LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Kinesin motor domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinesin motor domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I2C4_LEIIN
TriTrypDb:
LINF_260024900
Length:
803

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1
GO:0005875 microtubule associated complex 2 2
GO:0030286 dynein complex 3 2
GO:0032991 protein-containing complex 1 2
GO:1902494 catalytic complex 2 2

Phosphorylation

Amastigote: 611, 697, 703, 707, 757, 787, 792, 794
Promastigote: 261
Promastigote/Amastigote: 10, 17, 257, 259, 5, 7, 708, 753, 788

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I2C4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2C4

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 2
GO:0007018 microtubule-based movement 3 2
GO:0009987 cellular process 1 2
Molecular functions
Term Name Level Count
GO:0003774 cytoskeletal motor activity 1 2
GO:0003777 microtubule motor activity 2 2
GO:0005488 binding 1 2
GO:0005515 protein binding 2 2
GO:0008569 minus-end-directed microtubule motor activity 3 2
GO:0045505 dynein intermediate chain binding 3 2
GO:0051959 dynein light intermediate chain binding 3 2
GO:0140657 ATP-dependent activity 1 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 150 154 PF00656 0.511
CLV_C14_Caspase3-7 368 372 PF00656 0.513
CLV_NRD_NRD_1 156 158 PF00675 0.482
CLV_NRD_NRD_1 170 172 PF00675 0.515
CLV_NRD_NRD_1 229 231 PF00675 0.417
CLV_NRD_NRD_1 251 253 PF00675 0.628
CLV_NRD_NRD_1 433 435 PF00675 0.579
CLV_NRD_NRD_1 478 480 PF00675 0.449
CLV_NRD_NRD_1 662 664 PF00675 0.523
CLV_NRD_NRD_1 781 783 PF00675 0.689
CLV_PCSK_FUR_1 229 233 PF00082 0.515
CLV_PCSK_KEX2_1 156 158 PF00082 0.483
CLV_PCSK_KEX2_1 229 231 PF00082 0.489
CLV_PCSK_KEX2_1 249 251 PF00082 0.662
CLV_PCSK_KEX2_1 366 368 PF00082 0.489
CLV_PCSK_KEX2_1 478 480 PF00082 0.451
CLV_PCSK_KEX2_1 505 507 PF00082 0.601
CLV_PCSK_KEX2_1 781 783 PF00082 0.759
CLV_PCSK_PC1ET2_1 231 233 PF00082 0.457
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.712
CLV_PCSK_PC1ET2_1 366 368 PF00082 0.519
CLV_PCSK_PC1ET2_1 505 507 PF00082 0.609
CLV_PCSK_SKI1_1 106 110 PF00082 0.539
CLV_PCSK_SKI1_1 121 125 PF00082 0.400
CLV_PCSK_SKI1_1 315 319 PF00082 0.552
CLV_PCSK_SKI1_1 498 502 PF00082 0.540
CLV_PCSK_SKI1_1 635 639 PF00082 0.539
CLV_PCSK_SKI1_1 663 667 PF00082 0.671
CLV_Separin_Metazoa 410 414 PF03568 0.364
DEG_APCC_DBOX_1 155 163 PF00400 0.529
DEG_APCC_DBOX_1 314 322 PF00400 0.541
DOC_CDC14_PxL_1 666 674 PF14671 0.607
DOC_CYCLIN_yCln2_LP_2 547 553 PF00134 0.448
DOC_MAPK_gen_1 156 164 PF00069 0.572
