PF00017	0.716
LIG_SH2_PTP2	731	734	PF00017	0.549
LIG_SH2_STAP1	817	821	PF00017	0.671
LIG_SH2_STAT5	173	176	PF00017	0.686
LIG_SH2_STAT5	261	264	PF00017	0.584
LIG_SH2_STAT5	363	366	PF00017	0.637
LIG_SH2_STAT5	374	377	PF00017	0.637
LIG_SH2_STAT5	4	7	PF00017	0.760
LIG_SH2_STAT5	418	421	PF00017	0.698
LIG_SH2_STAT5	731	734	PF00017	0.763
LIG_SH2_STAT5	773	776	PF00017	0.669
LIG_SH2_STAT5	804	807	PF00017	0.656
LIG_SH2_STAT5	817	820	PF00017	0.643
LIG_SH3_1	374	380	PF00018	0.789
LIG_SH3_3	138	144	PF00018	0.728
LIG_SH3_3	215	221	PF00018	0.703
LIG_SH3_3	290	296	PF00018	0.787
LIG_SH3_3	362	368	PF00018	0.673
LIG_SH3_3	374	380	PF00018	0.756
LIG_SH3_3	669	675	PF00018	0.624
LIG_SH3_3	806	812	PF00018	0.549
LIG_SUMO_SIM_par_1	555	561	PF11976	0.700
LIG_TRAF2_2	296	301	PF00917	0.542
LIG_TYR_ITIM	361	366	PF00017	0.682
LIG_TYR_ITIM	819	824	PF00017	0.637
LIG_UBA3_1	27	36	PF00899	0.644
LIG_WRC_WIRS_1	196	201	PF05994	0.551
MOD_CDK_SPK_2	292	297	PF00069	0.784
MOD_CDK_SPK_2	460	465	PF00069	0.750
MOD_CDK_SPxK_1	545	551	PF00069	0.588
MOD_CK1_1	120	126	PF00069	0.727
MOD_CK1_1	18	24	PF00069	0.718
MOD_CK1_1	267	273	PF00069	0.629
MOD_CK1_1	292	298	PF00069	0.728
MOD_CK1_1	34	40	PF00069	0.599
MOD_CK1_1	437	443	PF00069	0.682
MOD_CK1_1	63	69	PF00069	0.642
MOD_CK1_1	701	707	PF00069	0.735
MOD_CK2_1	361	367	PF00069	0.628
MOD_CK2_1	416	422	PF00069	0.773
MOD_CK2_1	513	519	PF00069	0.700
MOD_CK2_1	613	619	PF00069	0.637
MOD_GlcNHglycan	101	104	PF01048	0.694
MOD_GlcNHglycan	107	110	PF01048	0.726
MOD_GlcNHglycan	122	125	PF01048	0.761
MOD_GlcNHglycan	217	221	PF01048	0.614
MOD_GlcNHglycan	270	273	PF01048	0.609
MOD_GlcNHglycan	328	331	PF01048	0.797
MOD_GlcNHglycan	33	36	PF01048	0.626
MOD_GlcNHglycan	389	393	PF01048	0.679
MOD_GlcNHglycan	406	409	PF01048	0.781
MOD_GlcNHglycan	436	439	PF01048	0.698
MOD_GlcNHglycan	510	513	PF01048	0.665
MOD_GlcNHglycan	61	65	PF01048	0.622
MOD_GlcNHglycan	642	645	PF01048	0.680
MOD_GlcNHglycan	666	669	PF01048	0.722
MOD_GlcNHglycan	700	703	PF01048	0.765
MOD_GlcNHglycan	809	812	PF01048	0.629
MOD_GSK3_1	120	127	PF00069	0.645
MOD_GSK3_1	129	136	PF00069	0.648
MOD_GSK3_1	142	149	PF00069	0.557
MOD_GSK3_1	179	186	PF00069	0.609
MOD_GSK3_1	264	271	PF00069	0.637
MOD_GSK3_1	299	306	PF00069	0.662
MOD_GSK3_1	309	316	PF00069	0.613
MOD_GSK3_1	34	41	PF00069	0.657
MOD_GSK3_1	430	437	PF00069	0.696
MOD_GSK3_1	454	461	PF00069	0.687
MOD_GSK3_1	530	537	PF00069	0.692
MOD_GSK3_1	579	586	PF00069	0.707
MOD_GSK3_1	658	665	PF00069	0.736
MOD_GSK3_1	690	697	PF00069	0.706
MOD_GSK3_1	698	705	PF00069	0.671
MOD_GSK3_1	740	747	PF00069	0.741
