Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2D6_LEIIN

TriTrypDb:

LINF_260026100

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I2D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.443
CLV_NRD_NRD_1	19	21	PF00675	0.604
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.415
DOC_MAPK_MEF2A_6	181	189	PF00069	0.648
DOC_PP2B_LxvP_1	187	190	PF13499	0.567
DOC_PP2B_LxvP_1	284	287	PF13499	0.430
DOC_PP2B_LxvP_1	296	299	PF13499	0.356
DOC_USP7_MATH_1	101	105	PF00917	0.557
DOC_USP7_MATH_1	201	205	PF00917	0.693
DOC_USP7_MATH_1	24	28	PF00917	0.680
DOC_USP7_MATH_1	245	249	PF00917	0.495
DOC_USP7_MATH_1	30	34	PF00917	0.615
DOC_USP7_UBL2_3	215	219	PF12436	0.633
DOC_WW_Pin1_4	126	131	PF00397	0.694
DOC_WW_Pin1_4	138	143	PF00397	0.573
DOC_WW_Pin1_4	155	160	PF00397	0.673
DOC_WW_Pin1_4	161	166	PF00397	0.567
DOC_WW_Pin1_4	207	212	PF00397	0.630
DOC_WW_Pin1_4	226	231	PF00397	0.502
DOC_WW_Pin1_4	282	287	PF00397	0.424
DOC_WW_Pin1_4	57	62	PF00397	0.505
DOC_WW_Pin1_4	64	69	PF00397	0.494
LIG_14-3-3_CanoR_1	188	194	PF00244	0.581
LIG_14-3-3_CanoR_1	200	208	PF00244	0.588
LIG_BRCT_BRCA1_1	146	150	PF00533	0.605
LIG_FHA_1	139	145	PF00498	0.754
LIG_FHA_1	184	190	PF00498	0.696
LIG_FHA_1	203	209	PF00498	0.477
LIG_FHA_1	41	47	PF00498	0.591
LIG_FHA_1	78	84	PF00498	0.481
LIG_FHA_2	114	120	PF00498	0.673
LIG_FHA_2	126	132	PF00498	0.515
LIG_FHA_2	260	266	PF00498	0.550
LIG_Integrin_isoDGR_2	40	42	PF01839	0.519
LIG_LIR_Apic_2	154	159	PF02991	0.611
LIG_LIR_Apic_2	55	59	PF02991	0.526
LIG_LIR_LC3C_4	229	233	PF02991	0.532
LIG_LIR_Nem_3	147	153	PF02991	0.608
LIG_LIR_Nem_3	19	25	PF02991	0.469
LIG_LIR_Nem_3	241	246	PF02991	0.409
LIG_Pex14_2	297	301	PF04695	0.368
LIG_SH2_PTP2	56	59	PF00017	0.499
LIG_SH2_SRC	56	59	PF00017	0.499
LIG_SH2_STAT5	242	245	PF00017	0.456
LIG_SH2_STAT5	56	59	PF00017	0.534
LIG_SH3_3	208	214	PF00018	0.631
LIG_SH3_3	273	279	PF00018	0.457
LIG_SH3_3	280	286	PF00018	0.524
LIG_SH3_3	55	61	PF00018	0.526
LIG_SH3_3	62	68	PF00018	0.547
LIG_SUMO_SIM_par_1	229	235	PF11976	0.425
LIG_SUMO_SIM_par_1	67	72	PF11976	0.466
LIG_TRAF2_1	117	120	PF00917	0.638
LIG_TRAF2_1	262	265	PF00917	0.460
MOD_CDK_SPK_2	207	212	PF00069	0.637
MOD_CK1_1	121	127	PF00069	0.712
MOD_CK1_1	129	135	PF00069	0.665
MOD_CK1_1	146	152	PF00069	0.742
MOD_CK1_1	199	205	PF00069	0.660
MOD_CK1_1	210	216	PF00069	0.582
MOD_CK1_1	33	39	PF00069	0.616
MOD_CK1_1	6	12	PF00069	0.585
MOD_CK2_1	113	119	PF00069	0.568
MOD_CK2_1	125	131	PF00069	0.526
MOD_CK2_1	259	265	PF00069	0.528
MOD_GlcNHglycan	103	106	PF01048	0.577
MOD_GlcNHglycan	11	14	PF01048	0.618
MOD_GlcNHglycan	131	134	PF01048	0.656
MOD_GlcNHglycan	153	156	PF01048	0.643
MOD_GlcNHglycan	165	168	PF01048	0.492
MOD_GlcNHglycan	223	226	PF01048	0.556
MOD_GlcNHglycan	71	74	PF01048	0.590
MOD_GSK3_1	119	126	PF00069	0.703
MOD_GSK3_1	129	136	PF00069	0.616
MOD_GSK3_1	138	145	PF00069	0.707
MOD_GSK3_1	151	158	PF00069	0.533
MOD_GSK3_1	171	178	PF00069	0.391
MOD_GSK3_1	179	186	PF00069	0.565
MOD_GSK3_1	191	198	PF00069	0.493
MOD_GSK3_1	2	9	PF00069	0.582
MOD_GSK3_1	71	78	PF00069	0.527
MOD_LATS_1	161	167	PF00433	0.584
MOD_N-GLC_1	267	272	PF02516	0.410
MOD_N-GLC_1	9	14	PF02516	0.641
MOD_NEK2_1	123	128	PF00069	0.711
MOD_NEK2_1	144	149	PF00069	0.628
MOD_NEK2_1	231	236	PF00069	0.513
MOD_NEK2_1	267	272	PF00069	0.431
MOD_NEK2_2	30	35	PF00069	0.579
MOD_NMyristoyl	1	7	PF02799	0.569
MOD_PIKK_1	191	197	PF00454	0.524
MOD_PKA_2	113	119	PF00069	0.575
MOD_PKA_2	180	186	PF00069	0.587
MOD_PKA_2	199	205	PF00069	0.622
MOD_Plk_1	118	124	PF00069	0.790
MOD_Plk_1	267	273	PF00069	0.411
MOD_Plk_4	267	273	PF00069	0.432
MOD_Plk_4	77	83	PF00069	0.635
MOD_ProDKin_1	126	132	PF00069	0.694
MOD_ProDKin_1	138	144	PF00069	0.573
MOD_ProDKin_1	155	161	PF00069	0.673
MOD_ProDKin_1	207	213	PF00069	0.630
MOD_ProDKin_1	226	232	PF00069	0.495
MOD_ProDKin_1	282	288	PF00069	0.414
MOD_ProDKin_1	57	63	PF00069	0.510
MOD_ProDKin_1	64	70	PF00069	0.496
TRG_ER_diArg_1	111	114	PF00400	0.595
TRG_ER_diArg_1	15	18	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU5	Leptomonas seymouri	49%	97%
A0A3S7X039	Leishmania donovani	100%	100%
A4HF52	Leishmania braziliensis	66%	100%
E9AYI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8Y4	Leishmania major	89%	100%