LeishMANIAdb
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HNH endonuclease

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
HNH endonuclease
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I2D0_LEIIN
TriTrypDb:
LINF_260025500
Length:
94

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2D0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2D0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 33 35 PF00675 0.601
CLV_NRD_NRD_1 64 66 PF00675 0.632
CLV_NRD_NRD_1 9 11 PF00675 0.558
CLV_PCSK_KEX2_1 33 35 PF00082 0.686
CLV_PCSK_KEX2_1 8 10 PF00082 0.566
CLV_PCSK_KEX2_1 85 87 PF00082 0.645
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.690
CLV_PCSK_PC7_1 29 35 PF00082 0.676
CLV_PCSK_SKI1_1 10 14 PF00082 0.536
CLV_PCSK_SKI1_1 22 26 PF00082 0.572
CLV_PCSK_SKI1_1 33 37 PF00082 0.622
DOC_USP7_UBL2_3 13 17 PF12436 0.619
DOC_USP7_UBL2_3 54 58 PF12436 0.609
DOC_USP7_UBL2_3 90 94 PF12436 0.667
LIG_BRCT_BRCA1_1 74 78 PF00533 0.618
LIG_BRCT_BRCA1_2 74 80 PF00533 0.672
LIG_LIR_Nem_3 51 55 PF02991 0.609
LIG_SH2_CRK 52 56 PF00017 0.679
LIG_SH3_1 15 21 PF00018 0.639
LIG_SH3_3 15 21 PF00018 0.612
LIG_TYR_ITIM 50 55 PF00017 0.679
MOD_GlcNHglycan 58 61 PF01048 0.541
MOD_GlcNHglycan 68 71 PF01048 0.597
MOD_GlcNHglycan 74 77 PF01048 0.579
MOD_GSK3_1 56 63 PF00069 0.650
MOD_N-GLC_1 72 77 PF02516 0.623
MOD_NEK2_1 1 6 PF00069 0.551
MOD_PIKK_1 60 66 PF00454 0.601
MOD_PKA_1 48 54 PF00069 0.628
MOD_PKA_1 8 14 PF00069 0.613
MOD_PKA_2 8 14 PF00069 0.559
TRG_ENDOCYTIC_2 52 55 PF00928 0.607
TRG_ER_diArg_1 33 35 PF00400 0.693
TRG_ER_diArg_1 8 10 PF00400 0.564
TRG_ER_diLys_1 90 94 PF00400 0.700

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3T8 Leptomonas seymouri 82% 98%
A0A0S4JJD5 Bodo saltans 53% 97%
A0A3Q8IDZ7 Leishmania donovani 100% 100%
A4HF46 Leishmania braziliensis 90% 100%
E9AYI2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q8Z0 Leishmania major 98% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS