RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2E1_LEIIN

TriTrypDb:

LINF_260026600

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.711
CLV_NRD_NRD_1	114	116	PF00675	0.455
CLV_NRD_NRD_1	120	122	PF00675	0.426
CLV_NRD_NRD_1	70	72	PF00675	0.465
CLV_PCSK_KEX2_1	120	122	PF00082	0.464
CLV_PCSK_KEX2_1	24	26	PF00082	0.757
CLV_PCSK_KEX2_1	70	72	PF00082	0.465
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.757
CLV_PCSK_SKI1_1	228	232	PF00082	0.399
CLV_PCSK_SKI1_1	242	246	PF00082	0.380
CLV_PCSK_SKI1_1	25	29	PF00082	0.720
CLV_PCSK_SKI1_1	70	74	PF00082	0.393
DEG_SPOP_SBC_1	33	37	PF00917	0.595
DOC_CDC14_PxL_1	158	166	PF14671	0.407
DOC_CKS1_1	168	173	PF01111	0.542
DOC_CYCLIN_yCln2_LP_2	145	148	PF00134	0.494
DOC_PP2B_LxvP_1	145	148	PF13499	0.443
DOC_PP4_FxxP_1	144	147	PF00568	0.489
DOC_USP7_MATH_1	181	185	PF00917	0.690
DOC_WW_Pin1_4	167	172	PF00397	0.480
DOC_WW_Pin1_4	184	189	PF00397	0.560
DOC_WW_Pin1_4	9	14	PF00397	0.671
LIG_14-3-3_CanoR_1	213	219	PF00244	0.449
LIG_14-3-3_CanoR_1	25	30	PF00244	0.616
LIG_14-3-3_CanoR_1	71	81	PF00244	0.444
LIG_APCC_ABBA_1	241	246	PF00400	0.389
LIG_BIR_III_4	197	201	PF00653	0.580
LIG_FHA_1	102	108	PF00498	0.418
LIG_FHA_1	236	242	PF00498	0.421
LIG_FHA_1	34	40	PF00498	0.608
LIG_FHA_1	92	98	PF00498	0.560
LIG_FHA_2	168	174	PF00498	0.567
LIG_LIR_Apic_2	142	147	PF02991	0.479
LIG_LIR_Nem_3	202	206	PF02991	0.530
LIG_PCNA_yPIPBox_3	62	73	PF02747	0.519
LIG_Pex14_1	122	126	PF04695	0.432
LIG_REV1ctd_RIR_1	106	114	PF16727	0.450
LIG_SH2_CRK	61	65	PF00017	0.483
LIG_SH2_STAT3	206	209	PF00017	0.614
LIG_SH2_STAT5	126	129	PF00017	0.555
LIG_SH3_3	168	174	PF00018	0.563
LIG_SxIP_EBH_1	156	167	PF03271	0.519
LIG_TRAF2_2	188	193	PF00917	0.563
LIG_TYR_ITIM	59	64	PF00017	0.507
LIG_UBA3_1	53	62	PF00899	0.527
LIG_WRC_WIRS_1	164	169	PF05994	0.536
LIG_WRC_WIRS_1	215	220	PF05994	0.369
MOD_CDC14_SPxK_1	12	15	PF00782	0.613
MOD_CDK_SPxK_1	9	15	PF00069	0.618
MOD_CK1_1	101	107	PF00069	0.558
MOD_CK1_1	184	190	PF00069	0.600
MOD_CK1_1	35	41	PF00069	0.583
MOD_CK1_1	8	14	PF00069	0.785
MOD_CK2_1	127	133	PF00069	0.478
MOD_CK2_1	167	173	PF00069	0.547
MOD_Cter_Amidation	118	121	PF01082	0.467
MOD_GlcNHglycan	129	132	PF01048	0.512
MOD_GlcNHglycan	158	161	PF01048	0.501
MOD_GlcNHglycan	220	225	PF01048	0.397
MOD_GlcNHglycan	231	234	PF01048	0.441
MOD_GlcNHglycan	238	241	PF01048	0.459
MOD_GlcNHglycan	3	6	PF01048	0.696
MOD_GlcNHglycan	74	77	PF01048	0.437
MOD_GSK3_1	1	8	PF00069	0.679
MOD_GSK3_1	163	170	PF00069	0.479
MOD_GSK3_1	33	40	PF00069	0.602
MOD_N-GLC_1	193	198	PF02516	0.676
MOD_N-GLC_1	65	70	PF02516	0.508
MOD_N-GLC_1	91	96	PF02516	0.560
MOD_NEK2_1	214	219	PF00069	0.501
MOD_NEK2_1	235	240	PF00069	0.423
MOD_NEK2_1	7	12	PF00069	0.704
MOD_NEK2_1	72	77	PF00069	0.423
MOD_NEK2_2	65	70	PF00069	0.423
MOD_Plk_1	65	71	PF00069	0.543
MOD_Plk_1	91	97	PF00069	0.551
MOD_Plk_2-3	193	199	PF00069	0.636
MOD_Plk_4	163	169	PF00069	0.504
MOD_Plk_4	48	54	PF00069	0.486
MOD_ProDKin_1	167	173	PF00069	0.489
MOD_ProDKin_1	184	190	PF00069	0.563
MOD_ProDKin_1	9	15	PF00069	0.672
MOD_SUMO_rev_2	98	104	PF00179	0.490
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.453
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.630
TRG_ENDOCYTIC_2	61	64	PF00928	0.575
TRG_ER_diArg_1	120	122	PF00400	0.437
TRG_ER_diArg_1	69	71	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA87	Leptomonas seymouri	74%	100%
A0A0S4J0K3	Bodo saltans	38%	100%
A0A1X0P8R4	Trypanosomatidae	39%	87%
A0A3R7JYN8	Trypanosoma rangeli	41%	100%
A0A3S7X040	Leishmania donovani	100%	100%
A4HF57	Leishmania braziliensis	79%	100%
C9ZX66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	92%
E9AYJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8X9	Leishmania major	94%	100%
V5BA09	Trypanosoma cruzi	39%	83%