AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA ATPase domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I2E8_LEIIN

TriTrypDb:

LINF_260027500

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I2E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2E8

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000076	DNA replication checkpoint signaling	6	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007165	signal transduction	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0009987	cellular process	1	1
GO:0010389	regulation of G2/M transition of mitotic cell cycle	7	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	8	1
GO:0022402	cell cycle process	2	1
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0033314	mitotic DNA replication checkpoint signaling	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0044818	mitotic G2/M transition checkpoint	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1901991	negative regulation of mitotic cell cycle phase transition	7	1
GO:1902749	regulation of cell cycle G2/M phase transition	7	1
GO:1902750	negative regulation of cell cycle G2/M phase transition	8	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003688	DNA replication origin binding	7	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.534
CLV_C14_Caspase3-7	39	43	PF00656	0.591
CLV_C14_Caspase3-7	658	662	PF00656	0.603
CLV_NRD_NRD_1	13	15	PF00675	0.709
CLV_NRD_NRD_1	147	149	PF00675	0.681
CLV_NRD_NRD_1	271	273	PF00675	0.648
CLV_NRD_NRD_1	29	31	PF00675	0.562
CLV_NRD_NRD_1	412	414	PF00675	0.583
CLV_NRD_NRD_1	524	526	PF00675	0.726
CLV_NRD_NRD_1	555	557	PF00675	0.396
CLV_NRD_NRD_1	72	74	PF00675	0.398
CLV_NRD_NRD_1	745	747	PF00675	0.413
CLV_PCSK_FUR_1	11	15	PF00082	0.654
CLV_PCSK_FUR_1	250	254	PF00082	0.578
CLV_PCSK_KEX2_1	13	15	PF00082	0.709
CLV_PCSK_KEX2_1	147	149	PF00082	0.583
CLV_PCSK_KEX2_1	252	254	PF00082	0.613
CLV_PCSK_KEX2_1	29	31	PF00082	0.562
CLV_PCSK_KEX2_1	411	413	PF00082	0.605
CLV_PCSK_KEX2_1	72	74	PF00082	0.398
CLV_PCSK_KEX2_1	747	749	PF00082	0.378
CLV_PCSK_KEX2_1	852	854	PF00082	0.446
CLV_PCSK_KEX2_1	97	99	PF00082	0.400
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.615
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.605
CLV_PCSK_PC1ET2_1	747	749	PF00082	0.378
CLV_PCSK_PC1ET2_1	852	854	PF00082	0.446
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.400
CLV_PCSK_SKI1_1	150	154	PF00082	0.673
CLV_PCSK_SKI1_1	219	223	PF00082	0.654
CLV_PCSK_SKI1_1	272	276	PF00082	0.646
CLV_PCSK_SKI1_1	337	341	PF00082	0.455
CLV_PCSK_SKI1_1	436	440	PF00082	0.453
