RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2B6_LEIIN

TriTrypDb:

LINF_260023600

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2B6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.652
CLV_C14_Caspase3-7	482	486	PF00656	0.608
CLV_NRD_NRD_1	124	126	PF00675	0.728
CLV_NRD_NRD_1	153	155	PF00675	0.621
CLV_NRD_NRD_1	23	25	PF00675	0.531
CLV_NRD_NRD_1	500	502	PF00675	0.601
CLV_NRD_NRD_1	51	53	PF00675	0.654
CLV_NRD_NRD_1	551	553	PF00675	0.682
CLV_NRD_NRD_1	572	574	PF00675	0.704
CLV_NRD_NRD_1	63	65	PF00675	0.678
CLV_PCSK_FUR_1	549	553	PF00082	0.629
CLV_PCSK_FUR_1	570	574	PF00082	0.602
CLV_PCSK_KEX2_1	124	126	PF00082	0.728
CLV_PCSK_KEX2_1	153	155	PF00082	0.621
CLV_PCSK_KEX2_1	25	27	PF00082	0.527
CLV_PCSK_KEX2_1	500	502	PF00082	0.601
CLV_PCSK_KEX2_1	51	53	PF00082	0.654
CLV_PCSK_KEX2_1	551	553	PF00082	0.686
CLV_PCSK_KEX2_1	572	574	PF00082	0.649
CLV_PCSK_KEX2_1	63	65	PF00082	0.678
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.476
DEG_SCF_FBW7_2	224	229	PF00400	0.644
DEG_SPOP_SBC_1	113	117	PF00917	0.714
DEG_SPOP_SBC_1	208	212	PF00917	0.633
DEG_SPOP_SBC_1	521	525	PF00917	0.637
DOC_ANK_TNKS_1	332	339	PF00023	0.668
DOC_CKS1_1	427	432	PF01111	0.720
DOC_CYCLIN_RxL_1	333	347	PF00134	0.622
DOC_PP2B_LxvP_1	300	303	PF13499	0.719
DOC_PP4_FxxP_1	518	521	PF00568	0.780
DOC_USP7_MATH_1	114	118	PF00917	0.709
DOC_USP7_MATH_1	165	169	PF00917	0.578
DOC_USP7_MATH_1	2	6	PF00917	0.652
DOC_USP7_MATH_1	208	212	PF00917	0.697
DOC_USP7_MATH_1	37	41	PF00917	0.629
DOC_USP7_MATH_1	444	448	PF00917	0.727
DOC_USP7_MATH_1	474	478	PF00917	0.729
DOC_USP7_MATH_1	522	526	PF00917	0.653
DOC_USP7_MATH_1	72	76	PF00917	0.706
DOC_USP7_UBL2_3	25	29	PF12436	0.477
DOC_WW_Pin1_4	100	105	PF00397	0.742
DOC_WW_Pin1_4	204	209	PF00397	0.735
DOC_WW_Pin1_4	222	227	PF00397	0.600
DOC_WW_Pin1_4	288	293	PF00397	0.719
DOC_WW_Pin1_4	304	309	PF00397	0.534
DOC_WW_Pin1_4	353	358	PF00397	0.780
DOC_WW_Pin1_4	423	428	PF00397	0.707
DOC_WW_Pin1_4	454	459	PF00397	0.622
DOC_WW_Pin1_4	467	472	PF00397	0.556
DOC_WW_Pin1_4	511	516	PF00397	0.646
LIG_14-3-3_CanoR_1	176	182	PF00244	0.578
LIG_14-3-3_CanoR_1	393	401	PF00244	0.661
LIG_14-3-3_CanoR_1	404	413	PF00244	0.624
LIG_14-3-3_CanoR_1	460	469	PF00244	0.640
LIG_14-3-3_CanoR_1	489	499	PF00244	0.596
LIG_14-3-3_CanoR_1	551	561	PF00244	0.598