MOD_N-GLC_1	183	188	PF02516	0.665
MOD_N-GLC_1	411	416	PF02516	0.640
MOD_N-GLC_1	434	439	PF02516	0.682
MOD_N-GLC_1	48	53	PF02516	0.692
MOD_N-GLC_1	534	539	PF02516	0.616
MOD_N-GLC_1	545	550	PF02516	0.585
MOD_N-GLC_1	683	688	PF02516	0.755
MOD_NEK2_1	105	110	PF00069	0.531
MOD_NEK2_1	161	166	PF00069	0.593
MOD_NEK2_1	195	200	PF00069	0.556
MOD_NEK2_1	31	36	PF00069	0.626
MOD_NEK2_1	416	421	PF00069	0.690
MOD_NEK2_1	425	430	PF00069	0.717
MOD_NEK2_1	534	539	PF00069	0.712
MOD_NEK2_1	563	568	PF00069	0.705
MOD_NEK2_1	694	699	PF00069	0.744
MOD_NEK2_1	91	96	PF00069	0.685
MOD_PIKK_1	133	139	PF00454	0.761
MOD_PIKK_1	259	265	PF00454	0.678
MOD_PIKK_1	416	422	PF00454	0.773
MOD_PIKK_1	613	619	PF00454	0.677
MOD_PKA_1	489	495	PF00069	0.550
MOD_PKA_1	662	668	PF00069	0.648
MOD_PKA_2	259	265	PF00069	0.639
MOD_PKA_2	361	367	PF00069	0.615
MOD_PKA_2	484	490	PF00069	0.588
MOD_PKA_2	539	545	PF00069	0.651
MOD_PKA_2	563	569	PF00069	0.717
MOD_PKA_2	662	668	PF00069	0.724
MOD_PKA_2	91	97	PF00069	0.640
MOD_PKB_1	662	670	PF00069	0.647
MOD_Plk_1	133	139	PF00069	0.761
MOD_Plk_1	183	189	PF00069	0.663
MOD_Plk_1	2	8	PF00069	0.621
MOD_Plk_1	595	601	PF00069	0.604
MOD_Plk_1	721	727	PF00069	0.677
MOD_Plk_4	172	178	PF00069	0.616
MOD_Plk_4	361	367	PF00069	0.753
MOD_Plk_4	454	460	PF00069	0.683
MOD_Plk_4	513	519	PF00069	0.718
MOD_Plk_4	571	577	PF00069	0.756
MOD_Plk_4	607	613	PF00069	0.668
MOD_ProDKin_1	289	295	PF00069	0.743
MOD_ProDKin_1	460	466	PF00069	0.743
MOD_ProDKin_1	545	551	PF00069	0.710
MOD_ProDKin_1	738	744	PF00069	0.733
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.664
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.716
TRG_ENDOCYTIC_2	173	176	PF00928	0.575
TRG_ENDOCYTIC_2	193	196	PF00928	0.374
TRG_ENDOCYTIC_2	363	366	PF00928	0.625
TRG_ENDOCYTIC_2	481	484	PF00928	0.588
TRG_ENDOCYTIC_2	731	734	PF00928	0.549
TRG_ENDOCYTIC_2	804	807	PF00928	0.626
TRG_ENDOCYTIC_2	821	824	PF00928	0.484
TRG_ER_diArg_1	257	260	PF00400	0.643
TRG_ER_diArg_1	345	347	PF00400	0.792
TRG_ER_diArg_1	504	506	PF00400	0.721
TRG_ER_diArg_1	662	664	PF00400	0.720
TRG_ER_diArg_1	72	74	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.675
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z2	Leptomonas seymouri	55%	99%
A0A1X0P794	Trypanosomatidae	33%	100%
A0A3Q8IG16	Leishmania donovani	100%	100%
A0A3R7KYT8	Trypanosoma rangeli	35%	100%
A4HF69	Leishmania braziliensis	76%	98%
C9ZX52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AYK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8W7	Leishmania major	93%	100%
V5AUK1	Trypanosoma cruzi	35%	100%