Putative electon transport protein SCO1/SCO2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

electon transport protein SCO1/SCO2 - putative

Species:

Leishmania infantum

UniProt:

A4I2C5_LEIIN

TriTrypDb:

LINF_260025000

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005743	mitochondrial inner membrane	5	5
GO:0016020	membrane	2	14
GO:0019866	organelle inner membrane	4	5
GO:0031090	organelle membrane	3	5
GO:0031966	mitochondrial membrane	4	5
GO:0110165	cellular anatomical entity	1	14
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4I2C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2C5

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	5
GO:0006875	obsolete intracellular metal ion homeostasis	6	5
GO:0006878	intracellular copper ion homeostasis	8	5
GO:0008535	respiratory chain complex IV assembly	7	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0017004	cytochrome complex assembly	6	6
GO:0019725	cellular homeostasis	2	5
GO:0022607	cellular component assembly	4	6
GO:0030003	intracellular monoatomic cation homeostasis	5	5
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	2
GO:0042592	homeostatic process	3	5
GO:0043933	protein-containing complex organization	4	6
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	5
GO:0048878	chemical homeostasis	4	5
GO:0050801	monoatomic ion homeostasis	5	5
GO:0055065	obsolete metal ion homeostasis	7	5
GO:0055070	copper ion homeostasis	9	5
GO:0055076	obsolete transition metal ion homeostasis	8	5
GO:0055080	monoatomic cation homeostasis	6	5
GO:0055082	intracellular chemical homeostasis	3	5
GO:0065003	protein-containing complex assembly	5	6
GO:0065007	biological regulation	1	5
GO:0065008	regulation of biological quality	2	5
GO:0071840	cellular component organization or biogenesis	2	6
GO:0098771	inorganic ion homeostasis	6	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	5
GO:0005507	copper ion binding	6	5
GO:0016491	oxidoreductase activity	2	4
GO:0016530	metallochaperone activity	2	5
GO:0016531	copper chaperone activity	3	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5
GO:0140104	molecular carrier activity	1	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.404
CLV_C14_Caspase3-7	153	157	PF00656	0.355
CLV_C14_Caspase3-7	405	409	PF00656	0.684
CLV_NRD_NRD_1	10	12	PF00675	0.446
CLV_NRD_NRD_1	182	184	PF00675	0.347
CLV_NRD_NRD_1	365	367	PF00675	0.307
CLV_NRD_NRD_1	4	6	PF00675	0.442
CLV_PCSK_FUR_1	180	184	PF00082	0.339
CLV_PCSK_KEX2_1	10	12	PF00082	0.442
CLV_PCSK_KEX2_1	182	184	PF00082	0.363
CLV_PCSK_KEX2_1	219	221	PF00082	0.270
CLV_PCSK_KEX2_1	277	279	PF00082	0.329
CLV_PCSK_KEX2_1	365	367	PF00082	0.307
CLV_PCSK_KEX2_1	4	6	PF00082	0.439
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.249
