PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2C9_LEIIN

TriTrypDb:

LINF_260025400

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2C9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.428
CLV_C14_Caspase3-7	302	306	PF00656	0.635
CLV_C14_Caspase3-7	422	426	PF00656	0.539
CLV_C14_Caspase3-7	433	437	PF00656	0.536
CLV_NRD_NRD_1	130	132	PF00675	0.514
CLV_NRD_NRD_1	147	149	PF00675	0.327
CLV_NRD_NRD_1	157	159	PF00675	0.433
CLV_NRD_NRD_1	450	452	PF00675	0.695
CLV_NRD_NRD_1	464	466	PF00675	0.588
CLV_NRD_NRD_1	473	475	PF00675	0.635
CLV_NRD_NRD_1	476	478	PF00675	0.638
CLV_NRD_NRD_1	554	556	PF00675	0.625
CLV_NRD_NRD_1	558	560	PF00675	0.622
CLV_NRD_NRD_1	569	571	PF00675	0.624
CLV_NRD_NRD_1	573	575	PF00675	0.504
CLV_NRD_NRD_1	634	636	PF00675	0.645
CLV_NRD_NRD_1	653	655	PF00675	0.554
CLV_NRD_NRD_1	663	665	PF00675	0.543
CLV_NRD_NRD_1	698	700	PF00675	0.688
CLV_PCSK_FUR_1	474	478	PF00082	0.593
CLV_PCSK_FUR_1	554	558	PF00082	0.695
CLV_PCSK_KEX2_1	130	132	PF00082	0.554
CLV_PCSK_KEX2_1	147	149	PF00082	0.436
CLV_PCSK_KEX2_1	362	364	PF00082	0.634
CLV_PCSK_KEX2_1	371	373	PF00082	0.521
CLV_PCSK_KEX2_1	450	452	PF00082	0.704
CLV_PCSK_KEX2_1	475	477	PF00082	0.658
CLV_PCSK_KEX2_1	523	525	PF00082	0.630
CLV_PCSK_KEX2_1	554	556	PF00082	0.654
CLV_PCSK_KEX2_1	557	559	PF00082	0.659
CLV_PCSK_KEX2_1	569	571	PF00082	0.624
CLV_PCSK_KEX2_1	573	575	PF00082	0.504
CLV_PCSK_KEX2_1	634	636	PF00082	0.658
CLV_PCSK_KEX2_1	652	654	PF00082	0.559
CLV_PCSK_KEX2_1	663	665	PF00082	0.536
CLV_PCSK_KEX2_1	697	699	PF00082	0.695
CLV_PCSK_KEX2_1	711	713	PF00082	0.517
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.610
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.477
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.639
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.619
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.666
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.522
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.627
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.514
CLV_PCSK_PC7_1	554	560	PF00082	0.642
CLV_PCSK_PC7_1	569	575	PF00082	0.531
CLV_PCSK_SKI1_1	268	272	PF00082	0.591
CLV_PCSK_SKI1_1	372	376	PF00082	0.504
CLV_PCSK_SKI1_1	604	608	PF00082	0.602
CLV_PCSK_SKI1_1	64	68	PF00082	0.403
DEG_SPOP_SBC_1	249	253	PF00917	0.670
DEG_SPOP_SBC_1	692	696	PF00917	0.724
DEG_SPOP_SBC_1	716	720	PF00917	0.607
DOC_CKS1_1	141	146	PF01111	0.452
DOC_MAPK_DCC_7	312	322	PF00069	0.491
DOC_MAPK_gen_1	147	155	PF00069	0.484
DOC_MAPK_gen_1	362	369	PF00069	0.599
DOC_MAPK_gen_1	371	379	PF00069	0.501
DOC_PP2B_LxvP_1	210	213	PF13499	0.523
DOC_PP2B_LxvP_1	46	49	PF13499	0.543
DOC_PP2B_LxvP_1	461	464	PF13499	0.569
DOC_PP2B_LxvP_1	625	628	PF13499	0.568
DOC_PP2B_LxvP_1	689	692	PF13499	0.598
DOC_USP7_MATH_1	132	136	PF00917	0.447
