Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FtsJ-like methyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4I2E3_LEIIN

TriTrypDb:

LINF_260026800

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2E3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	5
GO:0032259	methylation	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0008168	methyltransferase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016741	transferase activity, transferring one-carbon groups	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.435
CLV_NRD_NRD_1	121	123	PF00675	0.485
CLV_NRD_NRD_1	291	293	PF00675	0.320
CLV_NRD_NRD_1	427	429	PF00675	0.578
CLV_NRD_NRD_1	43	45	PF00675	0.520
CLV_NRD_NRD_1	524	526	PF00675	0.400
CLV_NRD_NRD_1	540	542	PF00675	0.727
CLV_NRD_NRD_1	543	545	PF00675	0.704
CLV_NRD_NRD_1	64	66	PF00675	0.504
CLV_PCSK_FUR_1	289	293	PF00082	0.251
CLV_PCSK_FUR_1	522	526	PF00082	0.389
CLV_PCSK_FUR_1	541	545	PF00082	0.731
CLV_PCSK_KEX2_1	121	123	PF00082	0.425
CLV_PCSK_KEX2_1	291	293	PF00082	0.322
CLV_PCSK_KEX2_1	43	45	PF00082	0.551
CLV_PCSK_KEX2_1	524	526	PF00082	0.390
CLV_PCSK_KEX2_1	540	542	PF00082	0.603
CLV_PCSK_KEX2_1	543	545	PF00082	0.594
CLV_PCSK_KEX2_1	552	554	PF00082	0.504
CLV_PCSK_KEX2_1	64	66	PF00082	0.504
CLV_PCSK_KEX2_1	92	94	PF00082	0.679
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.552
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.679
CLV_PCSK_PC7_1	117	123	PF00082	0.466
CLV_PCSK_SKI1_1	121	125	PF00082	0.385
CLV_PCSK_SKI1_1	354	358	PF00082	0.331
CLV_PCSK_SKI1_1	478	482	PF00082	0.506
DEG_Nend_UBRbox_3	1	3	PF02207	0.621
DEG_SPOP_SBC_1	450	454	PF00917	0.414
DOC_MAPK_DCC_7	149	158	PF00069	0.364
DOC_MAPK_gen_1	482	489	PF00069	0.376
DOC_MAPK_RevD_3	77	93	PF00069	0.572
DOC_PP2B_LxvP_1	348	351	PF13499	0.506
DOC_PP2B_LxvP_1	5	8	PF13499	0.644
DOC_USP7_MATH_1	246	250	PF00917	0.423
DOC_USP7_MATH_1	301	305	PF00917	0.537
DOC_USP7_MATH_1	80	84	PF00917	0.728
DOC_WW_Pin1_4	132	137	PF00397	0.342
DOC_WW_Pin1_4	149	154	PF00397	0.441
DOC_WW_Pin1_4	328	333	PF00397	0.541
DOC_WW_Pin1_4	392	397	PF00397	0.499
DOC_WW_Pin1_4	452	457	PF00397	0.496
DOC_WW_Pin1_4	465	470	PF00397	0.626
DOC_WW_Pin1_4	78	83	PF00397	0.756
LIG_14-3-3_CanoR_1	30	35	PF00244	0.528
LIG_14-3-3_CanoR_1	463	469	PF00244	0.706
LIG_14-3-3_CanoR_1	51	61	PF00244	0.493
LIG_14-3-3_CanoR_1	543	551	PF00244	0.742
LIG_14-3-3_CanoR_1	71	79	PF00244	0.428
LIG_14-3-3_CanoR_1	84	91	PF00244	0.717
