Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2D3_LEIIN

TriTrypDb:

LINF_260025800

Length:

893

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.711
CLV_C14_Caspase3-7	360	364	PF00656	0.678
CLV_C14_Caspase3-7	402	406	PF00656	0.643
CLV_C14_Caspase3-7	688	692	PF00656	0.715
CLV_C14_Caspase3-7	707	711	PF00656	0.593
CLV_C14_Caspase3-7	760	764	PF00656	0.763
CLV_NRD_NRD_1	220	222	PF00675	0.601
CLV_NRD_NRD_1	227	229	PF00675	0.694
CLV_NRD_NRD_1	247	249	PF00675	0.502
CLV_NRD_NRD_1	459	461	PF00675	0.801
CLV_NRD_NRD_1	500	502	PF00675	0.740
CLV_NRD_NRD_1	642	644	PF00675	0.751
CLV_NRD_NRD_1	720	722	PF00675	0.692
CLV_PCSK_KEX2_1	220	222	PF00082	0.594
CLV_PCSK_KEX2_1	227	229	PF00082	0.710
CLV_PCSK_KEX2_1	247	249	PF00082	0.506
CLV_PCSK_KEX2_1	458	460	PF00082	0.671
CLV_PCSK_KEX2_1	500	502	PF00082	0.740
CLV_PCSK_KEX2_1	641	643	PF00082	0.798
CLV_PCSK_KEX2_1	720	722	PF00082	0.692
CLV_PCSK_KEX2_1	871	873	PF00082	0.638
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.798
CLV_PCSK_PC1ET2_1	871	873	PF00082	0.638
CLV_PCSK_SKI1_1	17	21	PF00082	0.670
CLV_PCSK_SKI1_1	205	209	PF00082	0.705
CLV_PCSK_SKI1_1	228	232	PF00082	0.664
CLV_PCSK_SKI1_1	29	33	PF00082	0.473
CLV_PCSK_SKI1_1	34	38	PF00082	0.382
CLV_PCSK_SKI1_1	41	45	PF00082	0.498
CLV_PCSK_SKI1_1	501	505	PF00082	0.735
CLV_PCSK_SKI1_1	715	719	PF00082	0.682
CLV_PCSK_SKI1_1	759	763	PF00082	0.685
DEG_APCC_DBOX_1	16	24	PF00400	0.671
DEG_MDM2_SWIB_1	718	725	PF02201	0.667
DEG_Nend_UBRbox_2	1	3	PF02207	0.700
DEG_SCF_FBW7_2	736	743	PF00400	0.624
DEG_SPOP_SBC_1	787	791	PF00917	0.656
DOC_CDC14_PxL_1	625	633	PF14671	0.718
DOC_CKS1_1	384	389	PF01111	0.822
DOC_CKS1_1	555	560	PF01111	0.800
DOC_CKS1_1	737	742	PF01111	0.627
DOC_CKS1_1	75	80	PF01111	0.711
DOC_CYCLIN_RxL_1	221	232	PF00134	0.622
DOC_CYCLIN_RxL_1	715	728	PF00134	0.686
DOC_CYCLIN_RxL_1	753	766	PF00134	0.680
DOC_CYCLIN_yCln2_LP_2	463	469	PF00134	0.749
DOC_CYCLIN_yCln2_LP_2	886	892	PF00134	0.686
DOC_MAPK_gen_1	220	231	PF00069	0.611
DOC_MAPK_gen_1	458	467	PF00069	0.606
DOC_MAPK_MEF2A_6	458	467	PF00069	0.606
DOC_MAPK_MEF2A_6	46	54	PF00069	0.632
DOC_MAPK_NFAT4_5	460	468	PF00069	0.608
DOC_PP2B_LxvP_1	321	324	PF13499	0.776
DOC_PP2B_LxvP_1	463	466	PF13499	0.831
DOC_PP2B_LxvP_1	61	64	PF13499	0.686
DOC_PP2B_LxvP_1	734	737	PF13499	0.764
DOC_PP2B_LxvP_1	886	889	PF13499	0.728
DOC_SPAK_OSR1_1	682	686	PF12202	0.604
DOC_USP7_MATH_1	148	152	PF00917	0.707
DOC_USP7_MATH_1	347	351	PF00917	0.533