DOC_MAPK_gen_1 229 236 PF00069 0.452
DOC_MAPK_gen_1 495 504 PF00069 0.516
DOC_MAPK_gen_1 663 669 PF00069 0.563
DOC_MAPK_MEF2A_6 319 328 PF00069 0.557
DOC_MAPK_MEF2A_6 495 504 PF00069 0.575
DOC_PP1_RVXF_1 212 219 PF00149 0.491
DOC_PP1_RVXF_1 597 603 PF00149 0.489
DOC_PP2B_LxvP_1 547 550 PF13499 0.377
DOC_PP4_FxxP_1 623 626 PF00568 0.445
DOC_USP7_MATH_1 114 118 PF00917 0.593
DOC_USP7_MATH_1 20 24 PF00917 0.644
DOC_USP7_MATH_1 267 271 PF00917 0.605
DOC_USP7_MATH_1 415 419 PF00917 0.450
DOC_USP7_MATH_1 772 776 PF00917 0.782
DOC_USP7_UBL2_3 599 603 PF12436 0.483
DOC_USP7_UBL2_3 93 97 PF12436 0.384
DOC_WW_Pin1_4 18 23 PF00397 0.687
DOC_WW_Pin1_4 220 225 PF00397 0.456
DOC_WW_Pin1_4 256 261 PF00397 0.728
DOC_WW_Pin1_4 43 48 PF00397 0.587
DOC_WW_Pin1_4 603 608 PF00397 0.503
LIG_14-3-3_CanoR_1 214 219 PF00244 0.459
LIG_14-3-3_CanoR_1 325 331 PF00244 0.543
LIG_14-3-3_CanoR_1 453 459 PF00244 0.556
LIG_14-3-3_CanoR_1 479 485 PF00244 0.541
LIG_Actin_WH2_2 145 162 PF00022 0.522
LIG_APCC_ABBA_1 189 194 PF00400 0.495
LIG_APCC_ABBA_1 593 598 PF00400 0.488
LIG_BIR_II_1 1 5 PF00653 0.720
LIG_BIR_III_2 356 360 PF00653 0.599
LIG_BIR_III_4 397 401 PF00653 0.533
LIG_CtBP_PxDLS_1 224 228 PF00389 0.529
LIG_FHA_1 122 128 PF00498 0.541
LIG_FHA_1 144 150 PF00498 0.552
LIG_FHA_1 358 364 PF00498 0.485
LIG_FHA_1 499 505 PF00498 0.539
LIG_FHA_1 603 609 PF00498 0.469
LIG_FHA_1 62 68 PF00498 0.556
LIG_FHA_2 195 201 PF00498 0.504
LIG_FHA_2 405 411 PF00498 0.403
LIG_FHA_2 457 463 PF00498 0.466
LIG_FHA_2 645 651 PF00498 0.654
LIG_LIR_Apic_2 620 626 PF02991 0.434
LIG_LIR_Gen_1 166 175 PF02991 0.555
LIG_LIR_Gen_1 3 14 PF02991 0.670
LIG_LIR_Gen_1 329 338 PF02991 0.396
LIG_LIR_Gen_1 399 409 PF02991 0.499
LIG_LIR_Gen_1 508 518 PF02991 0.439
LIG_LIR_Gen_1 519 529 PF02991 0.479
LIG_LIR_Gen_1 674 684 PF02991 0.714
LIG_LIR_LC3C_4 261 266 PF02991 0.583
LIG_LIR_Nem_3 166 170 PF02991 0.456
LIG_LIR_Nem_3 197 202 PF02991 0.569
LIG_LIR_Nem_3 3 9 PF02991 0.574
LIG_LIR_Nem_3 329 333 PF02991 0.439
LIG_LIR_Nem_3 38 42 PF02991 0.383
LIG_LIR_Nem_3 399 404 PF02991 0.499
LIG_LIR_Nem_3 508 514 PF02991 0.429
LIG_LIR_Nem_3 519 525 PF02991 0.384
LIG_LIR_Nem_3 674 679 PF02991 0.688
LIG_NRBOX 468 474 PF00104 0.514
LIG_PTB_Apo_2 302 309 PF02174 0.545
LIG_PTB_Apo_2 584 591 PF02174 0.311
LIG_SH2_CRK 511 515 PF00017 0.509
LIG_SH2_GRB2like 641 644 PF00017 0.618
LIG_SH2_NCK_1 597 601 PF00017 0.442
LIG_SH2_NCK_1 676 680 PF00017 0.646
LIG_SH2_PTP2 401 404 PF00017 0.485
LIG_SH2_SRC 192 195 PF00017 0.530
LIG_SH2_SRC 676 679 PF00017 0.662
LIG_SH2_STAP1 192 196 PF00017 0.527
LIG_SH2_STAP1 676 680 PF00017 0.516
LIG_SH2_STAT5 401 404 PF00017 0.452