DOC_USP7_MATH_1	199	203	PF00917	0.642
DOC_USP7_MATH_1	206	210	PF00917	0.608
DOC_USP7_MATH_1	235	239	PF00917	0.654
DOC_USP7_MATH_1	249	253	PF00917	0.571
DOC_USP7_MATH_1	269	273	PF00917	0.465
DOC_USP7_MATH_1	288	292	PF00917	0.517
DOC_USP7_MATH_1	496	500	PF00917	0.670
DOC_USP7_MATH_1	540	544	PF00917	0.650
DOC_USP7_MATH_1	579	583	PF00917	0.726
DOC_USP7_MATH_1	680	684	PF00917	0.649
DOC_USP7_MATH_1	693	697	PF00917	0.693
DOC_USP7_MATH_1	704	708	PF00917	0.582
DOC_USP7_MATH_1	717	721	PF00917	0.553
DOC_USP7_UBL2_3	443	447	PF12436	0.635
DOC_USP7_UBL2_3	519	523	PF12436	0.586
DOC_WW_Pin1_4	122	127	PF00397	0.479
DOC_WW_Pin1_4	140	145	PF00397	0.398
DOC_WW_Pin1_4	186	191	PF00397	0.410
DOC_WW_Pin1_4	283	288	PF00397	0.620
DOC_WW_Pin1_4	303	308	PF00397	0.494
DOC_WW_Pin1_4	31	36	PF00397	0.671
DOC_WW_Pin1_4	623	628	PF00397	0.661
DOC_WW_Pin1_4	645	650	PF00397	0.688
DOC_WW_Pin1_4	684	689	PF00397	0.587
DOC_WW_Pin1_4	95	100	PF00397	0.523
LIG_14-3-3_CanoR_1	100	106	PF00244	0.361
LIG_14-3-3_CanoR_1	131	141	PF00244	0.488
LIG_14-3-3_CanoR_1	268	278	PF00244	0.589
LIG_14-3-3_CanoR_1	372	379	PF00244	0.471
LIG_14-3-3_CanoR_1	453	463	PF00244	0.607
LIG_14-3-3_CanoR_1	506	511	PF00244	0.615
LIG_BRCT_BRCA1_1	134	138	PF00533	0.417
LIG_BRCT_BRCA1_1	216	220	PF00533	0.605
LIG_BRCT_BRCA1_1	266	270	PF00533	0.601
LIG_BRCT_BRCA1_1	53	57	PF00533	0.508
LIG_CSL_BTD_1	228	231	PF09270	0.598
LIG_DLG_GKlike_1	506	514	PF00625	0.609
LIG_FAT_LD_1	106	114	PF03623	0.414
LIG_FHA_1	116	122	PF00498	0.545
LIG_FHA_1	162	168	PF00498	0.503
LIG_FHA_1	269	275	PF00498	0.566
LIG_FHA_1	313	319	PF00498	0.594
LIG_FHA_1	456	462	PF00498	0.571
LIG_FHA_1	582	588	PF00498	0.576
LIG_FHA_1	598	604	PF00498	0.626
LIG_FHA_2	300	306	PF00498	0.656
LIG_FHA_2	337	343	PF00498	0.489
LIG_FHA_2	40	46	PF00498	0.748
LIG_FHA_2	416	422	PF00498	0.645
LIG_LIR_Gen_1	161	167	PF02991	0.501
LIG_LIR_Nem_3	135	141	PF02991	0.471
LIG_LIR_Nem_3	161	166	PF02991	0.453
LIG_LIR_Nem_3	227	232	PF02991	0.644
LIG_LIR_Nem_3	54	60	PF02991	0.444
LIG_PCNA_TLS_4	395	402	PF02747	0.525
LIG_PTB_Apo_2	273	280	PF02174	0.637
LIG_PTB_Phospho_1	273	279	PF10480	0.633
LIG_Rb_pABgroove_1	108	116	PF01858	0.367
LIG_SH2_CRK	163	167	PF00017	0.507
LIG_SH2_GRB2like	279	282	PF00017	0.536
LIG_SH2_NCK_1	76	80	PF00017	0.442
LIG_SH2_PTP2	60	63	PF00017	0.422
LIG_SH2_STAP1	163	167	PF00017	0.507
LIG_SH2_STAT5	112	115	PF00017	0.373
LIG_SH2_STAT5	163	166	PF00017	0.456
LIG_SH2_STAT5	19	22	PF00017	0.444
LIG_SH2_STAT5	401	404	PF00017	0.538
LIG_SH2_STAT5	60	63	PF00017	0.433
LIG_SH3_2	624	629	PF14604	0.669
LIG_SH3_3	184	190	PF00018	0.437
LIG_SH3_3	215	221	PF00018	0.605
LIG_SH3_3	225	231	PF00018	0.528
LIG_SH3_3	23	29	PF00018	0.559
LIG_SH3_3	349	355	PF00018	0.526
LIG_SH3_3	621	627	PF00018	0.673
LIG_SH3_3	685	691	PF00018	0.679
LIG_SH3_3	83	89	PF00018	0.623
LIG_TRAF2_1	53	56	PF00917	0.513
LIG_TRAF2_1	628	631	PF00917	0.638
LIG_UBA3_1	152	159	PF00899	0.416
LIG_WW_3	462	466	PF00397	0.625
LIG_WW_3	626	630	PF00397	0.621
MOD_CDC14_SPxK_1	125	128	PF00782	0.461
MOD_CDC14_SPxK_1	34	37	PF00782	0.641
MOD_CDC14_SPxK_1	626	629	PF00782	0.644
MOD_CDK_SPK_2	95	100	PF00069	0.494
MOD_CDK_SPxK_1	122	128	PF00069	0.469
MOD_CDK_SPxK_1	31	37	PF00069	0.639
MOD_CDK_SPxK_1	623	629	PF00069	0.647
MOD_CDK_SPxxK_3	140	147	PF00069	0.467
MOD_CDK_SPxxK_3	645	652	PF00069	0.686
MOD_CK1_1	119	125	PF00069	0.596
MOD_CK1_1	233	239	PF00069	0.563
MOD_CK1_1	380	386	PF00069	0.721
MOD_CK1_1	388	394	PF00069	0.567
MOD_CK1_1	409	415	PF00069	0.570
MOD_CK1_1	487	493	PF00069	0.671
MOD_CK1_1	494	500	PF00069	0.624
MOD_CK1_1	50	56	PF00069	0.492
MOD_CK1_1	582	588	PF00069	0.710
MOD_CK1_1	589	595	PF00069	0.612
MOD_CK1_1	596	602	PF00069	0.535
MOD_CK1_1	682	688	PF00069	0.785
MOD_CK1_1	718	724	PF00069	0.724
MOD_CK1_1	98	104	PF00069	0.478
MOD_CK2_1	143	149	PF00069	0.409
MOD_CK2_1	336	342	PF00069	0.486
MOD_CK2_1	388	394	PF00069	0.567
MOD_CK2_1	39	45	PF00069	0.715
MOD_CK2_1	49	55	PF00069	0.622
MOD_CK2_1	574	580	PF00069	0.740
MOD_CK2_1	605	611	PF00069	0.554
MOD_CK2_1	98	104	PF00069	0.620
MOD_Cter_Amidation	360	363	PF01082	0.602
MOD_Cter_Amidation	567	570	PF01082	0.646
MOD_GlcNHglycan	118	121	PF01048	0.503
MOD_GlcNHglycan	134	137	PF01048	0.443
MOD_GlcNHglycan	237	240	PF01048	0.780
MOD_GlcNHglycan	242	245	PF01048	0.669
MOD_GlcNHglycan	271	274	PF01048	0.654
MOD_GlcNHglycan	411	414	PF01048	0.570
MOD_GlcNHglycan	429	432	PF01048	0.607
MOD_GlcNHglycan	490	493	PF01048	0.600
MOD_GlcNHglycan	496	499	PF01048	0.546
MOD_GlcNHglycan	506	509	PF01048	0.477
MOD_GlcNHglycan	526	529	PF01048	0.504
MOD_GlcNHglycan	542	545	PF01048	0.577
MOD_GlcNHglycan	576	579	PF01048	0.607
MOD_GlcNHglycan	592	595	PF01048	0.602
MOD_GlcNHglycan	619	622	PF01048	0.742
MOD_GlcNHglycan	658	661	PF01048	0.638
MOD_GlcNHglycan	671	677	PF01048	0.434
MOD_GlcNHglycan	682	685	PF01048	0.595
MOD_GlcNHglycan	702	705	PF01048	0.626
MOD_GlcNHglycan	706	709	PF01048	0.583
MOD_GSK3_1	115	122	PF00069	0.474
MOD_GSK3_1	161	168	PF00069	0.500
MOD_GSK3_1	260	267	PF00069	0.617
MOD_GSK3_1	290	297	PF00069	0.651
MOD_GSK3_1	299	306	PF00069	0.588
MOD_GSK3_1	308	315	PF00069	0.515
MOD_GSK3_1	377	384	PF00069	0.548
MOD_GSK3_1	385	392	PF00069	0.588
MOD_GSK3_1	47	54	PF00069	0.549
MOD_GSK3_1	480	487	PF00069	0.686
MOD_GSK3_1	490	497	PF00069	0.588
MOD_GSK3_1	498	505	PF00069	0.500
MOD_GSK3_1	579	586	PF00069	0.617
MOD_GSK3_1	588	595	PF00069	0.594
MOD_GSK3_1	612	619	PF00069	0.666
MOD_GSK3_1	634	641	PF00069	0.627
MOD_GSK3_1	678	685	PF00069	0.747
MOD_GSK3_1	700	707	PF00069	0.624
MOD_GSK3_1	715	722	PF00069	0.566
MOD_GSK3_1	95	102	PF00069	0.461
MOD_LATS_1	310	316	PF00433	0.562
MOD_LATS_1	572	578	PF00433	0.591
MOD_N-GLC_1	377	382	PF02516	0.529
MOD_N-GLC_1	416	421	PF02516	0.646
MOD_N-GLC_1	704	709	PF02516	0.656
MOD_N-GLC_2	262	264	PF02516	0.616
MOD_N-GLC_2	368	370	PF02516	0.471
MOD_N-GLC_2	80	82	PF02516	0.464
MOD_NEK2_1	114	119	PF00069	0.453
MOD_NEK2_1	174	179	PF00069	0.472
MOD_NEK2_1	308	313	PF00069	0.537
MOD_NEK2_1	336	341	PF00069	0.479
MOD_NEK2_1	377	382	PF00069	0.529
MOD_NEK2_1	386	391	PF00069	0.590
MOD_NEK2_1	587	592	PF00069	0.632
MOD_NEK2_1	605	610	PF00069	0.505
MOD_PIKK_1	166	172	PF00454	0.563
MOD_PIKK_1	174	180	PF00454	0.338
MOD_PIKK_1	199	205	PF00454	0.597
MOD_PIKK_1	336	342	PF00454	0.465
MOD_PIKK_1	605	611	PF00454	0.604
MOD_PIKK_1	612	618	PF00454	0.620
MOD_PKA_1	574	580	PF00069	0.590
MOD_PKA_1	634	640	PF00069	0.552
MOD_PKA_2	214	220	PF00069	0.564
MOD_PKA_2	386	392	PF00069	0.587
MOD_PKA_2	634	640	PF00069	0.558
MOD_PKA_2	99	105	PF00069	0.388
MOD_Plk_1	206	212	PF00069	0.667
MOD_Plk_1	406	412	PF00069	0.568
MOD_Plk_1	582	588	PF00069	0.587
MOD_Plk_1	672	678	PF00069	0.485
MOD_Plk_4	161	167	PF00069	0.501
MOD_Plk_4	214	220	PF00069	0.564
MOD_Plk_4	224	230	PF00069	0.559
MOD_ProDKin_1	122	128	PF00069	0.481
MOD_ProDKin_1	140	146	PF00069	0.401
MOD_ProDKin_1	186	192	PF00069	0.415
MOD_ProDKin_1	283	289	PF00069	0.620
MOD_ProDKin_1	303	309	PF00069	0.496
MOD_ProDKin_1	31	37	PF00069	0.672
MOD_ProDKin_1	623	629	PF00069	0.662
MOD_ProDKin_1	645	651	PF00069	0.688
MOD_ProDKin_1	684	690	PF00069	0.587
MOD_ProDKin_1	95	101	PF00069	0.506
TRG_DiLeu_BaEn_4	672	678	PF01217	0.570
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.397
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.618
TRG_ENDOCYTIC_2	163	166	PF00928	0.465
TRG_ER_diArg_1	130	132	PF00400	0.470
TRG_ER_diArg_1	450	453	PF00400	0.570
TRG_ER_diArg_1	474	477	PF00400	0.599
TRG_ER_diArg_1	554	557	PF00400	0.628
TRG_ER_diArg_1	558	561	PF00400	0.626
TRG_ER_diArg_1	634	636	PF00400	0.823
TRG_ER_diArg_1	652	654	PF00400	0.516
TRG_ER_diArg_1	662	664	PF00400	0.532
TRG_NLS_Bipartite_1	465	479	PF00514	0.593
TRG_NLS_Bipartite_1	555	577	PF00514	0.646
TRG_NLS_Bipartite_1	697	715	PF00514	0.604
TRG_NLS_MonoCore_2	473	478	PF00514	0.594
TRG_NLS_MonoCore_2	554	559	PF00514	0.695
TRG_NLS_MonoCore_2	572	577	PF00514	0.512
TRG_NLS_MonoExtC_3	473	478	PF00514	0.572
TRG_NLS_MonoExtC_3	554	559	PF00514	0.695
TRG_NLS_MonoExtN_4	472	479	PF00514	0.648
TRG_NLS_MonoExtN_4	554	560	PF00514	0.693
TRG_NLS_MonoExtN_4	570	577	PF00514	0.530
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	663	667	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I226	Leptomonas seymouri	40%	100%
A0A3S5H7G6	Leishmania donovani	99%	100%
A4HF45	Leishmania braziliensis	63%	100%
E9AYI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q8Z1	Leishmania major	86%	100%