LIG_BRCT_BRCA1_1	128	132	PF00533	0.416
LIG_BRCT_BRCA1_1	38	42	PF00533	0.416
LIG_deltaCOP1_diTrp_1	511	520	PF00928	0.347
LIG_EVH1_1	7	11	PF00568	0.581
LIG_FHA_1	100	106	PF00498	0.638
LIG_FHA_1	133	139	PF00498	0.373
LIG_FHA_1	21	27	PF00498	0.574
LIG_FHA_1	252	258	PF00498	0.451
LIG_FHA_1	407	413	PF00498	0.368
LIG_FHA_1	443	449	PF00498	0.383
LIG_FHA_1	466	472	PF00498	0.505
LIG_FHA_1	546	552	PF00498	0.602
LIG_FHA_2	12	18	PF00498	0.669
LIG_LIR_Gen_1	207	215	PF02991	0.590
LIG_LIR_Gen_1	225	234	PF02991	0.371
LIG_LIR_Gen_1	377	385	PF02991	0.376
LIG_LIR_Nem_3	174	180	PF02991	0.522
LIG_LIR_Nem_3	207	211	PF02991	0.511
LIG_LIR_Nem_3	39	45	PF02991	0.354
LIG_LIR_Nem_3	501	506	PF02991	0.443
LIG_MLH1_MIPbox_1	128	132	PF16413	0.416
LIG_PALB2_WD40_1	341	349	PF16756	0.436
LIG_REV1ctd_RIR_1	129	135	PF16727	0.500
LIG_SH2_STAT5	170	173	PF00017	0.492
LIG_SH2_STAT5	25	28	PF00017	0.456
LIG_SH2_STAT5	322	325	PF00017	0.420
LIG_SH2_STAT5	34	37	PF00017	0.348
LIG_SH2_STAT5	359	362	PF00017	0.531
LIG_SH2_STAT5	418	421	PF00017	0.311
LIG_SH2_STAT5	470	473	PF00017	0.455
LIG_SH3_3	147	153	PF00018	0.514
LIG_SH3_3	212	218	PF00018	0.531
LIG_SH3_3	338	344	PF00018	0.451
LIG_SH3_3	386	392	PF00018	0.305
LIG_SH3_3	421	427	PF00018	0.426
LIG_SH3_3	5	11	PF00018	0.603
LIG_SH3_3	76	82	PF00018	0.748
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.477
LIG_WW_3	425	429	PF00397	0.498
MOD_CDC14_SPxK_1	81	84	PF00782	0.606
MOD_CDK_SPK_2	132	137	PF00069	0.312
MOD_CDK_SPK_2	452	457	PF00069	0.496
MOD_CDK_SPxK_1	78	84	PF00069	0.757
MOD_CK1_1	140	146	PF00069	0.687
MOD_CK1_1	201	207	PF00069	0.472
MOD_CK1_1	235	241	PF00069	0.443
MOD_CK1_1	330	336	PF00069	0.511
MOD_CK1_1	432	438	PF00069	0.465
MOD_CK1_1	452	458	PF00069	0.582
MOD_CK2_1	11	17	PF00069	0.747
MOD_CK2_1	82	88	PF00069	0.761
MOD_GlcNHglycan	128	131	PF01048	0.439
MOD_GlcNHglycan	20	23	PF01048	0.532
MOD_GlcNHglycan	203	206	PF01048	0.377
MOD_GlcNHglycan	224	227	PF01048	0.331
MOD_GlcNHglycan	249	252	PF01048	0.260
MOD_GlcNHglycan	260	263	PF01048	0.204
MOD_GlcNHglycan	268	271	PF01048	0.163
MOD_GlcNHglycan	301	304	PF01048	0.302
MOD_GlcNHglycan	314	317	PF01048	0.355
MOD_GlcNHglycan	397	400	PF01048	0.655
MOD_GlcNHglycan	533	536	PF01048	0.614
MOD_GlcNHglycan	55	58	PF01048	0.464
MOD_GlcNHglycan	72	75	PF01048	0.687
MOD_GlcNHglycan	84	87	PF01048	0.597
MOD_GSK3_1	137	144	PF00069	0.694
MOD_GSK3_1	20	27	PF00069	0.531
MOD_GSK3_1	213	220	PF00069	0.531
MOD_GSK3_1	247	254	PF00069	0.468
MOD_GSK3_1	260	267	PF00069	0.404
MOD_GSK3_1	323	330	PF00069	0.502
MOD_GSK3_1	355	362	PF00069	0.482
MOD_GSK3_1	461	468	PF00069	0.647
MOD_GSK3_1	66	73	PF00069	0.591
MOD_GSK3_1	78	85	PF00069	0.597
MOD_LATS_1	119	125	PF00433	0.462
MOD_N-GLC_1	1	6	PF02516	0.654
MOD_N-GLC_1	138	143	PF02516	0.553
MOD_N-GLC_1	222	227	PF02516	0.257
MOD_NEK2_1	198	203	PF00069	0.473
MOD_NEK2_1	24	29	PF00069	0.506
MOD_NEK2_1	260	265	PF00069	0.452
MOD_NEK2_1	312	317	PF00069	0.574
MOD_NEK2_1	327	332	PF00069	0.459
MOD_NEK2_1	36	41	PF00069	0.313
MOD_NEK2_1	419	424	PF00069	0.376
MOD_NEK2_1	451	456	PF00069	0.492
MOD_NEK2_1	461	466	PF00069	0.577
MOD_PIKK_1	121	127	PF00454	0.477
MOD_PIKK_1	213	219	PF00454	0.531
MOD_PIKK_1	92	98	PF00454	0.605
MOD_PKA_1	121	127	PF00069	0.477
MOD_PKA_1	92	98	PF00069	0.670
MOD_PKA_2	121	127	PF00069	0.483
MOD_PKA_2	246	252	PF00069	0.396
MOD_PKA_2	462	468	PF00069	0.490
MOD_PKA_2	53	59	PF00069	0.471
MOD_PKA_2	70	76	PF00069	0.479
MOD_PKA_2	92	98	PF00069	0.561
MOD_Plk_1	107	113	PF00069	0.390
MOD_Plk_1	296	302	PF00069	0.435
MOD_Plk_1	323	329	PF00069	0.396
MOD_Plk_1	36	42	PF00069	0.423
MOD_Plk_4	107	113	PF00069	0.513
MOD_Plk_4	20	26	PF00069	0.642
MOD_Plk_4	204	210	PF00069	0.492
MOD_Plk_4	260	266	PF00069	0.479
MOD_Plk_4	355	361	PF00069	0.582
MOD_Plk_4	36	42	PF00069	0.327
MOD_Plk_4	374	380	PF00069	0.185
MOD_ProDKin_1	132	138	PF00069	0.352
MOD_ProDKin_1	149	155	PF00069	0.425
MOD_ProDKin_1	328	334	PF00069	0.541
MOD_ProDKin_1	392	398	PF00069	0.500
MOD_ProDKin_1	452	458	PF00069	0.493
MOD_ProDKin_1	465	471	PF00069	0.621
MOD_ProDKin_1	78	84	PF00069	0.757
MOD_SUMO_rev_2	141	151	PF00179	0.544
TRG_DiLeu_LyEn_5	192	197	PF01217	0.451
TRG_ENDOCYTIC_2	228	231	PF00928	0.428
TRG_ENDOCYTIC_2	506	509	PF00928	0.464
TRG_ER_diArg_1	121	123	PF00400	0.485
TRG_ER_diArg_1	289	292	PF00400	0.529
TRG_ER_diArg_1	401	404	PF00400	0.445
TRG_ER_diArg_1	42	44	PF00400	0.550
TRG_ER_diArg_1	521	524	PF00400	0.392
TRG_ER_diArg_1	539	541	PF00400	0.554
TRG_NLS_Bipartite_1	540	556	PF00514	0.566
TRG_NLS_MonoExtC_3	551	557	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL5	Leptomonas seymouri	47%	97%
A0A1X0P8D1	Trypanosomatidae	31%	100%
A0A3S7X044	Leishmania donovani	99%	100%
A0A422N0J7	Trypanosoma rangeli	34%	100%
A4HF59	Leishmania braziliensis	75%	100%
C9ZX64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AYJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8X7	Leishmania major	92%	100%
V5BJ25	Trypanosoma cruzi	31%	100%