LIG_SH2_STAT5 511 514 PF00017 0.471
LIG_SH2_STAT5 553 556 PF00017 0.515
LIG_SH3_3 257 263 PF00018 0.660
LIG_SH3_3 348 354 PF00018 0.640
LIG_SH3_3 678 684 PF00018 0.687
LIG_SH3_3 766 772 PF00018 0.717
LIG_SH3_3 777 783 PF00018 0.764
LIG_SUMO_SIM_anti_2 186 191 PF11976 0.468
LIG_SUMO_SIM_anti_2 273 280 PF11976 0.472
LIG_SUMO_SIM_anti_2 407 414 PF11976 0.357
LIG_SUMO_SIM_par_1 145 150 PF11976 0.391
LIG_SUMO_SIM_par_1 186 195 PF11976 0.359
LIG_SUMO_SIM_par_1 552 558 PF11976 0.517
LIG_SUMO_SIM_par_1 57 64 PF11976 0.474
LIG_TRAF2_1 459 462 PF00917 0.552
LIG_UBA3_1 335 339 PF00899 0.538
LIG_UBA3_1 342 350 PF00899 0.619
MOD_CDC14_SPxK_1 46 49 PF00782 0.599
MOD_CDK_SPxK_1 43 49 PF00069 0.585
MOD_CK1_1 2 8 PF00069 0.739
MOD_CK1_1 270 276 PF00069 0.538
MOD_CK1_1 294 300 PF00069 0.448
MOD_CK1_1 794 800 PF00069 0.756
MOD_CK2_1 114 120 PF00069 0.560
MOD_CK2_1 194 200 PF00069 0.505
MOD_CK2_1 2 8 PF00069 0.630
MOD_CK2_1 289 295 PF00069 0.514
MOD_CK2_1 326 332 PF00069 0.521
MOD_CK2_1 404 410 PF00069 0.445
MOD_CK2_1 456 462 PF00069 0.516
MOD_CK2_1 524 530 PF00069 0.538
MOD_CK2_1 644 650 PF00069 0.649
MOD_DYRK1A_RPxSP_1 256 260 PF00069 0.641
MOD_GlcNHglycan 116 119 PF01048 0.574
MOD_GlcNHglycan 176 179 PF01048 0.532
MOD_GlcNHglycan 23 26 PF01048 0.654
MOD_GlcNHglycan 252 255 PF01048 0.730
MOD_GlcNHglycan 417 420 PF01048 0.436
MOD_GlcNHglycan 518 521 PF01048 0.426
MOD_GlcNHglycan 572 575 PF01048 0.536
MOD_GlcNHglycan 590 593 PF01048 0.441
MOD_GlcNHglycan 629 632 PF01048 0.620
MOD_GlcNHglycan 696 699 PF01048 0.634
MOD_GlcNHglycan 716 722 PF01048 0.734
MOD_GlcNHglycan 742 745 PF01048 0.731
MOD_GlcNHglycan 774 777 PF01048 0.797
MOD_GSK3_1 14 21 PF00069 0.613
MOD_GSK3_1 170 177 PF00069 0.561
MOD_GSK3_1 214 221 PF00069 0.501
MOD_GSK3_1 250 257 PF00069 0.667
MOD_GSK3_1 267 274 PF00069 0.553
MOD_GSK3_1 566 573 PF00069 0.500
MOD_GSK3_1 598 605 PF00069 0.412
MOD_GSK3_1 700 707 PF00069 0.667
MOD_GSK3_1 717 724 PF00069 0.657
MOD_GSK3_1 740 747 PF00069 0.730
MOD_GSK3_1 750 757 PF00069 0.644
MOD_GSK3_1 785 792 PF00069 0.691
MOD_GSK3_1 793 800 PF00069 0.655
MOD_N-GLC_1 271 276 PF02516 0.553
MOD_N-GLC_1 608 613 PF02516 0.515
MOD_N-GLC_1 75 80 PF02516 0.646
MOD_N-GLC_1 754 759 PF02516 0.765
MOD_N-GLC_2 305 307 PF02516 0.549
MOD_N-GLC_2 587 589 PF02516 0.329
MOD_NEK2_1 170 175 PF00069 0.554
MOD_NEK2_1 225 230 PF00069 0.485
MOD_NEK2_1 279 284 PF00069 0.408
MOD_NEK2_1 509 514 PF00069 0.473
MOD_NEK2_1 602 607 PF00069 0.495
MOD_NEK2_1 608 613 PF00069 0.482
MOD_NEK2_1 705 710 PF00069 0.727
MOD_NEK2_1 730 735 PF00069 0.736
MOD_NEK2_1 740 745 PF00069 0.782
MOD_NEK2_2 359 364 PF00069 0.558