DOC_USP7_MATH_1	423	427	PF00917	0.721
DOC_USP7_MATH_1	469	473	PF00917	0.835
DOC_USP7_MATH_1	56	60	PF00917	0.738
DOC_USP7_MATH_1	62	66	PF00917	0.737
DOC_USP7_MATH_1	668	672	PF00917	0.632
DOC_USP7_MATH_1	798	802	PF00917	0.819
DOC_USP7_MATH_1	826	830	PF00917	0.644
DOC_USP7_MATH_1	873	877	PF00917	0.546
DOC_USP7_MATH_1	90	94	PF00917	0.709
DOC_USP7_UBL2_3	180	184	PF12436	0.448
DOC_WW_Pin1_4	114	119	PF00397	0.631
DOC_WW_Pin1_4	140	145	PF00397	0.717
DOC_WW_Pin1_4	375	380	PF00397	0.812
DOC_WW_Pin1_4	383	388	PF00397	0.646
DOC_WW_Pin1_4	46	51	PF00397	0.538
DOC_WW_Pin1_4	514	519	PF00397	0.823
DOC_WW_Pin1_4	554	559	PF00397	0.799
DOC_WW_Pin1_4	64	69	PF00397	0.656
DOC_WW_Pin1_4	736	741	PF00397	0.813
DOC_WW_Pin1_4	74	79	PF00397	0.614
DOC_WW_Pin1_4	783	788	PF00397	0.838
DOC_WW_Pin1_4	91	96	PF00397	0.602
LIG_14-3-3_CanoR_1	22	30	PF00244	0.673
LIG_14-3-3_CanoR_1	266	276	PF00244	0.622
LIG_14-3-3_CanoR_1	330	338	PF00244	0.791
LIG_14-3-3_CanoR_1	385	391	PF00244	0.816
LIG_14-3-3_CanoR_1	458	464	PF00244	0.680
LIG_14-3-3_CanoR_1	601	607	PF00244	0.788
LIG_14-3-3_CanoR_1	720	726	PF00244	0.683
LIG_14-3-3_CanoR_1	81	89	PF00244	0.710
LIG_14-3-3_CanoR_1	813	821	PF00244	0.716
LIG_14-3-3_CanoR_1	837	842	PF00244	0.728
LIG_Actin_WH2_2	737	755	PF00022	0.794
LIG_Actin_WH2_2	858	873	PF00022	0.633
LIG_BIR_III_4	494	498	PF00653	0.763
LIG_DLG_GKlike_1	721	729	PF00625	0.692
LIG_DLG_GKlike_1	753	761	PF00625	0.671
LIG_EVH1_1	465	469	PF00568	0.610
LIG_FHA_1	111	117	PF00498	0.722
LIG_FHA_1	162	168	PF00498	0.527
LIG_FHA_1	241	247	PF00498	0.767
LIG_FHA_1	284	290	PF00498	0.612
LIG_FHA_1	471	477	PF00498	0.845
LIG_FHA_1	502	508	PF00498	0.792
LIG_FHA_1	729	735	PF00498	0.796
LIG_FHA_1	75	81	PF00498	0.701
LIG_FHA_1	788	794	PF00498	0.754
LIG_FHA_1	803	809	PF00498	0.635
LIG_FHA_1	833	839	PF00498	0.638
LIG_FHA_2	400	406	PF00498	0.737
LIG_FHA_2	705	711	PF00498	0.807
LIG_LIR_Gen_1	746	754	PF02991	0.546
LIG_LIR_Nem_3	151	156	PF02991	0.516
LIG_LIR_Nem_3	350	355	PF02991	0.725
LIG_LIR_Nem_3	746	751	PF02991	0.616
LIG_LIR_Nem_3	756	761	PF02991	0.614
LIG_NRBOX	526	532	PF00104	0.607
LIG_PCNA_yPIPBox_3	345	353	PF02747	0.516
LIG_Pex14_2	718	722	PF04695	0.765
LIG_RPA_C_Fungi	858	870	PF08784	0.623
LIG_SH2_CRK	625	629	PF00017	0.722
LIG_SH2_CRK	748	752	PF00017	0.592
LIG_SH2_PTP2	555	558	PF00017	0.722
LIG_SH2_SRC	236	239	PF00017	0.615
LIG_SH2_STAP1	157	161	PF00017	0.540
LIG_SH2_STAP1	564	568	PF00017	0.603
LIG_SH2_STAP1	748	752	PF00017	0.767
LIG_SH2_STAT5	236	239	PF00017	0.638
LIG_SH2_STAT5	355	358	PF00017	0.719
LIG_SH2_STAT5	555	558	PF00017	0.722
LIG_SH3_3	124	130	PF00018	0.761
LIG_SH3_3	134	140	PF00018	0.698
LIG_SH3_3	356	362	PF00018	0.671
LIG_SH3_3	376	382	PF00018	0.541
LIG_SH3_3	463	469	PF00018	0.742
LIG_SH3_3	553	559	PF00018	0.720
LIG_SH3_3	589	595	PF00018	0.752
LIG_SH3_3	734	740	PF00018	0.764
LIG_SH3_3	781	787	PF00018	0.831
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.693
LIG_SUMO_SIM_anti_2	882	887	PF11976	0.587
LIG_SUMO_SIM_par_1	111	117	PF11976	0.684
LIG_SxIP_EBH_1	823	836	PF03271	0.565
LIG_TRAF2_1	372	375	PF00917	0.798
LIG_TRAF2_1	677	680	PF00917	0.642
MOD_CDK_SPK_2	140	145	PF00069	0.696
MOD_CDK_SPK_2	383	388	PF00069	0.836
MOD_CDK_SPK_2	91	96	PF00069	0.817
MOD_CDK_SPxxK_3	378	385	PF00069	0.747
MOD_CDK_SPxxK_3	74	81	PF00069	0.739
MOD_CK1_1	378	384	PF00069	0.856
MOD_CK1_1	633	639	PF00069	0.559
MOD_CK1_1	724	730	PF00069	0.776
MOD_CK1_1	786	792	PF00069	0.838
MOD_CK1_1	84	90	PF00069	0.660
MOD_CK1_1	854	860	PF00069	0.686
MOD_CK2_1	4	10	PF00069	0.487
MOD_CK2_1	674	680	PF00069	0.697
MOD_CK2_1	873	879	PF00069	0.553
MOD_Cter_Amidation	498	501	PF01082	0.735
MOD_DYRK1A_RPxSP_1	46	50	PF00069	0.616
MOD_GlcNHglycan	157	160	PF01048	0.706
MOD_GlcNHglycan	297	300	PF01048	0.701
MOD_GlcNHglycan	321	324	PF01048	0.854
MOD_GlcNHglycan	339	342	PF01048	0.538
MOD_GlcNHglycan	34	37	PF01048	0.638
MOD_GlcNHglycan	571	574	PF01048	0.736
MOD_GlcNHglycan	58	61	PF01048	0.719
MOD_GlcNHglycan	598	601	PF01048	0.630
MOD_GlcNHglycan	647	651	PF01048	0.722
MOD_GlcNHglycan	676	679	PF01048	0.825
MOD_GlcNHglycan	687	690	PF01048	0.645
MOD_GlcNHglycan	697	700	PF01048	0.703
MOD_GlcNHglycan	781	784	PF01048	0.723
MOD_GlcNHglycan	83	86	PF01048	0.713
MOD_GSK3_1	1	8	PF00069	0.502
MOD_GSK3_1	110	117	PF00069	0.632
MOD_GSK3_1	236	243	PF00069	0.765
MOD_GSK3_1	312	319	PF00069	0.786
MOD_GSK3_1	407	414	PF00069	0.812
MOD_GSK3_1	596	603	PF00069	0.796
MOD_GSK3_1	605	612	PF00069	0.688
MOD_GSK3_1	662	669	PF00069	0.761
MOD_GSK3_1	721	728	PF00069	0.687
MOD_GSK3_1	735	742	PF00069	0.585
MOD_GSK3_1	753	760	PF00069	0.505
MOD_GSK3_1	779	786	PF00069	0.743
MOD_GSK3_1	787	794	PF00069	0.672
MOD_GSK3_1	798	805	PF00069	0.515
MOD_GSK3_1	832	839	PF00069	0.743
MOD_GSK3_1	851	858	PF00069	0.376
MOD_N-GLC_1	451	456	PF02516	0.728
MOD_N-GLC_1	813	818	PF02516	0.652
MOD_NEK2_1	110	115	PF00069	0.579
MOD_NEK2_1	522	527	PF00069	0.607
MOD_NEK2_1	596	601	PF00069	0.631