CLV_PCSK_SKI1_1	556	560	PF00082	0.405
CLV_PCSK_SKI1_1	97	101	PF00082	0.407
CLV_Separin_Metazoa	876	880	PF03568	0.457
DEG_SCF_FBW7_1	153	160	PF00400	0.636
DEG_SCF_FBW7_1	181	186	PF00400	0.683
DEG_SPOP_SBC_1	211	215	PF00917	0.552
DEG_SPOP_SBC_1	326	330	PF00917	0.605
DEG_SPOP_SBC_1	403	407	PF00917	0.639
DEG_SPOP_SBC_1	599	603	PF00917	0.580
DEG_SPOP_SBC_1	692	696	PF00917	0.559
DOC_CKS1_1	154	159	PF01111	0.612
DOC_CYCLIN_RxL_1	147	158	PF00134	0.665
DOC_CYCLIN_RxL_1	554	563	PF00134	0.405
DOC_MAPK_DCC_7	411	421	PF00069	0.539
DOC_MAPK_gen_1	537	546	PF00069	0.495
DOC_MAPK_gen_1	556	562	PF00069	0.339
DOC_MAPK_MEF2A_6	412	421	PF00069	0.529
DOC_MAPK_MEF2A_6	777	786	PF00069	0.488
DOC_PP1_RVXF_1	797	803	PF00149	0.520
DOC_PP4_FxxP_1	446	449	PF00568	0.461
DOC_USP7_MATH_1	161	165	PF00917	0.625
DOC_USP7_MATH_1	183	187	PF00917	0.604
DOC_USP7_MATH_1	199	203	PF00917	0.618
DOC_USP7_MATH_1	221	225	PF00917	0.642
DOC_USP7_MATH_1	230	234	PF00917	0.577
DOC_USP7_MATH_1	324	328	PF00917	0.766
DOC_USP7_MATH_1	331	335	PF00917	0.613
DOC_USP7_MATH_1	347	351	PF00917	0.360
DOC_USP7_MATH_1	364	368	PF00917	0.426
DOC_USP7_MATH_1	386	390	PF00917	0.553
DOC_USP7_MATH_1	398	402	PF00917	0.575
DOC_USP7_MATH_1	514	518	PF00917	0.609
DOC_USP7_MATH_1	528	532	PF00917	0.611
DOC_USP7_MATH_1	599	603	PF00917	0.580
DOC_USP7_MATH_1	608	612	PF00917	0.601
DOC_USP7_MATH_1	646	650	PF00917	0.522
DOC_USP7_MATH_1	677	681	PF00917	0.618
DOC_USP7_MATH_1	68	72	PF00917	0.410
DOC_USP7_MATH_1	692	696	PF00917	0.602
DOC_USP7_MATH_1	754	758	PF00917	0.541
DOC_WW_Pin1_4	153	158	PF00397	0.633
DOC_WW_Pin1_4	171	176	PF00397	0.575
DOC_WW_Pin1_4	179	184	PF00397	0.596
DOC_WW_Pin1_4	19	24	PF00397	0.701
DOC_WW_Pin1_4	195	200	PF00397	0.584
DOC_WW_Pin1_4	243	248	PF00397	0.677
DOC_WW_Pin1_4	327	332	PF00397	0.637
DOC_WW_Pin1_4	412	417	PF00397	0.560
DOC_WW_Pin1_4	509	514	PF00397	0.566
DOC_WW_Pin1_4	6	11	PF00397	0.615
DOC_WW_Pin1_4	600	605	PF00397	0.634
DOC_WW_Pin1_4	695	700	PF00397	0.616
DOC_WW_Pin1_4	764	769	PF00397	0.670
LIG_14-3-3_CanoR_1	101	109	PF00244	0.447
LIG_14-3-3_CanoR_1	203	209	PF00244	0.705
LIG_14-3-3_CanoR_1	323	331	PF00244	0.556
LIG_14-3-3_CanoR_1	530	538	PF00244	0.620
LIG_14-3-3_CanoR_1	540	548	PF00244	0.408
LIG_14-3-3_CanoR_1	575	584	PF00244	0.409
LIG_14-3-3_CanoR_1	618	623	PF00244	0.564
LIG_14-3-3_CanoR_1	657	665	PF00244	0.684
LIG_14-3-3_CanoR_1	833	838	PF00244	0.414
LIG_14-3-3_CanoR_1	861	869	PF00244	0.565
LIG_Actin_WH2_2	415	433	PF00022	0.470
LIG_Actin_WH2_2	816	831	PF00022	0.451
LIG_APCC_ABBA_1	476	481	PF00400	0.409
LIG_BIR_III_2	111	115	PF00653	0.484