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.284
CLV_PCSK_SKI1_1	193	197	PF00082	0.441
CLV_PCSK_SKI1_1	219	223	PF00082	0.294
CLV_PCSK_SKI1_1	253	257	PF00082	0.256
CLV_PCSK_SKI1_1	5	9	PF00082	0.505
CLV_PCSK_SKI1_1	59	63	PF00082	0.703
DEG_APCC_DBOX_1	16	24	PF00400	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.712
DOC_CYCLIN_yClb5_NLxxxL_5	398	407	PF00134	0.596
DOC_MAPK_gen_1	180	188	PF00069	0.557
DOC_MAPK_gen_1	227	235	PF00069	0.513
DOC_MAPK_MEF2A_6	227	235	PF00069	0.513
DOC_MAPK_RevD_3	168	183	PF00069	0.293
DOC_PP1_RVXF_1	311	317	PF00149	0.456
DOC_PP4_FxxP_1	198	201	PF00568	0.610
DOC_PP4_FxxP_1	316	319	PF00568	0.456
DOC_USP7_MATH_1	194	198	PF00917	0.724
DOC_USP7_MATH_1	27	31	PF00917	0.365
DOC_USP7_MATH_1	77	81	PF00917	0.395
DOC_USP7_UBL2_3	256	260	PF12436	0.456
DOC_WW_Pin1_4	197	202	PF00397	0.614
DOC_WW_Pin1_4	277	282	PF00397	0.456
DOC_WW_Pin1_4	289	294	PF00397	0.515
DOC_WW_Pin1_4	42	47	PF00397	0.513
DOC_WW_Pin1_4	73	78	PF00397	0.567
LIG_14-3-3_CanoR_1	145	154	PF00244	0.345
LIG_14-3-3_CanoR_1	193	199	PF00244	0.728
LIG_14-3-3_CanoR_1	220	226	PF00244	0.472
LIG_14-3-3_CanoR_1	372	378	PF00244	0.543
LIG_14-3-3_CanoR_1	4	12	PF00244	0.682
LIG_14-3-3_CanoR_1	79	85	PF00244	0.431
LIG_BRCT_BRCA1_1	80	84	PF00533	0.565
LIG_CtBP_PxDLS_1	245	249	PF00389	0.470
LIG_deltaCOP1_diTrp_1	265	271	PF00928	0.456
LIG_FHA_1	1	7	PF00498	0.617
LIG_FHA_1	167	173	PF00498	0.298
LIG_FHA_1	53	59	PF00498	0.474
LIG_FHA_2	127	133	PF00498	0.352
LIG_FHA_2	144	150	PF00498	0.343
LIG_FHA_2	220	226	PF00498	0.481
LIG_FHA_2	299	305	PF00498	0.456
LIG_FHA_2	348	354	PF00498	0.503
LIG_FHA_2	388	394	PF00498	0.572
LIG_LIR_Apic_2	197	201	PF02991	0.707
LIG_LIR_Apic_2	265	269	PF02991	0.456
LIG_LIR_Gen_1	351	360	PF02991	0.509
LIG_LIR_Nem_3	129	133	PF02991	0.423
LIG_LIR_Nem_3	265	270	PF02991	0.456
LIG_LIR_Nem_3	343	349	PF02991	0.469
LIG_LIR_Nem_3	351	357	PF02991	0.450
LIG_LIR_Nem_3	358	363	PF02991	0.488
LIG_PCNA_PIPBox_1	251	260	PF02747	0.470
LIG_Pex14_1	163	167	PF04695	0.311
LIG_Pex14_1	230	234	PF04695	0.499
LIG_Pex14_1	267	271	PF04695	0.456
LIG_Pex14_1	356	360	PF04695	0.495
LIG_SH2_CRK	360	364	PF00017	0.493
LIG_SH2_STAP1	130	134	PF00017	0.324
LIG_SH2_STAP1	360	364	PF00017	0.493
LIG_SH2_STAT5	128	131	PF00017	0.360
LIG_SH2_STAT5	133	136	PF00017	0.320
LIG_SH2_STAT5	232	235	PF00017	0.537
LIG_SH2_STAT5	287	290	PF00017	0.499
LIG_SH2_STAT5	315	318	PF00017	0.450
LIG_SH2_STAT5	329	332	PF00017	0.495
LIG_SH2_STAT5	338	341	PF00017	0.446
LIG_SH2_STAT5	349	352	PF00017	0.500
LIG_SH3_3	198	204	PF00018	0.600
LIG_SUMO_SIM_par_1	173	178	PF11976	0.293
LIG_SUMO_SIM_par_1	211	217	PF11976	0.542
LIG_TRAF2_1	319	322	PF00917	0.510
LIG_TRAF2_1	414	417	PF00917	0.637
LIG_UBA3_1	270	277	PF00899	0.484