MOD_NEK2_1	683	688	PF00069	0.707
MOD_NEK2_1	725	730	PF00069	0.701
MOD_NEK2_1	757	762	PF00069	0.755
MOD_NEK2_1	832	837	PF00069	0.715
MOD_NEK2_1	855	860	PF00069	0.513
MOD_PIKK_1	161	167	PF00454	0.675
MOD_PIKK_1	267	273	PF00454	0.742
MOD_PIKK_1	29	35	PF00454	0.468
MOD_PIKK_1	323	329	PF00454	0.828
MOD_PIKK_1	357	363	PF00454	0.760
MOD_PIKK_1	630	636	PF00454	0.718
MOD_PKA_1	459	465	PF00069	0.681
MOD_PKA_2	21	27	PF00069	0.667
MOD_PKA_2	329	335	PF00069	0.786
MOD_PKA_2	459	465	PF00069	0.681
MOD_PKA_2	600	606	PF00069	0.791
MOD_PKA_2	812	818	PF00069	0.761
MOD_PKA_2	836	842	PF00069	0.695
MOD_PKB_1	27	35	PF00069	0.686
MOD_Plk_1	1	7	PF00069	0.610
MOD_Plk_1	110	116	PF00069	0.715
MOD_Plk_1	316	322	PF00069	0.745
MOD_Plk_1	798	804	PF00069	0.721
MOD_Plk_1	855	861	PF00069	0.608
MOD_Plk_2-3	425	431	PF00069	0.663
MOD_Plk_4	110	116	PF00069	0.715
MOD_Plk_4	128	134	PF00069	0.774
MOD_Plk_4	170	176	PF00069	0.562
MOD_Plk_4	347	353	PF00069	0.723
MOD_Plk_4	71	77	PF00069	0.750
MOD_Plk_4	725	731	PF00069	0.709
MOD_Plk_4	743	749	PF00069	0.591
MOD_Plk_4	753	759	PF00069	0.577
MOD_ProDKin_1	114	120	PF00069	0.632
MOD_ProDKin_1	140	146	PF00069	0.715
MOD_ProDKin_1	375	381	PF00069	0.810
MOD_ProDKin_1	383	389	PF00069	0.639
MOD_ProDKin_1	46	52	PF00069	0.542
MOD_ProDKin_1	514	520	PF00069	0.817
MOD_ProDKin_1	554	560	PF00069	0.800
MOD_ProDKin_1	64	70	PF00069	0.655
MOD_ProDKin_1	736	742	PF00069	0.812
MOD_ProDKin_1	74	80	PF00069	0.615
MOD_ProDKin_1	783	789	PF00069	0.838
MOD_ProDKin_1	91	97	PF00069	0.602
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.822
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.704
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.738
TRG_DiLeu_BaLyEn_6	769	774	PF01217	0.711
TRG_ENDOCYTIC_2	153	156	PF00928	0.581
TRG_ENDOCYTIC_2	157	160	PF00928	0.538
TRG_ENDOCYTIC_2	355	358	PF00928	0.719
TRG_ENDOCYTIC_2	625	628	PF00928	0.719
TRG_ENDOCYTIC_2	748	751	PF00928	0.591
TRG_ER_diArg_1	220	222	PF00400	0.594
TRG_ER_diArg_1	227	229	PF00400	0.705
TRG_ER_diArg_1	246	248	PF00400	0.548
TRG_ER_diArg_1	27	30	PF00400	0.686
TRG_ER_diArg_1	457	460	PF00400	0.673
TRG_ER_diArg_1	719	721	PF00400	0.690
TRG_NES_CRM1_1	580	594	PF08389	0.749
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	759	763	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICB4	Leishmania donovani	99%	88%
A4HF49	Leishmania braziliensis	60%	100%
E9AYI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q8Y7	Leishmania major	84%	100%