LIG_BIR_III_4	177	181	PF00653	0.625
LIG_BIR_III_4	661	665	PF00653	0.613
LIG_BRCT_BRCA1_1	648	652	PF00533	0.577
LIG_BRCT_BRCA1_1	669	673	PF00533	0.559
LIG_EH1_1	44	52	PF00400	0.537
LIG_FHA_1	236	242	PF00498	0.730
LIG_FHA_1	273	279	PF00498	0.664
LIG_FHA_1	371	377	PF00498	0.388
LIG_FHA_1	612	618	PF00498	0.614
LIG_FHA_1	7	13	PF00498	0.556
LIG_FHA_1	731	737	PF00498	0.372
LIG_FHA_1	779	785	PF00498	0.474
LIG_FHA_1	829	835	PF00498	0.472
LIG_FHA_1	838	844	PF00498	0.462
LIG_FHA_1	91	97	PF00498	0.385
LIG_FHA_2	120	126	PF00498	0.629
LIG_FHA_2	128	134	PF00498	0.560
LIG_FHA_2	195	201	PF00498	0.692
LIG_FHA_2	238	244	PF00498	0.686
LIG_FHA_2	277	283	PF00498	0.604
LIG_FHA_2	47	53	PF00498	0.502
LIG_FHA_2	490	496	PF00498	0.445
LIG_FHA_2	726	732	PF00498	0.407
LIG_LIR_Apic_2	443	449	PF02991	0.349
LIG_LIR_Apic_2	840	844	PF02991	0.507
LIG_LIR_Gen_1	60	70	PF02991	0.405
LIG_LIR_Gen_1	871	882	PF02991	0.508
LIG_LIR_Nem_3	310	316	PF02991	0.428
LIG_LIR_Nem_3	333	339	PF02991	0.482
LIG_LIR_Nem_3	578	584	PF02991	0.410
LIG_LIR_Nem_3	60	66	PF02991	0.415
LIG_LIR_Nem_3	630	636	PF02991	0.435
LIG_LIR_Nem_3	819	823	PF02991	0.458
LIG_LIR_Nem_3	871	877	PF02991	0.512
LIG_LYPXL_yS_3	313	316	PF13949	0.409
LIG_PCNA_PIPBox_1	786	795	PF02747	0.479
LIG_Pex14_2	336	340	PF04695	0.452
LIG_SH2_CRK	551	555	PF00017	0.371
LIG_SH2_CRK	793	797	PF00017	0.401
LIG_SH2_GRB2like	343	346	PF00017	0.371
LIG_SH2_NCK_1	304	308	PF00017	0.503
LIG_SH2_NCK_1	479	483	PF00017	0.435
LIG_SH2_SRC	551	554	PF00017	0.376
LIG_SH2_STAP1	304	308	PF00017	0.503
LIG_SH2_STAP1	551	555	PF00017	0.371
LIG_SH2_STAP1	63	67	PF00017	0.400
LIG_SH2_STAP1	793	797	PF00017	0.401
LIG_SH2_STAT5	308	311	PF00017	0.433
LIG_SH2_STAT5	343	346	PF00017	0.404
LIG_SH2_STAT5	429	432	PF00017	0.429
LIG_SH2_STAT5	553	556	PF00017	0.411
LIG_SH2_STAT5	735	738	PF00017	0.411
LIG_SH2_STAT5	793	796	PF00017	0.406
LIG_SH3_3	293	299	PF00018	0.571
LIG_SH3_3	346	352	PF00018	0.423
LIG_SH3_3	461	467	PF00018	0.419
LIG_SUMO_SIM_anti_2	738	744	PF11976	0.403
LIG_SUMO_SIM_par_1	350	356	PF11976	0.457
LIG_SUMO_SIM_par_1	420	426	PF11976	0.363
LIG_SUMO_SIM_par_1	738	744	PF11976	0.363
LIG_TRAF2_1	122	125	PF00917	0.656
LIG_TRAF2_1	168	171	PF00917	0.703
LIG_UBA3_1	376	385	PF00899	0.468
LIG_WW_3	295	299	PF00397	0.619
MOD_CDK_SPK_2	157	162	PF00069	0.617
MOD_CDK_SPK_2	6	11	PF00069	0.612
MOD_CDK_SPxxK_3	19	26	PF00069	0.598
MOD_CDK_SPxxK_3	243	250	PF00069	0.570
MOD_CDK_SPxxK_3	509	516	PF00069	0.569
MOD_CDK_SPxxK_3	6	13	PF00069	0.670
MOD_CK1_1	185	191	PF00069	0.615
MOD_CK1_1	19	25	PF00069	0.642
MOD_CK1_1	194	200	PF00069	0.605