MOD_PIKK_1 121 127 PF00454 0.527
MOD_PIKK_1 404 410 PF00454 0.534
MOD_PIKK_1 608 614 PF00454 0.497
MOD_PIKK_1 721 727 PF00454 0.796
MOD_PIKK_1 78 84 PF00454 0.716
MOD_PKA_1 250 256 PF00069 0.661
MOD_PKA_2 170 176 PF00069 0.530
MOD_PKA_2 250 256 PF00069 0.653
MOD_PKA_2 516 522 PF00069 0.528
MOD_PKB_1 256 264 PF00069 0.686
MOD_Plk_1 131 137 PF00069 0.529
MOD_Plk_1 165 171 PF00069 0.461
MOD_Plk_1 192 198 PF00069 0.579
MOD_Plk_1 2 8 PF00069 0.647
MOD_Plk_1 279 285 PF00069 0.402
MOD_Plk_1 498 504 PF00069 0.543
MOD_Plk_1 541 547 PF00069 0.499
MOD_Plk_1 566 572 PF00069 0.466
MOD_Plk_1 75 81 PF00069 0.630
MOD_Plk_1 797 803 PF00069 0.764
MOD_Plk_2-3 650 656 PF00069 0.655
MOD_Plk_4 359 365 PF00069 0.532
MOD_Plk_4 521 527 PF00069 0.486
MOD_Plk_4 542 548 PF00069 0.510
MOD_Plk_4 549 555 PF00069 0.487
MOD_Plk_4 560 566 PF00069 0.359
MOD_Plk_4 700 706 PF00069 0.730
MOD_ProDKin_1 18 24 PF00069 0.686
MOD_ProDKin_1 220 226 PF00069 0.458
MOD_ProDKin_1 256 262 PF00069 0.722
MOD_ProDKin_1 43 49 PF00069 0.588
MOD_ProDKin_1 603 609 PF00069 0.502
MOD_SUMO_rev_2 332 341 PF00179 0.444
MOD_SUMO_rev_2 46 54 PF00179 0.521
MOD_SUMO_rev_2 649 658 PF00179 0.541
TRG_DiLeu_BaEn_1 313 318 PF01217 0.451
TRG_DiLeu_BaEn_1 427 432 PF01217 0.510
TRG_DiLeu_BaEn_4 461 467 PF01217 0.454
TRG_DiLeu_BaLyEn_6 123 128 PF01217 0.488
TRG_ENDOCYTIC_2 401 404 PF00928 0.485
TRG_ENDOCYTIC_2 511 514 PF00928 0.435
TRG_ENDOCYTIC_2 532 535 PF00928 0.518
TRG_ENDOCYTIC_2 597 600 PF00928 0.391
TRG_ENDOCYTIC_2 676 679 PF00928 0.637
TRG_ER_diArg_1 229 232 PF00400 0.496
TRG_ER_diArg_1 250 252 PF00400 0.668
TRG_ER_diArg_1 445 448 PF00400 0.476
TRG_ER_diArg_1 780 782 PF00400 0.741
TRG_NES_CRM1_1 179 194 PF08389 0.400
TRG_NLS_Bipartite_1 230 252 PF00514 0.568
TRG_NLS_MonoCore_2 247 252 PF00514 0.716
TRG_NLS_MonoExtC_3 247 252 PF00514 0.726
TRG_NLS_MonoExtN_4 229 234 PF00514 0.411
TRG_NLS_MonoExtN_4 246 253 PF00514 0.737
TRG_Pf-PMV_PEXEL_1 157 161 PF00026 0.476
TRG_Pf-PMV_PEXEL_1 214 219 PF00026 0.541
TRG_Pf-PMV_PEXEL_1 315 320 PF00026 0.471

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHD7 Leptomonas seymouri 71% 97%
A0A1X0P7D5 Trypanosomatidae 20% 76%
A0A1X0P8A9 Trypanosomatidae 37% 96%
A0A3S7X009 Leishmania donovani 100% 100%
A0A422N0G0 Trypanosoma rangeli 34% 100%
A0A422NQU4 Trypanosoma rangeli 22% 98%
A4HF40 Leishmania braziliensis 69% 100%
C9ZX89 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZX90 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AYH6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q8Z6 Leishmania major 87% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS