ADP-ribosylation factor family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor family - putative

Species:

Leishmania infantum

UniProt:

A4I2E6_LEIIN

TriTrypDb:

LINF_260027200

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I2E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2E6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006893	Golgi to plasma membrane transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034067	protein localization to Golgi apparatus	6	1
GO:0043001	Golgi to plasma membrane protein transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061951	establishment of protein localization to plasma membrane	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0072659	protein localization to plasma membrane	5	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1
GO:1990778	protein localization to cell periphery	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0003924	GTPase activity	7	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.379
CLV_MEL_PAP_1	121	127	PF00089	0.458
CLV_MEL_PAP_1	355	361	PF00089	0.575
CLV_NRD_NRD_1	88	90	PF00675	0.701
CLV_PCSK_FUR_1	86	90	PF00082	0.569
CLV_PCSK_KEX2_1	108	110	PF00082	0.445
CLV_PCSK_KEX2_1	88	90	PF00082	0.675
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.439
CLV_PCSK_SKI1_1	177	181	PF00082	0.398
CLV_PCSK_SKI1_1	248	252	PF00082	0.401
CLV_PCSK_SKI1_1	65	69	PF00082	0.576
DEG_APCC_DBOX_1	176	184	PF00400	0.325
DEG_APCC_DBOX_1	247	255	PF00400	0.459
DEG_Nend_Nbox_1	1	3	PF02207	0.482
DOC_CDC14_PxL_1	260	268	PF14671	0.356
DOC_CKS1_1	13	18	PF01111	0.518
DOC_CKS1_1	40	45	PF01111	0.505
DOC_CKS1_1	78	83	PF01111	0.699
DOC_CKS1_1	94	99	PF01111	0.505
DOC_CYCLIN_yCln2_LP_2	255	261	PF00134	0.461
DOC_MAPK_gen_1	108	116	PF00069	0.452
DOC_MAPK_gen_1	136	142	PF00069	0.554
DOC_MAPK_MEF2A_6	108	116	PF00069	0.447
DOC_MAPK_MEF2A_6	351	359	PF00069	0.521
DOC_PP4_FxxP_1	125	128	PF00568	0.475
DOC_PP4_FxxP_1	13	16	PF00568	0.546
DOC_USP7_MATH_1	144	148	PF00917	0.598
DOC_USP7_MATH_1	218	222	PF00917	0.574
DOC_USP7_MATH_1	28	32	PF00917	0.410
DOC_USP7_MATH_1	55	59	PF00917	0.618
DOC_USP7_UBL2_3	237	241	PF12436	0.502
DOC_WW_Pin1_4	12	17	PF00397	0.543
DOC_WW_Pin1_4	123	128	PF00397	0.457
DOC_WW_Pin1_4	216	221	PF00397	0.580
DOC_WW_Pin1_4	336	341	PF00397	0.706
DOC_WW_Pin1_4	39	44	PF00397	0.483
DOC_WW_Pin1_4	77	82	PF00397	0.699
DOC_WW_Pin1_4	93	98	PF00397	0.529
LIG_14-3-3_CanoR_1	214	223	PF00244	0.544
LIG_14-3-3_CanoR_1	57	67	PF00244	0.580
LIG_FHA_1	111	117	PF00498	0.403
LIG_FHA_1	174	180	PF00498	0.404
LIG_FHA_1	225	231	PF00498	0.546
LIG_FHA_1	270	276	PF00498	0.513
LIG_FHA_1	40	46	PF00498	0.561
LIG_FHA_1	68	74	PF00498	0.773
LIG_FHA_2	234	240	PF00498	0.530
LIG_FHA_2	280	286	PF00498	0.471
LIG_FHA_2	30	36	PF00498	0.337
LIG_FHA_2	348	354	PF00498	0.684
LIG_GBD_Chelix_1	203	211	PF00786	0.367
LIG_LIR_Apic_2	11	16	PF02991	0.557
LIG_LIR_Gen_1	17	23	PF02991	0.438
LIG_LIR_Gen_1	6	16	PF02991	0.564
LIG_LIR_Nem_3	15	21	PF02991	0.408
LIG_LIR_Nem_3	191	196	PF02991	0.418
LIG_LIR_Nem_3	295	301	PF02991	0.672
LIG_LIR_Nem_3	362	367	PF02991	0.562
LIG_LIR_Nem_3	6	12	PF02991	0.519
LIG_NRBOX	250	256	PF00104	0.464
LIG_PCNA_PIPBox_1	186	195	PF02747	0.389
LIG_PCNA_yPIPBox_3	181	193	PF02747	0.385
LIG_PDZ_Class_1	399	404	PF00595	0.529
LIG_Pex14_1	193	197	PF04695	0.331
LIG_PTB_Apo_2	7	14	PF02174	0.567
LIG_SH2_CRK	118	122	PF00017	0.482
LIG_SH2_CRK	18	22	PF00017	0.336
LIG_SH2_CRK	9	13	PF00017	0.482
LIG_SH2_NCK_1	118	122	PF00017	0.482
LIG_SH2_STAP1	157	161	PF00017	0.498
LIG_SH2_STAT3	299	302	PF00017	0.630
LIG_SH2_STAT5	205	208	PF00017	0.379
LIG_SH2_STAT5	41	44	PF00017	0.522
LIG_SH3_1	88	94	PF00018	0.627
LIG_SH3_3	146	152	PF00018	0.645
LIG_SH3_3	217	223	PF00018	0.604
LIG_SH3_3	75	81	PF00018	0.798
LIG_SH3_3	88	94	PF00018	0.626
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.570
LIG_SUMO_SIM_par_1	263	269	PF11976	0.345
LIG_SUMO_SIM_par_1	370	375	PF11976	0.442
LIG_TRAF2_1	236	239	PF00917	0.469
LIG_TRAF2_1	282	285	PF00917	0.413
LIG_TRAF2_1	310	313	PF00917	0.707
LIG_TYR_ITIM	116	121	PF00017	0.481
LIG_UBA3_1	33	38	PF00899	0.386
MOD_CK1_1	11	17	PF00069	0.624
MOD_CK1_1	130	136	PF00069	0.709
MOD_CK1_1	147	153	PF00069	0.618
MOD_CK1_1	216	222	PF00069	0.584
MOD_CK1_1	269	275	PF00069	0.476
MOD_CK1_1	328	334	PF00069	0.659
MOD_CK1_1	58	64	PF00069	0.639
MOD_CK2_1	11	17	PF00069	0.533
MOD_CK2_1	222	228	PF00069	0.711
MOD_CK2_1	233	239	PF00069	0.549
MOD_CK2_1	279	285	PF00069	0.422
MOD_CK2_1	29	35	PF00069	0.236
MOD_CK2_1	347	353	PF00069	0.664
MOD_CK2_1	58	64	PF00069	0.654
MOD_GlcNHglycan	129	132	PF01048	0.562
MOD_GlcNHglycan	216	219	PF01048	0.349
MOD_GlcNHglycan	224	227	PF01048	0.689
MOD_GlcNHglycan	327	330	PF01048	0.601
MOD_GlcNHglycan	361	364	PF01048	0.544
MOD_GlcNHglycan	373	377	PF01048	0.388
MOD_GlcNHglycan	60	63	PF01048	0.651
MOD_GSK3_1	123	130	PF00069	0.558
MOD_GSK3_1	169	176	PF00069	0.562
MOD_GSK3_1	214	221	PF00069	0.305
MOD_GSK3_1	269	276	PF00069	0.528
MOD_GSK3_1	343	350	PF00069	0.665
MOD_GSK3_1	68	75	PF00069	0.788
MOD_GSK3_1	8	15	PF00069	0.534
MOD_N-GLC_1	269	274	PF02516	0.461
MOD_N-GLC_1	302	307	PF02516	0.604
MOD_NEK2_1	213	218	PF00069	0.355
MOD_NEK2_1	266	271	PF00069	0.365
MOD_NEK2_2	365	370	PF00069	0.510
MOD_PIKK_1	100	106	PF00454	0.504
MOD_PIKK_1	135	141	PF00454	0.590
MOD_PIKK_1	197	203	PF00454	0.392
MOD_PIKK_1	313	319	PF00454	0.693
MOD_PIKK_1	328	334	PF00454	0.514
MOD_PKA_2	110	116	PF00069	0.405
MOD_PKA_2	213	219	PF00069	0.438
MOD_PKA_2	56	62	PF00069	0.628
MOD_Plk_1	207	213	PF00069	0.291
MOD_Plk_1	273	279	PF00069	0.484
MOD_Plk_1	365	371	PF00069	0.423
MOD_Plk_1	372	378	PF00069	0.344
MOD_Plk_4	130	136	PF00069	0.570
MOD_Plk_4	29	35	PF00069	0.372
MOD_Plk_4	294	300	PF00069	0.691
MOD_Plk_4	49	55	PF00069	0.542
MOD_Plk_4	8	14	PF00069	0.473
MOD_ProDKin_1	12	18	PF00069	0.528
MOD_ProDKin_1	123	129	PF00069	0.471
MOD_ProDKin_1	216	222	PF00069	0.584
MOD_ProDKin_1	336	342	PF00069	0.704
MOD_ProDKin_1	39	45	PF00069	0.497
MOD_ProDKin_1	77	83	PF00069	0.702
MOD_ProDKin_1	93	99	PF00069	0.519
MOD_SUMO_rev_2	233	243	PF00179	0.448
TRG_DiLeu_BaEn_1	17	22	PF01217	0.440
TRG_DiLeu_BaEn_2	34	40	PF01217	0.445
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.378
TRG_ENDOCYTIC_2	118	121	PF00928	0.477
TRG_ENDOCYTIC_2	18	21	PF00928	0.337
TRG_ENDOCYTIC_2	9	12	PF00928	0.482
TRG_ER_diArg_1	109	112	PF00400	0.452
TRG_ER_diArg_1	86	89	PF00400	0.710
TRG_NLS_MonoExtC_3	107	112	PF00514	0.414
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD1	Leptomonas seymouri	59%	100%
A0A3Q8ICC5	Leishmania donovani	100%	100%
A0A422P3R7	Trypanosoma rangeli	30%	100%
A4HF63	Leishmania braziliensis	72%	98%
C9ZX62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AYJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8X3	Leishmania major	94%	100%