MOD_CK1_1	202	208	PF00069	0.601
MOD_CK1_1	224	230	PF00069	0.622
MOD_CK1_1	231	237	PF00069	0.620
MOD_CK1_1	264	270	PF00069	0.636
MOD_CK1_1	28	34	PF00069	0.648
MOD_CK1_1	318	324	PF00069	0.708
MOD_CK1_1	327	333	PF00069	0.627
MOD_CK1_1	407	413	PF00069	0.635
MOD_CK1_1	611	617	PF00069	0.601
MOD_CK1_1	653	659	PF00069	0.624
MOD_CK1_1	680	686	PF00069	0.557
MOD_CK1_1	695	701	PF00069	0.643
MOD_CK1_1	75	81	PF00069	0.416
MOD_CK2_1	118	124	PF00069	0.563
MOD_CK2_1	127	133	PF00069	0.564
MOD_CK2_1	237	243	PF00069	0.647
MOD_CK2_1	276	282	PF00069	0.607
MOD_CK2_1	46	52	PF00069	0.496
MOD_CK2_1	489	495	PF00069	0.448
MOD_CK2_1	624	630	PF00069	0.492
MOD_CK2_1	725	731	PF00069	0.412
MOD_GlcNHglycan	103	106	PF01048	0.442
MOD_GlcNHglycan	18	21	PF01048	0.556
MOD_GlcNHglycan	185	188	PF01048	0.553
MOD_GlcNHglycan	204	207	PF01048	0.691
MOD_GlcNHglycan	216	219	PF01048	0.480
MOD_GlcNHglycan	266	269	PF01048	0.688
MOD_GlcNHglycan	282	285	PF01048	0.514
MOD_GlcNHglycan	3	6	PF01048	0.777
MOD_GlcNHglycan	30	33	PF01048	0.648
MOD_GlcNHglycan	318	321	PF01048	0.652
MOD_GlcNHglycan	348	352	PF01048	0.427
MOD_GlcNHglycan	370	373	PF01048	0.367
MOD_GlcNHglycan	394	397	PF01048	0.584
MOD_GlcNHglycan	406	409	PF01048	0.663
MOD_GlcNHglycan	531	534	PF01048	0.626
MOD_GlcNHglycan	561	565	PF01048	0.438
MOD_GlcNHglycan	577	580	PF01048	0.437
MOD_GlcNHglycan	652	655	PF01048	0.727
MOD_GlcNHglycan	673	676	PF01048	0.623
MOD_GlcNHglycan	700	703	PF01048	0.517
MOD_GSK3_1	139	146	PF00069	0.698
MOD_GSK3_1	153	160	PF00069	0.556
MOD_GSK3_1	179	186	PF00069	0.768
MOD_GSK3_1	191	198	PF00069	0.604
MOD_GSK3_1	201	208	PF00069	0.605
MOD_GSK3_1	21	28	PF00069	0.797
MOD_GSK3_1	210	217	PF00069	0.489
MOD_GSK3_1	221	228	PF00069	0.551
MOD_GSK3_1	230	237	PF00069	0.670
MOD_GSK3_1	272	279	PF00069	0.666
MOD_GSK3_1	315	322	PF00069	0.585
MOD_GSK3_1	326	333	PF00069	0.557
MOD_GSK3_1	358	365	PF00069	0.403
MOD_GSK3_1	366	373	PF00069	0.467
MOD_GSK3_1	398	405	PF00069	0.677
MOD_GSK3_1	524	531	PF00069	0.620
MOD_GSK3_1	595	602	PF00069	0.614
MOD_GSK3_1	646	653	PF00069	0.697
MOD_GSK3_1	667	674	PF00069	0.545
MOD_GSK3_1	68	75	PF00069	0.402
MOD_GSK3_1	691	698	PF00069	0.581
MOD_GSK3_1	702	709	PF00069	0.474
MOD_GSK3_1	749	756	PF00069	0.487
MOD_GSK3_1	833	840	PF00069	0.427
MOD_N-GLC_1	235	240	PF02516	0.646
MOD_N-GLC_1	618	623	PF02516	0.609
MOD_N-GLC_1	78	83	PF02516	0.457
MOD_N-GLC_1	837	842	PF02516	0.440
MOD_NEK2_1	193	198	PF00069	0.629
MOD_NEK2_1	316	321	PF00069	0.451
MOD_NEK2_1	652	657	PF00069	0.581
MOD_NEK2_1	706	711	PF00069	0.453
MOD_NEK2_1	837	842	PF00069	0.442
MOD_NEK2_2	307	312	PF00069	0.467
MOD_NEK2_2	730	735	PF00069	0.392
MOD_NEK2_2	780	785	PF00069	0.457
MOD_OFUCOSY	359	366	PF10250	0.400
MOD_PIKK_1	21	27	PF00454	0.667
MOD_PIKK_1	331	337	PF00454	0.558
MOD_PIKK_1	370	376	PF00454	0.470
MOD_PK_1	36	42	PF00069	0.546
MOD_PK_1	618	624	PF00069	0.552
MOD_PKA_1	272	278	PF00069	0.611
MOD_PKA_1	72	78	PF00069	0.419
MOD_PKA_2	146	152	PF00069	0.693
MOD_PKA_2	161	167	PF00069	0.595
MOD_PKA_2	202	208	PF00069	0.689
MOD_PKA_2	228	234	PF00069	0.622
MOD_PKA_2	25	31	PF00069	0.723
MOD_PKA_2	322	328	PF00069	0.618
MOD_PKA_2	362	368	PF00069	0.467
MOD_PKA_2	507	513	PF00069	0.604
MOD_PKA_2	524	530	PF00069	0.652
MOD_PKA_2	539	545	PF00069	0.398
MOD_PKA_2	608	614	PF00069	0.577
MOD_PKA_2	656	662	PF00069	0.661
MOD_PKA_2	671	677	PF00069	0.514
MOD_PKA_2	72	78	PF00069	0.482
MOD_PKA_2	828	834	PF00069	0.454
MOD_PKA_2	860	866	PF00069	0.544
MOD_Plk_1	231	237	PF00069	0.648
MOD_Plk_1	618	624	PF00069	0.579
MOD_Plk_1	730	736	PF00069	0.385
MOD_Plk_1	749	755	PF00069	0.491
MOD_Plk_1	78	84	PF00069	0.455
MOD_Plk_2-3	634	640	PF00069	0.475
MOD_Plk_4	237	243	PF00069	0.612
MOD_Plk_4	436	442	PF00069	0.398
MOD_Plk_4	46	52	PF00069	0.496
MOD_Plk_4	62	68	PF00069	0.401
MOD_Plk_4	730	736	PF00069	0.385
MOD_Plk_4	78	84	PF00069	0.337
MOD_ProDKin_1	153	159	PF00069	0.631
MOD_ProDKin_1	171	177	PF00069	0.576
MOD_ProDKin_1	179	185	PF00069	0.593
MOD_ProDKin_1	19	25	PF00069	0.703
MOD_ProDKin_1	195	201	PF00069	0.585
MOD_ProDKin_1	243	249	PF00069	0.676
MOD_ProDKin_1	327	333	PF00069	0.634
MOD_ProDKin_1	412	418	PF00069	0.544
MOD_ProDKin_1	509	515	PF00069	0.567
MOD_ProDKin_1	6	12	PF00069	0.615
MOD_ProDKin_1	600	606	PF00069	0.639
MOD_ProDKin_1	695	701	PF00069	0.609
MOD_ProDKin_1	764	770	PF00069	0.672
MOD_SUMO_rev_2	267	275	PF00179	0.545
MOD_SUMO_rev_2	531	539	PF00179	0.597
TRG_DiLeu_BaEn_1	880	885	PF01217	0.493
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.381
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.406
TRG_ENDOCYTIC_2	308	311	PF00928	0.453
TRG_ENDOCYTIC_2	313	316	PF00928	0.387
TRG_ENDOCYTIC_2	551	554	PF00928	0.376
TRG_ENDOCYTIC_2	63	66	PF00928	0.404
TRG_ENDOCYTIC_2	793	796	PF00928	0.445
TRG_ER_diArg_1	10	13	PF00400	0.656
TRG_ER_diArg_1	147	150	PF00400	0.574
TRG_ER_diArg_1	546	549	PF00400	0.380
TRG_ER_diArg_1	72	74	PF00400	0.398
TRG_ER_diArg_1	745	748	PF00400	0.367
TRG_NLS_MonoExtN_4	250	256	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL4	Leptomonas seymouri	54%	100%
A0A3S7X053	Leishmania donovani	99%	100%
A4HF65	Leishmania braziliensis	76%	100%
E9AYK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8X1	Leishmania major	91%	98%