LIG_WRC_WIRS_1	195	200	PF05994	0.702
MOD_CDC14_SPxK_1	76	79	PF00782	0.393
MOD_CDK_SPK_2	289	294	PF00069	0.515
MOD_CDK_SPxK_1	277	283	PF00069	0.456
MOD_CDK_SPxK_1	73	79	PF00069	0.393
MOD_CDK_SPxxK_3	42	49	PF00069	0.513
MOD_CK1_1	197	203	PF00069	0.731
MOD_CK1_1	289	295	PF00069	0.537
MOD_CK1_1	30	36	PF00069	0.405
MOD_CK1_1	347	353	PF00069	0.586
MOD_CK1_1	80	86	PF00069	0.505
MOD_CK2_1	126	132	PF00069	0.407
MOD_CK2_1	143	149	PF00069	0.393
MOD_CK2_1	298	304	PF00069	0.456
MOD_CK2_1	347	353	PF00069	0.501
MOD_CK2_1	387	393	PF00069	0.732
MOD_CMANNOS	160	163	PF00535	0.293
MOD_Cter_Amidation	217	220	PF01082	0.273
MOD_GlcNHglycan	100	103	PF01048	0.702
MOD_GlcNHglycan	80	83	PF01048	0.748
MOD_GlcNHglycan	88	91	PF01048	0.649
MOD_GSK3_1	122	129	PF00069	0.381
MOD_GSK3_1	171	178	PF00069	0.297
MOD_GSK3_1	344	351	PF00069	0.582
MOD_GSK3_1	425	432	PF00069	0.794
MOD_GSK3_1	73	80	PF00069	0.520
MOD_GSK3_1	82	89	PF00069	0.450
MOD_NEK2_1	235	240	PF00069	0.483
MOD_NEK2_1	298	303	PF00069	0.484
MOD_NEK2_1	88	93	PF00069	0.478
MOD_NEK2_2	426	431	PF00069	0.754
MOD_PIKK_1	122	128	PF00454	0.383
MOD_PIKK_1	298	304	PF00454	0.456
MOD_PIKK_1	5	11	PF00454	0.595
MOD_PKA_1	219	225	PF00069	0.470
MOD_PKA_2	122	128	PF00069	0.428
MOD_PKA_2	219	225	PF00069	0.470
MOD_PKA_2	344	350	PF00069	0.534
MOD_PKA_2	78	84	PF00069	0.447
MOD_Plk_1	331	337	PF00069	0.494
MOD_Plk_2-3	322	328	PF00069	0.470
MOD_Plk_4	171	177	PF00069	0.354
MOD_Plk_4	331	337	PF00069	0.456
MOD_Plk_4	402	408	PF00069	0.584
MOD_ProDKin_1	197	203	PF00069	0.609
MOD_ProDKin_1	277	283	PF00069	0.456
MOD_ProDKin_1	289	295	PF00069	0.515
MOD_ProDKin_1	42	48	PF00069	0.512
MOD_ProDKin_1	73	79	PF00069	0.568
MOD_SUMO_rev_2	184	192	PF00179	0.598
MOD_SUMO_rev_2	211	217	PF00179	0.456
MOD_SUMO_rev_2	405	415	PF00179	0.602
TRG_DiLeu_BaEn_1	326	331	PF01217	0.456
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.616
TRG_ENDOCYTIC_2	232	235	PF00928	0.496
TRG_ENDOCYTIC_2	315	318	PF00928	0.499
TRG_ENDOCYTIC_2	360	363	PF00928	0.489
TRG_ER_diArg_1	10	13	PF00400	0.686
TRG_ER_diArg_1	179	182	PF00400	0.530
TRG_ER_diArg_1	364	366	PF00400	0.507
TRG_ER_diArg_1	4	6	PF00400	0.670
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G6	Leptomonas seymouri	83%	100%
A0A1X0P7F2	Trypanosomatidae	70%	98%
A0A3Q8ID19	Leishmania donovani	100%	100%
A0A3R7N2E4	Trypanosoma rangeli	66%	100%
A0A3S5H5E9	Leishmania donovani	39%	100%
A4H427	Leishmania braziliensis	39%	100%
A4HF41	Leishmania braziliensis	92%	100%
A4HSB1	Leishmania infantum	39%	100%
C9ZX87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AK94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AYH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O97196	Leishmania major	39%	100%
Q4Q8Z5	Leishmania major	97%	100%
V5BA25	Trypanosoma cruzi	64%	100%