LIG_14-3-3_CanoR_1	97	102	PF00244	0.612
LIG_Actin_RPEL_3	316	335	PF02755	0.558
LIG_Actin_WH2_2	254	270	PF00022	0.582
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_BRCT_BRCA1_1	306	310	PF00533	0.623
LIG_BRCT_BRCA1_1	513	517	PF00533	0.671
LIG_CSL_BTD_1	300	303	PF09270	0.719
LIG_deltaCOP1_diTrp_1	32	36	PF00928	0.587
LIG_FHA_1	142	148	PF00498	0.583
LIG_FHA_1	161	167	PF00498	0.634
LIG_FHA_1	192	198	PF00498	0.650
LIG_FHA_1	208	214	PF00498	0.511
LIG_FHA_1	242	248	PF00498	0.660
LIG_FHA_1	285	291	PF00498	0.672
LIG_FHA_1	97	103	PF00498	0.691
LIG_FHA_2	354	360	PF00498	0.623
LIG_HOMEOBOX	432	435	PF00046	0.684
LIG_LIR_Nem_3	11	16	PF02991	0.602
LIG_LIR_Nem_3	311	316	PF02991	0.714
LIG_LIR_Nem_3	514	520	PF02991	0.726
LIG_SH2_CRK	13	17	PF00017	0.595
LIG_SH2_CRK	327	331	PF00017	0.633
LIG_SH2_NCK_1	13	17	PF00017	0.595
LIG_SH2_STAP1	492	496	PF00017	0.700
LIG_SH2_STAT3	492	495	PF00017	0.705
LIG_SH2_STAT3	506	509	PF00017	0.627
LIG_SH2_STAT5	251	254	PF00017	0.620
LIG_SH2_STAT5	48	51	PF00017	0.790
LIG_SH3_1	424	430	PF00018	0.718
LIG_SH3_3	108	114	PF00018	0.660
LIG_SH3_3	171	177	PF00018	0.723
LIG_SH3_3	210	216	PF00018	0.664
LIG_SH3_3	278	284	PF00018	0.701
LIG_SH3_3	331	337	PF00018	0.664
LIG_SH3_3	354	360	PF00018	0.654
LIG_SH3_3	424	430	PF00018	0.725
LIG_SH3_3	505	511	PF00018	0.700
LIG_SH3_3	78	84	PF00018	0.818
LIG_SH3_3	98	104	PF00018	0.538
LIG_SUMO_SIM_par_1	286	291	PF11976	0.589
LIG_TRAF2_1	356	359	PF00917	0.579
LIG_TRAF2_1	4	7	PF00917	0.642
LIG_TRFH_1	518	522	PF08558	0.586
LIG_WRC_WIRS_1	166	171	PF05994	0.553
LIG_WRC_WIRS_1	178	183	PF05994	0.516
LIG_WW_3	497	501	PF00397	0.663
LIG_WW_3	559	563	PF00397	0.670
MOD_CDC14_SPxK_1	457	460	PF00782	0.575
MOD_CDK_SPxK_1	308	314	PF00069	0.593
MOD_CDK_SPxK_1	454	460	PF00069	0.578
MOD_CK1_1	105	111	PF00069	0.695
MOD_CK1_1	115	121	PF00069	0.591
MOD_CK1_1	207	213	PF00069	0.701
MOD_CK1_1	241	247	PF00069	0.568
MOD_CK1_1	35	41	PF00069	0.682
MOD_CK1_1	388	394	PF00069	0.572
MOD_CK1_1	395	401	PF00069	0.633
MOD_CK1_1	426	432	PF00069	0.683
MOD_CK1_1	525	531	PF00069	0.732
MOD_CK2_1	1	7	PF00069	0.666
MOD_CK2_1	353	359	PF00069	0.626
MOD_CMANNOS	33	36	PF00535	0.549
MOD_GlcNHglycan	169	172	PF01048	0.707
MOD_GlcNHglycan	182	185	PF01048	0.610
MOD_GlcNHglycan	252	255	PF01048	0.719
MOD_GlcNHglycan	365	368	PF01048	0.662
MOD_GlcNHglycan	397	400	PF01048	0.658
MOD_GlcNHglycan	446	449	PF01048	0.764
MOD_GlcNHglycan	492	495	PF01048	0.729
MOD_GlcNHglycan	527	530	PF01048	0.686
MOD_GlcNHglycan	93	96	PF01048	0.681
MOD_GSK3_1	102	109	PF00069	0.647
MOD_GSK3_1	115	122	PF00069	0.652
MOD_GSK3_1	153	160	PF00069	0.665
MOD_GSK3_1	204	211	PF00069	0.752
MOD_GSK3_1	284	291	PF00069	0.677
MOD_GSK3_1	304	311	PF00069	0.609
MOD_GSK3_1	32	39	PF00069	0.741
MOD_GSK3_1	358	365	PF00069	0.728
MOD_GSK3_1	385	392	PF00069	0.611
MOD_GSK3_1	400	407	PF00069	0.717
MOD_GSK3_1	422	429	PF00069	0.604
MOD_GSK3_1	521	528	PF00069	0.677
MOD_GSK3_1	93	100	PF00069	0.734
MOD_N-GLC_1	105	110	PF02516	0.667
MOD_N-GLC_1	42	47	PF02516	0.650
MOD_N-GLC_1	564	569	PF02516	0.642
MOD_NEK2_1	209	214	PF00069	0.585
MOD_NEK2_1	345	350	PF00069	0.782
MOD_NEK2_1	416	421	PF00069	0.731
MOD_NEK2_1	475	480	PF00069	0.778
MOD_NEK2_2	148	153	PF00069	0.688
MOD_PIKK_1	236	242	PF00454	0.669
MOD_PIKK_1	416	422	PF00454	0.594
MOD_PIKK_1	53	59	PF00454	0.740
MOD_PKA_1	153	159	PF00069	0.612
MOD_PKA_2	153	159	PF00069	0.757
MOD_PKA_2	392	398	PF00069	0.666
MOD_PKA_2	545	551	PF00069	0.809
MOD_PKA_2	578	584	PF00069	0.613
MOD_PKA_2	96	102	PF00069	0.610
MOD_Plk_1	72	78	PF00069	0.697
MOD_Plk_4	270	276	PF00069	0.643
MOD_Plk_4	358	364	PF00069	0.711
MOD_Plk_4	522	528	PF00069	0.627
MOD_Plk_4	97	103	PF00069	0.678
MOD_ProDKin_1	100	106	PF00069	0.743
MOD_ProDKin_1	204	210	PF00069	0.735
MOD_ProDKin_1	222	228	PF00069	0.599
MOD_ProDKin_1	288	294	PF00069	0.716
MOD_ProDKin_1	304	310	PF00069	0.535
MOD_ProDKin_1	353	359	PF00069	0.780
MOD_ProDKin_1	423	429	PF00069	0.708
MOD_ProDKin_1	454	460	PF00069	0.620
MOD_ProDKin_1	467	473	PF00069	0.558
MOD_ProDKin_1	511	517	PF00069	0.649
TRG_DiLeu_BaEn_1	359	364	PF01217	0.578
TRG_ENDOCYTIC_2	13	16	PF00928	0.600
TRG_ER_diArg_1	152	154	PF00400	0.628
TRG_ER_diArg_1	24	27	PF00400	0.532
TRG_ER_diArg_1	349	352	PF00400	0.637
TRG_ER_diArg_1	487	490	PF00400	0.591
TRG_ER_diArg_1	499	501	PF00400	0.552
TRG_ER_diArg_1	549	552	PF00400	0.726
TRG_ER_diArg_1	570	573	PF00400	0.606
TRG_ER_diArg_1	63	65	PF00400	0.714
TRG_ER_diArg_1	68	71	PF00400	0.687
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7G5	Leishmania donovani	100%	67%
E9AIS3	Leishmania braziliensis	58%	100%
E9AYG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q909	Leishmania major	85%	100%