LeishMANIAdb
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Methyltransf_11 domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransf_11 domain-containing protein
Gene product:
Methyltransferase domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I2C8_LEIIN
TriTrypDb:
LINF_260025300
Length:
349

Annotations

Annotations by Jardim et al.

Transferases, methyltransferase domain containing , putative (POMP1) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 8
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 8

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I2C8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2C8

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 2
GO:0032259 methylation 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0008168 methyltransferase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016741 transferase activity, transferring one-carbon groups 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 125 127 PF00675 0.457
CLV_NRD_NRD_1 23 25 PF00675 0.472
CLV_NRD_NRD_1 297 299 PF00675 0.407
CLV_NRD_NRD_1 347 349 PF00675 0.511
CLV_PCSK_KEX2_1 125 127 PF00082 0.426
CLV_PCSK_KEX2_1 191 193 PF00082 0.492
CLV_PCSK_KEX2_1 347 349 PF00082 0.532
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.450
CLV_PCSK_PC1ET2_1 191 193 PF00082 0.492
CLV_PCSK_SKI1_1 176 180 PF00082 0.427
CLV_PCSK_SKI1_1 310 314 PF00082 0.451
CLV_Separin_Metazoa 195 199 PF03568 0.277
DEG_Nend_UBRbox_3 1 3 PF02207 0.633
DOC_MAPK_gen_1 125 133 PF00069 0.229
DOC_MAPK_gen_1 24 32 PF00069 0.477
DOC_PP2B_LxvP_1 194 197 PF13499 0.290
DOC_USP7_MATH_1 62 66 PF00917 0.502
DOC_WW_Pin1_4 87 92 PF00397 0.312
LIG_14-3-3_CanoR_1 261 267 PF00244 0.216
LIG_14-3-3_CanoR_1 7 15 PF00244 0.633
LIG_14-3-3_CanoR_1 99 104 PF00244 0.341
LIG_APCC_ABBA_1 213 218 PF00400 0.253
LIG_BRCT_BRCA1_1 144 148 PF00533 0.196
LIG_BRCT_BRCA1_1 157 161 PF00533 0.196
LIG_FHA_1 179 185 PF00498 0.256
LIG_FHA_1 224 230 PF00498 0.216
LIG_FHA_1 31 37 PF00498 0.306
LIG_FHA_1 95 101 PF00498 0.419
LIG_FHA_2 61 67 PF00498 0.411
LIG_LIR_Apic_2 104 110 PF02991 0.267
LIG_LIR_Apic_2 119 123 PF02991 0.194
LIG_LIR_Apic_2 179 183 PF02991 0.226
LIG_LIR_Gen_1 156 165 PF02991 0.223
LIG_LIR_Nem_3 156 160 PF02991 0.232
LIG_LIR_Nem_3 227 233 PF02991 0.209
LIG_LIR_Nem_3 242 247 PF02991 0.179
LIG_LYPXL_S_1 229 233 PF13949 0.451
LIG_LYPXL_yS_3 230 233 PF13949 0.290
LIG_PCNA_yPIPBox_3 255 267 PF02747 0.216
LIG_Pex14_2 157 161 PF04695 0.290
LIG_SH2_CRK 107 111 PF00017 0.315
LIG_SH2_CRK 180 184 PF00017 0.290
LIG_SH2_CRK 27 31 PF00017 0.365
LIG_SH2_PTP2 120 123 PF00017 0.156
LIG_SH2_STAP1 75 79 PF00017 0.312
LIG_SH2_STAP1 96 100 PF00017 0.359
LIG_SH2_STAT5 120 123 PF00017 0.273
LIG_SH2_STAT5 180 183 PF00017 0.253
LIG_SH2_STAT5 89 92 PF00017 0.297
LIG_SH2_STAT5 96 99 PF00017 0.333
LIG_SH3_3 166 172 PF00018 0.216
LIG_SH3_3 253 259 PF00018 0.196
LIG_SUMO_SIM_anti_2 273 280 PF11976 0.252
LIG_SUMO_SIM_par_1 273 280 PF11976 0.201
MOD_CDK_SPxK_1 87 93 PF00069 0.274
MOD_CK1_1 220 226 PF00069 0.173
MOD_CK1_1 341 347 PF00069 0.234
MOD_CK1_1 69 75 PF00069 0.413
MOD_CK1_1 92 98 PF00069 0.352
MOD_CK2_1 137 143 PF00069 0.207
MOD_CK2_1 280 286 PF00069 0.213
MOD_CK2_1 60 66 PF00069 0.417
MOD_CK2_1 99 105 PF00069 0.327
MOD_Cter_Amidation 123 126 PF01082 0.433
MOD_Cter_Amidation 174 177 PF01082 0.451
MOD_Cter_Amidation 296 299 PF01082 0.407
MOD_GlcNHglycan 173 176 PF01048 0.468
MOD_GlcNHglycan 37 40 PF01048 0.285
MOD_GSK3_1 13 20 PF00069 0.638
MOD_GSK3_1 217 224 PF00069 0.285
MOD_GSK3_1 60 67 PF00069 0.530
MOD_N-GLC_1 320 325 PF02516 0.476
MOD_NEK2_1 142 147 PF00069 0.196
MOD_NEK2_1 262 267 PF00069 0.256
MOD_NEK2_1 338 343 PF00069 0.265
MOD_PIKK_1 94 100 PF00454 0.375
MOD_PK_1 99 105 PF00069 0.362
MOD_PKA_1 176 182 PF00069 0.268
MOD_PKA_2 6 12 PF00069 0.602
MOD_PKA_2 92 98 PF00069 0.293
MOD_PKB_1 99 107 PF00069 0.312
MOD_Plk_1 289 295 PF00069 0.233
MOD_Plk_2-3 280 286 PF00069 0.290
MOD_Plk_4 137 143 PF00069 0.210
MOD_Plk_4 262 268 PF00069 0.325
MOD_Plk_4 280 286 PF00069 0.156
MOD_Plk_4 341 347 PF00069 0.209
MOD_ProDKin_1 87 93 PF00069 0.316
MOD_SUMO_rev_2 217 223 PF00179 0.298
TRG_DiLeu_BaLyEn_6 258 263 PF01217 0.221
TRG_DiLeu_BaLyEn_6 265 270 PF01217 0.196
TRG_ENDOCYTIC_2 230 233 PF00928 0.210
TRG_ENDOCYTIC_2 27 30 PF00928 0.319
TRG_ENDOCYTIC_2 84 87 PF00928 0.293
TRG_ER_diArg_1 346 348 PF00400 0.282
TRG_NLS_MonoExtC_3 124 129 PF00514 0.199
TRG_NLS_MonoExtN_4 123 130 PF00514 0.306
TRG_Pf-PMV_PEXEL_1 268 273 PF00026 0.461

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3D1 Leptomonas seymouri 71% 100%
A0A1X0P7E4 Trypanosomatidae 51% 96%
A0A3S7X035 Leishmania donovani 100% 100%
A0A422N3J7 Trypanosoma rangeli 55% 100%
A4HF44 Leishmania braziliensis 82% 100%
C9ZX82 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 95%
E9AYI0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q8Z2 Leishmania major 95% 99%
V5AUM3 Trypanosoma cruzi 54% 85%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS